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Hur Laboratory Research | Overview

The Hur Laboratory is a Howard Hughes Medical Institute (HHMI) structural and cell biology research laboratory located at Boston Children’s Hospital and Harvard Medical School. The lab is seeking to reveal underlying principles of innate immunity that allow the body to detect and respond to invading pathogens. Specifically, Dr. Hur and her team are investigating how the vertebrate immune system discriminates between self and non-self on the basis of RNA structure and modifications. Using structural and biochemical approaches, the team focuses on immune receptors and modulators in antiviral innate immune response. The team also investigates other nucleic acid biology, such as transcriptional reprogramming and post-transcriptional regulation during development and maturation of the vertebrate immune system. Their work has implications for better understanding and treating viral infections and other diseases, such as autoimmune-based inflammatory disorders and cancer.

Antiviral Innate Immunity

pattern recognition receptors, antiviral immune response, auto-inflammatory disease, immuno-oncology application

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Transcriptional Regulation of Adaptive Immunity

transcription regulation of adaptive immunity, T cell development of self-tolerance, nuclear organization

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