Research

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William Barbaresi, MD

Department:
Medicine Research
Division
Developmental Medicine Research
Hospital Title:
Associate Chief, Division of Developmental Medicine
Academic Title:
Associate Professor of Pediatrics, Harvard Medical School
Research Focus Area:
ADHDAutism
Contact Via Email
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Research Overview

Dr. Barbaresi’s research focuses on population-based studies of developmental disorders. His research group has published the most comprehensive information to date on associations between treatment of childhood ADHD and long-term outcomes.  They also published the first long-term study of the changing incidence of autism in the US.  He is currently the PI of a prospective, population-based, NIH-funded study of ADHD.  This study includes all research-identified childhood ADHD cases and controls from a population-based birth cohort.  It will provide population-based answers to long-standing questions about the rate of persistence of ADHD into adulthood, as well as psychosocial, educational and psychiatric outcomes for adults with a history of childhood ADHD. The DNA repository created in this study will be employed in future studies of the genomics of ADHD.

Publications

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  1. Harstad E, Blum N, Gahman A, Shults J, Chan E, Barbaresi W. Management of Attention-Deficit/Hyperactivity Disorder by Developmental-Behavioral Pediatricians: A DBPNet Study. J Dev Behav Pediatr. 2016 Sep; 37(7):541-7.
  2. Lingren T, Chen P, Bochenek J, Doshi-Velez F, Manning-Courtney P, Bickel J, Wildenger Welchons L, Reinhold J, Bing N, Ni Y, Barbaresi W, Mentch F, Basford M, Denny J, Vazquez L, Perry C, Namjou B, Qiu H, Connolly J, Abrams D, Holm IA, Cobb BA, Lingren N, Solti I, Hakonarson H, Kohane IS, Harley J, Savova G. Electronic Health Record Based Algorithm to Identify Patients with Autism Spectrum Disorder. PLoS One. 2016; 11(7):e0159621.
  3. Barbaresi WJ. The Meaning of "Regression" in Children with Autism Spectrum Disorder: Why Does It Matter? J Dev Behav Pediatr. 2016 Jul-Aug; 37(6):506-7.
  4. Yoshimasu K, Barbaresi WJ, Colligan RC, Voigt RG, Weaver AL, Katusic SK. Mediating and Moderating Role of Depression, Conduct Disorder or Attention-Deficit/Hyperactivity Disorder in Developing Adolescent Substance Use Disorders: A Population-Based Study. PLoS One. 2016; 11(6):e0157488.
  5. Barbaresi WJ. Improving Care for Children With ADHD: The Information is Just a Rating Scale Away. Pediatrics. 2016 Mar; 137(3):e20154450.
  6. Aguirre Castaneda RL, Kumar S, Voigt RG, Leibson CL, Barbaresi WJ, Weaver AL, Killian JM, Katusic SK. Childhood Attention-Deficit/Hyperactivity Disorder, Sex, and Obesity: A Longitudinal Population-Based Study. Mayo Clin Proc. 2016 Mar; 91(3):352-61.
  7. Harstad EB, Fogler J, Sideridis G, Weas S, Mauras C, Barbaresi WJ. Comparing Diagnostic Outcomes of Autism Spectrum Disorder Using DSM-IV-TR and DSM-5 Criteria. J Autism Dev Disord. 2015 May; 45(5):1437-50.
  8. Koolwijk I, Stein DS, Chan E, Powell C, Driscoll K, Barbaresi WJ. "Complex" attention-deficit hyperactivity disorder, more norm than exception? Diagnoses and comorbidities in a developmental clinic. J Dev Behav Pediatr. 2014 Nov-Dec; 35(9):591-7.
  9. Barbaresi WJ, Katusic SK, Colligan RC, Weaver AL, Leibson CL, Jacobsen SJ. Long-term stimulant medication treatment of attention-deficit/hyperactivity disorder: results from a population-based study. J Dev Behav Pediatr. 2014 Sep; 35(7):448-57.
  10. Barbaresi WJ. Update on long-term stimulant medication treatment of attention-deficit hyperactivity disorder. J Dev Behav Pediatr. 2014 Sep; 35(7):446-7.
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  12. Levy S, Katusic SK, Colligan RC, Weaver AL, Killian JM, Voigt RG, Barbaresi WJ. Childhood ADHD and risk for substance dependence in adulthood: a longitudinal, population-based study. PLoS One. 2014; 9(8):e105640.
  13. Voigt RG, Mellon MW, Katusic SK, Weaver AL, Matern D, Mellon B, Jensen CL, Barbaresi WJ. Dietary docosahexaenoic acid supplementation in children with autism. J Pediatr Gastroenterol Nutr. 2014 Jun; 58(6):715-22.
