Masanori Takeoka, MD

Masanori Takeoka, M.D.

Assistant in Neurology

Assistant Professor of Neurology, Harvard Medical School

  • Contact: 617-355-8656

  • Fax: 617-730-0463

Medical Services


  • Epilepsy Seizures
  • Sturge-Weber Syndrome
  • Child Neurology


  • Neurology


  • English
  • Japanese


  • Epilepsy Center
  • END Technology Program
  • Sturge-Weber Syndrome Clinic
To schedule an appointment: Call 617-355-8656 or Request an Appointment

Experience and Education


Graduate School

Keio University, 1989

Tokyo, JAPAN

Medical School

Keio University School of Medicine, 1993

Tokyo, JAPAN


Keio University, 1995

Tokyo, JAPAN


Massachusetts General Hospital, 1998

Boston, MA


Boston Children's Hospital, 2000

Boston, MA


  • Child Neurology

  • Epilepsy

  • Clinical Neurophysiology


Publications powered by Harvard Catalyst Profiles
  1. Pinto AL, Chen L, Friedman R, Grant PE, Poduri A, Takeoka M, Prabhu SP, Sahin M. Sturge-Weber Syndrome: Brain Magnetic Resonance Imaging and Neuropathology Findings. Pediatr Neurol. 2016 May; 58:25-30.
  2. Harini C, Nagarajan E, Kimia AA, de Carvalho RM, An S, Bergin AM, Takeoka M, Pearl PL, Loddenkemper T. Utility of initial EEG in first complex febrile seizure. Epilepsy Behav. 2015 Nov; 52(Pt A):200-4.
  3. Aravamuthan BR, Sánchez Fernández I, Zurawski J, Olson H, Gorman M, Takeoka M. Pediatric anti-Hu-associated encephalitis with clinical features of Rasmussen encephalitis. Neurol Neuroimmunol Neuroinflamm. 2015 Oct; 2(5):e150.
  4. Harini C, Das RR, Prabhu SP, Singh K, Haldar A, Takeoka M, Bergin AM, Loddenkemper T, Kothare SV. Clinical and Neuroimaging Profile of Children with Lesions in the Corpus Callosum. J Neuroimaging. 2015 Sep-Oct; 25(5):824-31.
  5. Thome-Souza S, Kadish NE, Ramgopal S, Sánchez Fernández I, Bergin AM, Bolton J, Harini C, Libenson M, Olson H, Peters J, Poduri A, Rotenberg A, Takeoka M, Kothare SV, Kapur K, Bourgeois BF, Loddenkemper T. Safety and retention rate of rufinamide in 300 patients: a single pediatric epilepsy center experience. Epilepsia. 2014 Aug; 55(8):1235-44.
  6. Olson H, Shen Y, Avallone J, Sheidley BR, Pinsky R, Bergin AM, Berry GT, Duffy FH, Eksioglu Y, Harris DJ, Hisama FM, Ho E, Irons M, Jacobsen CM, James P, Kothare S, Khwaja O, Lipton J, Loddenkemper T, Markowitz J, Maski K, Megerian JT, Neilan E, Raffalli PC, Robbins M, Roberts A, Roe E, Rollins C, Sahin M, Sarco D, Schonwald A, Smith SE, Soul J, Stoler JM, Takeoka M, Tan WH, Torres AR, Tsai P, Urion DK, Weissman L, Wolff R, Wu BL, Miller DT, Poduri A. Copy number variation plays an important role in clinical epilepsy. Ann Neurol. 2014 Jun; 75(6):943-58.
  7. Pinto AL, Lohani S, Bergin AM, Bourgeois BF, Black PM, Prabhu SP, Madsen JR, Takeoka M, Poduri A. Surgery for intractable epilepsy due to unilateral brain disease: a retrospective study comparing hemispherectomy techniques. Pediatr Neurol. 2014 Sep; 51(3):336-43.
  8. Klehm J, Thome-Souza S, Sánchez Fernández I, Bergin AM, Bolton J, Harini C, Kadish NE, Libenson M, Peters J, Poduri A, Rotenberg A, Takeoka M, Bourgeois B, Loddenkemper T. Clobazam: effect on frequency of seizures and safety profile in different subgroups of children with epilepsy. Pediatr Neurol. 2014 Jul; 51(1):60-6.
