Current Environment: Production

Jacob Bledsoe | Education

Undergraduate School

Northwestern University

Evanston, IL

Medical School

Drexel University College of Medicine

Philadelphia, PA

Residency

Massachusetts General Hospital

Boston, MA

Fellowship

Massachusetts General Hospital

Boston, MA

Jacob Bledsoe | Certifications

  • American Board of Pathology (Anatomic Clinical Pathology)
  • American Board of Pathology (Hematopathology)

Jacob Bledsoe | Publications

  1. ANKRD26-related Thrombocytopenia 2 with a Baseline Increase in Blasts: Implications for Clinical Surveillance. Blood. 2025 May 07. View ANKRD26-related Thrombocytopenia 2 with a Baseline Increase in Blasts: Implications for Clinical Surveillance. Abstract

  2. Clinicopathologic Features and the Spectrum of Myelokathexis in Warts, Hypogammaglobulinemia, Infections, Myelokathexis Syndrome. Lab Invest. 2025 Apr 14; 105(8):104174. View Clinicopathologic Features and the Spectrum of Myelokathexis in Warts, Hypogammaglobulinemia, Infections, Myelokathexis Syndrome. Abstract

  3. Clinical Characteristics and Treatment of Histiocytic Disorders in Children. Hematol Oncol Clin North Am. 2025 Jun; 39(3):513-529. View Clinical Characteristics and Treatment of Histiocytic Disorders in Children. Abstract

  4. CYLD-mutated anal squamous cell carcinoma: An uncommon entity associated with cylindroma-like morphology and adverse clinical features. Hum Pathol. 2025 Mar; 157:105765. View CYLD-mutated anal squamous cell carcinoma: An uncommon entity associated with cylindroma-like morphology and adverse clinical features. Abstract

  5. Chronic Stenosing Enteritis: A Variant of Chronic Non-specific Stenosing Ulceration (CNSU) that Is Distinct from Crohn's Disease. Dig Dis Sci. 2025 Apr; 70(4):1449-1456. View Chronic Stenosing Enteritis: A Variant of Chronic Non-specific Stenosing Ulceration (CNSU) that Is Distinct from Crohn's Disease. Abstract

  6. Erythroblastic Sarcoma in Adults and Children: Different Pathways to the Same Destination. Mod Pathol. 2025 Feb 14; 100716. View Erythroblastic Sarcoma in Adults and Children: Different Pathways to the Same Destination. Abstract

  7. Clinical, immunophenotypic, and genomic findings of acute myeloid leukemia with RAM immunophenotype: Comparison with other CD56-positive acute leukemias. EJHaem. 2025 Feb; 6(1):e1052. View Clinical, immunophenotypic, and genomic findings of acute myeloid leukemia with RAM immunophenotype: Comparison with other CD56-positive acute leukemias. Abstract

  8. Features of hyperinflammation link the biology of Epstein-Barr virus infection and cytokine storm syndromes. J Allergy Clin Immunol. 2025 Apr; 155(4):1346-1356.e9. View Features of hyperinflammation link the biology of Epstein-Barr virus infection and cytokine storm syndromes. Abstract

  9. Hematologic Cancer after Gene Therapy for Cerebral Adrenoleukodystrophy. N Engl J Med. 2024 10 10; 391(14):1287-1301. View Hematologic Cancer after Gene Therapy for Cerebral Adrenoleukodystrophy. Abstract

  10. Primary CNS histiocytic sarcoma: Two case reports highlighting a novel MIGA2::BRAF gene fusion and genome-wide DNA methylation profiling results. J Neuropathol Exp Neurol. 2024 Oct 01; 83(10):882-886. View Primary CNS histiocytic sarcoma: Two case reports highlighting a novel MIGA2::BRAF gene fusion and genome-wide DNA methylation profiling results. Abstract

  11. Discerning clinicopathological features of congenital neutropenia syndromes: an approach to diagnostically challenging differential diagnoses. J Clin Pathol. 2024 Aug 16; 77(9):586-604. View Discerning clinicopathological features of congenital neutropenia syndromes: an approach to diagnostically challenging differential diagnoses. Abstract

  12. Induction of remission after donor lymphocyte infusion following allogeneic transplant in a case of pediatric primary myelofibrosis. Pediatr Blood Cancer. 2024 Oct; 71(10):e31248. View Induction of remission after donor lymphocyte infusion following allogeneic transplant in a case of pediatric primary myelofibrosis. Abstract

