Current Environment: Production

Medical Services

Specialties

Programs & Services

Languages

  • English

Education

Undergraduate School

University of Utah

1976, Salt Lake City, UT

Medical School

Harvard-MIT Program in Health, Science, and Technology

1981, Boston, MA

Internship

Surgery

Beth Israel Deaconess Medical Center

1982, Boston, MA

Residency

Massachusetts General Hospital

1989, Boston, MA

Fellowship

Beth Israel Deaconess Medical Center/Massachusetts General Hospital

1983, Boston, MA

Certifications

  • American Board of Neurological Surgery

Professional History

I am a pediatric neurosurgeon with a strong interest in innovative approaches to the dynamic brain maladies of children, especially epilepsy and hydrocephalus. My clinical efforts are closely tied to my research program, the Neurodynamics Laboratory.

I received my medical degree in 1981 from a joint program poised uniquely at the intersection between engineering and medicine, the Harvard-MIT Program in Health, Science and Technology. I hold the Webster Family Chair in Neurosurgery and Neuroengineering at Boston Children's Hospital, direct the hospital's Epilepsy Surgery Program and am an associate professor at Harvard Medical School. My work is multidisciplinary and focused on applying engineering and mathematical approaches to my practice.

I have brought several innovations to clinical practice. These include a new technique to monitor shunt flow in patients with hydrocephalus, including the use of cardiac-gated MRI scans, thermal detection of shunt flow, and a valve massager technology. I have also developed a new technique to predict seizure focus using intracranial data gathered from implanted electrodes, which will one day allow surgeons like myself to better plan epilepsy surgeries. My practice has grown in part because of successful patient approaches developed during planning of such research programs.

I also have a strong interest in improving pediatric neurosurgery and epilepsy surgery abroad, specifically in China. In that context, I have been an adjunct professor in functional neurosurgery at Xuanwu Hospital, affiliated with Capitol Medical University, Bejing Institute of Functional Neurosurgery. I have been specifically working on a mechanism to review surgical cases in real time with colleagues at Beijing's Children's Hospital.

Media

Caregiver Profile

Meet Dr. Joseph Madsen

Ask an Expert

Epilepsy Q&A: Understanding the anatomy of the brain

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Epilepsy Q&A: What is vagal nerve stimulation?

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Epilepsy Q&A: What is single stage resection?

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Epilepsy Q&A: How surgical techniques map the brain

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Epilepsy Q&A: What is a laser ablation?

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Epilepsy Q&A: What is a hemispherectomy?

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Epilepsy Q&A: What are the different types of epilepsy surgery?

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Epilepsy Q&A: What is a deep brain stimulator?

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Epilepsy Q&A: What is a corpus callosotomy?

Publications

  1. Specialized Large Language Model Outperforms Neurologists at Complex Diagnosis in Blinded Case-Based Evaluation. Brain Sci. 2025 Mar 27; 15(4). View Abstract

  2. Epilepsy surgery in Sturge-Weber syndrome with unilateral or bilateral asymmetric brain involvement: Boston Children's Hospital experience. Epilepsia. 2025 Mar 24. View Abstract

  3. Analysis of DNA from brain tissue on stereo-EEG electrodes reveals mosaic epilepsy-related variants. Brain Commun. 2025; 7(2):fcaf113. View Abstract

  4. Neural correlates of minimal recognizable configurations in the human brain. Cell Rep. 2025 Mar 25; 44(3):115429. View Abstract

  5. Measurement of Atmospheric Neutrino Oscillation Parameters Using Convolutional Neural Networks with 9.3 Years of Data in IceCube DeepCore. Phys Rev Lett. 2025 Mar 07; 134(9):091801. View Abstract

  6. Machine learning on interictal intracranial EEG predicts surgical outcome in drug resistant epilepsy. NPJ Digit Med. 2025 Mar 05; 8(1):138. View Abstract

  7. Spikes on ripples are better interictal biomarkers of epilepsy than spikes or ripples. Brain Commun. 2025; 7(1):fcaf056. View Abstract

  8. Search for an eV-Scale Sterile Neutrino Using Improved High-Energy ?_{µ} Event Reconstruction in IceCube. Phys Rev Lett. 2024 Nov 15; 133(20):201804. View Abstract

  9. Expert opinion on use of vagus nerve stimulation therapy in the management of pediatric epilepsy: A Delphi consensus study. Seizure. 2024 Dec; 123:97-103. View Abstract

  10. Overlap of spike and ripple propagation onset predicts surgical outcome in epilepsy. Ann Clin Transl Neurol. 2024 Oct; 11(10):2530-2547. View Abstract

  11. Safety of Pregnancy and Delivery With Shunted Hydrocephalus. JAMA Netw Open. 2024 Sep 03; 7(9):e2434688. View Abstract

  12. Intralesional epileptiform activity in a fourth ventricular hamartoma associated with epileptic hemifacial spasm in a toddler: illustrative case. J Neurosurg Case Lessons. 2024 Jul 29; 8(5). View Abstract

  13. Analysis of DNA from brain tissue on stereo-EEG electrodes reveals mosaic epilepsy-related variants. medRxiv. 2024 Jul 22. View Abstract

  14. Differential cortical layer engagement during seizure initiation and spread in humans. Nat Commun. 2024 Jun 17; 15(1):5153. View Abstract

  15. Characterizing the safety profile of vagus nerve stimulation devices for epilepsy from 21,448 manufacturer and user reports. J Neurosurg. 2024 Dec 01; 141(6):1505-1519. View Abstract

  16. Letter to the Editor. Rise of large language models in neurosurgery. J Neurosurg. 2024 May 17; 141(3):878-880. View Abstract

  17. Observation of Seven Astrophysical Tau Neutrino Candidates with IceCube. Phys Rev Lett. 2024 Apr 12; 132(15):151001. View Abstract

  18. Interictal EEG source connectivity to localize the epileptogenic zone in patients with drug-resistant epilepsy: A machine learning approach. Epilepsia. 2024 Apr; 65(4):944-960. View Abstract

  19. Aberrant fast spiking interneuronal activity precedes seizure transitions in humans. medRxiv. 2024 Jan 26. View Abstract

  20. Somatic Mosaicism in PIK3CA Variant Correlates With Stereoelectroencephalography-Derived Electrophysiology. Neurol Genet. 2024 Feb; 10(1):e200117. View Abstract

  21. Complications of Intracranial Multimodal Monitoring for Neurocritical Care: A Systematic Review and Meta-Analysis. Neurocrit Care. 2024 Jun; 40(3):1182-1192. View Abstract

  22. Influence of extent and age at corpus callosotomy on seizure outcomes. A single center experience. Epilepsia Open. 2023 Dec; 8(4):1596-1601. View Abstract

  23. Machine learning models for predicting seizure outcome after MR-guided laser interstitial thermal therapy in children. J Neurosurg Pediatr. 2023 10 01; 32(6):739-749. View Abstract

  24. Sleep Spindle Generation Before and After Epilepsy Surgery: A Source Imaging Study in Children with Drug-Resistant Epilepsy. Brain Topogr. 2024 01; 37(1):88-101. View Abstract

  25. Spike propagation mapping reveals effective connectivity and predicts surgical outcome in epilepsy. Brain. 2023 09 01; 146(9):3898-3912. View Abstract

  26. Electromagnetic source imaging predicts surgical outcome in children with focal cortical dysplasia. Clin Neurophysiol. 2023 09; 153:88-101. View Abstract

  27. Observation of high-energy neutrinos from the Galactic plane. Science. 2023 Jun 30; 380(6652):1338-1343. View Abstract

  28. Focal drug-resistant temporal lobe epilepsy associated with an ipsilateral anterior choroidal artery aneurysm: illustrative case. J Neurosurg Case Lessons. 2023 Jun 26; 5(26). View Abstract

  29. The role of superficial and deep layers in the generation of high frequency oscillations and interictal epileptiform discharges in the human cortex. Sci Rep. 2023 06 14; 13(1):9620. View Abstract

  30. Functional connectivity discriminates epileptogenic states and predicts surgical outcome in children with drug resistant epilepsy. Sci Rep. 2023 06 14; 13(1):9622. View Abstract

  31. Non-invasive mapping of epileptogenic networks predicts surgical outcome. Brain. 2023 05 02; 146(5):1916-1931. View Abstract

  32. Spatiotemporal spike-centered averaging reveals symmetry of temporal and spatial components of the spike-LFP relationship during human focal seizures. Commun Biol. 2023 03 25; 6(1):317. View Abstract

  33. Reply to: "How to disconnect the splenium and fornix in posterior quadrant disconnection, hemispherotomy, and subtotal hemispherotomy". Acta Neurochir (Wien). 2023 03; 165(3):741. View Abstract

  34. Cross-task specificity and within-task invariance of cognitive control processes. Cell Rep. 2023 01 31; 42(1):111919. View Abstract

