Research

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Lois Lee, MD, MPH

Department:
Medicine Research
Division
Emergency Medicine Research
Hospital Title:
Assistant in Medicine; Director, Trauma Research
Academic Title:
Assistant Professor, Harvard Medical School
Research Focus Area:
Head Trauma/Concussions
Contact:
617-355-5089
Contact Via Email
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Research Overview

Trauma care and injury prevention in children and adolescents are longstanding clinical and research interests for Dr. Lee. Her research has focused on motor vehicle child passenger safety, drowning injuries, firearm injuries, and the epidemiology of pediatric injuries. In addition she has conducted research focusing on the management of head, neck, abdominal, and orthopedic trauma. She is the site primary investigator for the Pediatric Emergency Care Applied Research Network (PECARN) studies on traumatic brain injury and intra-abdominal injury. She has been elected as a member of The Society for Pediatric Research.

About Lois Lee

After earning an MD from the University of Pennsylvania School of Medicine in 1996, she completed her Masters of Public Health in Quantitative Methods at the Harvard School of Public Health in 2003. In between that time, Lois’ residency took place at Children’s Hospital Philadelphia and she was awarded an NRSA Training Grant in Pediatric Emergency Medicine during her fellowship with Boston Children’s Hospital.

Peer reviewed articles

  1. Kuppermann N, Holmes JF, Dayan PS, Hoyle JD, Atabaki SM, Holubkov R, Nadel FM, Monroe D, Stanley RM, Borgialli DA, Badawy MK, Schunk JE, Quayle KS, Mahajan P, Lichenstein R, Lillis KA, Tunik MF, Jacobs ES, Callahan JM, Gorelick MR, Glass TF, Lee LK, Bachman MC, Cooper A, Powell EC, Gerardi MJ, Melville KA, Muizelaar JP, Wisner DH, Zuspan SJ, Dean JM, Wootton-Gorges SL, for the Pediatric Emergency Care Applied Research Network (PECARN). Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study. Lancet. 2009; 374: 1160-1170.
  2. Mannix R, Bourgeois FT, Schutzman SA, Bernstein A, Lee LK. Neuroimaging for pediatric head trauma: do patient and hospital characteristics influence who gets imaged? Acad Emerg Med. 2010; 17: 694-700.
  3. Lee LK, Dayan PS, Gerardi MJ, Borgialli DA, Badawy MK, Callahan JM, Lillis KA, Stanley RM, Gorelick MH, Dong L, Zuspan SJ, Holmes JF, Kuppermann N, d the Traumatic Brain Injury Study Group for the Pediatric Emergency Care Applied Research network (PECARN). Intracranial hemorrhage after blunt head trauma in children with bleeding disorders. J Peds. 2011; 158: 1003-8.
  4. Pryor SD, Lee LK. Clinical outcomes and diagnostic imaging of pediatric patients with pneumomediastinum secondary to blunt trauma to the chest. J Trauma. 2011; 71: 904-908.
  5. Mannix R, Nigrovic LE, Schutzman SA, Hennelly K, Meehan WP, Fleisher G, Monuteaux M, Lee LK. Factors associated with the use of cervical spine computed tomography imaging in pediatric trauma patients. Acad Emerg Med. 2011; 18: 906-911.
  6. Fleegler EW, Monuteaux MC, Bauer SR, Lee LK. Attempts to silence firearm injury prevention. Am J Prev Med. 2012;42: 99-102.
  7. Thompson RW, Krauss B, Kim Y-J, Monuteaux MC, Zerriny S, Lee LK. Extremity Fracture Pain After Emergency Department Reduction and Casting: Predictors of Pain After Discharge. Ann Emerg Med. 2012; 60: 269-277.
  8. Mannix R, Fleegler EW, Meehan WP, Schutzman SA, Hennelly KE, Nigrovic L, Lee LK. Booster seat laws reduce fatalities and injuries in children 4-7 years of age. Pediatrics. 2012; 130: 1-7.
  9. Holmes JF, Lillis K, Monroe D, Borgialli D, Kerrey BT, Mahajan P, Adelgais K, Ellison AM, Yen K, Atabaki S, Menaker J, Bonsu B, Quayle KS, Garcia M, Rogers A, Blumberg S, Lee L, Tunik M, Kooistra J, Kwok M, Cook LJ, Dean JM, Sokolove PE, Wisner DH, Ehrlich P, Cooper A, Dayan PS, Wootton-Gorges S, Kuppermann N, for the Pediatric Emergency Care Applied Research Network (PECARN). Identifying children at very low risk of clinically important blunt abdominal injuries. Ann Emerg Med. 2013; 62: 107-116.
  10. Fleegler EW, Lee LK, Monuteaux MC, Hemenway D, Mannix R. Firearm legislation and firearm-related fatalities in the United States. JAMA Intern Med. 2013; 173: 732-740.
  11. Kiley K, Damian F, MacClaren W, Dupuis JM, Salvatore D, Nolan M, Lee LK. A computerized child passenger safety assessment program in the emergency department. Pediatr Emerg Care. 2013: in press.
  12. Srinivasan S, Mannix R, Lee LK. Epidemiology of Pediatric Firearm Injuries in the United States, 2001-2010. Arch Dis Child. 2013: in press.

