Current Environment: Production

Erica Esrick | Medical Services

Programs & Services

Languages

  • English

Erica Esrick | Education

Medical School

Pediatrics

Harvard Medical School

2004, Boston, MA

Internship

Pediatrics

Children's Memorial Hospital

2005, Chicago, IL

Residency

Pediatrics

Boston Combined Residency Program (BCRP)

2007, Boston, MA

Fellowship

Pediatric Hematology-Oncology

Boston Children's Hospital/Dana-Farber Cancer Institute

2010, Boston, MA

Erica Esrick | Certifications

  • American Board of Pediatrics (Hematology-Oncology)

Erica Esrick | Media

Research

Gene therapy for sickle cell disease: The journey to a new treatment

Erica Esrick | Publications

  1. ß-Thalassemia minor is associated with high rates of worsening anemia in pregnancy. Blood. 2025 Feb 06; 145(6):648-651. View ß-Thalassemia minor is associated with high rates of worsening anemia in pregnancy. Abstract

  2. Clonal selection of hematopoietic stem cells after gene therapy for sickle cell disease. Nat Med. 2023 Dec; 29(12):3175-3183. View Clonal selection of hematopoietic stem cells after gene therapy for sickle cell disease. Abstract

  3. Genetic reversal of the globin switch concurrently modulates both fetal and sickle hemoglobin and reduces red cell sickling. Nat Commun. 2023 09 20; 14(1):5850. View Genetic reversal of the globin switch concurrently modulates both fetal and sickle hemoglobin and reduces red cell sickling. Abstract

  4. Bidirectional processes linking social determinants of health and pediatric sickle cell anemia management: A qualitative study. Pediatr Blood Cancer. 2023 10; 70(10):e30539. View Bidirectional processes linking social determinants of health and pediatric sickle cell anemia management: A qualitative study. Abstract

  5. Defining global strategies to improve outcomes in sickle cell disease: a Lancet Haematology Commission. Lancet Haematol. 2023 08; 10(8):e633-e686. View Defining global strategies to improve outcomes in sickle cell disease: a Lancet Haematology Commission. Abstract

  6. Secondary Neoplasms After Hematopoietic Cell Transplant for Sickle Cell Disease. J Clin Oncol. 2023 04 20; 41(12):2227-2237. View Secondary Neoplasms After Hematopoietic Cell Transplant for Sickle Cell Disease. Abstract

  7. Metformin for treatment of cytopenias in children and young adults with Fanconi anemia. Blood Adv. 2022 06 28; 6(12):3803-3811. View Metformin for treatment of cytopenias in children and young adults with Fanconi anemia. Abstract

  8. Investigational curative gene therapy approaches to sickle cell disease. Blood Adv. 2021 12 14; 5(23):5452. View Investigational curative gene therapy approaches to sickle cell disease. Abstract

  9. ß-Thalassemia: evolving treatment options beyond transfusion and iron chelation. Hematology Am Soc Hematol Educ Program. 2021 12 10; 2021(1):600-606. View ß-Thalassemia: evolving treatment options beyond transfusion and iron chelation. Abstract

  10. Post-Transcriptional Genetic Silencing of BCL11A to Treat Sickle Cell Disease. N Engl J Med. 2021 01 21; 384(3):205-215. View Post-Transcriptional Genetic Silencing of BCL11A to Treat Sickle Cell Disease. Abstract

  11. Preclinical Evaluation of a Novel Lentiviral Vector Driving Lineage-Specific BCL11A Knockdown for Sickle Cell Gene Therapy. Mol Ther Methods Clin Dev. 2020 Jun 12; 17:589-600. View Preclinical Evaluation of a Novel Lentiviral Vector Driving Lineage-Specific BCL11A Knockdown for Sickle Cell Gene Therapy. Abstract

  12. Highly efficient therapeutic gene editing of human hematopoietic stem cells. Nat Med. 2019 May; 25(5):776-783. View Highly efficient therapeutic gene editing of human hematopoietic stem cells. Abstract

  13. Successful hematopoietic stem cell mobilization and apheresis collection using plerixafor alone in sickle cell patients. Blood Adv. 2018 10 09; 2(19):2505-2512. View Successful hematopoietic stem cell mobilization and apheresis collection using plerixafor alone in sickle cell patients. Abstract

  14. Genetic therapies for sickle cell disease. Semin Hematol. 2018 04; 55(2):76-86. View Genetic therapies for sickle cell disease. Abstract

  15. Phase 1/2 trial of vorinostat in patients with sickle cell disease who have not benefitted from hydroxyurea. Blood. 2015 Jun 04; 125(23):3668-9. View Phase 1/2 trial of vorinostat in patients with sickle cell disease who have not benefitted from hydroxyurea. Abstract

  16. Inactivation of HDAC1 or HDAC2 induces gamma globin expression without altering cell cycle or proliferation. Am J Hematol. 2015 Jul; 90(7):624-8. View Inactivation of HDAC1 or HDAC2 induces gamma globin expression without altering cell cycle or proliferation. Abstract

  17. Howell-Jolly–like bodies in neutrophils. Blood. 2015 Apr 23; 125(17):2729. View Howell-Jolly–like bodies in neutrophils. Abstract

  18. Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. Science. 2011 Nov 18; 334(6058):993-6. View Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. Abstract

  19. Preoperative visual acuity as a prognostic indicator for laser treatment of macular edema due to branch retinal vein occlusion. Ophthalmic Surg Lasers Imaging. 2006 Nov-Dec; 37(6):462-7. View Preoperative visual acuity as a prognostic indicator for laser treatment of macular edema due to branch retinal vein occlusion. Abstract

  20. Multiple laser treatments for macular edema attributable to branch retinal vein occlusion. Am J Ophthalmol. 2005 Apr; 139(4):653-7. View Multiple laser treatments for macular edema attributable to branch retinal vein occlusion. Abstract

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