  35. Stereoelectroencephalography followed by combined electrode removal and MRI-guided laser interstitial thermal therapy or open resection: a single-center series in pediatric patients with medically refractory epilepsy. J Neurosurg Pediatr. 2023 03 01; 31(3):206-211. View Abstract

  36. Seizure outcome of pediatric magnetic resonance-guided laser interstitial thermal therapy versus open surgery: A matched noninferiority cohort study. Epilepsia. 2023 01; 64(1):114-126. View Abstract

  37. Evidence for neutrino emission from the nearby active galaxy NGC 1068. Science. 2022 11 04; 378(6619):538-543. View Abstract

  38. Search for Unstable Sterile Neutrinos with the IceCube Neutrino Observatory. Phys Rev Lett. 2022 Oct 07; 129(15):151801. View Abstract

  39. Interictal Connectivity Revealed by Granger Analysis of Stereoelectroencephalography: Association With Ictal Onset Zone, Resection, and Outcome. Neurosurgery. 2022 10 01; 91(4):583-589. View Abstract

  40. Discrepant expressive language lateralization in children and adolescents with epilepsy. Ann Clin Transl Neurol. 2022 09; 9(9):1459-1464. View Abstract

  41. Strong Constraints on Neutrino Nonstandard Interactions from TeV-Scale ?_{µ} Disappearance at IceCube. Phys Rev Lett. 2022 Jul 01; 129(1):011804. View Abstract

  42. Limited utility of structural MRI to identify the epileptogenic zone in young children with tuberous sclerosis. J Neuroimaging. 2022 09; 32(5):991-1000. View Abstract

  43. Reply to "Added value of high-resolution electrical source imaging of ictal activity in children with structural focal epilepsy". Clin Neurophysiol. 2022 08; 140:254-255. View Abstract

  44. Posterior quadrant disconnection for refractory epilepsy: how I do it. Acta Neurochir (Wien). 2022 08; 164(8):2159-2164. View Abstract

  45. Complete Corpus Callosotomy for Refractory Epilepsy in Children. World Neurosurg. 2022 08; 164:69. View Abstract

  46. Virtual implantation using conventional scalp EEG delineates seizure onset and predicts surgical outcome in children with epilepsy. Clin Neurophysiol. 2022 07; 139:49-57. View Abstract

  47. Single-stage resection of bottom-of-a-sulcus dysplasia involving eloquent cortex using navigated transcranial magnetic stimulation and intraoperative modalities. Childs Nerv Syst. 2022 07; 38(7):1365-1370. View Abstract

  48. Novel User-Friendly Application for MRI Segmentation of Brain Resection following Epilepsy Surgery. Diagnostics (Basel). 2022 Apr 18; 12(4). View Abstract

  49. Search for Relativistic Magnetic Monopoles with Eight Years of IceCube Data. Phys Rev Lett. 2022 Feb 04; 128(5):051101. View Abstract

  50. Mapping Propagation of Interictal Spikes, Ripples, and Fast Ripples in Intracranial EEG of Children with Refractory Epilepsy. Annu Int Conf IEEE Eng Med Biol Soc. 2021 11; 2021:194-197. View Abstract

  51. Mapping Functional Connectivity of Epileptogenic Networks through Virtual Implantation. Annu Int Conf IEEE Eng Med Biol Soc. 2021 11; 2021:408-411. View Abstract

  52. Electric Source Imaging on Intracranial EEG Localizes Spatiotemporal Propagation of Interictal Spikes in Children with Epilepsy. Annu Int Conf IEEE Eng Med Biol Soc. 2021 11; 2021:2668-2671. View Abstract

  53. A Standardized Electrode Nomenclature for Stereoelectroencephalography Applications. J Clin Neurophysiol. 2021 Nov 01; 38(6):509-515. View Abstract

  54. Extensions of Granger Causality Calculations on Brain Networks for Efficient and Accurate Seizure Focus Identification via iEEGs. Brain Sci. 2021 Sep 01; 11(9). View Abstract

  55. Mesoscopic physiological interactions in the human brain reveal small-world properties. Cell Rep. 2021 08 24; 36(8):109585. View Abstract

  56. Changes in the Functional Brain Network of Children Undergoing Repeated Epilepsy Surgery: An EEG Source Connectivity Study. Diagnostics (Basel). 2021 Jul 09; 11(7). View Abstract

  57. Microscale Physiological Events on the Human Cortical Surface. Cereb Cortex. 2021 07 05; 31(8):3678-3700. View Abstract

  58. Source imaging of seizure onset predicts surgical outcome in pediatric epilepsy. Clin Neurophysiol. 2021 07; 132(7):1622-1635. View Abstract

  59. Presurgical accuracy of dipole clustering in MRI-negative pediatric patients with epilepsy: Validation against intracranial EEG and resection. Clin Neurophysiol. 2022 09; 141:126-138. View Abstract

  60. Noninvasive Mapping of Ripple Onset Predicts Outcome in Epilepsy Surgery. Ann Neurol. 2021 05; 89(5):911-925. View Abstract

  61. Travelling spindles create necessary conditions for spike-timing-dependent plasticity in humans. Nat Commun. 2021 02 15; 12(1):1027. View Abstract

  62. Anesthetic management and outcomes for MRI-guided laser interstitial thermal therapy (LITT) for seizure focus in pediatrics: A single-centre experience with 10 consecutive patients. Paediatr Anaesth. 2021 02; 31(2):234-236. View Abstract

  63. Magnetic resonance imaging-guided laser-induced thermal therapy for functional hemispherotomy in a child with refractory epilepsy and multiple medical comorbidities. J Neurosurg Pediatr. 2021 01 01; 27(1):30-35. View Abstract

  64. Diagnostic Accuracy of Non-Invasive Thermal Evaluation of Ventriculoperitoneal Shunt Flow in Shunt Malfunction: A Prospective, Multi-Site, Operator-Blinded Study. Neurosurgery. 2020 10 15; 87(5):939-948. View Abstract

  65. eV-Scale Sterile Neutrino Search Using Eight Years of Atmospheric Muon Neutrino Data from the IceCube Neutrino Observatory. Phys Rev Lett. 2020 Oct 02; 125(14):141801. View Abstract

  66. Characteristics of the Diffuse Astrophysical Electron and Tau Neutrino Flux with Six Years of IceCube High Energy Cascade Data. Phys Rev Lett. 2020 Sep 18; 125(12):121104. View Abstract

  67. Drug-Responsive Inhomogeneous Cortical Modulation by Direct Current Stimulation. Ann Neurol. 2020 09; 88(3):489-502. View Abstract

  68. Corpus Callosotomy for Refractory Epilepsy in Aicardi Syndrome: Case Report and Focused Review of the Literature. World Neurosurg. 2020 10; 142:450-455. View Abstract

  69. A Noninvasive Retrograde Flushing System for Shunted Hydrocephalus: Initial Case Series of 25 Patients. Cureus. 2020 Jul 01; 12(7):e8940. View Abstract

  70. In situ clearance of a proximal shunt malfunction in a child with hydrocephalus post cerebral arteriovenous malformation rupture noted intraoperatively. Surg Neurol Int. 2020; 11:116. View Abstract

  71. Pilot Study of Neurodevelopmental Impact of Early Epilepsy Surgery in Tuberous Sclerosis Complex. Pediatr Neurol. 2020 08; 109:39-46. View Abstract

  72. Posterior-onset Rasmussen's encephalitis with ipsilateral cerebellar atrophy and uveitis resistant to rituximab. Epilepsy Behav Rep. 2020; 14:100360. View Abstract

  73. Scalp ripples as prognostic biomarkers of epileptogenicity in pediatric surgery. Ann Clin Transl Neurol. 2020 03; 7(3):329-342. View Abstract

  74. Time-Integrated Neutrino Source Searches with 10 Years of IceCube Data. Phys Rev Lett. 2020 Feb 07; 124(5):051103. View Abstract

  75. Ictal and interictal source imaging on intracranial EEG predicts epilepsy surgery outcome in children with focal cortical dysplasia. Clin Neurophysiol. 2020 03; 131(3):734-743. View Abstract

  76. Lesion-Constrained Electrical Source Imaging: A Novel Approach in Epilepsy Surgery for Tuberous Sclerosis Complex. J Clin Neurophysiol. 2020 Jan; 37(1):79-86. View Abstract

  77. Neural Interactions Underlying Visuomotor Associations in the Human Brain. Cereb Cortex. 2019 12 17; 29(11):4551-4567. View Abstract

  78. Noninvasive Thermal Evaluation of Ventriculoperitoneal Shunt Patency and Cerebrospinal Fluid Flow Using a Flow Enhancing Device. Neurosurgery. 2019 08 01; 85(2):240-249. View Abstract

