Current Environment: Production

Medical Services

Programs & Services

Languages

  • English

Education

Medical School

University of Pennsylvania School of Medicine

2004, Philadelphia, PA

Internship

Children’s Hospital of Philadelphia

2005, Philadelphia, PA

Residency

Pediatrics

Children’s Hospital of Philadelphia

2006, Philadelphia, PA

Fellowship

Pediatric Infectious Diseases

Boston Children's Hospital

2010, Boston, MA

Certifications

  • American Board of Pediatrics (General)
  • American Board of Pediatrics (Infectious Diseases)

Publications

  1. PfFBXO1 is essential for inner membrane complex formation in Plasmodium falciparum during both asexual and transmission stages. Commun Biol. 2025 Feb 07; 8(1):190. View Abstract

  2. The dynamin-related protein PfDyn2 is essential for both apicoplast and mitochondrial fission in Plasmodium falciparum. mBio. 2025 Jan 08; 16(1):e0303624. View Abstract

  3. Plasmodium SEY1 is a novel druggable target that contributes to imidazolopiperazine mechanism of action. Res Sq. 2024 Sep 23. View Abstract

  4. CRISPR-based functional profiling of the Toxoplasma gondii genome during acute murine infection. Nat Microbiol. 2024 Sep; 9(9):2323-2343. View Abstract

  5. Elucidating the spatio-temporal dynamics of the Plasmodium falciparum basal complex. PLoS Pathog. 2024 Jun; 20(6):e1012265. View Abstract

  6. Artemisinin resistance mutations in Pfcoronin impede hemoglobin uptake. bioRxiv. 2024 May 30. View Abstract

  7. PfCAP-H is essential for assembly of condensin I complex and karyokinesis during asexual proliferation of Plasmodium falciparum. mBio. 2024 May 08; 15(5):e0285023. View Abstract

  8. The dynamin-related protein Dyn2 is essential for both apicoplast and mitochondrial fission in Plasmodium falciparum. bioRxiv. 2024 Mar 17. View Abstract

  9. PfCAP-H is essential for assembly of condensin I complex and karyokinesis during asexual proliferation of Plasmodium falciparum. bioRxiv. 2024 Feb 29. View Abstract

  10. Atlas of Plasmodium falciparum intraerythrocytic development using expansion microscopy. Elife. 2023 Dec 18; 12. View Abstract

  11. Atlas of Plasmodium falciparum intraerythrocytic development using expansion microscopy. bioRxiv. 2023 Oct 09. View Abstract

  12. Essential function of alveolin PfIMC1g in the Plasmodium falciparum asexual blood stage. mBio. 2023 Oct 31; 14(5):e0150723. View Abstract

  13. From Archeology to the Malaria Parasite, the Exciting Quests of Microscopy. Microsc Microanal. 2023 07 22; 29(Suppl 1):86-87. View Abstract

  14. A PPP-type pseudophosphatase is required for the maintenance of basal complex integrity in Plasmodium falciparum. Nat Commun. 2023 07 03; 14(1):3916. View Abstract

  15. Phenotypic Screens Identify Genetic Factors Associated with Gametocyte Development in the Human Malaria Parasite Plasmodium falciparum. Microbiol Spectr. 2023 06 15; 11(3):e0416422. View Abstract

  16. Functional profiling of the Toxoplasma genome during acute mouse infection. bioRxiv. 2023 Mar 06. View Abstract

  17. Identification of basal complex protein that is essential for maturation of transmission-stage malaria parasites. Proc Natl Acad Sci U S A. 2022 08 23; 119(34):e2204167119. View Abstract

  18. Plasmodium Egress Across the Parasite Life Cycle. Annu Rev Microbiol. 2022 09 08; 76:67-90. View Abstract

  19. The Basal Complex Protein PfMORN1 Is Not Required for Asexual Replication of Plasmodium falciparum. mSphere. 2021 12 22; 6(6):e0089521. View Abstract

  20. Automated detection and staging of malaria parasites from cytological smears using convolutional neural networks. Biol Imaging. 2021; 1:e2. View Abstract

  21. The Ringleaders: Understanding the Apicomplexan Basal Complex Through Comparison to Established Contractile Ring Systems. Front Cell Infect Microbiol. 2021; 11:656976. View Abstract

  22. ?d T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis. Nat Immunol. 2021 03; 22(3):347-357. View Abstract

  23. Depletion of the mini-chromosome maintenance complex binding protein allows the progression of cytokinesis despite abnormal karyokinesis during the asexual development of Plasmodium falciparum. Cell Microbiol. 2021 03; 23(3):e13284. View Abstract

