Kristin Moffitt, MD | Boston Children's Hospital

Kristin Moffitt | Medical Services

Specialties

Programs & Services

Languages

English

Kristin Moffitt | Education

Medical School

University of Vermont College of Medicine

2004, Burlington, VT

Internship

Rhode Island Hospital

Providence, RI

Residency

Pediatrics

Rhode Island Hospital

2007, Providence, RI

Fellowship

Pediatric Infectious Diseases

Boston Children's Hospital

2010, Boston, MA

Kristin Moffitt | Certifications

American Board of Pediatrics (General)
American Board of Pediatrics (Infectious Diseases)

Kristin Moffitt | Professional History

Dr. Moffitt joined the faculty of the Pediatric Infectious Diseases Division at Boston Children’s Hospital upon completion of her fellowship training in 2010. In her last year of fellowship, she received the Kass Award for Excellence in Clinical Care from the Massachusetts Infectious Diseases Society and has since received awards from the Pediatric Infectious Diseases Society and the Charles Hood Foundation to support her research in bacterial vaccine development and immunity to bacterial infections. In addition to caring for patients seen by the Infectious Diseases consult service, Dr. Moffitt devotes her time to studying how bacteria cause disease. Of particular interest is furthering our understanding of how people develop immunity to infection with several common bacteria, such as Staphylococcus aureus. Through several clinical and translational studies, Dr. Moffitt is investigating the role of specific bacterial factors during infection and immune responses in affected patients and hopes that findings from this research will contribute to the development of therapies to prevent and treat such infections.