  79. Intracortical neural activity distal to seizure-onset-areas predicts human focal seizures. PLoS One. 2019; 14(7):e0211847. View Abstract

  80. Noninvasive Localization of High-Frequency Oscillations in Children with Epilepsy: Validation against Intracranial Gold-Standard. Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul; 2019:1555-1558. View Abstract

  81. White matter mean diffusivity correlates with myelination in tuberous sclerosis complex. Ann Clin Transl Neurol. 2019 07; 6(7):1178-1190. View Abstract

  82. Early Detection of Human Epileptic Seizures Based on Intracortical Microelectrode Array Signals. IEEE Trans Biomed Eng. 2020 03; 67(3):817-831. View Abstract

  83. Constraints on Minute-Scale Transient Astrophysical Neutrino Sources. Phys Rev Lett. 2019 Feb 08; 122(5):051102. View Abstract

  84. Assessing the localization accuracy and clinical utility of electric and magnetic source imaging in children with epilepsy. Clin Neurophysiol. 2019 04; 130(4):491-504. View Abstract

  85. Delay differential analysis for dynamical sleep spindle detection. J Neurosci Methods. 2019 03 15; 316:12-21. View Abstract

  86. Search for neutrinos from decaying dark matter with IceCube: IceCube Collaboration. Eur Phys J C Part Fields. 2018; 78(10):831. View Abstract

  87. Simulating human sleep spindle MEG and EEG from ion channel and circuit level dynamics. J Neurosci Methods. 2019 03 15; 316:46-57. View Abstract

  88. Surgical resection of ripple onset predicts outcome in pediatric epilepsy. Ann Neurol. 2018 09; 84(3):331-346. View Abstract

  89. Magnetoencephalographic Mapping of Epileptic Spike Population Using Distributed Source Analysis: Comparison With Intracranial Electroencephalographic Spikes. J Clin Neurophysiol. 2018 Jul; 35(4):339-345. View Abstract

  90. Somatic SLC35A2 variants in the brain are associated with intractable neocortical epilepsy. Ann Neurol. 2018 06; 83(6):1133-1146. View Abstract

  91. Magnetoencephalographic Spike Analysis in Patients With Focal Cortical Dysplasia: What Defines a "Dipole Cluster"? Pediatr Neurol. 2018 06; 83:25-31. View Abstract

  92. Measurement of Atmospheric Neutrino Oscillations at 6-56 GeV with IceCube DeepCore. Phys Rev Lett. 2018 Feb 16; 120(7):071801. View Abstract

  93. Heterogeneous Origins of Human Sleep Spindles in Different Cortical Layers. J Neurosci. 2018 03 21; 38(12):3013-3025. View Abstract

  94. Superficial Slow Rhythms Integrate Cortical Processing in Humans. Sci Rep. 2018 02 01; 8(1):2055. View Abstract

  95. VEGF Signaling in Neurological Disorders. Int J Mol Sci. 2018 Jan 17; 19(1). View Abstract

  96. Granger Causality Analysis of Interictal iEEG Predicts Seizure Focus and Ultimate Resection. Neurosurgery. 2018 Jan 01; 82(1):99-109. View Abstract

  97. Somatic Mutations Activating the mTOR Pathway in Dorsal Telencephalic Progenitors Cause a Continuum of Cortical Dysplasias. Cell Rep. 2017 12 26; 21(13):3754-3766. View Abstract

  98. Measurement of the ?µ energy spectrum with IceCube-79: IceCube Collaboration. Eur Phys J C Part Fields. 2017; 77(10):692. View Abstract

  99. What is changing when: Decoding visual information in movies from human intracranial recordings. Neuroimage. 2018 10 15; 180(Pt A):147-159. View Abstract

  100. Human seizures couple across spatial scales through travelling wave dynamics. Nat Commun. 2017 04 04; 8:14896. View Abstract

  101. Current and Emerging Potential of Magnetoencephalography in the Detection and Localization of High-Frequency Oscillations in Epilepsy. Front Neurol. 2017; 8:14. View Abstract

  102. Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics. Cancer Cell. 2017 01 09; 31(1):142-156. View Abstract

  103. Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy. J Vis Exp. 2016 12 06; (118). View Abstract

  104. Neuroimaging of Children With Surgically Treated Hydrocephalus: A Practical Approach. AJR Am J Roentgenol. 2017 Feb; 208(2):413-419. View Abstract

  105. Somatic GNAQ Mutation is Enriched in Brain Endothelial Cells in Sturge-Weber Syndrome. Pediatr Neurol. 2017 02; 67:59-63. View Abstract

  106. Active delineation of Meyer's loop using oriented priors through MAGNEtic tractography (MAGNET). Hum Brain Mapp. 2017 01; 38(1):509-527. View Abstract

  107. Direct current stimulation induces mGluR5-dependent neocortical plasticity. Ann Neurol. 2016 08; 80(2):233-46. View Abstract

  108. Rasmussen encephalitis tissue transfer program. Epilepsia. 2016 06; 57(6):1005-7. View Abstract

  109. Excess HB-EGF, which promotes VEGF signaling, leads to hydrocephalus. Sci Rep. 2016 05 31; 6:26794. View Abstract

  110. Cascade of neural processing orchestrates cognitive control in human frontal cortex. Elife. 2016 Feb 18; 5. View Abstract

  111. The role of simulation in neurosurgery. Childs Nerv Syst. 2016 Jan; 32(1):43-54. View Abstract

  112. Demonstration that a new flow sensor can operate in the clinical range for cerebrospinal fluid flow. Sens Actuators A Phys. 2015 Oct 01; 234:223-231. View Abstract

  113. Combining task-evoked and spontaneous activity to improve pre-operative brain mapping with fMRI. Neuroimage. 2016 Jan 01; 124(Pt A):714-723. View Abstract

  114. Microscale spatiotemporal dynamics during neocortical propagation of human focal seizures. Neuroimage. 2015 Nov 15; 122:114-30. View Abstract

  115. Autonomic changes following generalized tonic clonic seizures: An analysis of adult and pediatric patients with epilepsy. Epilepsy Res. 2015 Sep; 115:113-8. View Abstract

  116. Central 5-HT neurotransmission modulates weight loss following gastric bypass surgery in obese individuals. J Neurosci. 2015 Apr 08; 35(14):5884-9. View Abstract

  117. Laminar profile of spontaneous and evoked theta: Rhythmic modulation of cortical processing during word integration. Neuropsychologia. 2015 Sep; 76:108-24. View Abstract

  118. Decrease in gamma-band activity tracks sequence learning. Front Syst Neurosci. 2014; 8:222. View Abstract

  119. Lexical retrieval pre- and posttemporal lobe epilepsy surgery in a pediatric sample. Epilepsy Behav. 2015 Jan; 42:61-5. View Abstract

  120. Sensitivity to timing and order in human visual cortex. J Neurophysiol. 2015 Mar 01; 113(5):1656-69. View Abstract

  121. Passive fMRI mapping of language function for pediatric epilepsy surgical planning: validation using Wada, ECS, and FMAER. Epilepsy Res. 2014 Dec; 108(10):1874-88. View Abstract

  122. VEGF: a potential target for hydrocephalus. Cell Tissue Res. 2014 Dec; 358(3):667-83. View Abstract

  123. 183 Intracranial arachnoid cysts and hemorrhage. Neurosurgery. 2014 Aug; 61 Suppl 1:220. View Abstract

  124. Neuronal ensemble synchrony during human focal seizures. J Neurosci. 2014 Jul 23; 34(30):9927-44. View Abstract

  125. Spatiotemporal dynamics underlying object completion in human ventral visual cortex. Neuron. 2014 Aug 06; 83(3):736-48. View Abstract

  126. Comparison of rapid cranial MRI to CT for ventricular shunt malfunction. Pediatrics. 2014 Jul; 134(1):e47-54. View Abstract

  127. 3 Tesla intraoperative MRI for brain tumor surgery. J Magn Reson Imaging. 2014 Jun; 39(6):1357-65. View Abstract

  128. Surgery for intractable epilepsy due to unilateral brain disease: a retrospective study comparing hemispherectomy techniques. Pediatr Neurol. 2014 Sep; 51(3):336-43. View Abstract

  129. Rasmussen's encephalitis presenting as focal cortical dysplasia. Epilepsy Behav Case Rep. 2014; 2:86-9. View Abstract

  130. Neural dynamics underlying target detection in the human brain. J Neurosci. 2014 Feb 19; 34(8):3042-55. View Abstract

  131. Clinical value of magnetoencephalographic spike propagation represented by spatiotemporal source analysis: correlation with surgical outcome. Epilepsy Res. 2014 Feb; 108(2):280-8. View Abstract

  132. Outcomes of vagal nerve stimulation in a pediatric population: a single center experience. Seizure. 2014 Feb; 23(2):105-11. View Abstract