  9. Sánchez Fernández I, Peters JM, An S, Bergin AM, Takeoka M, Rotenberg A, Kothare SV, Riviello JJ, Loddenkemper T. Long-term response to high-dose diazepam treatment in continuous spikes and waves during sleep. Pediatr Neurol. 2013 Sep; 49(3):163-170.e4.
  10. Taimouri V, Akhondi-Asl A, Tomas-Fernandez X, Peters JM, Prabhu SP, Poduri A, Takeoka M, Loddenkemper T, Bergin AM, Harini C, Madsen JR, Warfield SK. Electrode localization for planning surgical resection of the epileptogenic zone in pediatric epilepsy. Int J Comput Assist Radiol Surg. 2014 Jan; 9(1):91-105.
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  12. Harini C, Singh K, Takeoka M, Parulkar I, Bergin AM, Loddenkemper T, Kothare SV. Predictors of seizure occurrence in children undergoing pre-surgical monitoring. Seizure. 2013 Oct; 22(8):640-6.
  13. Andrade-Machado R. Early thalamic lesions in patients with sleep-potentiated epileptiform activity. Neurology. 2012 Nov 27; 79(22):2218; author reply 2218-9.
  14. Fernández IS, Peters JM, Hadjiloizou S, Prabhu SP, Zarowski M, Stannard KM, Takeoka M, Rotenberg A, Kothare SV, Loddenkemper T. Clinical staging and electroencephalographic evolution of continuous spikes and waves during sleep. Epilepsia. 2012 Jul; 53(7):1185-95.
  15. Sánchez Fernández I, Hadjiloizou S, Eksioglu Y, Peters JM, Takeoka M, Tas E, Abdelmoumen I, Rotenberg A, Kothare SV, Riviello JJ, Loddenkemper T. Short-term response of sleep-potentiated spiking to high-dose diazepam in electric status epilepticus during sleep. Pediatr Neurol. 2012 May; 46(5):312-8.
  16. Sánchez Fernández I, Takeoka M, Tas E, Peters JM, Prabhu SP, Stannard KM, Gregas M, Eksioglu Y, Rotenberg A, Riviello JJ, Kothare SV, Loddenkemper T. Early thalamic lesions in patients with sleep-potentiated epileptiform activity. Neurology. 2012 May 29; 78(22):1721-7.
  17. Fernández IS, Peters J, Takeoka M, Rotenberg A, Prabhu S, Gregas M, Riviello JJ, Kothare S, Loddenkemper T. Patients with electrical status epilepticus in sleep share similar clinical features regardless of their focal or generalized sleep potentiation of epileptiform activity. J Child Neurol. 2013 Jan; 28(1):83-9.
  18. Sarco DP, Boyer K, Lundy-Krigbaum SM, Takeoka M, Jensen F, Gregas M, Waber DP. Benign rolandic epileptiform discharges are associated with mood and behavior problems. Epilepsy Behav. 2011 Oct; 22(2):298-303.
  19. Herman ST, Takeoka M, Hughes JR, Drislane FW. Electroencephalography in clinical epilepsy research. Epilepsy Behav. 2011 Sep; 22(1):126-33.
  20. Guilhoto LM, Loddenkemper T, Gooty VD, Rotenberg A, Takeoka M, Duffy FH, Coulter D, Urion D, Bourgeois BF, Kothare SV. Experience with lacosamide in a series of children with drug-resistant focal epilepsy. Pediatr Neurol. 2011 Jun; 44(6):414-9.
  21. Eksioglu YZ, Pong AW, Takeoka M. A novel mutation in the aristaless domain of the ARX gene leads to Ohtahara syndrome, global developmental delay, and ambiguous genitalia in males and neuropsychiatric disorders in females. Epilepsia. 2011 May; 52(5):984-92.