  14. Harstad E, Huntington N, Bacic J, Barbaresi W. Disparity of care for children with parent-reported autism spectrum disorders. Acad Pediatr. 2013 Jul-Aug; 13(4):334-9.
  15. Mellon MW, Natchev BE, Katusic SK, Colligan RC, Weaver AL, Voigt RG, Barbaresi WJ. Incidence of enuresis and encopresis among children with attention-deficit/hyperactivity disorder in a population-based birth cohort. Acad Pediatr. 2013 Jul-Aug; 13(4):322-7.
  16. Ehrhardt J, Huntington N, Molino J, Barbaresi W. Special education and later academic achievement. J Dev Behav Pediatr. 2013 Feb; 34(2):111-9.
  17. Blum NJ, Feldman HM, Barbaresi WJ, Schonfeld DJ, Hansen RL, Forrest CB. Research priorities for developmental-behavioral pediatrics: a DBPNet consensus study. J Dev Behav Pediatr. 2012 Jul; 33(6):509-16.
  18. Stein DS, Blum NJ, Barbaresi WJ. Developmental and behavioral disorders through the life span. Pediatrics. 2011 Aug; 128(2):364-73.
  19. Wickremasinghe AC, Hartman TK, Voigt RG, Katusic SK, Weaver AL, Colby CE, Barbaresi WJ. Evaluation of the ability of neurobiological, neurodevelopmental and socio-economic variables to predict cognitive outcome in premature infants. Child Care Health Dev. 2012 Sep; 38(5):683-9.
  20. Katusic MZ, Voigt RG, Colligan RC, Weaver AL, Homan KJ, Barbaresi WJ. Author reply: attention-deficit hyperactivity disorder and high intelligence quotient. J Dev Behav Pediatr. 2011 Jun; 32(5):438.
  21. Johnson JN, Hartman TK, Barbaresi W, Raffel C, Colby CE. Developmental outcomes for neonatal dural arteriovenous fistulas. J Neurosurg Pediatr. 2009 Feb; 3(2):105-9.
  22. Stancin T, Wang P, Barbaresi W. Developmental and behavioral pediatrics grown up: a new JDBP review series. J Dev Behav Pediatr. 2008 Dec; 29(6):523.
  23. Froehlich TE, Lanphear BP, Epstein JN, Barbaresi WJ, Katusic SK, Kahn RS. Prevalence, recognition, and treatment of attention-deficit/hyperactivity disorder in a national sample of US children. Arch Pediatr Adolesc Med. 2007 Sep; 161(9):857-64.
  24. Barbaresi WJ, Katusic SK, Colligan RC, Weaver AL, Jacobsen SJ. Modifiers of long-term school outcomes for children with attention-deficit/hyperactivity disorder: does treatment with stimulant medication make a difference? Results from a population-based study. J Dev Behav Pediatr. 2007 Aug; 28(4):274-87.
  25. Barbaresi WJ, Katusic SK, Colligan RC, Weaver AL, Jacobsen SJ. Long-term school outcomes for children with attention-deficit/hyperactivity disorder: a population-based perspective. J Dev Behav Pediatr. 2007 Aug; 28(4):265-73.
  26. Voigt RG, Llorente AM, Jensen CL, Fraley JK, Barbaresi WJ, Heird WC. Comparison of the validity of direct pediatric developmental evaluation versus developmental screening by parent report. Clin Pediatr (Phila). 2007 Jul; 46(6):523-9.
  27. Barbaresi WJ, Katusic SK, Voigt RG. Autism: a review of the state of the science for pediatric primary health care clinicians. Arch Pediatr Adolesc Med. 2006 Nov; 160(11):1167-75.
  28. Voigt RG, Barbaresi WJ, Colligan RC, Weaver AL, Katusic SK. Developmental dissociation, deviance, and delay: Occurrence of attention-deficit-hyperactivity disorder in individuals with and without borderline-to-mild intellectual disability. Dev Med Child Neurol. 2006 Oct; 48(10):831-5.
  29. Barbaresi WJ, Katusic SK, Colligan RC, Weaver AL, Leibson CL, Jacobsen SJ. Long-term stimulant medication treatment of attention-deficit/hyperactivity disorder: results from a population-based study. J Dev Behav Pediatr. 2006 Feb; 27(1):1-10.
  30. Leibson CL, Barbaresi WJ, Ransom J, Colligan RC, Kemner J, Weaver AL, Katusic SK. Emergency department use and costs for youth with attention-deficit/hyperactivity disorder: associations with stimulant treatment. Ambul Pediatr. 2006 Jan-Feb; 6(1):45-53.