  133. Resection of supratentorial lobar cavernous malformations in children: clinical article.. J Neurosurg Pediatr. 2013 Oct; 12(4):367-73. View Abstract

  134. Electrode localization for planning surgical resection of the epileptogenic zone in pediatric epilepsy. Int J Comput Assist Radiol Surg. 2014 Jan; 9(1):91-105. View Abstract

  135. Perfusion Imaging of Focal Cortical Dysplasia Using Arterial Spin Labeling: Correlation With Histopathological Vascular Density. J Child Neurol. 2013 Nov; 28(11):1474-1482. View Abstract

  136. Moyamoya disease with mesial temporal sclerosis. J Neurosurg Pediatr. 2013 Jun; 11(6):713-6. View Abstract

  137. First result from the Alpha Magnetic Spectrometer on the International Space Station: precision measurement of the positron fraction in primary cosmic rays of 0.5-350 GeV. Phys Rev Lett. 2013 Apr 05; 110(14):141102. View Abstract

  138. VEGF, which is elevated in the CSF of patients with hydrocephalus, causes ventriculomegaly and ependymal changes in rats. Exp Neurol. 2013 Sep; 247:703-9. View Abstract

  139. The frequency modulated auditory evoked response (FMAER), a technical advance for study of childhood language disorders: cortical source localization and selected case studies. BMC Neurol. 2013 Jan 25; 13:12. View Abstract

  140. Detecting epileptic regions based on global brain connectivity patterns. Med Image Comput Comput Assist Interv. 2013; 16(Pt 1):98-105. View Abstract

  141. The postnatal human filum terminale is a source of autologous multipotent neurospheres capable of generating motor neurons. Neurosurgery. 2013 Jan; 72(1):118-29; discussion 129. View Abstract

  142. Human seizures self-terminate across spatial scales via a critical transition. Proc Natl Acad Sci U S A. 2012 Dec 18; 109(51):21116-21. View Abstract

  143. Postshunting corpus callosum swelling with depiction on tractography. J Neurosurg Pediatr. 2013 Feb; 11(2):178-80. View Abstract

  144. Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness. Proc Natl Acad Sci U S A. 2012 Dec 04; 109(49):E3377-86. View Abstract

  145. Impaired pulsation absorber mechanism in idiopathic normal pressure hydrocephalus: laboratory investigation. J Neurosurg. 2012 Dec; 117(6):1189-96. View Abstract

  146. Temporal stability of visually selective responses in intracranial field potentials recorded from human occipital and temporal lobes. J Neurophysiol. 2012 Dec; 108(11):3073-86. View Abstract

  147. Language lateralization represented by spatiotemporal mapping of magnetoencephalography. AJNR Am J Neuroradiol. 2013 Mar; 34(3):558-63. View Abstract

  148. Thiol-Functionalized Block Copolymer Vesicles. ACS Macro Lett. 2012 Aug 21; 1(8):1041-1045. View Abstract

  149. Predictors of ventricular shunt infection among children presenting to a pediatric emergency department. Pediatr Emerg Care. 2012 May; 28(5):405-9. View Abstract

  150. Autonomic changes with seizures correlate with postictal EEG suppression. Neurology. 2012 Jun 05; 78(23):1868-76. View Abstract

  151. Altered inhibition in tuberous sclerosis and type IIb cortical dysplasia. Ann Neurol. 2012 Apr; 71(4):539-51. View Abstract

  152. Convulsive seizure detection using a wrist-worn electrodermal activity and accelerometry biosensor. Epilepsia. 2012 May; 53(5):e93-7. View Abstract

  153. Spatiotemporal dynamics of neocortical excitation and inhibition during human sleep. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):1731-6. View Abstract

  154. Robotic Neuro-Endoscope with Concentric Tube Augmentation. Rep U S. 2012. View Abstract

  155. Individualized localization and cortical surface-based registration of intracranial electrodes. Neuroimage. 2012 Feb 15; 59(4):3563-70. View Abstract

  156. Multimodal imaging of spike propagation: a technical case report. AJNR Am J Neuroradiol. 2012 Jun; 33(6):E82-4. View Abstract

  157. Widespread Brain Areas Engaged during a Classical Auditory Streaming Task Revealed by Intracranial EEG. Front Hum Neurosci. 2011; 5:74. View Abstract

  158. Nasal glioma: prenatal diagnosis and multidisciplinary surgical approach. Skull Base Rep. 2011 Nov; 1(2):83-8. View Abstract

  159. Algorithms for Design of Continuum Robots Using the Concentric Tubes Approach: A Neurosurgical Example. IEEE Int Conf Robot Autom. 2011 May 09; 667-673. View Abstract

  160. Single-neuron dynamics in human focal epilepsy. Nat Neurosci. 2011 May; 14(5):635-41. View Abstract

  161. Localization of focal epileptic discharges using functional connectivity magnetic resonance imaging. J Neurosurg. 2011 Jun; 114(6):1693-7. View Abstract

  162. The pulsating brain: A review of experimental and clinical studies of intracranial pulsatility. Fluids Barriers CNS. 2011 Jan 18; 8(1):5. View Abstract

  163. Evaluation of the ShuntCheck noninvasive thermal technique for shunt flow detection in hydrocephalic patients. Neurosurgery. 2011 Jan; 68(1):198-205; discussion 205. View Abstract

  164. Idiopathic syrinx in the pediatric population: a combined center experience. J Neurosurg Pediatr. 2011 Jan; 7(1):30-6. View Abstract

  165. Modeling of blood flow in arterial trees. Wiley Interdiscip Rev Syst Biol Med. 2010 Sep-Oct; 2(5):612-623. View Abstract

  166. Alterations of pulsation absorber characteristics in experimental hydrocephalus. J Neurosurg Pediatr. 2010 Aug; 6(2):159-70. View Abstract

  167. Modeling blood flow circulation in intracranial arterial networks: a comparative 3D/1D simulation study. Ann Biomed Eng. 2011 Jan; 39(1):297-309. View Abstract

  168. Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex. Brain. 2010 Jun; 133(Pt 6):1668-81. View Abstract

  169. Current dipole orientation and distribution of epileptiform activity correlates with cortical thinning in left mesiotemporal epilepsy. Neuroimage. 2010 Oct 01; 52(4):1238-42. View Abstract

  170. Right-lateralized brain oscillations in human spatial navigation. J Cogn Neurosci. 2010 May; 22(5):824-36. View Abstract

  171. Robust selectivity to two-object images in human visual cortex. Curr Biol. 2010 May 11; 20(9):872-9. View Abstract

  172. A dynamic nonlinear relationship between the static and pulsatile components of intracranial pressure in patients with subarachnoid hemorrhage. J Neurosurg. 2010 Mar; 112(3):616-25. View Abstract

  173. Arterial blood pressure vs intracranial pressure in normal pressure hydrocephalus. Acta Neurol Scand. 2010 Oct; 122(4):262-9. View Abstract

  174. Continuous monitoring of electrodermal activity during epileptic seizures using a wearable sensor. Annu Int Conf IEEE Eng Med Biol Soc. 2010; 2010:4415-8. View Abstract

  175. Propagation of epileptic spikes reconstructed from spatiotemporal magnetoencephalographic and electroencephalographic source analysis. Neuroimage. 2010 Mar; 50(1):217-22. View Abstract

  176. Magnetoencephalographic analysis in patients with vagus nerve stimulator. Pediatr Neurol. 2009 Nov; 41(5):383-7. View Abstract

  177. Task-free presurgical mapping using functional magnetic resonance imaging intrinsic activity. J Neurosurg. 2009 Oct; 111(4):746-54. View Abstract

  178. Estimation of Eeg Signal Dispersion During Seizure Propagation. Int Conf Digit Signal Process Proc. 2009 Sep 18; 2009:1-5. View Abstract

  179. Urological outcome following multiple repeat spinal cord untethering operations. Clinical article. J Neurosurg Pediatr. 2009 Sep; 4(3):275-9. View Abstract

  180. Gender and the use of hormonal contraception in women are not associated with cerebral cortical 5-HT 2A receptor binding. Neuroscience. 2009 Oct 06; 163(2):640-5. View Abstract

  181. Simulation of the human intracranial arterial tree. Philos Trans A Math Phys Eng Sci. 2009 Jun 13; 367(1896):2371-86. View Abstract

  182. The human K-complex represents an isolated cortical down-state. Science. 2009 May 22; 324(5930):1084-7. View Abstract

  183. Timing, timing, timing: fast decoding of object information from intracranial field potentials in human visual cortex. Neuron. 2009 Apr 30; 62(2):281-90. View Abstract

  184. Dynamic statistical parametric mapping for analyzing ictal magnetoencephalographic spikes in patients with intractable frontal lobe epilepsy. Epilepsy Res. 2009 Aug; 85(2-3):279-86. View Abstract

  185. Brain serotonin 2A receptor binding: relations to body mass index, tobacco and alcohol use. Neuroimage. 2009 May 15; 46(1):23-30. View Abstract

  186. Task-free presurgical mapping using fMRI intrinsic activity. J Neurosurgery,in press. 2009.

  187. Large-scale simulation of the human arterial tree. Clin Exp Pharmacol Physiol. 2009 Feb; 36(2):194-205. View Abstract

  188. Intracranial pressure waves: characterization of a pulsation absorber with notch filter properties using systems analysis: laboratory investigation. J Neurosurg Pediatr. 2008 Jul; 2(1):83-94. View Abstract

  189. Identification of endogenous morphine and a mu3-like opiate alkaloid receptor in human brain tissue taken from a patient with intractable complex partial epilepsy. Med Sci Monit. 2008 Jun; 14(6):CS45-49. View Abstract

  190. Nonresective Surgical Management of Refractory Epilepsy: Callosotomy and Vagal Stimulation. Principles and Practice of Pediatric Neurosurgery. 2008.

