Thomas Martin

Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report. Am J Respir Cell Mol Biol. 2022 02; 66(2):e1-e14. View Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report. Abstract

Genetic variation of a bacterial pathogen within individuals with cystic fibrosis provides a record of selective pressures. Nat Genet. 2014 Jan; 46(1):82-7. View Genetic variation of a bacterial pathogen within individuals with cystic fibrosis provides a record of selective pressures. Abstract

Mechanisms of acute respiratory distress syndrome in children and adults: a review and suggestions for future research. Pediatr Crit Care Med. 2013 Jul; 14(6):631-43. View Mechanisms of acute respiratory distress syndrome in children and adults: a review and suggestions for future research. Abstract

The Fas/FasL pathway impairs the alveolar fluid clearance in mouse lungs. Am J Physiol Lung Cell Mol Physiol. 2013 Sep; 305(5):L377-88. View The Fas/FasL pathway impairs the alveolar fluid clearance in mouse lungs. Abstract

Phenazine content in the cystic fibrosis respiratory tract negatively correlates with lung function and microbial complexity. Am J Respir Cell Mol Biol. 2012 Dec; 47(6):738-45. View Phenazine content in the cystic fibrosis respiratory tract negatively correlates with lung function and microbial complexity. Abstract

Targeting pan-resistant bacteria with antibodies to a broadly conserved surface polysaccharide expressed during infection. J Infect Dis. 2012 Jun; 205(11):1709-18. View Targeting pan-resistant bacteria with antibodies to a broadly conserved surface polysaccharide expressed during infection. Abstract

Syndecan-4 regulates early neutrophil migration and pulmonary inflammation in response to lipopolysaccharide. Am J Respir Cell Mol Biol. 2012 Aug; 47(2):196-202. View Syndecan-4 regulates early neutrophil migration and pulmonary inflammation in response to lipopolysaccharide. Abstract

Th17 cytokines are critical for respiratory syncytial virus-associated airway hyperreponsiveness through regulation by complement C3a and tachykinins. J Immunol. 2011 Oct 15; 187(8):4245-55. View Th17 cytokines are critical for respiratory syncytial virus-associated airway hyperreponsiveness through regulation by complement C3a and tachykinins. Abstract

Role of the Fas/FasL system in a model of RSV infection in mechanically ventilated mice. Am J Physiol Lung Cell Mol Physiol. 2011 Oct; 301(4):L451-60. View Role of the Fas/FasL system in a model of RSV infection in mechanically ventilated mice. Abstract

The biological activity of FasL in human and mouse lungs is determined by the structure of its stalk region. J Clin Invest. 2011 Mar; 121(3):1174-90. View The biological activity of FasL in human and mouse lungs is determined by the structure of its stalk region. Abstract

Clinically useful spirometry in preschool-aged children: evaluation of the 2007 American Thoracic Society Guidelines. J Asthma. 2010 Sep; 47(7):762-7. View Clinically useful spirometry in preschool-aged children: evaluation of the 2007 American Thoracic Society Guidelines. Abstract

Febrile-range hyperthermia augments lipopolysaccharide-induced lung injury by a mechanism of enhanced alveolar epithelial apoptosis. J Immunol. 2010 Apr 01; 184(7):3801-13. View Febrile-range hyperthermia augments lipopolysaccharide-induced lung injury by a mechanism of enhanced alveolar epithelial apoptosis. Abstract

Relationship between cystic fibrosis respiratory tract bacterial communities and age, genotype, antibiotics and Pseudomonas aeruginosa. Environ Microbiol. 2010 May; 12(5):1293-303. View Relationship between cystic fibrosis respiratory tract bacterial communities and age, genotype, antibiotics and Pseudomonas aeruginosa. Abstract

Kinetics of chemokine-glycosaminoglycan interactions control neutrophil migration into the airspaces of the lungs. J Immunol. 2010 Mar 01; 184(5):2677-85. View Kinetics of chemokine-glycosaminoglycan interactions control neutrophil migration into the airspaces of the lungs. Abstract

Effects of age on the synergistic interactions between lipopolysaccharide and mechanical ventilation in mice. Am J Respir Cell Mol Biol. 2010 Oct; 43(4):475-86. View Effects of age on the synergistic interactions between lipopolysaccharide and mechanical ventilation in mice. Abstract

Depletion of phagocytes in the reticuloendothelial system causes increased inflammation and mortality in rabbits with Pseudomonas aeruginosa pneumonia. Am J Physiol Lung Cell Mol Physiol. 2009 Feb; 296(2):L198-209. View Depletion of phagocytes in the reticuloendothelial system causes increased inflammation and mortality in rabbits with Pseudomonas aeruginosa pneumonia. Abstract