  24. Ultrasensitive CRISPR-based diagnostic for field-applicable detection of Plasmodium species in symptomatic and asymptomatic malaria. Proc Natl Acad Sci U S A. 2020 10 13; 117(41):25722-25731. View Abstract

  25. Three-dimensional ultrastructure of Plasmodium falciparum throughout cytokinesis. PLoS Pathog. 2020 06; 16(6):e1008587. View Abstract

  26. Anti-PfGARP activates programmed cell death of parasites and reduces severe malaria. Nature. 2020 06; 582(7810):104-108. View Abstract

  27. A Novel Antiparasitic Compound Kills Ring-Stage Plasmodium falciparum and Retains Activity Against Artemisinin-Resistant Parasites. J Infect Dis. 2020 03 02; 221(6):956-962. View Abstract

  28. Influence of Plasmodium falciparum Calcium-Dependent Protein Kinase 5 (PfCDPK5) on the Late Schizont Stage Phosphoproteome. mSphere. 2020 01 08; 5(1). View Abstract

  29. An essential contractile ring protein controls cell division in Plasmodium falciparum. Nat Commun. 2019 05 16; 10(1):2181. View Abstract

  30. Calcium-Dependent Protein Kinase 5 Is Required for Release of Egress-Specific Organelles in Plasmodium falciparum. mBio. 2018 02 27; 9(1). View Abstract

  31. Getting Your Head around Cerebral Malaria. Cell Host Microbe. 2017 11 08; 22(5):586-588. View Abstract

  32. Functional Analysis Reveals Geographical Variation in Inhibitory Immune Responses Against a Polymorphic Malaria Antigen. J Infect Dis. 2017 07 15; 216(2):267-275. View Abstract

  33. PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum. Nat Commun. 2017 07 05; 8(1):63. View Abstract

  34. The Malaria Parasite Cyclin H Homolog PfCyc1 Is Required for Efficient Cytokinesis in Blood-Stage Plasmodium falciparum. mBio. 2017 06 13; 8(3). View Abstract

  35. Erratum: Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony. Nat Microbiol. 2017 Mar 06; 2:17038. View Abstract

  36. Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony. Nat Microbiol. 2017 Feb 17; 2:17017. View Abstract

  37. Receptor for Activated C-Kinase 1 (PfRACK1) is required for Plasmodium falciparum intra-erythrocytic proliferation. Mol Biochem Parasitol. 2017 01; 211:62-66. View Abstract

  38. An essential malaria protein defines the architecture of blood-stage and transmission-stage parasites. Nat Commun. 2016 04 28; 7:11449. View Abstract

  39. Dynamical features of the Plasmodium falciparum ribosome during translation. Nucleic Acids Res. 2015 Dec 02; 43(21):10515-24. View Abstract

  40. Antibodies to PfSEA-1 block parasite egress from RBCs and protect against malaria infection. Science. 2014 May 23; 344(6186):871-7. View Abstract

  41. Inside scoop on outside proteins. Infect Immun. 2014 Mar; 82(3):921-3. View Abstract

  42. A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis. Science. 2012 Jan 13; 335(6065):218-21. View Abstract

  43. Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors. Chem Biol. 2011 Dec 23; 18(12):1602-10. View Abstract

  44. A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. Science. 2010 May 14; 328(5980):910-2. View Abstract

  45. Functional diversification between two related Plasmodium falciparum merozoite invasion ligands is determined by changes in the cytoplasmic domain. Mol Microbiol. 2010 Feb; 75(4):990-1006. View Abstract

  46. Suggestive evidence for Darwinian Selection against asparagine-linked glycans of Plasmodium falciparum and Toxoplasma gondii. Eukaryot Cell. 2010 Feb; 9(2):228-41. View Abstract

  47. Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors. Bioorg Med Chem Lett. 2009 Feb 01; 19(3):972-5. View Abstract

  48. Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem. 2008 Dec 12; 283(50):35078-85. View Abstract

  49. Emergence of community-associated methicillin resistant Staphylococcus aureus in Hawaii, 2001-2003. J Infect. 2007 Apr; 54(4):349-57. View Abstract

  50. Intracellular trafficking of HIV-1 cores: journey to the center of the cell. Curr Top Microbiol Immunol. 2003; 281:179-208. View Abstract

  51. Reassessment of the roles of integrase and the central DNA flap in human immunodeficiency virus type 1 nuclear import. J Virol. 2002 Dec; 76(23):12087-96. View Abstract

  52. HIV-1 infection requires a functional integrase NLS. Mol Cell. 2001 May; 7(5):1025-35. View Abstract

  53. In vivo attenuation of simian immunodeficiency virus by disruption of a tyrosine-dependent sorting signal in the envelope glycoprotein cytoplasmic tail. J Virol. 2001 Jan; 75(1):278-91. View Abstract
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