  191. Gamma oscillations distinguish true from false memories. Psychol Sci. 2007 Nov; 18(11):927-32. View Abstract

  192. Priorities for hydrocephalus research: report from a National Institutes of Health-sponsored workshop. J Neurosurg. 2007 Nov; 107(5 Suppl):345-57. View Abstract

  193. Minimal heating of titanium skull plates during 1Hz repetitive transcranial magnetic stimulation. Clin Neurophysiol. 2007 Nov; 118(11):2536-8. View Abstract

  194. Apparatus and method for measuring a human head. 2007.

  195. Outcome following multiple repeated spinal cord untethering operations. J Neurosurg. 2007 Jun; 106(6 Suppl):434-8. View Abstract

  196. Treatment of subdural hematomas in infants. J Neurosurg. 2007 Mar; 106(3 Suppl):171. View Abstract

  197. The emerging field of third circulation research. Clin Neurosurg. 2007; 54:129-33. View Abstract

  198. Limits on the high-energy gamma and neutrino fluxes from the SGR 1806-20 giant flare of 27 December 2004 with the AMANDA-II detector. Phys Rev Lett. 2006 Dec 01; 97(22):221101. View Abstract

  199. MRI and Physiologically Guided Brain Tumor Removal (Live Webcast, ORLive). 2006.

  200. Hippocampal and neocortical gamma oscillations predict memory formation in humans. Cereb Cortex. 2007 May; 17(5):1190-6. View Abstract

  201. Electroencephalography in epilepsy surgery planning. Childs Nerv Syst. 2006 Aug; 22(8):760-5. View Abstract

  202. Human neocortical oscillations exhibit theta phase differences between encoding and retrieval. Neuroimage. 2006 Jul 01; 31(3):1352-8. View Abstract

  203. The value of multichannel MEG and EEG in the presurgical evaluation of 70 epilepsy patients. Epilepsy Res. 2006 Apr; 69(1):80-6. View Abstract

  204. What we don't (but should) know about hydrocephalus. J Neurosurg. 2006 Mar; 104(3 Suppl):157-9. View Abstract

  205. Cerebrospinal fluid pulsatility and hydrocephalus: the fourth circulation. Clin Neurosurg. 2006; 53:48-52. View Abstract

  206. Treatment of refractory epilepsy: General approach and nonresective strategies. Albright L et al, eds., Pediatric Neurosurgery. 2006.

  207. Theta oscillations in human cortex during a working-memory task: evidence for local generators. J Neurophysiol. 2006 Mar; 95(3):1630-8. View Abstract

  208. GMFM 1 year after continuous intrathecal baclofen infusion. Pediatr Rehabil. 2005 Jul-Sep; 8(3):207-13. View Abstract

  209. Invasive group A, B, C and G streptococcal infections in Denmark 1999-2002: epidemiological and clinical aspects. Clin Microbiol Infect. 2005 Jul; 11(7):569-76. View Abstract

  210. Ictal asystole with convulsive syncope mimicking secondary generalisation: a depth electrode study. J Neurol Neurosurg Psychiatry. 2005 Jun; 76(6):885-7. View Abstract

  211. Increased Phase Synchronization between Intracranial Pressure and Arterial Blood Pressure during Elevated Intracranial Pressure in Dogs. Conf Proc IEEE Eng Med Biol Soc. 2005; 2006:315-8. View Abstract

  212. Direction-oriented and spatially controlled bipolar for in-situ cauterization of adherent cranial tissue occluding a ventricular catheter previously implanted in-vivo. 2004.

  213. Gamma EEG dynamics in neocortex and hippocampus during human wakefulness and sleep. Neuroimage. 2004 Jul; 22(3):1271-80. View Abstract

  214. Cerebral pathophysiology and critical care neurology: basic hemodynamic principles, cerebral perfusion, and intracranial pressure. Semin Pediatr Neurol. 2004 Jun; 11(2):89-104. View Abstract

  215. Neurosurgical aspects of critical care neurology. Semin Pediatr Neurol. 2004 Jun; 11(2):169-78. View Abstract

  216. Antenatal neurosurgical counseling: approach to the unborn patient. Pediatr Clin North Am. 2004 Apr; 51(2):491-505. View Abstract

  217. Hip status in cerebral palsy after one year of continuous intrathecal baclofen infusion. Pediatr Neurol. 2004 Mar; 30(3):163-8. View Abstract

  218. Search for extraterrestrial point sources of neutrinos with AMANDA-II. Phys Rev Lett. 2004 Feb 20; 92(7):071102. View Abstract

  219. Long-term outcome in children with moyamoya syndrome after cranial revascularization by pial synangiosis. J Neurosurg. 2004 Feb; 100(2 Suppl Pediatrics):142-9. View Abstract

  220. Laminar analysis of human neocortical interictal spike generation and propagation: current source density and multiunit analysis in vivo. Epilepsia. 2004; 45 Suppl 4:48-56. View Abstract

  221. Treatment of epilepsy by vagal nerve stimulation. Schmidek H, ed., Operative Neurosurgery (in press). 2004.

  222. Antenatal Neurosurgical counseling: Approach to the unborn patient. Pedi Clin N Amer. 2004; 51:491-505.

  223. Gamma oscillations correlate with working memory load in humans. Cereb Cortex. 2003 Dec; 13(12):1369-74. View Abstract

  224. Theta and gamma oscillations during encoding predict subsequent recall. J Neurosci. 2003 Nov 26; 23(34):10809-14. View Abstract

  225. Sleep-dependent theta oscillations in the human hippocampus and neocortex. J Neurosci. 2003 Nov 26; 23(34):10897-903. View Abstract

  226. Limits on diffuse fluxes of high energy extraterrestrial neutrinos with the AMANDA-B10 detector. Phys Rev Lett. 2003 Jun 27; 90(25 Pt 1):251101. View Abstract

  227. Reset of human neocortical oscillations during a working memory task. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7931-6. View Abstract

  228. Human theta oscillations related to sensorimotor integration and spatial learning. J Neurosci. 2003 Jun 01; 23(11):4726-36. View Abstract

  229. Pharyngeal dysesthesia in refractory complex partial epilepsy: new seizure or adverse effect of vagal nerve stimulation? Epilepsia. 2003 Jun; 44(6):855-8. View Abstract

  230. Non-invasive in vivo pressure measurement. 2003.

  231. Neonatal hydrocephalus. Hansen AR, Puder M, eds., Manual of Neonatal Surgical Intensive Care. 2003; 394-405.

  232. Syringomyelia. Adelman G, Smith BH, eds., Encylcopedia of Neuroscience (in press). 2003.

  233. Neurosurgery of the Newborn. Avery GB, Fletcher MA, McDonald MG, eds., Neonatology: Pathophysiology and Management of the Newborn (in press). 2003.

  234. Carotid and vertebral artery dissections in children and adults. Batjer HH, Loftus CM, eds. Textbook of Neurological Surgery: Principles and Practice. 2003; 1:1121-1127.

  235. Surgical treatment of pain in the child. Schechter NL, Berde CB, Yaster M, eds., Pain Management in Infants, Children and Adolescents. 2003; 329-339.

  236. Neonatal hydrocephalus. Hansen AR, Puder M, eds., Manual of Neonatal Surgical Intensive Care. 2003; 381-393.

  237. Syringomyelia. Aminoff M, Daroff R, eds., Encyclopedia of Neurological Sciences. 2003; 4:465-469.

  238. Shunt technology: Contemporary concepts and prospects. Contemporary Neurosurgery. 2003.

  239. Gamma oscillations increase with working memory load in humans. Cerebral Cortex. 2003; 13(12):1369-74.

  240. Shunt technology: contemporary concepts and prospects. Clin Neurosurg. 2003; 50:256-67. View Abstract

  241. Biochemical characterization of pediatric brain tumors by using in vivo and ex vivo magnetic resonance spectroscopy. J Neurosurg. 2002 Jun; 96(6):1023-31. View Abstract

  242. Variable anti-siphon valve apparatus and method. 2002.

  243. Congenital malformations of the cerebellum and posterior fossa. Manto M-U, Pandolfo M, eds, The Cerebellum and Its Disorders. 2002; 161-177.

