Current Environment: Production

Shannon Manzi | Education

Undergraduate School

University of Rhode Island

1996, Kingston, RI

Shannon Manzi | Professional History

I am a clinical pharmacist and have practiced pediatric pharmacy for more than 20 years, currently serving as the Director of the Clinical Pharmacogenomics Service and the Manager for ED and ICU Pharmacy Services.

Dr. Manzi serves as an expert for the Pharmacy program for Boston Children's Hospital Precision Medicine Service. For more information about the Precision Medicine Service please visit bostonchildrens.org/precisionmed.

Shannon Manzi | Publications

  1. Comparison of 2-Bag Method With Serial Bag Method for Treatment of Pediatric Diabetic Ketoacidosis. Dimens Crit Care Nurs. 2025 Mar-Apr 01; 44(2):85-90. View Comparison of 2-Bag Method With Serial Bag Method for Treatment of Pediatric Diabetic Ketoacidosis. Abstract

  2. Recommendations for the Management of Initial and Refractory Pediatric Status Dystonicus. Mov Disord. 2024 Sep; 39(9):1435-1445. View Recommendations for the Management of Initial and Refractory Pediatric Status Dystonicus. Abstract

  3. A Life Less Ordinary. J Pediatr Pharmacol Ther. 2023; 28(6):480-489. View A Life Less Ordinary. Abstract

  4. Dispensing Medications at the Hospital Upon Discharge From an Emergency Department. Pediatrics. 2023 06 01; 151(6). View Dispensing Medications at the Hospital Upon Discharge From an Emergency Department. Abstract

  5. Experience of pharmacy involvement in a disaster simulation exercise within a pediatric hospital emergency department: A pilot project. Am J Health Syst Pharm. 2022 04 19; 79(9):e124-e134. View Experience of pharmacy involvement in a disaster simulation exercise within a pediatric hospital emergency department: A pilot project. Abstract

  6. Fluvoxamine for the treatment of COVID-19. Lancet Glob Health. 2022 03; 10(3):e330. View Fluvoxamine for the treatment of COVID-19. Abstract

  7. Weaning Dexmedetomidine in Non-ICU Areas: An Implementation Effort. Pediatr Crit Care Med. 2022 05 01; 23(5):353-360. View Weaning Dexmedetomidine in Non-ICU Areas: An Implementation Effort. Abstract

  8. Patients dispensed medications with actionable pharmacogenomic biomarkers: rates and characteristics. Genet Med. 2021 04; 23(4):782-786. View Patients dispensed medications with actionable pharmacogenomic biomarkers: rates and characteristics. Abstract

  9. Adverse drug event presentation and tracking (ADEPT): semiautomated, high throughput pharmacovigilance using real-world data. JAMIA Open. 2020 Oct; 3(3):413-421. View Adverse drug event presentation and tracking (ADEPT): semiautomated, high throughput pharmacovigilance using real-world data. Abstract

  10. Benzalkonium Chloride in Albuterol Solutions: Time for a Change? Pediatrics. 2020 04; 145(4). View Benzalkonium Chloride in Albuterol Solutions: Time for a Change? Abstract

  11. Off-label use of prescription analgesics among hospitalized children in the United States. Pharmacoepidemiol Drug Saf. 2020 04; 29(4):474-481. View Off-label use of prescription analgesics among hospitalized children in the United States. Abstract

  12. Adverse drug event rates in pediatric pulmonary hypertension: a comparison of real-world data sources. J Am Med Inform Assoc. 2020 02 01; 27(2):294-300. View Adverse drug event rates in pediatric pulmonary hypertension: a comparison of real-world data sources. Abstract

  13. Recurrent SLC1A2 variants cause epilepsy via a dominant negative mechanism. Ann Neurol. 2019 06; 85(6):921-926. View Recurrent SLC1A2 variants cause epilepsy via a dominant negative mechanism. Abstract

  14. Whole-Exome Sequencing Enables a Precision Medicine Approach for Kidney Transplant Recipients. J Am Soc Nephrol. 2019 02; 30(2):201-215. View Whole-Exome Sequencing Enables a Precision Medicine Approach for Kidney Transplant Recipients. Abstract

  15. Pharmacist Outpatient Prescription Review in the Emergency Department: A Pediatric Tertiary Hospital Experience. Pediatr Emerg Care. 2018 Jul; 34(7):497-500. View Pharmacist Outpatient Prescription Review in the Emergency Department: A Pediatric Tertiary Hospital Experience. Abstract

  16. HLA-A*31:01 and Oxcarbazepine-Induced DRESS in a Patient With Seizures and Complete DCX Deletion. Pediatrics. 2018 04; 141(Suppl 5):S434-S438. View HLA-A*31:01 and Oxcarbazepine-Induced DRESS in a Patient With Seizures and Complete DCX Deletion. Abstract