  13. A novel transmembrane CXCR4 variant that expands the WHIM genotype-phenotype paradigm. Blood Adv. 2024 07 23; 8(14):3754-3759. View A novel transmembrane CXCR4 variant that expands the WHIM genotype-phenotype paradigm. Abstract

  14. Frameshift Mutations in Leukemia-Associated Genes Correlate With Superior Outcomes in Patients Undergoing Allogeneic Stem Cell Transplant for De Novo Acute Myeloid Leukemia. J Hematol. 2024 Jun; 13(3):86-93. View Frameshift Mutations in Leukemia-Associated Genes Correlate With Superior Outcomes in Patients Undergoing Allogeneic Stem Cell Transplant for De Novo Acute Myeloid Leukemia. Abstract

  15. Acute Promyelocytic Leukemia With Torque Teno Mini Virus::RARA Fusion: An Approach to Screening and Diagnosis. Mod Pathol. 2024 Jul; 37(7):100509. View Acute Promyelocytic Leukemia With Torque Teno Mini Virus::RARA Fusion: An Approach to Screening and Diagnosis. Abstract

  16. IgG4-related lymphadenopathy. Semin Diagn Pathol. 2024 Mar; 41(2):108-115. View IgG4-related lymphadenopathy. Abstract

  17. Treatment of recurrent pediatric myelodysplastic syndrome post hematopoietic stem cell transplantation. Clin Case Rep. 2023 Nov; 11(11):e8190. View Treatment of recurrent pediatric myelodysplastic syndrome post hematopoietic stem cell transplantation. Abstract

  18. Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma. Clin Cancer Res. 2023 11 14; 29(22):4613-4626. View Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma. Abstract

  19. IGJ and SPATS2L immunohistochemistry sensitively and specifically identify BCR::ABL1+ and BCR::ABL1-like B-acute lymphoblastic leukaemia. Br J Haematol. 2024 01; 204(1):229-239. View IGJ and SPATS2L immunohistochemistry sensitively and specifically identify BCR::ABL1+ and BCR::ABL1-like B-acute lymphoblastic leukaemia. Abstract

  20. Vascular leiomyoma of the thigh: Classic presentation of a rare tumor with imaging and pathology correlation. Radiol Case Rep. 2023 Nov; 18(11):4071-4075. View Vascular leiomyoma of the thigh: Classic presentation of a rare tumor with imaging and pathology correlation. Abstract

  21. Inherited bone marrow failure syndromes and germline predisposition to myeloid neoplasia: A practical approach for the pathologist. Semin Diagn Pathol. 2023 Nov; 40(6):429-442. View Inherited bone marrow failure syndromes and germline predisposition to myeloid neoplasia: A practical approach for the pathologist. Abstract

  22. Impact of cytoreduction and remission status on hematopoietic cell transplantation outcomes in pediatric myelodysplastic syndrome and related disorders. Pediatr Blood Cancer. 2023 Jun 27; e30530. View Impact of cytoreduction and remission status on hematopoietic cell transplantation outcomes in pediatric myelodysplastic syndrome and related disorders. Abstract

  23. Immunoglobulin G4-Related Disease, Lymphadenopathy, and Lymphoma: Histopathologic Features and Diagnostic Approach. Surg Pathol Clin. 2023 Jun; 16(2):177-195. View Immunoglobulin G4-Related Disease, Lymphadenopathy, and Lymphoma: Histopathologic Features and Diagnostic Approach. Abstract

  24. Old links revisited: Co-occurring thymoma and Castleman disease. Am J Hematol. 2023 09; 98(9):1497-1498. View Old links revisited: Co-occurring thymoma and Castleman disease. Abstract

  25. Sporadic hyperplastic polyp associated with above-average risk of developing metachronous colorectal cancer. Am J Cancer Res. 2023; 13(2):669-677. View Sporadic hyperplastic polyp associated with above-average risk of developing metachronous colorectal cancer. Abstract

  26. Loss of heat shock factor 1 promotes hepatic stellate cell activation and drives liver fibrosis. Hepatol Commun. 2022 10; 6(10):2781-2797. View Loss of heat shock factor 1 promotes hepatic stellate cell activation and drives liver fibrosis. Abstract

  27. Metformin for treatment of cytopenias in children and young adults with Fanconi anemia. Blood Adv. 2022 06 28; 6(12):3803-3811. View Metformin for treatment of cytopenias in children and young adults with Fanconi anemia. Abstract

