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Research & Innovation

Children with congenital and acquired heart disease often require specialized antithrombosis strategies to reduce the risks of blood clots and bleeding, both in the hospital and at home.

Our program is recognized worldwide for its leadership in developing and refining innovative anticoagulation and antiplatelet strategies through clinical research, innovation, and advocacy. We continually update our treatment approaches and evaluate new medications to optimize safety and effectiveness, ensuring families are equipped to manage their child’s complex anticoagulation needs across all stages of care.

Here are some examples of how we’re advancing antithrombosis management and helping children live fuller, healthier lives.

Selected publications

  • Stroke in pediatric ventricular assist device support; Aug 21, 2025; pubmed:40837542.
  • Contemporary outcomes of mechanical circulatory support using paracorporeal continuous flow pump in children: A report from the ACTION learning network; Jul 2, 2025; pubmed:40602507.
  • Cardiac Medication Use in ACTION for Duchenne Muscular Dystrophy Cardiomyopathy; Jun 20, 2025; pubmed:40540017.
  • Impact of Anticoagulation Therapy After Bioprosthetic and Homograft Pulmonary Valve Replacement; Jan 19, 2025; pubmed:39828075.
  • Development and Validation of a Postprocedure Stroke Screening Tool in Children With Cardiac Disease; Jan 13, 2025; pubmed:39801153.
  • A Thrombolytic Protocol of Bivalirudin for Giant Coronary Artery Aneurysms and Thrombosis in Kawasaki Disease; Aug 15, 2024; pubmed:39147272.
  • Apixaban overdose in children: case report and proposed management. A brief communication from the Pediatric and Neonatal Thrombosis and Hemostasis SSC of ISTH; Feb 8, 2024; pubmed:38327612.
  • Use of apixaban in children awaiting heart transplantation; Oct 28, 2023; pubmed:37897124.
  • Real-world use of apixaban for the treatment and prevention of thrombosis in children with cardiac disease; Mar 15, 2023; pubmed:36921920.
  • Apixaban Anticoagulation in Children and Young Adults Supported With the HeartMate 3 Ventricular Assist Device; Feb 10, 2023; pubmed:36763905.
  • Cost-effectiveness of bivalirudin in pediatric ventricular assist devices; Nov 4, 2022; pubmed:36333207.
  • Online KidClot education for patients and families initiating warfarin therapy: The eKITE study; May 20, 2022; pubmed:35594736.
  • Decreased Risk of Strokes in Children with Ventricular Assist Devices Within ACTION; Mar 5, 2022; pubmed:35247057.
  • American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 and Hyperinflammation in Pediatric COVID-19: Version 3; Feb 4, 2022; pubmed:35118829.
  • Acute Management of High-Risk and Intermediate-Risk Pulmonary Embolism in Children: A Review; Sep 29, 2021; pubmed:34587483.
  • Coagulation profiles and viscoelastic testing in multisystem inflammatory syndrome in children; Sep 17, 2021; pubmed:34532964.
  • Difference in the prevalence of intracardiac thrombus on the first presentation of atrial fibrillation versus flutter in the pediatric and congenital heart disease population; Oct 28, 2020; pubmed:33112018.
  • Time in Therapeutic Range for Bivalirudin Among Pediatric Ventricular Assist Device Recipients; Aug 23, 2020; pubmed:32826396.
  • Cardiac manifestations in SARS-CoV-2-associated multisystem inflammatory syndrome in children: a comprehensive review and proposed clinical approach; Aug 18, 2020; pubmed:32803422.
  • Utilization and Outcomes of Children Treated with Direct Thrombin Inhibitors on Paracorporeal Ventricular Assist Device Support; Aug 3, 2020; pubmed:32740356.
  • Apixaban for treatment of intracardiac thrombosis in children with congenital heart disease; Mar 30, 2020; pubmed:32221595.
  • An anticoagulation protocol for use after congenital cardiac surgery; May 1, 2018; pubmed:29706371.
  • Antithrombotic therapies in children on durable Ventricular Assist Devices: A literature review; Mar 5, 2018; pubmed:29501323.
  • Low molecular weight heparin as an anticoagulation strategy for left-sided ablation procedures; Nov 29, 2017; pubmed:29181868.
  • Safety and Efficacy of Warfarin Therapy in Kawasaki Disease; May 30, 2017; pubmed:28552449.
  • Utility of a dedicated pediatric cardiac anticoagulation program: the Boston Children's Hospital experience; Jan 10, 2015; pubmed:25573076.