Current Environment: Production

Medical Services

Specialties

Programs & Services

Languages

  • English
  • French

Education

Undergraduate School

McGill University

Montreal, Quebec, Canada

Medical School

McGill University

Montreal, Quebec, Canada

Residency

Pediatrics

Boston City Hospital

Boston, MA

Fellowship

Neurology & Neonatal Neurology

Boston Children's Hospital

Boston, MA

Certifications

  • American Board of Psychiatry and Neurology (Child and Adolescent Neurology)

Professional History

Dr. Janet Soul is the Director of the Fetal-Neonatal Neurology Program where she and her team provide care to fetuses, newborns, and children whose neurologic disorders begin in utero or during the newborn period. This multidisciplinary clinical program also provides specialized training for neurology, neonatology and pediatric fellows, residents, and medical students.

Dr. Soul’s clinical research is focused on improving the management and outcome of neonatal seizures and brain injury, particularly hypoxic-ischemic brain injury. She led a randomized, double-blind, controlled trial of bumetanide to treat neonatal seizures (NCT00830531), the first neonatal seizure trial to employ a standard therapy control group. She co-chaired the Seizure Workgroup of the International Neonatal Consortium (Critical Path Institute) to develop consensus recommendations for design of neonatal seizure treatment trials. She has been funded by the NIH, March of Dimes, Hood Foundation, United Cerebral Palsy Foundation, and others, and has served on DSMBs for NIH-funded multicenter trials. Dr. Soul has held leadership roles in the major societies and committees; she serves on the Board of the Newborn Brain Society as the Chair of the QI & Research Committee and was elected to a 2-year term on the Executive Committee of the Child Neurology Society in 2021.

Publications

  1. Association of Two Neonatal Encephalopathy Scores with Neurophysiology in Newborns with Suspected Hypoxic Ischemic Encephalopathy. Neonatology. 2025 May 11; 1-16. View Abstract

  2. Updates in Neonatal Seizures. Clin Perinatol. 2025 Jun; 52(2):375-393. View Abstract

  3. Data Collection Variability Across Neonatal Hypoxic-Ischemic Encephalopathy Registries. J Pediatr. 2025 Apr; 279:114476. View Abstract

  4. Preferred Parental Language and Neurodevelopmental Outcomes Among Infants With Acute Provoked Neonatal Seizures in the United States. Pediatr Neurol. 2025 Mar; 164:115-121. View Abstract

  5. Neonatal Seizures and Associated Neurobehavioral Profiles in Preschool Age Children. Pediatr Neurol. 2025 Feb; 163:76-81. View Abstract

  6. Sleep Disorders Five Years After Acute Provoked Neonatal Seizures. J Pediatr. 2025 Mar; 278:114412. View Abstract

  7. Life After Neonatal Seizures: Characterizing the Longitudinal Parent Experience. Pediatr Neurol. 2024 Dec; 161:76-83. View Abstract

  8. Practice Variations for Therapeutic Hypothermia in Neonates with Hypoxic-ischemic Encephalopathy: An International Survey. J Pediatr. 2024 Nov; 274:114181. View Abstract

  9. Proceedings of the 15th International Newborn Brain Conference: Neonatal Neurocritical Care, seizures, and continuous aEEG and /or EEG monitoring. J Neonatal Perinatal Med. 2024; 17(3):S345-S392. View Abstract

  10. The importance of not increasing confusion around neonatal encephalopathy and hypoxic-ischemic encephalopathy. Pediatr Res. 2024 Mar; 95(4):871-872. View Abstract

  11. Neuroprotective therapies in the NICU in preterm infants: present and future (Neonatal Neurocritical Care Series). Pediatr Res. 2024 Apr; 95(5):1224-1236. View Abstract

  12. Establishing a regional registry for neonatal encephalopathy: impact on identification of gaps in practice. Pediatr Res. 2024 Jan; 95(1):213-222. View Abstract

  13. Association of cerebral metabolic rate following therapeutic hypothermia with 18-month neurodevelopmental outcomes after neonatal hypoxic ischemic encephalopathy. EBioMedicine. 2023 Aug; 94:104673. View Abstract

  14. Abnormal development of transient fetal zones in mild isolated fetal ventriculomegaly. Cereb Cortex. 2023 02 07; 33(4):1130-1139. View Abstract

  15. Effect of neonatal seizure burden and etiology on the long-term outcome: data from a randomized, controlled trial. Ann Child Neurol Soc. 2023 Mar; 1(1):53-65. View Abstract

