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Clinical Trials

We’re always striving to better understand the medications that help children with weight management. One way we do that is through clinical trials. These are research studies that help us determine if a medication is effective and safe. We need patients to volunteer for clinical trials; it’s only with their help that we’re able to improve treatment for them and future patients.

Here are the clinical trials we’re currently holding:

DISCOVERY Study of risk factors for type 2 diabetes in youth

The goal of this study is to understand why some children with overweight and obesity develop type 2 diabetes while others do not. We are recruiting youth aged 9-14 years with a BMI ≥ 85th percentile and hemoglobin A1c ≥ 5.5%. This is a multi-year observational study conducted at 15 centers across the U.S., with BCH, MGH, and the Joslin Diabetes Center making up the Boston site. Learn about the DISCOVERY Trial.

Download the related flyer.

Setmelanotide in acquired hypothalamic obesity

The goal of this trial is to learn how well Setmelanotide works to improve weight reduction, hunger, and quality of life in patients 4 years of age and older with acquired hypothalamic obesity. Learn about the Setmelanotide trial.

RM-718 in Healthy Subjects and in Patients With HO

The purpose of this study is to evaluate the safety, tolerability, and PK of RM-718 in healthy subjects with obesity and in patients with hypothalamic obesity. Learn about the RM-718 trial.

If your family is interested in participating or wants to learn more about upcoming clinical trials, please call our administrative team at 617-355-5159.

Compass PWS (Prader-Willi syndrome) Study

This is a multi-center, randomized, double-blind, placebo-controlled study where participants will receive either a carbetocin nasal spray or a placebo nasal spray three times a day to evaluate the efficacy of treatment in people with Prader-Willi syndrome (PWS). For more information, please email Allison Bernique and Kiana Summers at CompassPWS@childrens.harvard.edu, or call 617-919-7678 or 617-919-5365.

Learn about the Compass PWS study.