EDUCATION

Graduate School
  • Keio University , Tokyo , JAPAN

Medical School

  • Keio University School of Medicine , Tokyo , JAPAN

Internship

  • Keio University , Tokyo , JAPAN

Graduate Degree

  • Massachusetts General Hospital , Boston , MA

Fellowship

  • Boston Children's Hospital , Boston , MA

CERTIFICATIONS

  • American Board of Psychiatry and Neurology, Child and Adolescent Neurology
  • American Board of Psychiatry and Neurology Epilepsy
  • American Board of Psychiatry and Neurology Clinical Neurophysiology

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Almuqbil M, Rivkin MJ, Takeoka M, Yang E, Rodan LH. Transient regional cerebral hypoperfusion during a paroxysmal hemiplegic event in GLUT1 deficiency syndrome. Eur J Paediatr Neurol. 2018 May; 22(3):544-547. View abstract
  2. Vega C, Sánchez Fernández I, Peters J, Thome-Souza MS, Jackson M, Takeoka M, Wilkening GN, Pearl PL, Chapman K, Loddenkemper T. Response to clobazam in continuous spike-wave during sleep. Dev Med Child Neurol. 2018 Mar; 60(3):283-289. View abstract
  3. Guerriero RM, Patel AA, Walsh B, Baumer FM, Shah AS, Peters JM, Rodan LH, Agrawal PB, Pearl PL, Takeoka M. Systemic Manifestations in Pyridox(am)ine 5'-Phosphate Oxidase Deficiency. Pediatr Neurol. 2017 Nov; 76:47-53. View abstract
  4. Olson HE, Kelly M, LaCoursiere CM, Pinsky R, Tambunan D, Shain C, Ramgopal S, Takeoka M, Libenson MH, Julich K, Loddenkemper T, Marsh ED, Segal D, Koh S, Salman MS, Paciorkowski AR, Yang E, Bergin AM, Sheidley BR, Poduri A. Genetics and genotype-phenotype correlations in early onset epileptic encephalopathy with burst suppression. Ann Neurol. 2017 Mar; 81(3):419-429. View abstract
  5. Pinto AL, Chen L, Friedman R, Grant PE, Poduri A, Takeoka M, Prabhu SP, Sahin M. Sturge-Weber Syndrome: Brain Magnetic Resonance Imaging and Neuropathology Findings. Pediatr Neurol. 2016 05; 58:25-30. View abstract
  6. Harini C, Nagarajan E, Kimia AA, de Carvalho RM, An S, Bergin AM, Takeoka M, Pearl PL, Loddenkemper T. Utility of initial EEG in first complex febrile seizure. Epilepsy Behav. 2015 Nov; 52(Pt A):200-4. View abstract
  7. Aravamuthan BR, Sánchez Fernández I, Zurawski J, Olson H, Gorman M, Takeoka M. Pediatric anti-Hu-associated encephalitis with clinical features of Rasmussen encephalitis. Neurol Neuroimmunol Neuroinflamm. 2015 Oct; 2(5):e150. View abstract
  8. Harini C, Das RR, Prabhu SP, Singh K, Haldar A, Takeoka M, Bergin AM, Loddenkemper T, Kothare SV. Clinical and Neuroimaging Profile of Children with Lesions in the Corpus Callosum. J Neuroimaging. 2015 Sep-Oct; 25(5):824-31. View abstract
  9. Thome-Souza S, Kadish NE, Ramgopal S, Sánchez Fernández I, Bergin AM, Bolton J, Harini C, Libenson M, Olson H, Peters J, Poduri A, Rotenberg A, Takeoka M, Kothare SV, Kapur K, Bourgeois BF, Loddenkemper T. Safety and retention rate of rufinamide in 300 patients: a single pediatric epilepsy center experience. Epilepsia. 2014 Aug; 55(8):1235-44. View abstract
  10. Olson H, Shen Y, Avallone J, Sheidley BR, Pinsky R, Bergin AM, Berry GT, Duffy FH, Eksioglu Y, Harris DJ, Hisama FM, Ho E, Irons M, Jacobsen CM, James P, Kothare S, Khwaja O, Lipton J, Loddenkemper T, Markowitz J, Maski K, Megerian JT, Neilan E, Raffalli PC, Robbins M, Roberts A, Roe E, Rollins C, Sahin M, Sarco D, Schonwald A, Smith SE, Soul J, Stoler JM, Takeoka M, Tan WH, Torres AR, Tsai P, Urion DK, Weissman L, Wolff R, Wu BL, Miller DT, Poduri A. Copy number variation plays an important role in clinical epilepsy. Ann Neurol. 2014 Jun; 75(6):943-58. View abstract