  16. Feeding and developmental outcomes after neonatal seizures-A prospective observational study. Ann Child Neurol Soc. 2023 Sep; 1(3):209-217. View Abstract

  17. Neuroprotective therapies in the NICU in term infants: present and future. Pediatr Res. 2023 Jun; 93(7):1819-1827. View Abstract

  18. Seizure Burden, EEG, and Outcome in Neonates With Acute Intracranial Infections: A Prospective Multicenter Cohort Study. Pediatr Neurol. 2022 12; 137:54-61. View Abstract

  19. Continuous EEG monitoring still recommended for neonatal seizure management: commentary on NEST trial. Pediatr Res. 2023 02; 93(3):469-470. View Abstract

  20. Fetal Brain Volume Predicts Neurodevelopment in Congenital Heart Disease. Circulation. 2022 04 12; 145(15):1108-1119. View Abstract

  21. Impact of COVID-19 Pandemic on Developmental Service Delivery in Children With a History of Neonatal Seizures. Pediatr Neurol. 2022 04; 129:14-18. View Abstract

  22. Proceedings of the 13th International Newborn Brain Conference: Neonatal Neurocritical Care, Seizures, and Continuous EEG monitoring. J Neonatal Perinatal Med. 2022; 15(2):467-485. View Abstract

  23. Parent Mental Health and Family Coping over Two Years after the Birth of a Child with Acute Neonatal Seizures. Children (Basel). 2021 Dec 22; 9(1). View Abstract

  24. Seizure Severity and Treatment Response in Newborn Infants with Seizures Attributed to Intracranial Hemorrhage. J Pediatr. 2022 Mar; 242:121-128.e1. View Abstract

  25. Characteristics of Neonates with Cardiopulmonary Disease Who Experience Seizures: A Multicenter Study. J Pediatr. 2022 03; 242:63-73. View Abstract

  26. Treatment of Neonatal Seizures: Comparison of Treatment Pathways From 11 Neonatal Intensive Care Units. Pediatr Neurol. 2022 03; 128:67-74. View Abstract

  27. Training in neonatal neurocritical care: a proposal for a hybrid model of competence by design and time-based methods. Pediatr Res. 2024 Sep; 96(4):1013-1020. View Abstract

  28. Management of seizures in neonates with neonatal encephalopathy treated with hypothermia. Semin Fetal Neonatal Med. 2021 08; 26(4):101279. View Abstract

  29. Family-Centered Care for Children and Families Impacted by Neonatal Seizures: Advice From Parents. Pediatr Neurol. 2021 11; 124:26-32. View Abstract

  30. Early-life epilepsy after acute symptomatic neonatal seizures: A prospective multicenter study. Epilepsia. 2021 08; 62(8):1871-1882. View Abstract

  31. Safety of Early Discontinuation of Antiseizure Medication After Acute Symptomatic Neonatal Seizures. JAMA Neurol. 2021 07 01; 78(7):817-825. View Abstract

  32. Seizure Control in Neonates Undergoing Screening vs Confirmatory EEG Monitoring. Neurology. 2021 08 10; 97(6):e587-e596. View Abstract

  33. A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures. Ann Neurol. 2021 02; 89(2):327-340. View Abstract

  34. Fetal magnetic resonance imaging: supratentorial brain malformations. Pediatr Radiol. 2020 12; 50(13):1934-1947. View Abstract

  35. Regional Brain Growth Trajectories in Fetuses with Congenital Heart Disease. Ann Neurol. 2021 01; 89(1):143-157. View Abstract

  36. Predicting Autism Spectrum Disorder in Very Preterm Infants. Pediatrics. 2020 10; 146(4). View Abstract

  37. Characterization of Death in Infants With Neonatal Seizures. Pediatr Neurol. 2020 12; 113:21-25. View Abstract

  38. Parent experience of caring for neonates with seizures. Arch Dis Child Fetal Neonatal Ed. 2020 Nov; 105(6):634-639. View Abstract

  39. Associations between Infant and Parent Characteristics and Measures of Family Well-Being in Neonates with Seizures: A Cohort Study. J Pediatr. 2020 06; 221:64-71.e4. View Abstract

  40. Early exit from neonatal therapeutic hypothermia: A single institution experience using MRI to guide decision-making. J Neonatal Perinatal Med. 2020; 13(4):441-447. View Abstract

  41. Neonatal seizures: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine. 2019 12 10; 37(52):7596-7609. View Abstract