  22. Olson HE, Loddenkemper T, Vendrame M, Poduri A, Takeoka M, Bergin AM, Libenson MH, Duffy FH, Rotenberg A, Coulter D, Bourgeois BF, Kothare SV. Rufinamide for the treatment of epileptic spasms. Epilepsy Behav. 2011 Feb; 20(2):344-8.
  23. Vendrame M, Loddenkemper T, Gooty VD, Takeoka M, Rotenberg A, Bergin AM, Eksioglu YZ, Poduri A, Duffy FH, Libenson M, Bourgeois BF, Kothare SV. Experience with rufinamide in a pediatric population: a single center's experience. Pediatr Neurol. 2010 Sep; 43(3):155-8.
  24. Nakajima K, Takeoka M, Mori M, Hashimoto S, Sakurai A, Nose H, Higuchi K, Itano N, Shiohara M, Oh T, Taniguchi S. Exercise effects on methylation of ASC gene. Int J Sports Med. 2010 Sep; 31(9):671-5.
  25. Depositario-Cabacar DT, Peters JM, Pong AW, Roth J, Rotenberg A, Riviello JJ, Takeoka M. High-dose intravenous levetiracetam for acute seizure exacerbation in children with intractable epilepsy. Epilepsia. 2010 Jul; 51(7):1319-22.
  26. Thibert RL, Burns JD, Bhadelia R, Takeoka M. Reversible uncal herniation in a neonate with a large MCA infarct. Brain Dev. 2009 Nov; 31(10):763-5.
  27. Rotenberg A, Bae EH, Takeoka M, Tormos JM, Schachter SC, Pascual-Leone A. Repetitive transcranial magnetic stimulation in the treatment of epilepsia partialis continua. Epilepsy Behav. 2009 Jan; 14(1):253-7.
  28. Miller DT, Shen Y, Weiss LA, Korn J, Anselm I, Bridgemohan C, Cox GF, Dickinson H, Gentile J, Harris DJ, Hegde V, Hundley R, Khwaja O, Kothare S, Luedke C, Nasir R, Poduri A, Prasad K, Raffalli P, Reinhard A, Smith SE, Sobeih MM, Soul JS, Stoler J, Takeoka M, Tan WH, Thakuria J, Wolff R, Yusupov R, Gusella JF, Daly MJ, Wu BL. Microdeletion/duplication at 15q13.2q13.3 among individuals with features of autism and other neuropsychiatric disorders. J Med Genet. 2009 Apr; 46(4):242-8.
  29. Rotenberg A, Depositario-Cabacar D, Bae EH, Harini C, Pascual-Leone A, Takeoka M. Transient suppression of seizures by repetitive transcranial magnetic stimulation in a case of Rasmussen's encephalitis. Epilepsy Behav. 2008 Jul; 13(1):260-2.
  30. Depositario-Cabacar DT, Riviello JJ, Takeoka M. Present status of surgical intervention for children with intractable seizures. Curr Neurol Neurosci Rep. 2008 Mar; 8(2):123-9.
  31. Raju GP, Sarco DP, Poduri A, Riviello JJ, Bergin AM, Takeoka M. Oxcarbazepine in children with nocturnal frontal-lobe epilepsy. Pediatr Neurol. 2007 Nov; 37(5):345-9.
  32. Poduri A, Golja A, Takeoka M, Bourgeois BF, Connolly L, Riviello JJ. Focal cortical malformations can show asymmetrically higher uptake on interictal fluorine-18 fluorodeoxyglucose positron emission tomography (PET). J Child Neurol. 2007 Feb; 22(2):232-7.
  33. Yoshii A, Takeoka M, Kelly PJ, Krishnamoorthy KS. Focal status epilepticus as atypical presentation of pyridoxine-dependent epilepsy. J Child Neurol. 2005 Aug; 20(8):696-8.
  34. Poduri A, Golja A, Riviello JJ, Bourgeois BF, Duffy FH, Takeoka M. A distinct asymmetrical pattern of cortical malformation: large unilateral malformation of cortical development with contralateral periventricular nodular heterotopia in three pediatric cases. Epilepsia. 2005 Aug; 46(8):1317-21.
