MEDICAL SERVICES
Departments
Programs
- Fetal-Neonatal Neurology Program
- Maternal Fetal Care Center
- NICU Growth and Developmental Support Programs (GraDS)
Languages
-
English
-
French
EDUCATION
Medical School
- McGill University Faculty of Medicine , 1991 , Montreal , Canada
Internship
- Boston City Hospital , 1992 , Boston , MA
Residency
Pediatrics
- Boston City Hospital , 1994 , Boston , MA
Fellowship
Neurology
- Boston Children's Hospital , 1997 , Boston , MA
Fellowship
Neonatal Neurology
- Boston Children's Hospital , 1998 , Boston , MA
PROFESSIONAL HISTORY
I am a pediatric neurologist whose area of clinical expertise and research is in Fetal and Neonatal Neurology with a focus on the etiology, pathogenesis, outcome and prevention of early acquired brain injury. I direct the Fetal-Neonatal Neurology Program that provides specialized care to fetuses, newborns and children with neurologic disorders that begin in utero or in the neonatal period. This program, with its associated clinical services, provides specialized training for neurology, neonatology and pediatric fellows and residents. My research and writing are focused on early acquired brain injury, particularly hypoxic-ischemic brain injury, involving a lack of oxygen and blood flow to the brain; the treatment of seizures in term newborns; and periventricular leukomalacia (injury to the white matter of the brain), intraventricular hemorrhage (bleeding into the ventricles of the brain) and hydrocephalus in preterm newborns. I am the PI for a randomized, double-blind, controlled trial of bumetanide for the treatment of neonatal seizures, funded by an R01 from NINDS (NS066929), which is the first to study a novel drug (bumetanide) with an anticonvulsant mechanism specific to the newborn brain. The broad goal of my research is to understand the causes of these brain injuries and to detect them at their earliest onset in order to develop and test neuroprotective therapies that prevent or minimize brain injury.
CERTIFICATIONS
- American Board of Psychiatry and Neurology, Child and Adolescent Neurology
PUBLICATIONS
Publications powered by Harvard Catalyst Profiles
- A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures. Ann Neurol. 2021 02; 89(2):327-340. View abstract
- Fetal magnetic resonance imaging: supratentorial brain malformations. Pediatr Radiol. 2020 12; 50(13):1934-1947. View abstract
- Regional Brain Growth Trajectories in Fetuses with Congenital Heart Disease. Ann Neurol. 2021 01; 89(1):143-157. View abstract
- Predicting Autism Spectrum Disorder in Very Preterm Infants. Pediatrics. 2020 10; 146(4). View abstract
- Characterization of Death in Infants With Neonatal Seizures. Pediatr Neurol. 2020 12; 113:21-25. View abstract
- Parent experience of caring for neonates with seizures. Arch Dis Child Fetal Neonatal Ed. 2020 Nov; 105(6):634-639. View abstract
- Associations between Infant and Parent Characteristics and Measures of Family Well-Being in Neonates with Seizures: A Cohort Study. J Pediatr. 2020 06; 221:64-71.e4. View abstract
- Early exit from neonatal therapeutic hypothermia: A single institution experience using MRI to guide decision-making. J Neonatal Perinatal Med. 2020; 13(4):441-447. View abstract
- Neonatal seizures: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine. 2019 12 10; 37(52):7596-7609. View abstract
- Expanding the phenotypic spectrum of Mabry Syndrome with novel PIGO gene variants associated with hyperphosphatasia, intractable epilepsy, and complex gastrointestinal and urogenital malformations. Eur J Med Genet. 2020 Apr; 63(4):103802. View abstract
- Abnormalities in cerebral hemodynamics and changes with surgical intervention in neonates with congenital heart disease. J Thorac Cardiovasc Surg. 2020 05; 159(5):2012-2021. View abstract