  42. Expanding the phenotypic spectrum of Mabry Syndrome with novel PIGO gene variants associated with hyperphosphatasia, intractable epilepsy, and complex gastrointestinal and urogenital malformations. Eur J Med Genet. 2020 Apr; 63(4):103802. View Abstract

  43. Abnormalities in cerebral hemodynamics and changes with surgical intervention in neonates with congenital heart disease. J Thorac Cardiovasc Surg. 2020 05; 159(5):2012-2021. View Abstract

  44. Seizure Prediction Models in the Neonatal Intensive Care Unit. J Clin Neurophysiol. 2019 May; 36(3):186-194. View Abstract

  45. Pharmacologic Prevention and Treatment of Neonatal Brain Injury. Clin Perinatol. 2019 06; 46(2):311-325. View Abstract

  46. Correction to: De novo and inherited TCF20 pathogenic variants are associated with intellectual disability, dysmorphic features, hypotonia, and neurological impairments with similarities to Smith-Magenis syndrome. Genome Med. 2019 03 25; 11(1):16. View Abstract

  47. De novo and inherited TCF20 pathogenic variants are associated with intellectual disability, dysmorphic features, hypotonia, and neurological impairments with similarities to Smith-Magenis syndrome. Genome Med. 2019 02 28; 11(1):12. View Abstract

  48. Response to antiseizure medications in neonates with acute symptomatic seizures. Epilepsia. 2019 03; 60(3):e20-e24. View Abstract

  49. Monitoring and management of brain hemodynamics and oxygenation. Handb Clin Neurol. 2019; 162:295-314. View Abstract

  50. Recommendations for the design of therapeutic trials for neonatal seizures. Pediatr Res. 2019 06; 85(7):943-954. View Abstract

  51. Advanced diffusion imaging for assessing normal white matter development in neonates and characterizing aberrant development in congenital heart disease. Neuroimage Clin. 2018; 19:360-373. View Abstract

  52. Congenital muscular dystrophy-dystroglycanopathy, type A, featuring bilateral retinal dysplasia and vertical angle kappa. J AAPOS. 2018 06; 22(3):242-244.e1. View Abstract

  53. Post-arrest therapeutic hypothermia in pediatric patients with congenital heart disease. Resuscitation. 2018 05; 126:83-89. View Abstract

  54. Acute symptomatic seizures in term neonates: Etiologies and treatments. Semin Fetal Neonatal Med. 2018 06; 23(3):183-190. View Abstract

  55. Probabilistic tractography-based thalamic parcellation in healthy newborns and newborns with congenital heart disease. J Magn Reson Imaging. 2018 06; 47(6):1626-1637. View Abstract

  56. Imaging features and prognostic factors in fetal and postnatal torcular dural sinus malformations, part II: synthesis of the literature and patient management. J Neurointerv Surg. 2018 May; 10(5):471-475. View Abstract

  57. Imaging features and prognostic factors in fetal and postnatal torcular dural sinus malformations, part I: review of experience at Boston Children's Hospital. J Neurointerv Surg. 2018 May; 10(5):467-470. View Abstract

  58. Liver Failure as the Presentation of Ornithine Transcarbamylase Deficiency in a 13-Month-Old Female. JIMD Rep. 2018; 40:17-22. View Abstract

  59. The use of phenobarbital and other anti-seizure drugs in newborns. Semin Fetal Neonatal Med. 2017 10; 22(5):321-327. View Abstract

  60. Profile of neonatal epilepsies: Characteristics of a prospective US cohort. Neurology. 2017 Aug 29; 89(9):893-899. View Abstract

  61. Seizures in Preterm Neonates: A Multicenter Observational Cohort Study. Pediatr Neurol. 2017 Jul; 72:19-24. View Abstract

  62. Electroencephalographic discontinuity during sevoflurane anesthesia in infants and children. Paediatr Anaesth. 2017 Mar; 27(3):251-262. View Abstract

  63. White Matter Volume Predicts Language Development in Congenital Heart Disease. J Pediatr. 2017 02; 181:42-48.e2. View Abstract

  64. Treatment Duration After Acute Symptomatic Seizures in Neonates: A Multicenter Cohort Study. J Pediatr. 2017 02; 181:298-301.e1. View Abstract

  65. Corrigendum to "GJC2 promoter mutations causing Pelizaeus-Merzbacher-like disease" [Mol. Genet. Metab. 111 (2014) 393-398]. Mol Genet Metab. 2016 11; 119(3):293. View Abstract

  66. Fellowship Training in the Emerging Fields of Fetal-Neonatal Neurology and Neonatal Neurocritical Care. Pediatr Neurol. 2016 10; 63:39-44.e3. View Abstract