  28. Reply to "Limitations of multivariate survival analysis". Mod Pathol. 2022 07; 35(7):994-995. View Reply to "Limitations of multivariate survival analysis". Abstract

  29. Impact of pretransplant mutation status on survival after allogeneic stem cell transplant for acute myeloid leukemia. EJHaem. 2021 Aug; 2(3):514-519. View Impact of pretransplant mutation status on survival after allogeneic stem cell transplant for acute myeloid leukemia. Abstract

  30. Rapid and Deep Remission Induced by Blinatumomab for CD19-Positive Chronic Myeloid Leukemia in Lymphoid Blast Phase. JCO Precis Oncol. 2021 07; 5. View Rapid and Deep Remission Induced by Blinatumomab for CD19-Positive Chronic Myeloid Leukemia in Lymphoid Blast Phase. Abstract

  31. Polyclonal PAX8 expression in carcinomas of the biliary tract - Frequent non-specific staining represents a potential diagnostic pitfall. Ann Diagn Pathol. 2021 Aug; 53:151762. View Polyclonal PAX8 expression in carcinomas of the biliary tract - Frequent non-specific staining represents a potential diagnostic pitfall. Abstract

  32. CD56 expression in basaloid anal squamous cell carcinoma - A potential diagnostic pitfall. Ann Diagn Pathol. 2021 Aug; 53:151758. View CD56 expression in basaloid anal squamous cell carcinoma - A potential diagnostic pitfall. Abstract

  33. IgG4-related Lymphadenopathy: A Comparative Study of 41 Cases Reveals Distinctive Histopathologic Features. Am J Surg Pathol. 2021 02 01; 45(2):178-192. View IgG4-related Lymphadenopathy: A Comparative Study of 41 Cases Reveals Distinctive Histopathologic Features. Abstract

  34. Molecular and immunophenotypic characterization of anal squamous cell carcinoma reveals distinct clinicopathologic groups associated with HPV and TP53 mutation status. Mod Pathol. 2021 05; 34(5):1017-1030. View Molecular and immunophenotypic characterization of anal squamous cell carcinoma reveals distinct clinicopathologic groups associated with HPV and TP53 mutation status. Abstract

  35. LGR5 in Barrett's Esophagus and its Utility in Predicting Patients at Increased Risk of Advanced Neoplasia. Clin Transl Gastroenterol. 2020 12 22; 12(1):e00272. View LGR5 in Barrett's Esophagus and its Utility in Predicting Patients at Increased Risk of Advanced Neoplasia. Abstract

  36. A deep learning diagnostic platform for diffuse large B-cell lymphoma with high accuracy across multiple hospitals. Nat Commun. 2020 11 26; 11(1):6004. View A deep learning diagnostic platform for diffuse large B-cell lymphoma with high accuracy across multiple hospitals. Abstract

  37. Clonal IgH gene rearrangements identify Richter's transformation to diffuse large B cell lymphoma. Ann Hematol. 2021 Dec; 100(12):3075-3077. View Clonal IgH gene rearrangements identify Richter's transformation to diffuse large B cell lymphoma. Abstract

  38. Outcomes After Stereotactic Body Radiation Therapy as a Bridging Modality to Liver Transplantation for Hepatocellular Carcinoma. Adv Radiat Oncol. 2021 Jan-Feb; 6(1):100559. View Outcomes After Stereotactic Body Radiation Therapy as a Bridging Modality to Liver Transplantation for Hepatocellular Carcinoma. Abstract

  39. CYLD mutation characterizes a subset of HPV-positive head and neck squamous cell carcinomas with distinctive genomics and frequent cylindroma-like histologic features. Mod Pathol. 2021 02; 34(2):358-370. View CYLD mutation characterizes a subset of HPV-positive head and neck squamous cell carcinomas with distinctive genomics and frequent cylindroma-like histologic features. Abstract

  40. Extramedullary Acute Myeloid Leukemia of the Renal Pelvis: Insights into a Visceral Niche. Acta Haematol. 2021; 144(3):297-301. View Extramedullary Acute Myeloid Leukemia of the Renal Pelvis: Insights into a Visceral Niche. Abstract

  41. Resolution of Severe Graft Steatosis Before Living-Donor Liver Transplant After 86 Pounds of Weight Loss. Exp Clin Transplant. 2022 09; 20(9):874-877. View Resolution of Severe Graft Steatosis Before Living-Donor Liver Transplant After 86 Pounds of Weight Loss. Abstract