  31. Katusic SK, Barbaresi WJ, Colligan RC, Weaver AL, Leibson CL, Jacobsen SJ. Psychostimulant treatment and risk for substance abuse among young adults with a history of attention-deficit/hyperactivity disorder: a population-based, birth cohort study. J Child Adolesc Psychopharmacol. 2005 Oct; 15(5):764-76.
  32. Barbaresi WJ, Katusic SK, Colligan RC, Weaver AL, Jacobsen SJ. Math learning disorder: incidence in a population-based birth cohort, 1976-82, Rochester, Minn. Ambul Pediatr. 2005 Sep-Oct; 5(5):281-9.
  33. Katusic SK, Barbaresi WJ, Colligan RC, Weaver AL, Leibson CL, Jacobsen SJ. Case definition in epidemiologic studies of AD/HD. Ann Epidemiol. 2005 Jul; 15(6):430-7.
  34. Merritt JL, Jalal SM, Barbaresi WJ, Babovic-Vuksanovic D. 14q32.3 deletion syndrome with autism. Am J Med Genet A. 2005 Feb 15; 133A(1):99-100.
  35. Barbaresi WJ, Katusic SK, Colligan RC, Weaver AL, Jacobsen SJ. The incidence of autism in Olmsted County, Minnesota, 1976-1997: results from a population-based study. Arch Pediatr Adolesc Med. 2005 Jan; 159(1):37-44.
  36. Stein MT, Barbaresi W, Benuck I. An opportunity for office-based research. J Dev Behav Pediatr. 2004 Oct; 25(5 Suppl):S84-8.
  37. St Sauver JL, Barbaresi WJ, Katusic SK, Colligan RC, Weaver AL, Jacobsen SJ. Early life risk factors for attention-deficit/hyperactivity disorder: a population-based cohort study. Mayo Clin Proc. 2004 Sep; 79(9):1124-31.
  38. Barbaresi W, Katusic S, Colligan R, Weaver A, Pankratz V, Mrazek D, Jacobsen S. How common is attention-deficit/hyperactivity disorder? Towards resolution of the controversy: results from a population-based study. Acta Paediatr Suppl. 2004 May; 93(445):55-9.
  39. Challman TD, Barbaresi WJ, Katusic SK, Weaver A. The yield of the medical evaluation of children with pervasive developmental disorders. J Autism Dev Disord. 2003 Apr; 33(2):187-92.
  40. Barbaresi WJ. Use of psychotropic medications in young, preschool children: primum non nocere. Arch Pediatr Adolesc Med. 2003 Feb; 157(2):121-3.
  41. Barbaresi WJ, Katusic SK, Colligan RC, Pankratz VS, Weaver AL, Weber KJ, Mrazek DA, Jacobsen SJ. How common is attention-deficit/hyperactivity disorder? Incidence in a population-based birth cohort in Rochester, Minn. Arch Pediatr Adolesc Med. 2002 Mar; 156(3):217-24.
  42. St Sauver JL, Katusic SK, Barbaresi WJ, Colligan RC, Jacobsen SJ. Boy/girl differences in risk for reading disability: potential clues? Am J Epidemiol. 2001 Nov 1; 154(9):787-94.
  43. Katusic SK, Colligan RC, Barbaresi WJ, Schaid DJ, Jacobsen SJ. Incidence of reading disability in a population-based birth cohort, 1976-1982, Rochester, Minn. Mayo Clin Proc. 2001 Nov; 76(11):1081-92.
  44. Stein MT, Barbaresi WJ, Benuck I. An opportunity for office-based research. J Dev Behav Pediatr. 2001 Feb; 22(1):35-9.
  45. Leibson CL, Katusic SK, Barbaresi WJ, Ransom J, O'Brien PC. Use and costs of medical care for children and adolescents with and without attention-deficit/hyperactivity disorder. JAMA. 2001 Jan 3; 285(1):60-6.
  46. Katusic SK, Colligan RC, Barbaresi WJ, Schaid DJ, Jacobsen SJ. Potential influence of migration bias in birth cohort studies. Mayo Clin Proc. 1998 Nov; 73(11):1053-61.
  47. Barbaresi WJ, Olsen RD. An ADHD educational intervention for elementary schoolteachers: a pilot study. J Dev Behav Pediatr. 1998 Apr; 19(2):94-100.
  48. Barbaresi WJ. Primary-care approach to the diagnosis and management of attention-deficit hyperactivity disorder. Mayo Clin Proc. 1996 May; 71(5):463-71.
  49. Ibrahim SH, Voigt RG, Katusic SK, Weaver AL, Barbaresi WJ. Incidence of gastrointestinal symptoms in children with autism: a population-based study. Pediatrics. 2009 Aug; 124(2):680-6.