  67. BRAT1 mutations present with a spectrum of clinical severity. Am J Med Genet A. 2016 09; 170(9):2265-73. View Abstract

  68. Contemporary Profile of Seizures in Neonates: A Prospective Cohort Study. J Pediatr. 2016 Jul; 174:98-103.e1. View Abstract

  69. Perioperative cerebral hemodynamics and oxygen metabolism in neonates with single-ventricle physiology. Biomed Opt Express. 2015 Dec 01; 6(12):4749-67. View Abstract

  70. Copy number variation plays an important role in clinical epilepsy. Ann Neurol. 2014 Jun; 75(6):943-58. View Abstract

  71. Cerebral blood flow velocity and neurodevelopmental outcome in infants undergoing surgery for congenital heart disease. Ann Thorac Surg. 2014 Jul; 98(1):125-32. View Abstract

  72. GJC2 promoter mutations causing Pelizaeus-Merzbacher-like disease. Mol Genet Metab. 2014 03; 111(3):393-398. View Abstract

  73. Cerebral oxygen metabolism in neonatal hypoxic ischemic encephalopathy during and after therapeutic hypothermia. J Cereb Blood Flow Metab. 2014 Jan; 34(1):87-94. View Abstract

  74. Near-infrared spectroscopy versus magnetic resonance imaging to study brain perfusion in newborns with hypoxic-ischemic encephalopathy treated with hypothermia. Neuroimage. 2014 Jan 15; 85 Pt 1:287-93. View Abstract

  75. Passive cooling during transport of asphyxiated term newborns. J Perinatol. 2013 Jun; 33(6):435-40. View Abstract

  76. Good outcome with early empiric treatment of neural larva migrans due to Baylisascaris procyonis. Pediatrics. 2012 Mar; 129(3):e806-11. View Abstract

  77. Brain perfusion in asphyxiated newborns treated with therapeutic hypothermia. AJNR Am J Neuroradiol. 2011 Dec; 32(11):2023-9. View Abstract

  78. Sensitive isotope dilution liquid chromatography/tandem mass spectrometry method for quantitative analysis of bumetanide in serum and brain tissue. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Apr 15; 879(13-14):998-1002. View Abstract

  79. Early versus late MRI in asphyxiated newborns treated with hypothermia. Arch Dis Child Fetal Neonatal Ed. 2011 Jan; 96(1):F36-44. View Abstract

  80. Relationship of intraoperative cerebral oxygen saturation to neurodevelopmental outcome and brain magnetic resonance imaging at 1 year of age in infants undergoing biventricular repair. Circulation. 2010 Jul 20; 122(3):245-54. View Abstract

  81. Neurodevelopmental outcome of fetuses referred for ventriculomegaly. Ultrasound Obstet Gynecol. 2010 Apr; 35(4):405-16. View Abstract

  82. Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance. Cell. 2010 Jan 08; 140(1):74-87. View Abstract

  83. Elevated cerebral pressure passivity is associated with prematurity-related intracranial hemorrhage. Pediatrics. 2009 Jul; 124(1):302-9. View Abstract

  84. Subtle hemorrhagic brain injury is associated with neurodevelopmental impairment in infants with repaired congenital heart disease. J Thorac Cardiovasc Surg. 2009 Aug; 138(2):374-81. View Abstract

  85. Cerebral hemodynamic changes during intensive care of preterm infants. Pediatrics. 2008 Nov; 122(5):e1006-13. View Abstract

  86. Microdeletion/duplication at 15q13.2q13.3 among individuals with features of autism and other neuropsychiatric disorders. J Med Genet. 2009 Apr; 46(4):242-8. View Abstract

  87. Positive screening for autism in ex-preterm infants: prevalence and risk factors. Pediatrics. 2008 Apr; 121(4):758-65. View Abstract

  88. Randomized trial of hematocrit 25% versus 35% during hypothermic cardiopulmonary bypass in infant heart surgery. J Thorac Cardiovasc Surg. 2008 Feb; 135(2):347-54, 354.e1-4. View Abstract

  89. Current definitions of hypotension do not predict abnormal cranial ultrasound findings in preterm infants. Pediatrics. 2007 Nov; 120(5):966-77. View Abstract

  90. Neurodevelopmental outcome in survivors of periventricular hemorrhagic infarction. Pediatrics. 2007 Oct; 120(4):785-92. View Abstract