  35. Herbert MR, Ziegler DA, Deutsch CK, O'Brien LM, Kennedy DN, Filipek PA, Bakardjiev AI, Hodgson J, Takeoka M, Makris N, Caviness VS. Brain asymmetries in autism and developmental language disorder: a nested whole-brain analysis. Brain. 2005 Jan; 128(Pt 1):213-26.
  36. Takeoka M, Riviello JJ, Duffy FH, Kim F, Kennedy DN, Makris N, Caviness VS, Holmes GL. Bilateral volume reduction of the superior temporal areas in Landau-Kleffner syndrome. Neurology. 2004 Oct 12; 63(7):1289-92.
  37. Yoshida Y, Shimada H, Mori T, Yoshihara H, Takeoka M, Takahashi T. FK506-associated limbic injury following umbilical cord blood transplantation. Bone Marrow Transplant. 2003 Sep; 32(5):523-5.
  38. Koganehira Y, Takeoka M, Ehara T, Sasaki K, Murata H, Saida T, Taniguchi S. Reduced expression of actin-binding proteins, h-caldesmon and calponin h1, in the vascular smooth muscle inside melanoma lesions: an adverse prognostic factor for malignant melanoma. Br J Dermatol. 2003 May; 148(5):971-80.
  39. Takeoka M, Kim F, Caviness VS, Kennedy DN, Makris N, Holmes GL. MRI volumetric analysis in rasmussen encephalitis: a longitudinal study. Epilepsia. 2003 Feb; 44(2):247-51.
  40. Herbert MR, Harris GJ, Adrien KT, Ziegler DA, Makris N, Kennedy DN, Lange NT, Chabris CF, Bakardjiev A, Hodgson J, Takeoka M, Tager-Flusberg H, Caviness VS. Abnormal asymmetry in language association cortex in autism. Ann Neurol. 2002 Nov; 52(5):588-96.
  41. Takeoka M, Riviello JJ, Pfeifer H, Thiele EA. Concomitant treatment with topiramate and ketogenic diet in pediatric epilepsy. Epilepsia. 2002 Sep; 43(9):1072-5.
  42. Takeoka M, Takahashi T. Infectious and inflammatory disorders of the circulatory system and stroke in childhood. Curr Opin Neurol. 2002 Apr; 15(2):159-64.
  43. Takeoka M, Soman TB, Yoshii A, Caviness VS, Gonzalez RG, Grant PE, Krishnamoorthy KS. Diffusion-weighted images in neonatal cerebral hypoxic-ischemic injury. Pediatr Neurol. 2002 Apr; 26(4):274-81.
  44. Soman TB, Takeoka M, Dooling EC, Caviness V. Diffusion-weighted imaging in moyamoya disease. J Child Neurol. 2001 Jul; 16(7):526-30.
  45. Takeoka M, Holmes GL, Thiele E, Bourgeois BF, Helmers SL, Duffy FH, Riviello JJ. Topiramate and metabolic acidosis in pediatric epilepsy. Epilepsia. 2001 Mar; 42(3):387-92.
  46. Takeoka M, Soman TB, Shih VE, Caviness VS, Krishnamoorthy KS. Carbamyl phosphate synthetase 1 deficiency: a destructive encephalopathy. Pediatr Neurol. 2001 Mar; 24(3):193-9.
  47. Krishnamoorthy KS, Soman TB, Takeoka M, Schaefer PW. Diffusion-weighted imaging in neonatal cerebral infarction: clinical utility and follow-up. J Child Neurol. 2000 Sep; 15(9):592-602.
  48. Takeoka M, Krishnamoorthy KS, Soman TB, Caviness VS. Fosphenytoin in infants. J Child Neurol. 1998 Nov; 13(11):537-40.
  49. Shafqat S, Elkind MS, Chiocca EA, Takeoka M, Koroshetz WJ. Petroclival meningioma presenting with pathological laughter. Neurology. 1998 Jun; 50(6):1918-9.
To schedule an appointment: Call 617-355-8656 or Request an Appointment


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