  11. Pinto AL, Lohani S, Bergin AM, Bourgeois BF, Black PM, Prabhu SP, Madsen JR, Takeoka M, Poduri A. Surgery for intractable epilepsy due to unilateral brain disease: a retrospective study comparing hemispherectomy techniques. Pediatr Neurol. 2014 Sep; 51(3):336-43. View abstract
  12. Klehm J, Thome-Souza S, Sánchez Fernández I, Bergin AM, Bolton J, Harini C, Kadish NE, Libenson M, Peters J, Poduri A, Rotenberg A, Takeoka M, Bourgeois B, Loddenkemper T. Clobazam: effect on frequency of seizures and safety profile in different subgroups of children with epilepsy. Pediatr Neurol. 2014 Jul; 51(1):60-6. View abstract
  13. Sánchez Fernández I, Peters JM, An S, Bergin AM, Takeoka M, Rotenberg A, Kothare SV, Riviello JJ, Loddenkemper T. Long-term response to high-dose diazepam treatment in continuous spikes and waves during sleep. Pediatr Neurol. 2013 Sep; 49(3):163-170.e4. View abstract
  14. Taimouri V, Akhondi-Asl A, Tomas-Fernandez X, Peters JM, Prabhu SP, Poduri A, Takeoka M, Loddenkemper T, Bergin AM, Harini C, Madsen JR, Warfield SK. Electrode localization for planning surgical resection of the epileptogenic zone in pediatric epilepsy. Int J Comput Assist Radiol Surg. 2014 Jan; 9(1):91-105. View abstract
  15. Harini C, Singh K, Takeoka M, Parulkar I, Bergin AM, Loddenkemper T, Kothare SV. Predictors of seizure occurrence in children undergoing pre-surgical monitoring. Seizure. 2013 Oct; 22(8):640-6. View abstract
  16. Wintermark P, Lechpammer M, Warfield SK, Kosaras B, Takeoka M, Poduri A, Madsen JR, Bergin AM, Whalen S, Jensen FE. Perfusion Imaging of Focal Cortical Dysplasia Using Arterial Spin Labeling: Correlation With Histopathological Vascular Density. J Child Neurol. 2013 Nov; 28(11):1474-1482. View abstract
  17. Andrade-Machado R. Early thalamic lesions in patients with sleep-potentiated epileptiform activity. Neurology. 2012 Nov 27; 79(22):2218; author reply 2218-9. View abstract
  18. Fernández IS, Peters JM, Hadjiloizou S, Prabhu SP, Zarowski M, Stannard KM, Takeoka M, Rotenberg A, Kothare SV, Loddenkemper T. Clinical staging and electroencephalographic evolution of continuous spikes and waves during sleep. Epilepsia. 2012 Jul; 53(7):1185-95. View abstract
  19. Sánchez Fernández I, Hadjiloizou S, Eksioglu Y, Peters JM, Takeoka M, Tas E, Abdelmoumen I, Rotenberg A, Kothare SV, Riviello JJ, Loddenkemper T. Short-term response of sleep-potentiated spiking to high-dose diazepam in electric status epilepticus during sleep. Pediatr Neurol. 2012 May; 46(5):312-8. View abstract
  20. Sánchez Fernández I, Takeoka M, Tas E, Peters JM, Prabhu SP, Stannard KM, Gregas M, Eksioglu Y, Rotenberg A, Riviello JJ, Kothare SV, Loddenkemper T. Early thalamic lesions in patients with sleep-potentiated epileptiform activity. Neurology. 2012 May 29; 78(22):1721-7. View abstract
  21. Fernández IS, Peters J, Takeoka M, Rotenberg A, Prabhu S, Gregas M, Riviello JJ, Kothare S, Loddenkemper T. Patients with electrical status epilepticus in sleep share similar clinical features regardless of their focal or generalized sleep potentiation of epileptiform activity. J Child Neurol. 2013 Jan; 28(1):83-9. View abstract
  22. Sarco DP, Boyer K, Lundy-Krigbaum SM, Takeoka M, Jensen F, Gregas M, Waber DP. Benign rolandic epileptiform discharges are associated with mood and behavior problems. Epilepsy Behav. 2011 Oct; 22(2):298-303. View abstract
  23. Herman ST, Takeoka M, Hughes JR, Drislane FW. Electroencephalography in clinical epilepsy research. Epilepsy Behav. 2011 Sep; 22(1):126-33. View abstract