- Seizure Prediction Models in the Neonatal Intensive Care Unit. J Clin Neurophysiol. 2019 May; 36(3):186-194. View abstract
- Pharmacologic Prevention and Treatment of Neonatal Brain Injury. Clin Perinatol. 2019 06; 46(2):311-325. View abstract
- Correction to: De novo and inherited TCF20 pathogenic variants are associated with intellectual disability, dysmorphic features, hypotonia, and neurological impairments with similarities to Smith-Magenis syndrome. Genome Med. 2019 03 25; 11(1):16. View abstract
- De novo and inherited TCF20 pathogenic variants are associated with intellectual disability, dysmorphic features, hypotonia, and neurological impairments with similarities to Smith-Magenis syndrome. Genome Med. 2019 02 28; 11(1):12. View abstract
- Response to antiseizure medications in neonates with acute symptomatic seizures. Epilepsia. 2019 03; 60(3):e20-e24. View abstract
- Monitoring and management of brain hemodynamics and oxygenation. Handb Clin Neurol. 2019; 162:295-314. View abstract
- Recommendations for the design of therapeutic trials for neonatal seizures. Pediatr Res. 2019 06; 85(7):943-954. View abstract
- Advanced diffusion imaging for assessing normal white matter development in neonates and characterizing aberrant development in congenital heart disease. Neuroimage Clin. 2018; 19:360-373. View abstract
- Congenital muscular dystrophy-dystroglycanopathy, type A, featuring bilateral retinal dysplasia and vertical angle kappa. J AAPOS. 2018 06; 22(3):242-244.e1. View abstract
- Post-arrest therapeutic hypothermia in pediatric patients with congenital heart disease. Resuscitation. 2018 05; 126:83-89. View abstract
- Acute symptomatic seizures in term neonates: Etiologies and treatments. Semin Fetal Neonatal Med. 2018 06; 23(3):183-190. View abstract
- Probabilistic tractography-based thalamic parcellation in healthy newborns and newborns with congenital heart disease. J Magn Reson Imaging. 2018 06; 47(6):1626-1637. View abstract
- Imaging features and prognostic factors in fetal and postnatal torcular dural sinus malformations, part I: review of experience at Boston Children's Hospital. J Neurointerv Surg. 2018 May; 10(5):467-470. View abstract
- Imaging features and prognostic factors in fetal and postnatal torcular dural sinus malformations, part II: synthesis of the literature and patient management. J Neurointerv Surg. 2018 May; 10(5):471-475. View abstract
- Liver Failure as the Presentation of Ornithine Transcarbamylase Deficiency in a 13-Month-Old Female. JIMD Rep. 2018; 40:17-22. View abstract
- The use of phenobarbital and other anti-seizure drugs in newborns. Semin Fetal Neonatal Med. 2017 10; 22(5):321-327. View abstract
- Profile of neonatal epilepsies: Characteristics of a prospective US cohort. Neurology. 2017 Aug 29; 89(9):893-899. View abstract
- Seizures in Preterm Neonates: A Multicenter Observational Cohort Study. Pediatr Neurol. 2017 Jul; 72:19-24. View abstract
- Electroencephalographic discontinuity during sevoflurane anesthesia in infants and children. Paediatr Anaesth. 2017 Mar; 27(3):251-262. View abstract
- White Matter Volume Predicts Language Development in Congenital Heart Disease. J Pediatr. 2017 02; 181:42-48.e2. View abstract
- Treatment Duration After Acute Symptomatic Seizures in Neonates: A Multicenter Cohort Study. J Pediatr. 2017 02; 181:298-301.e1. View abstract
- Corrigendum to "GJC2 promoter mutations causing Pelizaeus-Merzbacher-like disease" [Mol. Genet. Metab. 111 (2014) 393-398]. Mol Genet Metab. 2016 11; 119(3):293. View abstract
- Fellowship Training in the Emerging Fields of Fetal-Neonatal Neurology and Neonatal Neurocritical Care. Pediatr Neurol. 2016 10; 63:39-44.e3. View abstract
- BRAT1 mutations present with a spectrum of clinical severity. . 2016 09; 170(9):2265-73. View abstract
