Menno Verhave MD

Menno Verhave, MD

Attending Physician; Clinical Director, Gastroenterology

Lecturer, Harvard Medical School

  • Contact: 617-355-7289

  • Fax: 617-730-0495

Medical Services

Specialties

  • Celiac Disease
  • Gastroenterology
  • Inflammatory Bowel Disease

Departments

  • Gastroenterology, Hepatology and Nutrition
  • Medicine

Programs

  • Inflammatory Bowel Disease Center
To schedule an appointment: Call 617-355-7289 or Request an Appointment

Experience and Education

Education

Undergraduate

Carleton College, 1978

Northfield, MN

Medical School

Harvard Medical School, 1982

Boston, MA

Internship

Boston Children's Hospital, 1982-1983

Boston, MA

Residency

Boston Children's Hospital, 1983-1985

Boston, MA

Fellowship, Clinical Fellowship in Pediatric Gastroenterology and Nutrition

New England Medical Center Hospital, The Floating Hospital for Children, 1988

Boston, MA

Fellowship, Research Fellowship in Division of Molecular Medicine

New England Medical Center Hospital, 1998

Boston, MA

Certifications

  • Pediatrics, Pediatric Gastroenterology

Professional History

Research

Long-term follow-up of children with inflammatory bowel disease treated with immunosuppressives