  24. Guilhoto LM, Loddenkemper T, Gooty VD, Rotenberg A, Takeoka M, Duffy FH, Coulter D, Urion D, Bourgeois BF, Kothare SV. Experience with lacosamide in a series of children with drug-resistant focal epilepsy. Pediatr Neurol. 2011 Jun; 44(6):414-9. View abstract
  25. Eksioglu YZ, Pong AW, Takeoka M. A novel mutation in the aristaless domain of the ARX gene leads to Ohtahara syndrome, global developmental delay, and ambiguous genitalia in males and neuropsychiatric disorders in females. Epilepsia. 2011 May; 52(5):984-92. View abstract
  26. Olson HE, Loddenkemper T, Vendrame M, Poduri A, Takeoka M, Bergin AM, Libenson MH, Duffy FH, Rotenberg A, Coulter D, Bourgeois BF, Kothare SV. Rufinamide for the treatment of epileptic spasms. Epilepsy Behav. 2011 Feb; 20(2):344-8. View abstract
  27. Vendrame M, Loddenkemper T, Gooty VD, Takeoka M, Rotenberg A, Bergin AM, Eksioglu YZ, Poduri A, Duffy FH, Libenson M, Bourgeois BF, Kothare SV. Experience with rufinamide in a pediatric population: a single center's experience. Pediatr Neurol. 2010 Sep; 43(3):155-8. View abstract
  28. Nakajima K, Takeoka M, Mori M, Hashimoto S, Sakurai A, Nose H, Higuchi K, Itano N, Shiohara M, Oh T, Taniguchi S. Exercise effects on methylation of ASC gene. Int J Sports Med. 2010 Sep; 31(9):671-5. View abstract
  29. Depositario-Cabacar DT, Peters JM, Pong AW, Roth J, Rotenberg A, Riviello JJ, Takeoka M. High-dose intravenous levetiracetam for acute seizure exacerbation in children with intractable epilepsy. Epilepsia. 2010 Jul; 51(7):1319-22. View abstract
  30. Thibert RL, Burns JD, Bhadelia R, Takeoka M. Reversible uncal herniation in a neonate with a large MCA infarct. Brain Dev. 2009 Nov; 31(10):763-5. View abstract
  31. Rotenberg A, Bae EH, Takeoka M, Tormos JM, Schachter SC, Pascual-Leone A. Repetitive transcranial magnetic stimulation in the treatment of epilepsia partialis continua. Epilepsy Behav. 2009 Jan; 14(1):253-7. View abstract
  32. Miller DT, Shen Y, Weiss LA, Korn J, Anselm I, Bridgemohan C, Cox GF, Dickinson H, Gentile J, Harris DJ, Hegde V, Hundley R, Khwaja O, Kothare S, Luedke C, Nasir R, Poduri A, Prasad K, Raffalli P, Reinhard A, Smith SE, Sobeih MM, Soul JS, Stoler J, Takeoka M, Tan WH, Thakuria J, Wolff R, Yusupov R, Gusella JF, Daly MJ, Wu BL. Microdeletion/duplication at 15q13.2q13.3 among individuals with features of autism and other neuropsychiatric disorders. J Med Genet. 2009 Apr; 46(4):242-8. View abstract
  33. Rotenberg A, Depositario-Cabacar D, Bae EH, Harini C, Pascual-Leone A, Takeoka M. Transient suppression of seizures by repetitive transcranial magnetic stimulation in a case of Rasmussen's encephalitis. Epilepsy Behav. 2008 Jul; 13(1):260-2. View abstract
  34. Depositario-Cabacar DT, Riviello JJ, Takeoka M. Present status of surgical intervention for children with intractable seizures. Curr Neurol Neurosci Rep. 2008 Mar; 8(2):123-9. View abstract
  35. Raju GP, Sarco DP, Poduri A, Riviello JJ, Bergin AM, Takeoka M. Oxcarbazepine in children with nocturnal frontal-lobe epilepsy. Pediatr Neurol. 2007 Nov; 37(5):345-9. View abstract
  36. Poduri A, Golja A, Takeoka M, Bourgeois BF, Connolly L, Riviello JJ. Focal cortical malformations can show asymmetrically higher uptake on interictal fluorine-18 fluorodeoxyglucose positron emission tomography (PET). J Child Neurol. 2007 Feb; 22(2):232-7. View abstract
  37. Yoshii A, Takeoka M, Kelly PJ, Krishnamoorthy KS. Focal status epilepticus as atypical presentation of pyridoxine-dependent epilepsy. J Child Neurol. 2005 Aug; 20(8):696-8. View abstract