Kristin Moffitt | Publications

Pre-existing Immunocompromising Conditions and Outcomes of Acute COVID-19 Patients Admitted for Pediatric Intensive Care. Clin Infect Dis. 2024 08 16; 79(2):395-404. View Pre-existing Immunocompromising Conditions and Outcomes of Acute COVID-19 Patients Admitted for Pediatric Intensive Care. Abstract
Molecular mimicry in multisystem inflammatory syndrome in children. Nature. 2024 Aug; 632(8025):622-629. View Molecular mimicry in multisystem inflammatory syndrome in children. Abstract
Community-Onset Bacterial Coinfection in Children Critically Ill With Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Open Forum Infect Dis. 2023 Mar; 10(3):ofad122. View Community-Onset Bacterial Coinfection in Children Critically Ill With Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Abstract
Life-Threatening Complications of Influenza vs Coronavirus Disease 2019 (COVID-19) in US Children. Clin Infect Dis. 2023 02 08; 76(3):e280-e290. View Life-Threatening Complications of Influenza vs Coronavirus Disease 2019 (COVID-19) in US Children. Abstract
NFKB2 haploinsufficiency identified via screening for IFN-a2 autoantibodies in children and adolescents hospitalized with SARS-CoV-2-related complications. J Allergy Clin Immunol. 2023 04; 151(4):926-930.e2. View NFKB2 haploinsufficiency identified via screening for IFN-a2 autoantibodies in children and adolescents hospitalized with SARS-CoV-2-related complications. Abstract
More Is Not Always Better. J Pediatric Infect Dis Soc. 2022 10 25; 11(10):429. View More Is Not Always Better. Abstract
Host Respiratory Transcriptome Signature Associated with Poor Outcome in Children with Influenza-Staphylococcus aureus Pneumonia. J Infect Dis. 2022 09 28; 226(7):1286-1294. View Host Respiratory Transcriptome Signature Associated with Poor Outcome in Children with Influenza-Staphylococcus aureus Pneumonia. Abstract
Author Correction: Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C. Nat Commun. 2022 Aug 12; 13(1):4732. View Author Correction: Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C. Abstract
Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C. Nat Commun. 2022 05 27; 13(1):2979. View Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C. Abstract
Analysis of Staphylococcus aureus Transcriptome in Pediatric Soft Tissue Abscesses and Comparison to Murine Infections. Infect Immun. 2021 03 17; 89(4). View Analysis of Staphylococcus aureus Transcriptome in Pediatric Soft Tissue Abscesses and Comparison to Murine Infections. Abstract
Process intensification for production of Streptococcus pneumoniae whole-cell vaccine. Biotechnol Bioeng. 2020 06; 117(6):1661-1672. View Process intensification for production of Streptococcus pneumoniae whole-cell vaccine. Abstract
Vancomycin Monotherapy May Be Insufficient to Treat Methicillin-resistant Staphylococcus aureus Coinfection in Children With Influenza-related Critical Illness. Clin Infect Dis. 2019 01 18; 68(3):365-372. View Vancomycin Monotherapy May Be Insufficient to Treat Methicillin-resistant Staphylococcus aureus Coinfection in Children With Influenza-related Critical Illness. Abstract
Evaluation of the Role of stat3 in Antibody and TH17-Mediated Responses to Pneumococcal Immunization and Infection by Use of a Mouse Model of Autosomal Dominant Hyper-IgE Syndrome. Infect Immun. 2018 05; 86(5). View Evaluation of the Role of stat3 in Antibody and TH17-Mediated Responses to Pneumococcal Immunization and Infection by Use of a Mouse Model of Autosomal Dominant Hyper-IgE Syndrome. Abstract
IL-17A and complement contribute to killing of pneumococci following immunization with a pneumococcal whole cell vaccine. Vaccine. 2017 03 01; 35(9):1306-1315. View IL-17A and complement contribute to killing of pneumococci following immunization with a pneumococcal whole cell vaccine. Abstract
Acute lymphoblastic leukemia in a patient with MonoMAC syndrome/GATA2 haploinsufficiency. Pediatr Blood Cancer. 2016 10; 63(10):1844-7. View Acute lymphoblastic leukemia in a patient with MonoMAC syndrome/GATA2 haploinsufficiency. Abstract
Rationale and prospects for novel pneumococcal vaccines. Hum Vaccin Immunother. 2016; 12(2):383-92. View Rationale and prospects for novel pneumococcal vaccines. Abstract
T(H)17-Mediated Protection against Pneumococcal Carriage by a Whole-Cell Vaccine Is Dependent on Toll-Like Receptor 2 and Surface Lipoproteins. Clin Vaccine Immunol. 2015 Aug; 22(8):909-16. View T(H)17-Mediated Protection against Pneumococcal Carriage by a Whole-Cell Vaccine Is Dependent on Toll-Like Receptor 2 and Surface Lipoproteins. Abstract
Toll-like receptor 2-dependent protection against pneumococcal carriage by immunization with lipidated pneumococcal proteins. Infect Immun. 2014 May; 82(5):2079-86. View Toll-like receptor 2-dependent protection against pneumococcal carriage by immunization with lipidated pneumococcal proteins. Abstract
Allograft-Transmitted Histoplasma capsulatum Infection in a Solid Organ Transplant Recipient. J Pediatric Infect Dis Soc. 2013 Sep; 2(3):270-3. View Allograft-Transmitted Histoplasma capsulatum Infection in a Solid Organ Transplant Recipient. Abstract
Identification of protective pneumococcal T(H)17 antigens from the soluble fraction of a killed whole cell vaccine. PLoS One. 2012; 7(8):e43445. View Identification of protective pneumococcal T(H)17 antigens from the soluble fraction of a killed whole cell vaccine. Abstract
Broad antibody and T cell reactivity induced by a pneumococcal whole-cell vaccine. Vaccine. 2012 Jun 19; 30(29):4316-22. View Broad antibody and T cell reactivity induced by a pneumococcal whole-cell vaccine. Abstract
B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood. 2012 Mar 22; 119(12):2819-28. View B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Abstract
Next generation pneumococcal vaccines. Curr Opin Immunol. 2011 Jun; 23(3):407-13. View Next generation pneumococcal vaccines. Abstract
Cell Host and Microbe. TH17-based vaccine design for prevention of Streptococcus pneumoniae colonization. 2011; 9(2):158-65.

The opportunity to contribute to the care and healing of people during a time that is often one of the most challenging of their lives inspired me to become a physician. When faced with a difficult to diagnose illness or an infection that is challenging to treat, every component of a patient’s underlying health and goals of care should be considered, and every patient is unique. As a pediatric infectious diseases provider, I strive to work collaboratively with each patient, family and care team to offer the most comprehensive and patient-centered guidance possible to diagnose, optimally treat, and prevent infections.