Sudden infant death syndrome (SIDS) is the sudden death of an infant under 1 year of age that cannot be explained following a thorough case investigation that includes an autopsy, a death scene investigation and a review of the clinical history. The syndrome is sometimes called crib death, because the death is usually associated with sleep and often occurs while a baby is sleeping in a crib.
SIDS is the leading cause of postneonatal (1 month to 1 year of age) death of babies in the United States. Ninety percent of SIDS deaths occur within the first 6 months of life, with the rate peaking between 1 to 4 months. Death comes suddenly and unpredictably, usually during sleep. In most cases, the baby seems healthy before death. Currently, the cause of SIDS is unknown. The possibility of the syndrome affecting your baby is very frightening. But knowing more about it — and taking certain very specific precautions — can reduce your baby’s risk of SIDS.
See diagnosis and treatments for more precautions.
If you’re concerned that your child or grandchild is in danger of SIDS, it will comfort you to know that Boston Children’s Hospital has a tremendous amount of experience counseling parents on techniques to greatly reduce the risk.
Sudden infant death syndrome (SIDS) is the sudden and unexplained death of a baby younger than 1 year old. A diagnosis of SIDS is made if the baby’s death remains unexplained even after a death scene investigation, an autopsy, and a review of the clinical history.
SIDS is part of a larger category of unexpected (as opposed to unexplained) infant deaths called SUDI (sudden unexpected death in infancy). Babies who die suddenly but whose causes of death are later explained (infection, brain abnormality, cardiac dysfunction, etc.) also fall into this SUDI category.
SIDS is a mysterious syndrome, since by its very definition the cause cannot be determined. But certain risk factors do exist.
About 2,300 babies in the United States die of SIDS each year. Some babies are more at risk than others. For example, SIDS is more likely to affect a baby who is between 1 and 4 months old, it is more common in boys than girls, and most deaths occur during the fall, winter and early spring months.
Factors that may place a baby at higher risk of dying from SIDS include the following:
While the cause of SIDS is unknown, many clinicians and researchers believe that SIDS is associated with problems in the ability of the baby to arouse from sleep, to detect low levels of oxygen, or a buildup of carbon dioxide in the blood. When babies sleep face down, they may re-breathe exhaled carbon dioxide. Normally, rising carbon dioxide levels activate nerve cells in the brainstem, which stimulate the brain's respiratory and arousal centers. The baby then wakes up, turns his head, and breathes faster to get more oxygen. SIDS babies, however, may fail to rouse.
The “Triple-Risk Model” for SIDS has been proposed to explain how SIDS occurs. The model holds that SIDS occurs when three conditions exist simultaneously:
A baby is determined to have died from SIDS if no cause of death can be identified following a death scene investigation, an autopsy, and a review of the clinical history. Thus, SIDS is a diagnosis of exclusion: SIDS as a cause of death is determined only when all other causes have been excluded.
Because researchers at Children’s and elsewhere are still researching the possible causes of SIDS, there is currently no way to “prevent” the syndrome from occurring. But you can vastly reduce your baby’s risk of SIDS by:
SIDS is a mysterious syndrome, and by its very definition the cause cannot be determined. Children’s researchers have uncovered strong evidence that SIDS has a biological basis, and are continuing to work towards determining the underlying causes and identifying at-risk babies.
Diseases caused by smoking kill almost a half-million people in the United States every year. Despite anti-smoking campaigns and medical warnings, more than 6,000 children and teens smoke their first cigarette each day — and half of those will become regular smokers. Pregnant moms who smoke increase their babies’ risk of SIDS. Quitting smoking is one of the best things you can do for your baby’s health — and your own.
There currently is no way of predicting which babies die from SIDS. However, early and regular prenatal care can help reduce the risk of SIDS. And there are many precautions that you can take to lower the risk of your baby dying from SIDS:
All parents can significantly reduce the risk of SIDS by being informed about, and implementing, simple but specific risk reduction strategies.
And for younger parents, Children’s Young Parents Program (YPP) and the Children's Hospital Primary Care Center (CHPCC) provide quality medical care and health education to teen parents and their children in low-income and at-risk environments. We’re dedicated to helping young parents learn positive parenting skills, attitudes and behaviors so their child has healthy development and growth during the critical first years.
Boston Children’s is also a world leader in SIDS research, investigating the key questions about this mysterious syndrome, including:
Children who are born prematurely benefit from special monitoring and intervention during their first years of life. Our Infant Follow-Up Program (IFUP) provides ongoing medical and developmental evaluation and support for very premature infants.
Becoming a parent is full of challenges, even in the best of circumstances. Those challenges are even greater for teen parents. Our Young Parents Program (YPP) is a special clinic dedicated to helping teen mothers and fathers from low-income and at-risk environments, since these young parents have the highest rates of pregnancies and the greatest risk of giving birth to babies with health problems. Our program includes doctors, social workers, nurses and nurse practitioners who have years of experience working with urban parents, adolescents, and children.
Sudden infant death syndrome (SIDS): Reviewed by David Paterson, PhD
© Boston Children’s Hospital, 2012
Our care is informed by our research, and our discoveries in the lab strengthen the care we provide at each child's bedside. In fact, our scientific research program is one of the largest and most active of any pediatric hospital in the world.
Currently, there is no way to identify living infants at risk of SIDS. But the development of such a test is a major goal of SIDS research at Children’s.
Among Children’s research projects that hold promise for preventing SIDS is research into a neurochemical abnormality in the brainstem that may be responsible for the failure of protective breathing, heart and arousal responses that are thought to be responsible for SIDS.
Recent autopsy data provide the strongest evidence yet that sudden infant death syndrome (SIDS) has a concrete biological basis. Children’s neuropathologist Hannah Kinney, MD, and colleagues have found that babies who die from SIDS have abnormalities in the brainstem, the part of the brain that controls breathing; that responds to re-breathing too much carbon dioxide; and that regulates blood pressure and body temperature — all of which are important in sleeping and waking.
Our researchers found that the brainstems of SIDS infants have lower levels of the neurochemical serotonin and a signaling protein called 14-3-3. They also had significantly fewer receptors for serotonin and another neurochemical gamma-amino-butyric acid (GABA). These abnormalities are thought to prevent SIDS infants from properly controlling the vital functions that keep them alive and ultimately to lead to their death.
Dr. Kinney and colleagues are currently working towards a means of identifying those infants who are at increased risk of SIDS, with the ultimate goal of developing a treatment that will protect them from SIDS.