- Contemporary Profile of Seizures in Neonates: A Prospective Cohort Study. J Pediatr. 2016 Jul; 174:98-103.e1. View abstract
- Perioperative cerebral hemodynamics and oxygen metabolism in neonates with single-ventricle physiology. Biomed Opt Express. 2015 Dec 01; 6(12):4749-67. View abstract
- Copy number variation plays an important role in clinical epilepsy. Ann Neurol. 2014 Jun; 75(6):943-58. View abstract
- Cerebral blood flow velocity and neurodevelopmental outcome in infants undergoing surgery for congenital heart disease. Ann Thorac Surg. 2014 Jul; 98(1):125-32. View abstract
- GJC2 promoter mutations causing Pelizaeus-Merzbacher-like disease. Mol Genet Metab. 2014 03; 111(3):393-398. View abstract
- Cerebral oxygen metabolism in neonatal hypoxic ischemic encephalopathy during and after therapeutic hypothermia. J Cereb Blood Flow Metab. 2014 Jan; 34(1):87-94. View abstract
- Near-infrared spectroscopy versus magnetic resonance imaging to study brain perfusion in newborns with hypoxic-ischemic encephalopathy treated with hypothermia. Neuroimage. 2014 Jan 15; 85 Pt 1:287-93. View abstract
- Passive cooling during transport of asphyxiated term newborns. J Perinatol. 2013 Jun; 33(6):435-40. View abstract
- Good outcome with early empiric treatment of neural larva migrans due to Baylisascaris procyonis. Pediatrics. 2012 Mar; 129(3):e806-11. View abstract
- Brain perfusion in asphyxiated newborns treated with therapeutic hypothermia. AJNR Am J Neuroradiol. 2011 Dec; 32(11):2023-9. View abstract
- Sensitive isotope dilution liquid chromatography/tandem mass spectrometry method for quantitative analysis of bumetanide in serum and brain tissue. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Apr 15; 879(13-14):998-1002. View abstract
- Early versus late MRI in asphyxiated newborns treated with hypothermia. Arch Dis Child Fetal Neonatal Ed. 2011 Jan; 96(1):F36-44. View abstract
- Relationship of intraoperative cerebral oxygen saturation to neurodevelopmental outcome and brain magnetic resonance imaging at 1 year of age in infants undergoing biventricular repair. Circulation. 2010 Jul 20; 122(3):245-54. View abstract
- Neurodevelopmental outcome of fetuses referred for ventriculomegaly. Ultrasound Obstet Gynecol. 2010 Apr; 35(4):405-16. View abstract
- Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance. Cell. 2010 Jan 08; 140(1):74-87. View abstract
- Elevated cerebral pressure passivity is associated with prematurity-related intracranial hemorrhage. Pediatrics. 2009 Jul; 124(1):302-9. View abstract
- Subtle hemorrhagic brain injury is associated with neurodevelopmental impairment in infants with repaired congenital heart disease. J Thorac Cardiovasc Surg. 2009 Aug; 138(2):374-81. View abstract
- Cerebral hemodynamic changes during intensive care of preterm infants. Pediatrics. 2008 Nov; 122(5):e1006-13. View abstract
- Microdeletion/duplication at 15q13.2q13.3 among individuals with features of autism and other neuropsychiatric disorders. J Med Genet. 2009 Apr; 46(4):242-8. View abstract
- Positive screening for autism in ex-preterm infants: prevalence and risk factors. Pediatrics. 2008 Apr; 121(4):758-65. View abstract
- Randomized trial of hematocrit 25% versus 35% during hypothermic cardiopulmonary bypass in infant heart surgery. J Thorac Cardiovasc Surg. 2008 Feb; 135(2):347-54, 354.e1-4. View abstract
- Current definitions of hypotension do not predict abnormal cranial ultrasound findings in preterm infants. Pediatrics. 2007 Nov; 120(5):966-77. View abstract
- Neurodevelopmental outcome in survivors of periventricular hemorrhagic infarction. Pediatrics. 2007 Oct; 120(4):785-92. View abstract
- Does cerebellar injury in premature infants contribute to the high prevalence of long-term cognitive, learning, and behavioral disability in survivors? Pediatrics. 2007 Sep; 120(3):584-93. View abstract
