Research

Research

The research enterprise at Boston Children’s Hospital, comprising more than 3,000 researchers, is the world’s largest at a pediatric center. Our work is fueled by a deep understanding of disease coupled with world-class discovery platforms, including genetics and genomics, gene editing, bioinformatics, proteomics, bioengineering, image analysis, multiple animal models, biobanks and disease-specific stem cell lines. We have special expertise in rare disease discovery and see large, highly diverse patient populations.

From ADHD to Zika virus, we partner closely with scientists worldwide. To accelerate translation of new therapies and technologies to the bedside, we partner with industry through such programs as the Technology and Innovation Development Office (TIDO), the Innovation & Digital Health Accelerator (IDHA) and the Translational Neuroscience Center.

Faja Lab: Labs of Cognitive Neuroscience

The Faja Lab studies social and cognitive development in typically developing children and in children with autism spectrum disorder and other neurodevelopmental conditions. Ongoing research projects include Gaming for Autism to Mold Executive Skills, the Executive Attention Skills in Youth Study and the Autism Biomarkers Consortium for Clinical Trials (ABC-CT).

Image of a mouse brain that received a direct transplantation of hematopoietic stem cells.

Gene therapy

Gene therapies offer powerful new options for addressing previously fatal or untreatable genetic diseases. Our investigators are at the forefront of pre-clinical research, vector development and clinical trials of gene therapies for a broad range of pediatric disorders.

Gene therapy news
blast cells in leukemia medical science concept

Pediatric cancer

Childhood cancers are driven by different genetic changes than adult cancers. Our scientists interrogate their complex origins with advanced genomic and drug screening techniques, and partner with clinical researchers to drive a new generation of pediatric cancer trials.

Cancer research news
Hands held in the shape of a brain, covered by EEG leads

Neuroscience

Understanding the nervous system at the genetic, molecular, cellular and systems level opens opportunities to tackle hard-to-treat disorders. From disease modeling in human neurons to clinical trials for genetic conditions, our basic and clinical scientists collaborate closely.

Neuroscience news

Genetics/Genomics

Next-generation DNA sequencing, chromosomal microarray, gene-expression studies, gene editing, genome-wide association studies and other tools are bringing fresh insights into the basic biology of disease, from common conditions like obesity to the exceedingly rare.

Genetics news

Immunology

New tools are fueling a burst of discoveries in immune deficiency, allergy, autoimmunity and inflammatory disease. We are learning new immunization strategies and how the immune system influences diseases not classically seen as immunologic, from neurodegenerative disorders to heart disease.

Immunology news

Regenerative medicine

Our labs are creating pluripotent stem cells for disease modeling and drug screening, investigating natural regenerative processes with cellular “barcodes,” developing cell-based therapies and testing chemical factors that stimulate regeneration pathways.

Regenerative medicine news

Boston Children's Hospital Innovation

BCH Innovation News @BCH_Innovation 6/21/2018 8:16:54 PM
Our intestinal #microbiome influences #metabolism—through the immune system: https://t.co/2jctjodOer https://t.co/FV7XCZPxTC
BCH Innovation News @BCH_Innovation 6/21/2018 3:29:30 PM
Boston Children’s developed an #application that collects quality improvement related #data directly from clinician… https://t.co/JUGYKvWKgO
BCH Innovation News @BCH_Innovation 6/18/2018 6:11:01 PM
The idea is to use #AR to teach children with #autism life skills, vocational skills, etc, says Dr. Shane. #LiveWorx
BCH Innovation News @BCH_Innovation 6/18/2018 6:01:53 PM
.@PTC and @BostonChildrens have built a prototype #AR interface to enhance language and learning for children with… https://t.co/et5MG1egZE
BCH Innovation News @BCH_Innovation 6/18/2018 5:55:44 PM
Augmented reality technology gives us the opportunity to place visual cues directly into the environment of children with #autism. #LiveWorx
BCH Innovation News @BCH_Innovation 6/18/2018 5:53:43 PM
Using technology and visual cues, we are trying to re-build a language system for children with autism, says Dr. Sh… https://t.co/Dphv9yflrD
We are grateful to have been ranked #1 on U.S. News & World Report's list of the best children's hospitals in the nation for the fourth year in a row, an honor we could not have achieved without the patients and families who inspire us to do our very best for them. Thanks to you, Boston Children's is a place where we can write the greatest children's stories ever told.

Sandra L. Fenwick, President and CEO

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