  38. Poduri A, Golja A, Riviello JJ, Bourgeois BF, Duffy FH, Takeoka M. A distinct asymmetrical pattern of cortical malformation: large unilateral malformation of cortical development with contralateral periventricular nodular heterotopia in three pediatric cases. Epilepsia. 2005 Aug; 46(8):1317-21. View abstract
  39. Herbert MR, Ziegler DA, Deutsch CK, O'Brien LM, Kennedy DN, Filipek PA, Bakardjiev AI, Hodgson J, Takeoka M, Makris N, Caviness VS. Brain asymmetries in autism and developmental language disorder: a nested whole-brain analysis. Brain. 2005 Jan; 128(Pt 1):213-26. View abstract
  40. Takeoka M, Riviello JJ, Duffy FH, Kim F, Kennedy DN, Makris N, Caviness VS, Holmes GL. Bilateral volume reduction of the superior temporal areas in Landau-Kleffner syndrome. Neurology. 2004 Oct 12; 63(7):1289-92. View abstract
  41. Yoshida Y, Shimada H, Mori T, Yoshihara H, Takeoka M, Takahashi T. FK506-associated limbic injury following umbilical cord blood transplantation. Bone Marrow Transplant. 2003 Sep; 32(5):523-5. View abstract
  42. Koganehira Y, Takeoka M, Ehara T, Sasaki K, Murata H, Saida T, Taniguchi S. Reduced expression of actin-binding proteins, h-caldesmon and calponin h1, in the vascular smooth muscle inside melanoma lesions: an adverse prognostic factor for malignant melanoma. Br J Dermatol. 2003 May; 148(5):971-80. View abstract
  43. Takeoka M, Kim F, Caviness VS, Kennedy DN, Makris N, Holmes GL. MRI volumetric analysis in rasmussen encephalitis: a longitudinal study. Epilepsia. 2003 Feb; 44(2):247-51. View abstract
  44. Herbert MR, Harris GJ, Adrien KT, Ziegler DA, Makris N, Kennedy DN, Lange NT, Chabris CF, Bakardjiev A, Hodgson J, Takeoka M, Tager-Flusberg H, Caviness VS. Abnormal asymmetry in language association cortex in autism. Ann Neurol. 2002 Nov; 52(5):588-96. View abstract
  45. Takeoka M, Riviello JJ, Pfeifer H, Thiele EA. Concomitant treatment with topiramate and ketogenic diet in pediatric epilepsy. Epilepsia. 2002 Sep; 43(9):1072-5. View abstract
  46. Takeoka M, Takahashi T. Infectious and inflammatory disorders of the circulatory system and stroke in childhood. Curr Opin Neurol. 2002 Apr; 15(2):159-64. View abstract
  47. Takeoka M, Soman TB, Yoshii A, Caviness VS, Gonzalez RG, Grant PE, Krishnamoorthy KS. Diffusion-weighted images in neonatal cerebral hypoxic-ischemic injury. Pediatr Neurol. 2002 Apr; 26(4):274-81. View abstract
  48. Soman TB, Takeoka M, Dooling EC, Caviness V. Diffusion-weighted imaging in moyamoya disease. J Child Neurol. 2001 Jul; 16(7):526-30. View abstract
  49. Takeoka M, Holmes GL, Thiele E, Bourgeois BF, Helmers SL, Duffy FH, Riviello JJ. Topiramate and metabolic acidosis in pediatric epilepsy. Epilepsia. 2001 Mar; 42(3):387-92. View abstract
  50. Takeoka M, Soman TB, Shih VE, Caviness VS, Krishnamoorthy KS. Carbamyl phosphate synthetase 1 deficiency: a destructive encephalopathy. Pediatr Neurol. 2001 Mar; 24(3):193-9. View abstract
  51. Krishnamoorthy KS, Soman TB, Takeoka M, Schaefer PW. Diffusion-weighted imaging in neonatal cerebral infarction: clinical utility and follow-up. J Child Neurol. 2000 Sep; 15(9):592-602. View abstract
  52. Takeoka M, Krishnamoorthy KS, Soman TB, Caviness VS. Fosphenytoin in infants. J Child Neurol. 1998 Nov; 13(11):537-40. View abstract
  53. Shafqat S, Elkind MS, Chiocca EA, Takeoka M, Koroshetz WJ. Petroclival meningioma presenting with pathological laughter. Neurology. 1998 Jun; 50(6):1918-9. View abstract