  91. Does cerebellar injury in premature infants contribute to the high prevalence of long-term cognitive, learning, and behavioral disability in survivors? Pediatrics. 2007 Sep; 120(3):584-93. View Abstract

  92. Neonatal hypocalcemic seizures in siblings exposed to topiramate in utero. Pediatr Neurol. 2007 Apr; 36(4):274-6. View Abstract

  93. Fluctuating pressure-passivity is common in the cerebral circulation of sick premature infants. Pediatr Res. 2007 Apr; 61(4):467-73. View Abstract

  94. Patient with novel interstitial deletion of chromosome 3q13.1q13.3 and agenesis of the corpus callosum. Clin Dysmorphol. 2006 Oct; 15(4):217-220. View Abstract

  95. Characterizing the shape of anatomical structures with Poisson's equation. IEEE Trans Med Imaging. 2006 Oct; 25(10):1249-57. View Abstract

  96. Periventricular hemorrhagic infarction: risk factors and neonatal outcome. Pediatr Neurol. 2006 Aug; 35(2):85-92. View Abstract

  97. Ultrasonographic features and severity scoring of periventricular hemorrhagic infarction in relation to risk factors and outcome. Pediatrics. 2006 Jun; 117(6):2111-8. View Abstract

  98. The current etiologic profile and neurodevelopmental outcome of seizures in term newborn infants. Pediatrics. 2006 Apr; 117(4):1270-80. View Abstract

  99. Measurement of cortical thickness in 3D brain MRI data: validation of the Laplacian method. J Neuroimaging. 2006 Apr; 16(2):146-53. View Abstract

  100. Impaired trophic interactions between the cerebellum and the cerebrum among preterm infants. Pediatrics. 2005 Oct; 116(4):844-50. View Abstract

  101. Talairach-based parcellation of neonatal brain magnetic resonance imaging data: validation of a new approach. J Neuroimaging. 2005 Oct; 15(4):305-14. View Abstract

  102. Video and CD-ROM as a training tool for performing neurologic examinations of 1-year-old children in a multicenter epidemiologic study. J Child Neurol. 2005 Oct; 20(10):829-31. View Abstract

  103. Development of visual acuity in children with cerebral visual impairment. Arch Ophthalmol. 2005 Sep; 123(9):1215-20. View Abstract

  104. Late gestation cerebellar growth is rapid and impeded by premature birth. Pediatrics. 2005 Mar; 115(3):688-95. View Abstract

  105. In vivo visualization of white matter fiber tracts of preterm- and term-infant brains with diffusion tensor magnetic resonance imaging. Invest Radiol. 2005 Feb; 40(2):110-5. View Abstract

  106. Identification of pressure passive cerebral perfusion and its mediators after infant cardiac surgery. Pediatr Res. 2005 Jan; 57(1):35-41. View Abstract

  107. Hemodilution elevates cerebral blood flow and oxygen metabolism during cardiopulmonary bypass in piglets. Ann Thorac Surg. 2004 May; 77(5):1656-63; discussion 1663. View Abstract

  108. CSF removal in infantile posthemorrhagic hydrocephalus results in significant improvement in cerebral hemodynamics. Pediatr Res. 2004 May; 55(5):872-6. View Abstract

  109. An elliptic PDE approach for shape characterization. Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:1521-4. View Abstract

  110. Peroneal neuropathy from ankle-foot orthoses. Pediatr Neurol. 2003 Jul; 29(1):72-4. View Abstract

  111. Time course of changes in diffusion-weighted magnetic resonance imaging in a case of neonatal encephalopathy with defined onset and duration of hypoxic-ischemic insult. Pediatrics. 2001 Nov; 108(5):1211-4. View Abstract

  112. Cerebral infarction in Menkes' disease. Pediatr Neurol. 2000 Nov; 23(5):425-8. View Abstract

  113. Noninvasive detection of changes in cerebral blood flow by near-infrared spectroscopy in a piglet model of hydrocephalus. Pediatr Res. 2000 Oct; 48(4):445-9. View Abstract

  114. New technologies in pediatric neurology. Near-infrared spectroscopy. Semin Pediatr Neurol. 1999 Jun; 6(2):101-10. View Abstract

  115. Sonographic ventriculography: a new potential use for sonographic contrast agents in neonatal hydrocephalus. AJNR Am J Neuroradiol. 1998 Nov-Dec; 19(10):1931-4. View Abstract

  116. Vestibular-contingent voluntary saccades based on cognitive estimates of remembered vestibular information. Adv Otorhinolaryngol. 1988; 41:71-5. View Abstract
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