Animal models of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2008 Sep; 295(3):L379-99. View Animal models of acute lung injury. Abstract

Effect of Toll-like receptor 4 blockade on pulmonary inflammation caused by mechanical ventilation and bacterial endotoxin. Exp Lung Res. 2008 Jun; 34(5):225-43. View Effect of Toll-like receptor 4 blockade on pulmonary inflammation caused by mechanical ventilation and bacterial endotoxin. Abstract

Essential role of MMP-12 in Fas-induced lung fibrosis. Am J Respir Cell Mol Biol. 2007 Aug; 37(2):210-21. View Essential role of MMP-12 in Fas-induced lung fibrosis. Abstract

The Duffy antigen modifies systemic and local tissue chemokine responses following lipopolysaccharide stimulation. J Immunol. 2006 Dec 01; 177(11):8086-94. View The Duffy antigen modifies systemic and local tissue chemokine responses following lipopolysaccharide stimulation. Abstract

Mechanical ventilation induces inflammation, lung injury, and extra-pulmonary organ dysfunction in experimental pneumonia. Lab Invest. 2006 Aug; 86(8):790-9. View Mechanical ventilation induces inflammation, lung injury, and extra-pulmonary organ dysfunction in experimental pneumonia. Abstract

Inflammatory cells as a source of airspace extracellular superoxide dismutase after pulmonary injury. Am J Respir Cell Mol Biol. 2006 Feb; 34(2):226-32. View Inflammatory cells as a source of airspace extracellular superoxide dismutase after pulmonary injury. Abstract

Fas-mediated acute lung injury requires fas expression on nonmyeloid cells of the lung. J Immunol. 2005 Sep 15; 175(6):4069-75. View Fas-mediated acute lung injury requires fas expression on nonmyeloid cells of the lung. Abstract

Modulation of lipopolysaccharide-induced gene transcription and promotion of lung injury by mechanical ventilation. J Immunol. 2005 Sep 01; 175(5):3369-76. View Modulation of lipopolysaccharide-induced gene transcription and promotion of lung injury by mechanical ventilation. Abstract

Sweat testing infants detected by cystic fibrosis newborn screening. J Pediatr. 2005 Sep; 147(3 Suppl):S69-72. View Sweat testing infants detected by cystic fibrosis newborn screening. Abstract

Identification of high and low responders to lipopolysaccharide in normal subjects: an unbiased approach to identify modulators of innate immunity. J Immunol. 2005 Aug 15; 175(4):2570-8. View Identification of high and low responders to lipopolysaccharide in normal subjects: an unbiased approach to identify modulators of innate immunity. Abstract

TLR-4 pathway mediates the inflammatory response but not bacterial elimination in E. coli pneumonia. Am J Physiol Lung Cell Mol Physiol. 2005 Nov; 289(5):L731-8. View TLR-4 pathway mediates the inflammatory response but not bacterial elimination in E. coli pneumonia. Abstract

Mechanical ventilation affects lung function and cytokine production in an experimental model of endotoxemia. Anesthesiology. 2005 Feb; 102(2):331-9. View Mechanical ventilation affects lung function and cytokine production in an experimental model of endotoxemia. Abstract

Blockade of the Fas/FasL system improves pneumococcal clearance from the lungs without preventing dissemination of bacteria to the spleen. J Infect Dis. 2005 Feb 15; 191(4):596-606. View Blockade of the Fas/FasL system improves pneumococcal clearance from the lungs without preventing dissemination of bacteria to the spleen. Abstract

Clinical issues and research in respiratory failure from severe acute respiratory syndrome. Am J Respir Crit Care Med. 2005 Mar 01; 171(5):518-26. View Clinical issues and research in respiratory failure from severe acute respiratory syndrome. Abstract

Direct lung injury by bacteria: clarifying the tools of the trade. Crit Care Med. 2004 Nov; 32(11):2360-1. View Direct lung injury by bacteria: clarifying the tools of the trade. Abstract

Enhancement of the endotoxin recognition pathway by ventilation with a large tidal volume in rabbits. Am J Physiol Lung Cell Mol Physiol. 2004 Jun; 286(6):L1114-21. View Enhancement of the endotoxin recognition pathway by ventilation with a large tidal volume in rabbits. Abstract

Duffy antigen facilitates movement of chemokine across the endothelium in vitro and promotes neutrophil transmigration in vitro and in vivo. J Immunol. 2003 May 15; 170(10):5244-51. View Duffy antigen facilitates movement of chemokine across the endothelium in vitro and promotes neutrophil transmigration in vitro and in vivo. Abstract