  244. Neurotrauma. Fleisher GR, Ludwig S, eds., Synopsis of Pediatric Emergency Medicine, Revised Edition. 2002; 474-486.

  245. Theta returns. Curr Opin Neurobiol. 2001 Dec; 11(6):739-44. View Abstract

  246. Vagus nerve stimulation in pediatric epilepsy: a review. Pediatr Neurol. 2001 Nov; 25(5):368-76. View Abstract

  247. Vagus nerve stimulation therapy in pediatric patients with refractory epilepsy: retrospective study. J Child Neurol. 2001 Nov; 16(11):843-8. View Abstract

  248. Non-invasive in vivo pressure measurement. 2001.

  249. Gentle dorsal root retraction and dissection can cause areflexia: implications for intraoperative monitoring during "selective" partial dorsal rhizotomy. Muscle Nerve. 2001 Oct; 24(10):1352-8. View Abstract

  250. Temporal lobectomy in early childhood: the need for long-term follow-up. J Child Neurol. 2001 Aug; 16(8):585-90. View Abstract

  251. Distinct patterns of brain oscillations underlie two basic parameters of human maze learning. J Neurophysiol. 2001 Jul; 86(1):368-80. View Abstract

  252. Gating of human theta oscillations by a working memory task. J Neurosci. 2001 May 01; 21(9):3175-83. View Abstract

  253. Observation of high-energy neutrinos using Cerenkov detectors embedded deep in Antarctic ice. Nature. 2001 Mar 22; 410(6827):441-3. View Abstract

  254. Prenatal diagnosis and counseling for the neurosurgeon. McLone DG, ed., Pediatric Neurosurgery. 2001; 332-341.

  255. Vagus nerve stimulation in pediatric epilepsy: A review. Pediatric Neurol. 2001; 25:368-76.

  256. Shunt Malfunction. In: Gilman S ed. Medlink Neurology. (electronic media). 2001.

  257. Corpus callosotomy. Albright AL, Pollack IF, Adelson PD, eds., Atlas of Operative Techniques in Pediatric Neurosurgery. 2001; 257-265.

  258. Long-term vagus nerve stimulation beneficial in refractory epilepsy. Journal Watch Neurology. 2000; 2:3.

  259. 834 Event Related Potentials (ERPs) for Memory: Toward Localization of Cognitive Functions in Children. Neurosurgery. 2000 Aug 01; 47(2):538. View Abstract

  260. Subdural electrode arrays for monitoring cortical electrical activity. 2000.

  261. Non-invasive in vivo pressure measurement. 2000.

  262. [Chronic inflammatory bowel disease--pathogenic concepts and therapeutic perspectives]. Ugeskr Laeger. 2000 Mar 06; 162(10):1361-6. View Abstract

  263. Intrathecal baclofen for management of spastic cerebral palsy: multicenter trial. J Child Neurol. 2000 Feb; 15(2):71-7. View Abstract

  264. Pathophysiology, prevention, and potential treatment of neural tube defects. Ment Retard Dev Disabil Res Rev. 2000; 6(1):6-14. View Abstract

  265. The effect of propofol on intraoperative electrocorticography and cortical stimulation during awake craniotomies in children. Paediatr Anaesth. 2000; 10(1):29-34. View Abstract

  266. The living shunt: a tissue engineering approach in the treatment of hydrocephalus. Neurol Res. 2000 Jan; 22(1):105-10. View Abstract

  267. Procedures for intrathecal pharmacological therapy. Kaye AH, Black PMcL, eds., Operative Neurosurgery. 2000; 1505-1512.

  268. Neurotrauma. Fleisher GR, Ludwig S, eds., Textbook of Pediatric Emergency Medicine. 2000; 1271-1296.

  269. Human Theta Oscillations are Gated by a Working Memory Task. Soc. for Neurosci. Abst. 2000; 26(2):1589.

  270. Treatment of intractable epilepsy by electrical stimulation of the vagus nerve. Schmidek HH, ed., Operative Neurosurgical Techniques. 2000; 1421-1428.

  271. Human Theta Oscillations During Virtual Maze Navigation. Soc. for Neurosci. Abst. 2000; 26(2):1589.

  272. Pathology, Prevention, and Potential Treatment of Neural Tube Defects. Mental Retardation and Develop Disabil Res Rev. 2000; 6:6-14.

  273. Theta Oscillations, memory and epilepsy. Soc. Neurosci. Abstr. 2000; 26(1):810.

  274. Case Records of the Massachusetts General Hospital. Case 34-2000: a 71-year-old woman with an enlarging pituitary mass. New Engl J Med. 2000; 343:1399-1407.

  275. Task dependence of human theta: the case for multiple cognitive functions. Neurocomputing. 2000; 32-33:659-665.

  276. Central nervous system abnormalities assessed with prenatal magnetic resonance imaging. Obstet Gynecol. 1999 Dec; 94(6):1011-9. View Abstract

  277. Inosine stimulates extensive axon collateral growth in the rat corticospinal tract after injury. Proc Natl Acad Sci U S A. 1999 Nov 09; 96(23):13486-90. View Abstract

  278. Using intracranial recordings to study thetaResponse to J. O'Keefe and N. Burgess (1999). Trends Cogn Sci. 1999 Nov; 3(11):406-407. View Abstract

  279. MRI signal changes in the white matter after corpus callosotomy. Pediatr Neurol. 1999 Oct; 21(4):691-5. View Abstract

  280. Seizure outcome after surgery in very young children. Journal Watch Neurology. 1999; 1:3.

  281. Human theta oscillations exhibit task dependence during virtual maze navigation. Nature. 1999 Jun 24; 399(6738):781-4. View Abstract

  282. Fetal CNS anomalies revealed on ultrafast MR imaging. AJR Am J Roentgenol. 1999 Mar; 172(3):813-8. View Abstract

  283. A 2-month-old female infant with progressive macrocephaly and irritability -clinical conference-. Pediatr Neurosurg. 1999 Mar; 30(3):157-63. View Abstract

  284. Using intracranial recordings to study theta: Response to J. O’Keefe and N. Burgess. Trends Cognit Sci. 1999; 3:406-407.

  285. Vagal Nerve Stimulation for Treatment of Epilepsy in Pediatric Patients. 1999.

  286. Vagal nerve stimulation in children with intractable epilepsy—results in five centers - Poster Presentation. 1999.

  287. The Role of Theta Oscillations in Human Spatial Cognition: Evidence from Intracranial Recordings. 1999.

  288. Neurosurgery of the Newborn. Avery GB, Fletcher MA, McDonald MG, eds., Neonatology: Pathophysiology and Management of the Newborn. 1999; 1231-1252.

  289. Corpus callosotomy in children. Albright AL, Pollack IF, Adelson PD, eds., Principles and Practice in Pediatric Neurosurgery. 1999; 1147-1156.

  290. Vagal Nerve Stimulation for Treatment of Epilepsy in Pediatric Patients. 1999.

  291. Intracranial Pressure during Seizures in Children - Poster Presentation. 1999.

  292. Task-related Theta Activity from Intracranial Recordings During Virtual Maze Navigation - Oral Presentation. 1999.

  293. Craniotomy of Unusual Interest: Issues for Medicine, Law, Journalism, and Society in a Highly Publicized Case of Nonaccidental Trauma. 1999.

  294. The Sternberg Task Evokes Theta Oscillations in Human Intracranial Recordings. 1999.

  295. Vagal Nerve Stimulation In Children With Medically Intractable Epilepsy Following Epilepsy Surgery. American Epilepsy Society Annual Meeting abstract. 1999.