- Fluctuating pressure-passivity is common in the cerebral circulation of sick premature infants. Pediatr Res. 2007 Apr; 61(4):467-73. View abstract
- Neonatal hypocalcemic seizures in siblings exposed to topiramate in utero. Pediatr Neurol. 2007 Apr; 36(4):274-6. View abstract
- Patient with novel interstitial deletion of chromosome 3q13.1q13.3 and agenesis of the corpus callosum. Clin Dysmorphol. 2006 Oct; 15(4):217-20. View abstract
- Characterizing the shape of anatomical structures with Poisson's equation. IEEE Trans Med Imaging. 2006 Oct; 25(10):1249-57. View abstract
- Periventricular hemorrhagic infarction: risk factors and neonatal outcome. Pediatr Neurol. 2006 Aug; 35(2):85-92. View abstract
- Ultrasonographic features and severity scoring of periventricular hemorrhagic infarction in relation to risk factors and outcome. Pediatrics. 2006 Jun; 117(6):2111-8. View abstract
- The current etiologic profile and neurodevelopmental outcome of seizures in term newborn infants. Pediatrics. 2006 Apr; 117(4):1270-80. View abstract
- Measurement of cortical thickness in 3D brain MRI data: validation of the Laplacian method. J Neuroimaging. 2006 Apr; 16(2):146-53. View abstract
- Talairach-based parcellation of neonatal brain magnetic resonance imaging data: validation of a new approach. J Neuroimaging. 2005 Oct; 15(4):305-14. View abstract
- Video and CD-ROM as a training tool for performing neurologic examinations of 1-year-old children in a multicenter epidemiologic study. J Child Neurol. 2005 Oct; 20(10):829-31. View abstract
- Impaired trophic interactions between the cerebellum and the cerebrum among preterm infants. Pediatrics. 2005 Oct; 116(4):844-50. View abstract
- Development of visual acuity in children with cerebral visual impairment. Arch Ophthalmol. 2005 Sep; 123(9):1215-20. View abstract
- Late gestation cerebellar growth is rapid and impeded by premature birth. Pediatrics. 2005 Mar; 115(3):688-95. View abstract
- In vivo visualization of white matter fiber tracts of preterm- and term-infant brains with diffusion tensor magnetic resonance imaging. Invest Radiol. 2005 Feb; 40(2):110-5. View abstract
- Identification of pressure passive cerebral perfusion and its mediators after infant cardiac surgery. Pediatr Res. 2005 Jan; 57(1):35-41. View abstract
- Hemodilution elevates cerebral blood flow and oxygen metabolism during cardiopulmonary bypass in piglets. Ann Thorac Surg. 2004 May; 77(5):1656-63; discussion 1663. View abstract
- CSF removal in infantile posthemorrhagic hydrocephalus results in significant improvement in cerebral hemodynamics. Pediatr Res. 2004 May; 55(5):872-6. View abstract
- An elliptic PDE approach for shape characterization. Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:1521-4. View abstract
- Peroneal neuropathy from ankle-foot orthoses. Pediatr Neurol. 2003 Jul; 29(1):72-4. View abstract
- Time course of changes in diffusion-weighted magnetic resonance imaging in a case of neonatal encephalopathy with defined onset and duration of hypoxic-ischemic insult. Pediatrics. 2001 Nov; 108(5):1211-4. View abstract
- Cerebral infarction in Menkes' disease. Pediatr Neurol. 2000 Nov; 23(5):425-8. View abstract
- Noninvasive detection of changes in cerebral blood flow by near-infrared spectroscopy in a piglet model of hydrocephalus. Pediatr Res. 2000 Oct; 48(4):445-9. View abstract
- New technologies in pediatric neurology. Near-infrared spectroscopy. Semin Pediatr Neurol. 1999 Jun; 6(2):101-10. View abstract
- Sonographic ventriculography: a new potential use for sonographic contrast agents in neonatal hydrocephalus. AJNR Am J Neuroradiol. 1998 Nov-Dec; 19(10):1931-4. View abstract
- Vestibular-contingent voluntary saccades based on cognitive estimates of remembered vestibular information. Adv Otorhinolaryngol. 1988; 41:71-5. View abstract