  17. Initial Pain Management in Pediatric Acute Pancreatitis: Opioid Versus Non-opioid. J Pediatr Gastroenterol Nutr. 2018 02; 66(2):295-298. View Initial Pain Management in Pediatric Acute Pancreatitis: Opioid Versus Non-opioid. Abstract

  18. Practical considerations for implementing genomic information resources. Experiences from eMERGE and CSER. Appl Clin Inform. 2016 09 21; 7(3):870-82. View Practical considerations for implementing genomic information resources. Experiences from eMERGE and CSER. Abstract

  19. Creating a scalable clinical pharmacogenomics service with automated interpretation and medical record result integration - experience from a pediatric tertiary care facility. J Am Med Inform Assoc. 2017 01; 24(1):74-80. View Creating a scalable clinical pharmacogenomics service with automated interpretation and medical record result integration - experience from a pediatric tertiary care facility. Abstract

  20. Lacerations and Embedded Needles Caused by Epinephrine Autoinjector Use in Children. Ann Emerg Med. 2016 Mar; 67(3):307-315.e8. View Lacerations and Embedded Needles Caused by Epinephrine Autoinjector Use in Children. Abstract

  21. Practical considerations in genomic decision support: The eMERGE experience. J Pathol Inform. 2015; 6:50. View Practical considerations in genomic decision support: The eMERGE experience. Abstract

  22. Electronic medication reconciliation and medication errors. Int J Qual Health Care. 2015 Aug; 27(4):314-9. View Electronic medication reconciliation and medication errors. Abstract

  23. 13-year-old girl with recurrent, episodic, persistent vomiting: out of the pot and into the fire. Pediatrics. 2015 Apr; 135(4):e1060-3. View 13-year-old girl with recurrent, episodic, persistent vomiting: out of the pot and into the fire. Abstract

  24. Utility of a dedicated pediatric cardiac anticoagulation program: the Boston Children's Hospital experience. Pediatr Cardiol. 2015 Apr; 36(4):842-50. View Utility of a dedicated pediatric cardiac anticoagulation program: the Boston Children's Hospital experience. Abstract

  25. Misinterpretation of TPMT by a DTC genetic testing company. Clin Pharmacol Ther. 2014 Jun; 95(6):598-600. View Misinterpretation of TPMT by a DTC genetic testing company. Abstract

  26. Pharmacointeraction network models predict unknown drug-drug interactions. PLoS One. 2013; 8(4):e61468. View Pharmacointeraction network models predict unknown drug-drug interactions. Abstract

  27. Development of a scalable pharmacogenomic clinical decision support service. AMIA Jt Summits Transl Sci Proc. 2013; 2013:60. View Development of a scalable pharmacogenomic clinical decision support service. Abstract

  28. Dispensing medications at the hospital upon discharge from an emergency department. Pediatrics. 2012 Feb; 129(2):e562. View Dispensing medications at the hospital upon discharge from an emergency department. Abstract

  29. Predicting adverse drug events using pharmacological network models. Sci Transl Med. 2011 Dec 21; 3(114):114ra127. View Predicting adverse drug events using pharmacological network models. Abstract

  30. Response to challenges and lessons learned from Hurricanes Katrina and Rita: a national perspective. Pediatrics. 2011 Aug; 128 Suppl 1:S31-3. View Response to challenges and lessons learned from Hurricanes Katrina and Rita: a national perspective. Abstract

  31. Patients providing the answers: narrowing the gap in data quality for emergency care. Qual Saf Health Care. 2010 Oct; 19(5):e34. View Patients providing the answers: narrowing the gap in data quality for emergency care. Abstract

  32. Getting the data right: information accuracy in pediatric emergency medicine. Qual Saf Health Care. 2006 Aug; 15(4):296-301. View Getting the data right: information accuracy in pediatric emergency medicine. Abstract

  33. FEMA's organized response with a pediatric subspecialty team: the National Disaster Medical System response: a pediatric perspective. Pediatrics. 2006 May; 117(5 Pt 3):S405-11. View FEMA's organized response with a pediatric subspecialty team: the National Disaster Medical System response: a pediatric perspective. Abstract

  34. Preprocedural fasting state and adverse events in children undergoing procedural sedation and analgesia in a pediatric emergency department. Ann Emerg Med. 2003 Nov; 42(5):636-46. View Preprocedural fasting state and adverse events in children undergoing procedural sedation and analgesia in a pediatric emergency department. Abstract

  35. Methylphenidate produces a false-positive urine amphetamine screen. Pediatr Emerg Care. 2002 Oct; 18(5):401. View Methylphenidate produces a false-positive urine amphetamine screen. Abstract

Patient safety is the ultimate driver behind everything we do, including making medication use safer in children by personalizing therapy and ensuring robust processes exist for medication preparation and delivery.

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