  296. Task-related Theta Activity from Intracranial Recordings During Virtual Maze Navigation. 1999.

  297. Tacrolimus (FK506) increases neuronal expression of GAP-43 and improves functional recovery after spinal cord injury in rats. Exp Neurol. 1998 Dec; 154(2):673-83. View Abstract

  298. Functional transplantation of the rat pituitary gland. Neurosurgery. 1998 Nov; 43(5):1157-63. View Abstract

  299. Focal cortical dysplasia with glioproliferative changes causing seizures: report of 3 cases. Pediatr Neurosurg. 1998 May; 28(5):261-6. View Abstract

  300. Intraventricular pressure dynamics in patients with ventriculopleural shunts: a telemetric study. Pediatr Neurosurg. 1998 Feb; 28(2):67-9. View Abstract

  301. Surgical management of cutis aplasia with high-flow sinus pericranii. Pediatr Neurosurg. 1998 Feb; 28(2):79-83. View Abstract

  302. Fas ligand- mediated killing by intestinal intraepithelial lymphocytes. Participation in intestinal graft-versus-host disease. J Clin Invest. 1998 Feb 01; 101(3):570-7. View Abstract

  303. Prenatal neurosurgical diagnosis and counseling. Neurosurg Clin N Am. 1998 Jan; 9(1):49-61. View Abstract

  304. Surgical management of neonatal hydrocephalus. Neurosurg Clin N Am. 1998 Jan; 9(1):105-10. View Abstract

  305. Syringomyelia. Adelman G, Smith BH, eds. Encylcopedia of Neuroscience . 1998.

  306. Tacrolimus (FK-506) increases neuronal expression of GAP-43 and improves neurological outcome after spinal cord injury in rats. Exper Neurol. 1998; 154:673-683.

  307. Cervical spinal cord injury in children. Contemp Neurosurg. 1998; 20(26):1-4.

  308. Antenatal diagnosis and counseling in neurosurgical anomalies. Neurosurgical Clin N America. 1998; 9:49-61.

  309. The use of clinical practice guidelines (CPGs) to evaluate practice and control costs in ventriculoperitoneal shunt management. Surg Neurol. 1997 Dec; 48(6):536-41. View Abstract

  310. Cerebral edema, cell volume regulation, and the role of ion channels in organic osmolyte transport. Pediatr Neurosurg. 1997 Dec; 27(6):279-85. View Abstract

  311. Identification of the volume-sensitive organic osmolyte/anion channel in human glial cells. Pediatr Neurosurg. 1997 Dec; 27(6):286-91. View Abstract

  312. Molecular biology of axonal outgrowth. 2. Pathfinding and molecular guidance cues. Pediatr Neurosurg. 1997 Oct; 27(4):168-75. View Abstract

  313. Intraventricular urokinase for the treatment of posthemorrhagic hydrocephalus. Pediatr Neurol. 1997 Oct; 17(3):213-7. View Abstract

  314. Fetal central nervous system anomalies: MR imaging augments sonographic diagnosis. Radiology. 1997 Sep; 204(3):635-42. View Abstract

  315. Connections of the hippocampal formation in humans: I. The mossy fiber pathway. J Comp Neurol. 1997 Sep 01; 385(3):325-51. View Abstract

  316. Connections of the hippocampal formation in humans: II. The endfolial fiber pathway. J Comp Neurol. 1997 Sep 01; 385(3):352-71. View Abstract

  317. Molecular biology of axonal outgrowth. 1. Growth cones and GAP-43. Pediatr Neurosurg. 1997 Sep; 27(3):113-20. View Abstract

  318. Optic chiasm astrocytomas of childhood. 1. Long-term follow-up. Pediatr Neurosurg. 1997 Sep; 27(3):121-8. View Abstract

  319. Presentation and management of Chiari I malformation in children. Pediatr Neurosurg. 1997 Apr; 26(4):190-6. View Abstract

  320. Solitary fibrous tumor presenting as a symptomatic intraspinal mass: case report. Neurosurgery. 1997 Apr; 40(4):844-7; discussion 847. View Abstract

  321. Clinical characteristics of complex partial seizures: a temporal versus a frontal lobe onset. Seizure. 1997 Feb; 6(1):57-61. View Abstract

  322. Intraventricular urokinase for the treatment of posthemorrhagic hydrocephalus: Fibrinolytic state does not preclude need for CSF shunt. Pediatric Neurology. 1997; 17:213-217.

  323. A tissue engineering approach for dural and cranial grafts - Oral Presentation. 1997.

  324. Miscellaneous benign tumors. Black PMcL, Loeffler JS,. eds., Tumors of the Central Nervous System. 1997; 431-440.

  325. Neck Pain [book review]. J Bone Joint Surgery. 1997; 79A:317.

  326. Tacrolimus (FK506) increases neuronal expression of GAP-43 as it improves neurological recovery after spinal cord injury in rats - Oral Presentation. 1997.

  327. The future of epilepsy surgery for children. Harvard Mahoney Neuroscience Institute Letter. 1997; 6(2):1-7.

  328. Intraventricular urokinase for the treatment of posthemorrhagic hydrocephalus. 1997.

  329. Neonatal hydrocephalus: hemodynamic response to fontanelle compression-- correlation with intracranial pressure and need for shunt placement. Radiology. 1996 Dec; 201(3):685-9. View Abstract

  330. Lamotrigine high-dose tolerability and safety in patients with epilepsy: a double-blind, placebo-controlled, eleven-week study. Epilepsia. 1996 Sep; 37(9):857-62. View Abstract

  331. The critical importance of stimulus intensity in intraoperative monitoring for partial dorsal rhizotomy. Muscle Nerve. 1996 Apr; 19(4):415-22. View Abstract

  332. Intraventricular urokinase for the treatment of posthemorrhagic hydrocephalus - abstract. 1996.

  333. Hemodynamic Response to Fontanelle Compression in Neonatal Hydrocephalus: Correlation with intracranial pressure and need for shunt placement - Radiology. 1996.

  334. FK-506 improvement in recovery after spinal cord injury: possible role of GAP-43 expression in calcineurin effect. Research Society of Neurological Surgeons meeting abstract. 1996.

  335. Congenital Malformations of the Cerebrum. In Tindall GT, Copper PR, Barrow DL., eds. The Practice of Neurosurgery. 1996; 3:2625-2634.

  336. FK-506 Improvement in Recovery after Spinal Cord Injury: Possible Role of GAP-43 Expression and Calcineurin Effect. 1996.

  337. After neurotrauma: brain and spinal cord repair. Harvard Mahoney Neuroscience Institute Letter. 1996; 5(2):1-7.

  338. FK-506 improves recovery after spinal cord injury: immunophilins as a new therapeutic target. Soc. Neurosci. Abstr. 1996; 22(1):264.

  339. FK-506 Improves Neurological Outcome and Increases Neuronal Expression of GAP-43 after Spinal Cord Injury in Rats. 1996.

  340. Posterior fossa arachnoid cyst: an in utero mimicker of Dandy-Walker malformation. J Ultrasound Med. 1995 Oct; 14(10):787-90. View Abstract

  341. Corpus callosotomy in children. Neurosurg Clin N Am. 1995 Jul; 6(3):541-8. View Abstract

  342. The future of pediatric epilepsy surgery. Signposts and science. Neurosurg Clin N Am. 1995 Jul; 6(3):589-97. View Abstract

  343. EEG prior to hemispherectomy: correlation with outcome and pathology. Electroencephalogr Clin Neurophysiol. 1995 Apr; 94(4):265-70. View Abstract

  344. A vaccine-elicited, single viral epitope-specific cytotoxic T lymphocyte response does not protect against intravenous, cell-free simian immunodeficiency virus challenge. J Virol. 1995 Apr; 69(4):2279-84. View Abstract

  345. Nitrous oxide depresses the H-reflex in children with cerebral palsy. Anesth Analg. 1995 Feb; 80(2):239-41. View Abstract

  346. Use of subdural grids and strip electrodes to identify a seizure focus in children. Pediatr Neurosurg. 1995; 22(4):174-80. View Abstract

  347. The latency test: criterion for valid reflexes in dorsal rhizotomy surgery. American Society of Pediatric Neurosurgeons abstract. 1995.

  348. The critical importance of stimulus intensity in intraoperative monitoring for selective dorsal rhizotomy (DR). American Society of Electrophysiology abstract. 1995.

  349. The role of surgery in the management of optic chiasm astrocytomas in childhood. American Association of Neurological Surgeons abstract. 1995.

  350. Technetium-99m HmPAO brain SPECT and outcome of hemispherectomy for intractable seizures. Pediatr Neurol. 1994 Oct; 11(3):203-7. View Abstract

  351. H reflex studies in cerebral palsy patients undergoing partial dorsal rhizotomy. Muscle Nerve. 1994 May; 17(5):539-49. View Abstract

  352. Identification of volume-sensitive organic osmolyte channels in human glial cells. Soc. Neurosci. Abstr. 1994; 20(2):1502.

  353. Nitrous oxide depresses the H-reflex in children with cerebral palsy. American Society for Anesthesiology Meeting abstract. 1994.

  354. Conditioned media from a transformed glial-like cell line enhances neurite outgrowth and GAP-43 expression. Soc. Neurosci. Abstr. 1994; 20(2):1687.