  42. Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma in Patients With Child-Pugh B or C Cirrhosis. Adv Radiat Oncol. 2020 Sep-Oct; 5(5):889-896. View Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma in Patients With Child-Pugh B or C Cirrhosis. Abstract

  43. Frozen section diagnosis of gastrointestinal poorly cohesive and signet-ring cell adenocarcinoma: useful morphologic features to avoid misdiagnosis. Virchows Arch. 2020 Oct; 477(4):497-506. View Frozen section diagnosis of gastrointestinal poorly cohesive and signet-ring cell adenocarcinoma: useful morphologic features to avoid misdiagnosis. Abstract

  44. Metastatic Signet Ring Cell Carcinoma of the Ampulla of Vater with an Unusually Prolonged Survival. J Gastrointest Cancer. 2020 Mar; 51(1):354-358. View Metastatic Signet Ring Cell Carcinoma of the Ampulla of Vater with an Unusually Prolonged Survival. Abstract

  45. The Use of Smartphone for Liver Graft Biopsy Assessment at the Time of Procurement. Transplantation. 2018 11; 102(11):e459-e460. View The Use of Smartphone for Liver Graft Biopsy Assessment at the Time of Procurement. Abstract

  46. IgG4-related disease: review of the histopathologic features, differential diagnosis, and therapeutic approach. APMIS. 2018 Jun; 126(6):459-476. View IgG4-related disease: review of the histopathologic features, differential diagnosis, and therapeutic approach. Abstract

  47. Lymphomas in IgG4-related disease: clinicopathologic features in a Western population. Virchows Arch. 2018 May; 472(5):839-852. View Lymphomas in IgG4-related disease: clinicopathologic features in a Western population. Abstract

  48. Atypical IgG4+ Plasmacytic Proliferations and Lymphomas: Characterization of 11 Cases. Am J Clin Pathol. 2017 Sep 01; 148(3):215-235. View Atypical IgG4+ Plasmacytic Proliferations and Lymphomas: Characterization of 11 Cases. Abstract

  49. Diverse repetitive element RNA expression defines epigenetic and immunologic features of colon cancer. JCI Insight. 2017 02 09; 2(3):e91078. View Diverse repetitive element RNA expression defines epigenetic and immunologic features of colon cancer. Abstract

  50. The immunophenotypic spectrum of primary mediastinal large B-cell lymphoma reveals prognostic biomarkers associated with outcome. Am J Hematol. 2016 10; 91(10):E436-41. View The immunophenotypic spectrum of primary mediastinal large B-cell lymphoma reveals prognostic biomarkers associated with outcome. Abstract

  51. PD-L1 expression in colorectal cancer is associated with microsatellite instability, BRAF mutation, medullary morphology and cytotoxic tumor-infiltrating lymphocytes. Mod Pathol. 2016 09; 29(9):1104-12. View PD-L1 expression in colorectal cancer is associated with microsatellite instability, BRAF mutation, medullary morphology and cytotoxic tumor-infiltrating lymphocytes. Abstract

  52. Amyloidosis of the liver on shear wave elastography: case report and review of literature. Abdom Imaging. 2015 Oct; 40(8):3078-83. View Amyloidosis of the liver on shear wave elastography: case report and review of literature. Abstract

  53. Difficult Diagnostic Problems in Pancreatobiliary Neoplasia. Arch Pathol Lab Med. 2015 Jul; 139(7):848-57. View Difficult Diagnostic Problems in Pancreatobiliary Neoplasia. Abstract

  54. Authors’ reply. Int J Chron Obstruct Pulmon Dis. 2015; 10:871. View Authors’ reply. Abstract

  55. Smoking-associated fibrosis and pulmonary asbestosis. Int J Chron Obstruct Pulmon Dis. 2015; 10:31-7. View Smoking-associated fibrosis and pulmonary asbestosis. Abstract

  56. BRAF V600E immunohistochemistry is reliable in primary and metastatic colorectal carcinoma regardless of treatment status and shows high intratumoral homogeneity. Am J Surg Pathol. 2014 Oct; 38(10):1418-28. View BRAF V600E immunohistochemistry is reliable in primary and metastatic colorectal carcinoma regardless of treatment status and shows high intratumoral homogeneity. Abstract

  57. Fine needle aspiration biopsy of an unusual follicular adenoma with sebaceous-like features. Endocr Pathol. 2012 Sep; 23(3):177-80. View Fine needle aspiration biopsy of an unusual follicular adenoma with sebaceous-like features. Abstract

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