  50. Wilder RT, Flick RP, Sprung J, Katusic SK, Barbaresi WJ, Mickelson C, Gleich SJ, Schroeder DR, Weaver AL, Warner DO. Early exposure to anesthesia and learning disabilities in a population-based birth cohort. Anesthesiology. 2009 Apr; 110(4):796-804.
  51. Katusic MZ, Voigt RG, Colligan RC, Weaver AL, Homan KJ, Barbaresi WJ. Attention-deficit hyperactivity disorder in children with high intelligence quotient: results from a population-based study. J Dev Behav Pediatr. 2011 Feb-Mar; 32(2):103-9.
  52. Yoshimasu K, Barbaresi WJ, Colligan RC, Killian JM, Voigt RG, Weaver AL, Katusic SK. Written-language disorder among children with and without ADHD in a population-based birth cohort. Pediatrics. 2011 Sep; 128(3):e605-12.
  53. Barbaresi WJ, Colligan RC, Weaver AL, Katusic SK. The incidence of clinically diagnosed versus research-identified autism in Olmsted County, Minnesota, 1976-1997: results from a retrospective, population-based study. J Autism Dev Disord. 2009 Mar; 39(3):464-70.
  54. Katusic SK, Colligan RC, Weaver AL, Barbaresi WJ. The forgotten learning disability: epidemiology of written-language disorder in a population-based birth cohort (1976-1982), Rochester, Minnesota. Pediatrics. 2009 May; 123(5):1306-13.
  55. Sprung J, Flick RP, Wilder RT, Katusic SK, Pike TL, Dingli M, Gleich SJ, Schroeder DR, Barbaresi WJ, Hanson AC, Warner DO. Anesthesia for cesarean delivery and learning disabilities in a population-based birth cohort. Anesthesiology. 2009 Aug; 111(2):302-10.
  56. Stoeckel RE, Colligan RC, Barbaresi WJ, Weaver AL, Killian JM, Katusic SK. Early speech-language impairment and risk for written language disorder: a population-based study. J Dev Behav Pediatr. 2013 Jan; 34(1):38-44.
  57. Yoshimasu K, Barbaresi WJ, Colligan RC, Voigt RG, Killian JM, Weaver AL, Katusic SK. Childhood ADHD is strongly associated with a broad range of psychiatric disorders during adolescence: a population-based birth cohort study. J Child Psychol Psychiatry. 2012 Oct; 53(10):1036-43.
  58. Yoshimasu K, Barbaresi WJ, Colligan RC, Killian JM, Voigt RG, Weaver AL, Katusic SK. Gender, attention-deficit/hyperactivity disorder, and reading disability in a population-based birth cohort. Pediatrics. 2010 Oct; 126(4):e788-95.
  59. Sprung J, Flick RP, Katusic SK, Colligan RC, Barbaresi WJ, Bojanic K, Welch TL, Olson MD, Hanson AC, Schroeder DR, Wilder RT, Warner DO. Attention-deficit/hyperactivity disorder after early exposure to procedures requiring general anesthesia. Mayo Clin Proc. 2012 Feb; 87(2):120-9.
  60. Davis SM, Katusic SK, Barbaresi WJ, Killian J, Weaver AL, Ottman R, Wirrell EC. Epilepsy in children with attention-deficit/hyperactivity disorder. Pediatr Neurol. 2010 May; 42(5):325-30.
  61. Nickels K, Katusic SK, Colligan RC, Weaver AL, Voigt RG, Barbaresi WJ. Stimulant medication treatment of target behaviors in children with autism: a population-based study. J Dev Behav Pediatr. 2008 Apr; 29(2):75-81.
  62. Barbaresi WJ, Colligan RC, Weaver AL, Voigt RG, Killian JM, Katusic SK. Mortality, ADHD, and psychosocial adversity in adults with childhood ADHD: a prospective study. Pediatrics. 2013 Apr; 131(4):637-44.
  63. Harris MN, Voigt RG, Barbaresi WJ, Voge GA, Killian JM, Weaver AL, Colby CE, Carey WA, Katusic SK. ADHD and learning disabilities in former late preterm infants: a population-based birth cohort. Pediatrics. 2013 Sep; 132(3):e630-6.
  64. Harstad EB, Weaver AL, Katusic SK, Colligan RC, Kumar S, Chan E, Voigt RG, Barbaresi WJ. ADHD, stimulant treatment, and growth: a longitudinal study. Pediatrics. 2014 Oct; 134(4):e935-44.
  65. Yoshimasu K, Barbaresi WJ, Colligan RC, Voigt RG, Killian JM, Weaver AL, Katusic SK. Adults With Persistent ADHD: Gender and Psychiatric Comorbidities-A Population-Based Longitudinal Study. J Atten Disord. 2016 Nov 18.
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