  355. Effect of surgical repair on the neurologic function in infants with lipomeningocele. Pediatr Neurosurg. 1993 Sep-Oct; 19(5):256-9. View Abstract

  356. Chiari malformations, syringomyelia, and intramedullary spinal cord tumors. Curr Opin Neurol Neurosurg. 1993 Aug; 6(4):559-63. View Abstract

  357. Thallium-201 versus technetium-99m-MIBI SPECT in evaluation of childhood brain tumors: a within-subject comparison. J Nucl Med. 1993 Jul; 34(7):1045-51. View Abstract

  358. Process variables as predictors of risk factor changes in a family health behavior change program. Health Educ Res. 1993 Jun; 8(2):193-204. View Abstract

  359. EEG patterns in patients undergoing hemispherectomy evaluation. 1993.

  360. SPECT scan findings in the evaluation of hemispherectomy for intractable seizures: A predictor of favorable outcome. 1993.

  361. Epilepsy surgery, ed by HO Luders [book review]. J Epilepsy. 1993; 6:131.

  362. Treatment of medulloblastoma with pre-irradiation chemotherapy: experience at Boston Children’s Hospital from 1984 to 1991 - Pediatric Session. 1993.

  363. Neurite outgrowth and GAP-43 expression: effects of glial substrate and of monoclonal antibodies recognizing glial cell surface proteins. Soc. Neurosci. Abstr. 1993; 19(1):626.

  364. HMPAO SPECT versus outcomes of hemispherectomy for intractable seizures. Child Neurology Society Meeting abstract. 1993.

  365. EEG Patterns in patients undergoing hemispherectomy correlation with outcome and pathology. Epilepsia. 1993.

  366. Discharge morphology and propagation patterns in temporal lobe epilepsy in children and adolescents: effects of age. American Epilepsy Society Meeting abstract. 1993.

  367. Astrocytomas of the cerebellum. Black PMcL, Schoene WC, Lampson LA, eds. Astrocytomas: Diagnosis, Treatment, and Biology. 1993; 175-180.

  368. The latency test: distinguishing valid reflexes in dorsal rhizotomy surgery - Pediatric SEssion. 1993.

  369. 201Tl versus 99mTc-MIBI SPECT in evaluation of childhood brain tumors: a within-subject comparison. J Nucl Med. 1993; 34:1045-1051.

  370. Neurosurgical procedures for the relief of pain in children and adolescents. Schechter NL, Berde CB, Yaster M, eds. Pain Management in Infants, Children and Adolescents. 1993; 237-243.

  371. Immunological approach to putative glial surface molecules affecting neurite outgrowth: changes with normal development and after lesions - Poster Session. 1992.

  372. Cavernous angioma of the posterior fossa dura mimicking a meningioma: case report and review of literature. Surg Neurol. 1992 Oct; 38(4):257-60. View Abstract

  373. Comparison of surface and intracranial electrode studies in children with temporal lobe seizures. American Epilepsy Society Meeting abstract. 1992.

  374. Case records of the Massachusetts General Hospital, case 16-1992: a 27-year-old woman with pain in the neck and shoulder. N Engl J Med. 1992; 326:1070-1076.

  375. Glial surface molecules in lesions and regeneration: generation of a panel of monoclonal antibodies. Soc. Neurosci. Abstr. 1992; 18(2):1448.

  376. Glial surface molecules affecting neurite outgrowth: immunological dissection using monoclonal antibodies - Poster Session. 1992.

  377. Chronic increased intracranial pressure. Asbury AK, McKhann GM, McDonald WI, eds. Diseases of the Nervous System. 1992; 967-977.

  378. The pediatric neurosurgical patient: a cooperative approach, ed. by LP Ivan. [book review]. J Neurosurg. 1991; 74:306-307.

  379. Glial surface molecules affecting neurite outgrowth: immunological dissection using monoclonal antibodies - Open Scientific Session. 1991.

  380. Spinal tumors in children and adolescents, ed by I Pascual-Castroviejo. [book review]. Surg Neurol. 1991; 36:73-74.

  381. Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. Am J Clin Nutr. 1990 May; 51(5):759-67. View Abstract

  382. Immunoreactivity for two promotors of neurite outgrowth in pituitary cell subsets - Poster Session,. 1990.

  383. Giant peripheral aneurysms of the posterior inferior cerebellar artery presenting as cerebellar masses. Sugita K, Shibuya M, eds. Intracranial Aneurysms and Arteriovenous Malformations: State of the Art. 1990; 277-282.

  384. Psychosis and aggressive behavior after corpus callosotomy - Poster Presentation. 1990.

  385. Giant peripheral aneurysms of the posterior inferior cerebellar artery presenting as cerebellar masses. 1989.

  386. An interview with Dr. HT Ballantine - video presentation. 1989.

  387. X Hapten immunoreactivity in oligodendrogliomas. Lab Invest; 60:23A. 1989.

  388. Immunoreactivity in pituitary gonadotropes and hypothalamic vasopressinergic neurons for the monoclonal antibody INO. J Neuroimmunol. 1988 Nov; 20(1):83-91. View Abstract

  389. Giant peripheral aneurysm of the posterior inferior cerebellar artery treated with excision and end-to-end anastomosis. Surg Neurol. 1988 Aug; 30(2):140-3. View Abstract

  390. Expression of X hapten immunoreactivity by human and rat adenohypophyseal cells. J Neurosurg. 1988 Jun; 68(6):938-46. View Abstract

  391. Spinal arteriovenous malformations and neurogenic claudication. Report of two cases. J Neurosurg. 1988 May; 68(5):793-7. View Abstract

  392. 1988.

  393. Spinal arteriovenous malformations and spinal claudication: a diagnostic dilemma. 1988.

  394. Neurosurgery of the Neonate. Neurosurgical Clinics of North America. 1988.

  395. Commentary on the transvenous treatment of antero-inferior dural venous fistulae. Schmidek HH, Sweet WH, eds. Operative Neurosurgical Techniques: Indications, Methods and Results. 1988; 849-854.

  396. Immunologically defined astrocyte subsets: implications for axonal regeneration after central nervous system injury. Surgical Forum. 1987; 37:512-515.

  397. Hemodynamic method to predict whether Hunterian ligation of the basilar artery will lead to thrombosis of basilar bifurcation aneurysms: Comment. Neurosurgery. 1987; 20:252-253.

  398. Immunohistochemistry of pituitary adenomas. Neurology Neurosurgery Update Series. 1987; 7(24):1-8.

  399. Neuromethods, volumes 1 and 2 [book review]. Am J Neuroradiology. 1987; 8:608.

  400. Expression of X-hapten immunoreactivity by human and rat adenohypophyseal cells: alterations in tumors and estrogen-induced hyperplasia. 1987.

  401. Transplantation of neonatal rat pituicytes into the third ventricle of hypophysectomized recipients leads to restitution of plasma adenohypophyseal hormone levels. 1987.

  402. Functional transplantation of the pituitary gland - Open Scientific Session. 1987.

  403. Neuropeptide investigations with an ovine surgical model. Neurosurgery. 1986 Jun; 18(6):748-55. View Abstract

  404. Re-expression of an antigen present in developing CNS by injured and sprouting adult neurons - Open Scientific Session. 1986.

  405. Cerebrospinal fluid anion transport: studies of pertechnetate in unanesthetized sheep. Neurosurgery. 1985 Nov; 17(5):778-83. View Abstract

  406. Pertechnetate as a probe of the anion clearance mechanisms of the brain - Poster Session. 1984.

  407. Circadian changes in the destruction and effects of haloperidol in the rat. Neuropharmacology. 1982 Jul; 21(7):663-9. View Abstract

  408. Chronopsychopharmacology. Psychopharm Bull. 1982; 17:112-113.

  409. Effects of prenatal treatment of rats with haloperidol due to altered drug distribution in neonatal brain. Neuropharmacology. 1981 Oct; 20(10):931-9. View Abstract

  410. Special report. The nature of aggression during epileptic seizures. N Engl J Med. 1981 Sep 17; 305(12):711-6. View Abstract

  411. Intoxication associated with lithium and ECT. Am J Psychiatry. 1980 Sep; 137(9):1107-9. View Abstract

  412. [Electro-clinical changes following traumatic cerebral contusion in children. Risk of epileptic sequela]. Rev Chil Pediatr. 1980 Jul-Aug; 51(4):253-6. View Abstract

  413. Diurnal changes in effects of haloperidol in rats. Neurosci Abst. 1980; 6:707.

  414. Occlusive arterial disease of the child and young adult. Clinical electroencephalographical analysis of 26 cases. Childs Brain. 1978; 4(1):1-14. View Abstract

  415. Unsaturated carbenes from primary vinyl triflates: competitive addition of isopropylidene to olefins. J Org Chem. 1977; 42:1802-1804.

  416. Lupus erythematosus and pregnancy. Obstet Gynecol. 1961 Oct; 18:492-4. View Abstract

The wide-open vistas of my youth and the pioneer spirit of the western settlers have had profound influences on my approach to care and research. I believe in taking my time to talk to patients and charting an individual direction in medicine.

BESbswy