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W. Nicholas  Haining, MB, BCh

Haining Laboratory
Research Center:
Dana-Farber/Boston Children’s Cancer and Blood Disorders Center
Medicine Research
Hematology/Oncology Research
Hospital Title:
Assistant in Medicine
Academic Title:
Assistant Professor of Pediatrics, Harvard Medical School; Associate Member, Broad Institute of Harvard and MIT
Research Focus Area:
Pediatric Oncology
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Research Overview

Visit The Haining Lab

Dr. Haining is a physician-scientist at the Dana-Farber Cancer Institute and the Broad Institute. His laboratory aims to understand the mechanisms that impair T cell function in cancer and chronic viral disease. To achieve this goal, he has applied genomic tools and computational biology to identify central mechanisms that regulate T cell function. As a post-doctoral fellow he developed new techniques to analyze the gene expression profile of antigen-specific T cells, allowing the signatures of these rare populations to be studied for the first time. He applied novel computational techniques to show that diverse populations of memory lymphocytes share a common differentiation program (J. Immunology 2008). His laboratory has pioneered the application of integrative genomic techniques to identify the mechanisms regulating T cell function in humans. His lab used these approaches to discover a new mechanism that explains defective T cell function in HIV, by showing that the transcription factor BATF is regulated by the receptor PD-1 and inhibits HIV-specific T cells (Nature Medicine, 2010). In recognition of these studies, he was awarded the 2010 Presidential Early Career Award for Scientists and Engineers.

About Nicholas Haining

Dr. Haining is a physician-scientist who received his undergraduate and medical degree from Oxford University, UK. He moved to the United States in 1993 to complete medical training in Pediatrics at Children's Hospital, Boston, and subsequently in Pediatric Hematology/Oncology at Dana-Farber Cancer Institute. After post-doctoral research at MIT and Dana-Farber Cancer Institute, he was appointed to the faculty as Assistant Professor of Pediatrics in 2007 in the Department of Pediatric Oncology. In 2011, he joined the faculty of the Broad Institute of Harvard and MIT as an Associate Member.

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Dana-Farber/Boston Children’s Cancer and Blood Disorders Center

Dana-Farber/Boston Children's Cancer and Blood Disorders Center is one of the top research centers in the world for pediatric cancers and blood diseases. It brings together laboratory scientists and clinical researchers from Dana-Farber Cancer Institute and Boston Children’s Hospital in a single program. We investigate pediatric cancers and non-malignant blood disorders from every angle—from examining cells under the microscope to tracking the effectiveness of current drug regimens using the most advanced molecular methods—so that we can create better treatments for children seen here and around the world.

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