Publications

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  1. Monuteaux MC, Mannix R, Fleegler EW, Lee LK. Predictors and Outcomes of Pediatric Firearm Injuries Treated in the Emergency Department: Differences by Mechanism of Intent. Acad Emerg Med. 2016 Jul; 23(7):790-5.
  2. Lee LK. One of the Challenges of Bringing Your Newborn Home Begins with Installing the Car Safety Seat. J Pediatr. 2016 Apr; 171:16-7.
  3. Lee LK, Mulvaney-Day N, Berger AM, Bhaumik U, Nguyen HT, Ward VL. The Patient Passport Program: An Intervention to Improve Patient-Provider Communication for Hospitalized Minority Children and Their Families. Acad Pediatr. 2016 Jul; 16(5):460-7.
  4. Lee LK, Farrell CA, Mannix R. Restraint use in motor vehicle crash fatalities in children 0 year to 9 years old. J Trauma Acute Care Surg. 2015 Sep; 79(3 Suppl 1):S55-60.
  5. Monuteaux MC, Lee LK, Hemenway D, Mannix R, Fleegler EW. Firearm Ownership and Violent Crime in the U.S.: An Ecologic Study. Am J Prev Med. 2015 Aug; 49(2):207-14.
  6. Kiley K, Damian F, MacClaren W, Dupuis JM, Salvatore D, Nolan M, Lee LK. A computerized child passenger safety screening program in the emergency department. Pediatr Emerg Care. 2014 Sep; 30(9):631-5.
  7. Elliott LN, DiGirolamo B, McMahon M, Damian F, Brostoff M, Shermont H, Mooney DP, Lee LK. An Inpatient Child Passenger Safety program. Clin Pediatr (Phila). 2013 Nov; 52(11):1022-8.
  8. Meehan WP, Lee LK, Fischer CM, Mannix RC. Bicycle helmet laws are associated with a lower fatality rate from bicycle-motor vehicle collisions. J Pediatr. 2013 Sep; 163(3):726-9.
  9. Fleegler EW, Lee LK, Monuteaux MC, Hemenway D, Mannix R. Firearm legislation and firearm-related fatalities in the United States. JAMA Intern Med. 2013 May 13; 173(9):732-40.
  10. Mannix R, Fleegler E, Meehan WP, Schutzman SA, Hennelly K, Nigrovic L, Lee LK. Booster seat laws and fatalities in children 4 to 7 years of age. Pediatrics. 2012 Dec; 130(6):996-1002.
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  12. Lee LK, Walia T, Forbes PW, Osganian SK, Samuels R, Cox JE, Mooney DP. Home safety practices in an urban low-income population: level of agreement between parental self-report and observed behaviors. Clin Pediatr (Phila). 2012 Dec; 51(12):1119-24.
  13. Thompson RW, Krauss B, Kim YJ, Monuteaux MC, Zerriny S, Lee LK. Extremity fracture pain after emergency department reduction and casting: predictors of pain after discharge. Ann Emerg Med. 2012 Sep; 60(3):269-77.
  14. Fleegler EW, Monuteaux MC, Bauer SR, Lee LK. Attempts to silence firearm injury prevention. Am J Prev Med. 2012 Jan; 42(1):99-102.
  15. Nigrovic LE, Lee LK, Hoyle J, Stanley RM, Gorelick MH, Miskin M, Atabaki SM, Dayan PS, Holmes JF, Kuppermann N. Prevalence of clinically important traumatic brain injuries in children with minor blunt head trauma and isolated severe injury mechanisms. Arch Pediatr Adolesc Med. 2012 Apr; 166(4):356-61.