Study of new treatment modalities for inflammatory bowel disease

Publications

Publications powered by Harvard Catalyst Profiles
  1. Baumer FM, Ouahed J, Verhave M, Rivkin MJ. Fatal Central Nervous System Disease Following First Infliximab Infusion in a Child With Inflammatory Bowel Disease. Pediatr Neurol. 2016 Apr; 57:91-4.
  2. Zitomersky NL, Levine AE, Atkinson BJ, Harney KM, Verhave M, Bousvaros A, Lightdale JR, Trenor CC. Risk factors, morbidity, and treatment of thrombosis in children and young adults with active inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2013 Sep; 57(3):343-7.
  3. Zitomersky NL, Verhave M, Trenor CC. Thrombosis and inflammatory bowel disease: a call for improved awareness and prevention. Inflamm Bowel Dis. 2011 Jan; 17(1):458-70.
  4. Verhave M, Krasinski SD, Christian SI, Van Schaik S, Van Den Brink GR, Doting EM, Maas SM, Wolthers KC, Grand RJ, Montgomery RK. Regulatory regions in the rat lactase-phlorizin hydrolase gene that control cell-specific expression. J Pediatr Gastroenterol Nutr. 2004 Sep; 39(3):275-85.
  5. Verhave M, Baldassano RN, Bousvaros A, Grand RJ, Kirschner BS. Research agenda for pediatric gastroenterology, hepatology and nutrition: chronic inflammatory bowel disease. Report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition for the Children's Digestive Health and Nutrition Foundation. J Pediatr Gastroenterol Nutr. 2002; 35 Suppl 3:S286-90.
  6. Montgomery RK, van den Brink G, Verhave M, Grand RJ, Krasinski SD. Regulation of rat lactase-phlorizin hydrolase (LPH) by C/EBP and HNF-3. 1999; 116:A567.
  7. Li W, Krasinski SD, Verhave M, Montgomery RK, Grand RJ. Three distinct messenger RNA distribution patterns in human jejunal enterocytes. Gastroenterology. 1998 Jul; 115(1):86-92.
  8. Barth JA, Li W, Krasinski SD, Montgomery RK, Verhave M, Grand RJ. Asymmetrical localization of mRNAs in enterocytes of human jejunum. J Histochem Cytochem. 1998 Mar; 46(3):335-43.
  9. Li W, Krasinski SD, Verhave M, Montgomery RK and Grand RJ. Three distrinct mRNA distribution patterns in human jejunal enterocytes. 1998; 114:A892.
  10. Krasinski SD, Lee MF, June RM, Verhave M, Montgomery RK, Grand RJ. Demonstration of dual function enhancer and silencer activity in the CE-LPH1 region of the human lactase-phlorizin hydrolase (LPH) gene. 1998; 116:A559.
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  12. Barth J and Verhave M: Lactose intolerance, in Altschuler SM and Liacouras CA (eds). Clinical Pediatric Gastroenterology. 1998; ; 229-233.
  13. Li W, Krasinski SD, Verhave M, Montgomery RK, Matsudaira P, Coluccio LM, and Grand, R.J. Distinct mRNA distribution patterns in human jejunal enterocytes. 1998; 26:553.
  14. Krasinski SD, Upchurch BH, Irons SJ, June RM, Mishra K, Grand RJ, Verhave M. Rat lactase-phlorizin hydrolase/human growth hormone transgene is expressed on small intestinal villi in transgenic mice. Gastroenterology. 1997 Sep; 113(3):844-55.
  15. Robertson FM, Jacir NN, Crombleholme TM, Moriarty KP, Verhave M. Thoracoscopic esophagomyotomy for achalasia in a child. J Pediatr Gastroenterol Nutr. 1997 Feb; 24(2):215-7.
  16. Barth JA, Li W, Krasinski SD, Montgomery RK, Verhave M, Grand RJ. Targeting of lactase-phlorizin hydrolase (LPH) and sucrase-isomaltase (SI) mRNAs to the apical domain of absorptive enterocytes of human jejunum. 1997; 112:A347.
  17. Verhave M, van Schaik S, van den Brink G, Christian SI, June RM, Doting MHE, Maas SM, Wolthers KC, Krasinski SD, Grand RJ. Identification of a negative cis-acting element in the rat lactase-phlorizin hydrolase (LPH) promoter. 1997; 112:A913.
  18. Saeed SA, Integlia MJ, Valicenti MR, Berhane R, Grand RJ, Verhave M. Immunosuppressive therapy for children with inflammatory bowel disease: a retrospective study with long-term follow-up. 1997; 112:A1079.
  19. Estrada, G., Krasinski, S.D., Grand, R.J., and Lopez-Tejero, M.D. Lactase-phlorizin hydrolase (LPH) is degraded before its insertion into the microvillus membrane in rats prenatally exposed to ethanol. 1997; 112:A361.
  20. Robertson FM, Crombleholme TM, Barlow SE, Verhave M, Brown D. Ceftriaxone choledocholithiasis. Pediatrics. 1996 Jul; 98(1):133-5.
  21. Ramakrishna J, Langhans N, Calenda K, Grand RJ, Verhave M. Combined use of cyclosporine and azathioprine or 6-mercaptopurine in pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 1996 Apr; 22(3):296-302.
  22. Neele AM, Einerhand AW, Dekker J, Büller HA, Freund JN, Verhave M, Grand RJ, Montgomery RK. Verification of the lactase site of rat lactase-phlorizin hydrolase by site-directed mutagenesis. Gastroenterology. 1995 Oct; 109(4):1234-40.
  23. Verhave M, Krasinski SD, Maas SM, Smiers FJ, Mishra K, Breeuwsma NG, Naim HY, Grand RJ. Further characterization of the 5'-flanking region of the rat lactase-phlorizin hydrolase gene. Biochem Biophys Res Commun. 1995 Apr 26; 209(3):989-95.
  24. Krasinski SD, Estrada G, Yeh KY, Yeh M, Traber PG, Rings EH, Büller HA, Verhave M, Montgomery RK, Grand RJ. Transcriptional regulation of intestinal hydrolase biosynthesis during postnatal development in rats. Am J Physiol. 1994 Oct; 267(4 Pt 1):G584-94.
  25. Verhave M, Krasinski SD, Maas SM, Smiers FJW, Wolthers K, Mishra K, Breeuwsma NG, Naim HY, Büller HA, and Grand RJ. Identification of positive and negative transcriptional regulatory regions in the rat lactase-phlorizin hydrolase gene, in Lentze MJ, Naim HY, and Grand RJ (eds). Mammalian Brush Border Membrane Proteins II. 1994; 26-29.
