Current Environment:


The goal of this study is to determine whether JASPER (Joint Attention, Symbolic Play, Engagement, Regulation), which is an intensive, targeted early behavioral intervention focused on a developmentally based approach for teaching joint engagement, joint attention, and play skills can improve behavioral / emotional regulation, social communication skills, and developmental trajectories in Down syndrome (DS). The investigators will also explore the potential use of EEG and event-related potentials (ERP) as outcome measures, as this approach may help elucidate mechanisms of change in behavior and development, and may help explain differences in development of social communication skills in individuals with DS. EEG and ERP measure may also help to predict treatment outcome.


Down Syndrome, Trisomy 21

Recruitment Status


Eligibility Criteria

Inclusion Criteria:

Confirmed diagnosis of Trisomy 21
Age 24-48 months
Able to walk independently across a room
Uses at least 5 words / signs
English speaking
Parent able to accompany participant to all study visits

Exclusion Criteria:

-Diagnosis of Mosaic / Translocation Down syndrome


Intervention Type

Intervention Name




Not Applicable



Min Age

24 Months

Max Age

48 Months

Download Date

January 18, 2022

Principal Investigator

Nicole Baumer

Primary Contact Information

For more information on this trial, visit


For more information and to contact the study team:

JASPER Intervention in Down Syndrome NCT03653143