  16. Lee LK, Dayan PS, Gerardi MJ, Borgialli DA, Badawy MK, Callahan JM, Lillis KA, Stanley RM, Gorelick MH, Dong L, Zuspan SJ, Holmes JF, Kuppermann N. Intracranial hemorrhage after blunt head trauma in children with bleeding disorders. J Pediatr. 2011 Jun; 158(6):1003-1008.e1-2.
  17. Lee LK, Fleegler EW, Forbes PW, Olson KL, Mooney DP. The modern paediatric injury pyramid: injuries in Massachusetts children and adolescents. Inj Prev. 2010 Apr; 16(2):123-6.
  18. Kimia A, Lee L, Shannon M, Capraro A, Mays D, Johnston P, Hummel D, Shuman M. Holiday ornament-related injuries in children. Pediatr Emerg Care. 2009 Dec; 25(12):819-22.
  19. Kimia AA, Waltzman ML, Shannon MW, Mays DL, Johnston PR, Hummel D, Ben-Joseph EP, Lee LK. Glass table-related injuries in children. Pediatr Emerg Care. 2009 Mar; 25(3):145-9.
  20. Lee LK. Surgical Emergencies: Orthopedic, Chest, and Neurosurgical. Pediatric Emergency Medicine Question Review Book. 2009.
  21. Aprahamian N, Lee LK, Shannon M, Hummel D, Johnson P, Kimia A. Glass thermometer injuries: it is not just about the mercury. Pediatric Emergency Care. 2009; in press.
  22. Lee LK. Pediatric Emergency Medicine Question Review Book. Surgical Emergencies: Orthopedic, Chest, and Neurosurgical. 2009.
  23. Lee LK. Pediatric Orthopedics: Children Are Not Little Adults. 2009.
  24. Aprahamian N, Lee LK, Shannon M, Hummel D, Johnson P, Kimia A. Pediatr Emerg Care. Glass thermometer injuries: it is not just about the mercury. 2009; 25:645-647.
  25. Wang VJ, Lee LK. Research Methods and Epidemiology. Pediatric Emergency Medicine Question Review Book. 2009.
  26. Wang VJ and Lee LK. Pediatric Emergency Medicine Question Review Book. Research Methods and Epidemiology. 2009.
  27. Lee LK. Booster Seat Demonstration. 2008.
  28. Lee LK, Damian F, Walia T. Booster Seat Educational Video. 2008.
  29. Lee LK and Fleisher GF. Trauma management: Unique pediatric considerations. 2008.
  30. Lee LK and Fleisher GF. Trauma management: Approach to the unstable child II. 2008.
  31. Lee, LK and Fleisher GF. Trauma Management: Approach to the Unstable Child I. 2008.
  32. Lee LK and Fleisher GF. Approach to the initially stable child. 2008.
  33. Lee LK. Controversies in the sequelae of pediatric mild traumatic brain injury. Pediatr Emerg Care. 2007 Aug; 23(8):580-3; quiz 584-6.
  34. Lee LK. Pediatric Non-Accidental Trauma. Emergency Medicine Handbook: Critical Concept for Clinical Practice. 2007; 1093-1099.
  35. Lee LK, Thompson KM. Parental survey of beliefs and practices about bathing and water safety and their children: guidance for drowning prevention. Accid Anal Prev. 2007 Jan; 39(1):58-62.
  36. Lee LK, Mao C, Thompson KM. Demographic factors and their association with outcomes in pediatric submersion injury. Acad Emerg Med. 2006 Mar; 13(3):308-13.
  37. Lee LK. Pallor. Signs and Symptoms in Pediatrics: Urgent and Emergent Care. 2005; 363-369.
  38. Lee LK, Shannon MW, Arnold J. The use of high frequency oscillatory ventilation in hydrocarbon pneumonitis. Internet Journal of Medical Toxicology. 2003; 6:6.