Conventional mechanical ventilation of healthy lungs induced pro-inflammatory cytokine gene transcription. Respir Physiol Neurobiol. 2002 Aug 30; 132(2):191-203. View Conventional mechanical ventilation of healthy lungs induced pro-inflammatory cytokine gene transcription. Abstract

Tissue-specific mechanisms control the retention of IL-8 in lungs and skin. J Immunol. 2002 Apr 01; 168(7):3550-6. View Tissue-specific mechanisms control the retention of IL-8 in lungs and skin. Abstract

The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness. Proc Natl Acad Sci U S A. 2002 Feb 05; 99(3):1479-84. View The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness. Abstract

Cytokine balance in the lungs of patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 2001 Nov 15; 164(10 Pt 1):1896-903. View Cytokine balance in the lungs of patients with acute respiratory distress syndrome. Abstract

Hyporesponsiveness of donor cells to lipopolysaccharide stimulation reduces the severity of experimental idiopathic pneumonia syndrome: potential role for a gut-lung axis of inflammation. J Immunol. 2000 Dec 01; 165(11):6612-9. View Hyporesponsiveness of donor cells to lipopolysaccharide stimulation reduces the severity of experimental idiopathic pneumonia syndrome: potential role for a gut-lung axis of inflammation. Abstract

CD40L, but not CD40, is required for allergen-induced bronchial hyperresponsiveness in mice. Am J Respir Cell Mol Biol. 2000 Nov; 23(5):646-51. View CD40L, but not CD40, is required for allergen-induced bronchial hyperresponsiveness in mice. Abstract

Effect of CD14 blockade in rabbits with Escherichia coli pneumonia and sepsis. J Immunol. 2000 May 15; 164(10):5439-45. View Effect of CD14 blockade in rabbits with Escherichia coli pneumonia and sepsis. Abstract

Genetic variability in pulmonary physiological, cellular, and antibody responses to antigen in mice. Am J Respir Crit Care Med. 1999 Oct; 160(4):1150-6. View Genetic variability in pulmonary physiological, cellular, and antibody responses to antigen in mice. Abstract

SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells. J Clin Invest. 1999 Jun; 103(12):1737-43. View SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells. Abstract

Mast cell activation is not required for induction of airway hyperresponsiveness by ozone in mice. J Appl Physiol (1985). 1999 Jan; 86(1):202-10. View Mast cell activation is not required for induction of airway hyperresponsiveness by ozone in mice. Abstract

The role of leukocyte emigration and IL-8 on the development of lipopolysaccharide-induced lung injury in rabbits. J Immunol. 1998 Nov 15; 161(10):5704-9. View The role of leukocyte emigration and IL-8 on the development of lipopolysaccharide-induced lung injury in rabbits. Abstract

Host reactive donor T cells are associated with lung injury after experimental allogeneic bone marrow transplantation. Blood. 1998 Oct 01; 92(7):2571-80. View Host reactive donor T cells are associated with lung injury after experimental allogeneic bone marrow transplantation. Abstract

Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice. J Clin Invest. 1998 Apr 15; 101(8):1614-22. View Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice. Abstract

Persistence of pulmonary pathology and abnormal lung function in IL-3/GM-CSF/IL-5 beta c receptor-deficient mice despite correction of alveolar proteinosis after BMT. Bone Marrow Transplant. 1997 Oct; 20(8):657-62. View Persistence of pulmonary pathology and abnormal lung function in IL-3/GM-CSF/IL-5 beta c receptor-deficient mice despite correction of alveolar proteinosis after BMT. Abstract

Pulmonary and systemic inflammatory responses in rabbits with gram-negative pneumonia. Am J Respir Crit Care Med. 1997 Jun; 155(6):2030-40. View Pulmonary and systemic inflammatory responses in rabbits with gram-negative pneumonia. Abstract

Suppression of herpes simplex virus type 1 (HSV-1)-induced pneumonia in mice by inhibition of inducible nitric oxide synthase (iNOS, NOS2). J Exp Med. 1997 May 05; 185(9):1533-40. View Suppression of herpes simplex virus type 1 (HSV-1)-induced pneumonia in mice by inhibition of inducible nitric oxide synthase (iNOS, NOS2). Abstract

T-lymphocytes regulate genetically determined airway hyperresponsiveness in mice. Nat Med. 1997 Apr; 3(4):460-2. View T-lymphocytes regulate genetically determined airway hyperresponsiveness in mice. Abstract

Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis. J Clin Invest. 1997 Mar 01; 99(5):901-14. View Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis. Abstract

Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1344-9. View Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma. Abstract

An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin. Blood. 1996 Oct 15; 88(8):3230-9. View An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin. Abstract

Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. Nat Genet. 1995 Oct; 11(2):150-4. View Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. Abstract

Effects of endotoxin in the lungs of neonatal rats: age-dependent impairment of the inflammatory response. J Infect Dis. 1995 Jan; 171(1):134-44. View Effects of endotoxin in the lungs of neonatal rats: age-dependent impairment of the inflammatory response. Abstract

Active anaphylaxis in IgE-deficient mice. Nature. 1994 Aug 04; 370(6488):367-70. View Active anaphylaxis in IgE-deficient mice. Abstract

Serotonin-induced pulmonary responses are mediated by the 5-HT2 receptor in the mouse. J Pharmacol Exp Ther. 1994 Jan; 268(1):104-9. View Serotonin-induced pulmonary responses are mediated by the 5-HT2 receptor in the mouse. Abstract

Mast cells contribute to the changes in heart rate, but not hypotension or death, associated with active anaphylaxis in mice. J Immunol. 1993 Jul 01; 151(1):367-76. View Mast cells contribute to the changes in heart rate, but not hypotension or death, associated with active anaphylaxis in mice. Abstract

Mast cell activation enhances airway responsiveness to methacholine in the mouse. J Clin Invest. 1993 Mar; 91(3):1176-82. View Mast cell activation enhances airway responsiveness to methacholine in the mouse. Abstract

Recombinant murine interferon-gamma reversibly activates rat alveolar macrophages to kill Legionella pneumophila. J Infect Dis. 1992 Dec; 166(6):1354-61. View Recombinant murine interferon-gamma reversibly activates rat alveolar macrophages to kill Legionella pneumophila. Abstract

The effect of type-specific polysaccharide capsule on the clearance of group B streptococci from the lungs of infant and adult rats. J Infect Dis. 1992 Feb; 165(2):306-14. View The effect of type-specific polysaccharide capsule on the clearance of group B streptococci from the lungs of infant and adult rats. Abstract

Alveolar macrophage function in rats with severe protein calorie malnutrition. Arachidonic acid metabolism, cytokine release, and antimicrobial activity. J Immunol. 1990 Feb 01; 144(3):1052-61. View Alveolar macrophage function in rats with severe protein calorie malnutrition. Arachidonic acid metabolism, cytokine release, and antimicrobial activity. Abstract

The trachea and esophagus after repair of esophageal atresia and distal fistula: computed tomographic observations. Pediatr Radiol. 1990; 20(6):447-50. View The trachea and esophagus after repair of esophageal atresia and distal fistula: computed tomographic observations. Abstract

Impaired clearance of aerosolized Legionella pneumophila in corticosteroid-treated rats: a model of Legionnaires' disease in the compromised host. J Infect Dis. 1989 Aug; 160(2):261-73. View Impaired clearance of aerosolized Legionella pneumophila in corticosteroid-treated rats: a model of Legionnaires' disease in the compromised host. Abstract

Role of mast cells in anaphylaxis. Evidence for the importance of mast cells in the cardiopulmonary alterations and death induced by anti-IgE in mice. J Clin Invest. 1989 Apr; 83(4):1375-83. View Role of mast cells in anaphylaxis. Evidence for the importance of mast cells in the cardiopulmonary alterations and death induced by anti-IgE in mice. Abstract

Relationship between maximal expiratory flows and lung volumes in growing humans. J Appl Physiol (1985). 1988 Aug; 65(2):822-8. View Relationship between maximal expiratory flows and lung volumes in growing humans. Abstract

Pulmonary responses to bronchoconstrictor agonists in the mouse. J Appl Physiol (1985). 1988 Jun; 64(6):2318-23. View Pulmonary responses to bronchoconstrictor agonists in the mouse. Abstract

Lung antibacterial defense mechanisms in infant and adult rats: implications for the pathogenesis of group B streptococcal infections in the neonatal lung. J Infect Dis. 1988 Jan; 157(1):91-100. View Lung antibacterial defense mechanisms in infant and adult rats: implications for the pathogenesis of group B streptococcal infections in the neonatal lung. Abstract

Controlled clinical trial of methylprednisolone in patients with chronic bronchitis and acute respiratory insufficiency. Ann Intern Med. 1980 Jun; 92(6):753-8. View Controlled clinical trial of methylprednisolone in patients with chronic bronchitis and acute respiratory insufficiency. Abstract