  26. Neele AM, Einerhand AWC, Dekker J, Büller, Freund J-N, Verhave M, Grand RJ, and Montgomery RK. Rat lactase-phlorizin hydrolase has a single main catalytic site with both ß-glucosidic and ß-galactosidic activities. 1994; 106:A1043.
  27. Rings EHHM, Van Beers EH, Krasinski SD, Verhave M, Montgomery RK, Grand RJ, Dekker J, and Büller HA. Lactase: origin, gene expression, localization, and function. 1994; (14):781-805.
  28. Ramakrishna J, Langhans N, Calenda K, Grand RJ, and Verhave M. Combined use of cyclosporin A (CSA) and azathioprine (AZA) in pediatric inflammatory bowel disease (IBD). 1994; 106:A23.
  29. Ramakrishna J, Langhans N, Calenda K, Grand RJ, and Verhave M. Combined use of cyclosporin A (CSA) and azathioprine (AZA) in pediatric inflammatory bowel disease (IBD). 1994; 106:A23.
  30. Krasinski SD, Upchurch BH, Irons SJ, Mishra K, Grand RJ, and Verhave M. Appropriate cell- and crypt/villus-specific expression of the rat lactase-phlorizin hydrolase gene in transgenic mice. 1994; 106:A244.
  31. Mulberg AE, Verhave M. Identification and treatment of nonsteroidal anti-inflammatory drug-induced gastroduodenal injury in children. Am J Dis Child. 1993 Dec; 147(12):1280-1.
  32. Mulberg AE, Linz C, Bern E, Tucker L, Verhave M, Grand RJ. Identification of nonsteroidal antiinflammatory drug-induced gastroduodenal injury in children with juvenile rheumatoid arthritis. J Pediatr. 1993 Apr; 122(4):647-9.
  33. Verhave M, Krasinski S, Maas S, Smiers F, Wolthers K, Mishra K, Breeuwsma N, Naim H, Büller HA, and Grand R. Identification of positive and negative transcriptional regulatory regions in the rat lactase-phlorizin hydrolase gene. 1993; 104:A287.
  34. Krasinski SD, Estrada G, Yeh K-Y, Yeh M, Traber PG, Verhave M, Rings EHHM, Büller HA, Montgomery RK, and Grand RJ. Transcriptional regulation of lactase-phlorizin hydrolase and sucrase-isomaltase in rat intestine. 1993; 104:A630.
  35. Krasinski SD, Estrada G, Yeh KY, Yeh M, Rings EHHM, Verhave M, Büller HA, Montgomery RK, and Grand RJ. Expression of the rat intestinal lactase-phlorizin hydrolase gene along the proximal to distal axis and during postnatal development. 1992; (3):199A.
  36. Mulberg AE, Linz C and Verhave M. Prevalence and treatment of gastroduodenal injury in children with juvenile rheumatoid arthritis receiving non-steroidal anti-inflammatory drugs. 1992; 102(4):A22.
  37. Fink JS, Verhave M, Walton K, Mandel G, Goodman RH. Cyclic AMP- and phorbol ester-induced transcriptional activation are mediated by the same enhancer element in the human vasoactive intestinal peptide gene. J Biol Chem. 1991 Feb 25; 266(6):3882-7.
  38. Verhave M, Winter HS, Grand RJ. Azathioprine in the treatment of children with inflammatory bowel disease. J Pediatr. 1990 Nov; 117(5):809-14.
  39. Goodman RH, Rehfuss RP, Verhave M, Ventimiglia R, Low MJ. Somatostatin gene regulation: an overview. Metabolism. 1990 Sep; 39(9 Suppl 2):2-5.
  40. Goodman RH, Walton K, Rehfuss R, Verhave M, Ventimiglia R, and Low MJ. Regulation of somatostatin gene expression, in Schwartz T (ed). Neuropeptides and Their Receptors. 1990; 60-70.
  41. Verhave M, Fink JS, Bos T, and Goodman RH. Regulation of somatostatin gene expression by phorbol esters. Presented at the American Gastroenterological Association 1989. 1989; 96:A527.
  42. Verhave M, Goodman R, and Fink JS. Fos and jun cooperate to activate transcription of the human VIP gene. Society for Neuroscience Abstracts. 1989; (15):1124.
  43. Goodman RH, Verhave M, Kasper S, Tsukada T, Mandel G, and Fink JS. Regulation of expression of the human pre-pro VIP gene, in Wass J and Scanlon M (eds). Neuroendocrine Perspectives. 1989; 6.
  44. Fink JS, Verhave M, Kasper S, Tsukada T, Mandel G, Goodman RH. The CGTCA sequence motif is essential for biological activity of the vasoactive intestinal peptide gene cAMP-regulated enhancer. Proc Natl Acad Sci U S A. 1988 Sep; 85(18):6662-6.
  45. Low MJ, Fink JS, Taukada T, Verhave M, Mandel G, and Goodman RH. The relevance of DNA mediated gene transfer in mammalian cells for neuroscience, in van Leeuwen FW, Buijs RM, Pool CW, and Pach O, (eds). Techniques in the Behavioual and Neural Sciences: Molecular Neuroanatomy. 1988; 3:79-94.
  46. Verhave M, Fink JS, Mandel G, and Goodman RH: Functional overlap of cAMP and TPA responsive DNA elements in the human vasoactive intestinal polypeptide gene. Presented at the American Gastroenterological Association 1988. 1988; (94):A479.
  47. Verhave M, Winter H, and Grand RJ. Efficacy and safety of azathioprine in children with IBD. Presented at the American Gastroenterological Association 1987. 1987; 92(5):1682.
  48. Fink JS, Tsukada M, Verhave M, and Goodman R. Characterization of a cyclic AMP responsive enhancer element in the human VIP gene. 1987.
  49. . Fink JS, Verhave M, Tsukada T, Mandel G, and Goodman R. Mutational analysis of a cyclic AMP responsive element in the human VIP gene. 1987; 13(1):34.
  50. Rodrick M, Rayner A, Steele G, Harte P, Finn D, Verhave M, Munroe A, Zamcheck N, Wilson R. An evaluation of two antigen nonspecific assays for circulating immune complexes using a model system. J Clin Lab Immunol. 1982 Apr; 7(3):193-8.
To schedule an appointment: Call 617-355-7289 or Request an Appointment

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