  39. Lee LK, Stack AM, Fleisher GR, Thompson CM, Malley R. Therapeutic Human Anticapsular Pneumococcal Antibody Protects against Bacteremia and Mortaility Due to Streptococcus pneumonia type 19f in Infant Rats. Pediatric Research. 2001; 49:241A.
  40. Koplin Winston F, Arbogast KB, Lee LA, Menon RA. Computer crash simulations in the development of child occupant safety policies. Arch Pediatr Adolesc Med. 2000 Mar; 154(3):276-80.
  41. Hamilton KK, Lee LK, Doetsch PW. A Novel Eukaryotic DNA Repeair Enzyme Recognizes UV-Light Induced Cyclobutane Pyrimidine Dimers. Photodermatology, photoimmunology, and photomedicine. 1991; 38.
  42. Kuppermann N, Holmes JF, Dayan PS, Hoyle JD, Atabaki SM, Holubkov R, Nadel FM, Monroe D, Stanley RM, Borgialli DA, Badawy MK, Schunk JE, Quayle KS, Mahajan P, Lichenstein R, Lillis KA, Tunik MG, Jacobs ES, Callahan JM, Gorelick MH, Glass TF, Lee LK, Bachman MC, Cooper A, Powell EC, Gerardi MJ, Melville KA, Muizelaar JP, Wisner DH, Zuspan SJ, Dean JM, Wootton-Gorges SL. Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study. Lancet. 2009 Oct 3; 374(9696):1160-70.
  43. Mannix R, Bourgeois FT, Schutzman SA, Bernstein A, Lee LK. Neuroimaging for pediatric head trauma: do patient and hospital characteristics influence who gets imaged? Acad Emerg Med. 2010 Jul; 17(7):694-700.
  44. Mannix R, Nigrovic LE, Schutzman SA, Hennelly K, Bourgeois FT, Meehan WP, Fleisher G, Monuteaux M, Lee LK. Factors associated with the use of cervical spine computed tomography imaging in pediatric trauma patients. Acad Emerg Med. 2011 Sep; 18(9):905-11.
  45. Schonfeld D, Lee LK. Blunt abdominal trauma in children. Curr Opin Pediatr. 2012 Jun; 24(3):314-8.
  46. Hennelly KE, Mannix R, Nigrovic LE, Lee LK, Thompson KM, Monuteaux MC, Proctor M, Schutzman S. Pediatric traumatic brain injury and radiation risks: a clinical decision analysis. J Pediatr. 2013 Feb; 162(2):392-7.
  47. Rudloe TF, Schutzman S, Lee LK, Kimia AA. No longer a "nursemaid's" elbow: mechanisms, caregivers, and prevention. Pediatr Emerg Care. 2012 Aug; 28(8):771-4.
  48. Pryor SD, Lee LK. Clinical outcomes and diagnostic imaging of pediatric patients with pneumomediastinum secondary to blunt trauma to the chest. J Trauma. 2011 Oct; 71(4):904-8.
  49. Lee LK, Rogers AJ, Ehrlich PF, Kwok M, Sokolove PE, Blumberg S, Kooistra J, Olsen CS, Wootton-Gorges S, Cooper A, Kuppermann N, Holmes JF. Occult pneumothoraces in children with blunt torso trauma. Acad Emerg Med. 2014 Apr; 21(4):440-8.
  50. Lee LK, Monroe D, Bachman MC, Glass TF, Mahajan PV, Cooper A, Stanley RM, Miskin M, Dayan PS, Holmes JF, Kuppermann N. Isolated loss of consciousness in children with minor blunt head trauma. JAMA Pediatr. 2014 Sep; 168(9):837-43.
  51. Lee LK, Fleegler EW, Farrell C, Avakame E, Srinivasan S, Hemenway D, Monuteaux MC. Firearm Laws and Firearm Homicides: A Systematic Review. JAMA Intern Med. 2016 Nov 14.
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