Research Overview

The Hur laboratory investigates molecular mechanisms of self and non-self discrimination by the immune systems. The lab currently focuses on two topics:

  1. The innate immune receptors involved in antiviral immune response
  2. The transcription factors involved in T cell development of self tolerance. They use a combination of structural biology, biochemistry and cell biology

For more information, visit Dr. Hur's research page with the Program in Cellular and Molecular Medicine (PCMM).

About the Researcher

Dr. Hur received her BS in physics from Ewha Women’s University in Korea in 2001, Ph.D. in physical chemistry with Dr. Thomas C. Bruice at the University of California, Santa Barbara in 2003 and did her post-doctoral work in X-ray crystallography with Dr. Robert M. Stroud at the University of California, San Francisco. Dr. Hur joined Harvard Medical School in 2008 as an assistant professor and joined Boston Children's Hospital in 2010. Dr. Hur is a recipient of the 2009 Massachusetts Life Sciences Young Investigator Award, the 2010 Pew Scholar Award, as well as the 2015 Vilcek Prize for Creative Promise in Biomedical Science and the 2015 Burroughs Wellcome Infectious Disease Investigator Award. She is Judy Lieberman Chair in Structural Biology.

Researcher Services

Researcher Areas

  • Protein-nucleic acid interaction in vetebrate immunity

Research Departments

Research Divisions

Researcher Programs

Researcher Labs

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Hur S. Double-Stranded RNA Sensors and Modulators in Innate Immunity. Annu Rev Immunol. 2019 Jan 23. View abstract
  2. Mu X, Greenwald E, Ahmad S, Hur S. An origin of the immunogenicity of in vitro transcribed RNA. Nucleic Acids Res. 2018 Jun 01; 46(10):5239-5249. View abstract
  3. Ahmad S, Mu X, Yang F, Greenwald E, Park JW, Jacob E, Zhang CZ, Hur S. Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation. Cell. 2018 02 08; 172(4):797-810.e13. View abstract
  4. Cadena C, Hur S. Antiviral Immunity and Circular RNA: No End in Sight. Mol Cell. 2017 Jul 20; 67(2):163-164. View abstract
  5. Wu B, Huoh YS, Hur S. Measuring Monomer-to-Filament Transition of MAVS as an In Vitro Activity Assay for RIG-I-Like Receptors. Methods Mol Biol. 2016; 1390:131-42. View abstract
  6. Ahmad S, Hur S. Helicases in Antiviral Immunity: Dual Properties as Sensors and Effectors. Trends Biochem Sci. 2015 Oct; 40(10):576-585. View abstract
  7. Wu B, Hur S. How RIG-I like receptors activate MAVS. Curr Opin Virol. 2015 Jun; 12:91-8. View abstract
  8. Yao H, Dittmann M, Peisley A, Hoffmann HH, Gilmore RH, Schmidt T, Schmidt-Burgk J, Hornung V, Rice CM, Hur S. ATP-dependent effector-like functions of RIG-I-like receptors. Mol Cell. 2015 May 07; 58(3):541-548. View abstract
  9. del Toro Duany Y, Wu B, Hur S. MDA5-filament, dynamics and disease. Curr Opin Virol. 2015 Jun; 12:20-5. View abstract
  10. Wu B, Peisley A, Tetrault D, Li Z, Egelman EH, Magor KE, Walz T, Penczek PA, Hur S. Molecular imprinting as a signal-activation mechanism of the viral RNA sensor RIG-I. Mol Cell. 2014 Aug 21; 55(4):511-23. View abstract
  11. Peisley A, Wu B, Xu H, Chen ZJ, Hur S. Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I. Nature. 2014 May 01; 509(7498):110-4. View abstract
  12. Peisley A, Wu B, Yao H, Walz T, Hur S. RIG-I forms signaling-competent filaments in an ATP-dependent, ubiquitin-independent manner. Mol Cell. 2013 Sep 12; 51(5):573-83. View abstract
  13. Wu B, Hur S. Viral counterattack against the host innate immune system. Cell Res. 2013 Jun; 23(6):735-6. View abstract
  14. Wu B, Peisley A, Richards C, Yao H, Zeng X, Lin C, Chu F, Walz T, Hur S. Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5. Cell. 2013 Jan 17; 152(1-2):276-89. View abstract
  15. Peisley A, Jo MH, Lin C, Wu B, Orme-Johnson M, Walz T, Hohng S, Hur S. Kinetic mechanism for viral dsRNA length discrimination by MDA5 filaments. Proc Natl Acad Sci U S A. 2012 Dec 04; 109(49):E3340-9. View abstract
  16. Peisley A, Hur S. Multi-level regulation of cellular recognition of viral dsRNA. Cell Mol Life Sci. 2013 Jun; 70(11):1949-63. View abstract
  17. Peisley A, Lin C, Wu B, Orme-Johnson M, Liu M, Walz T, Hur S. Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):21010-5. View abstract