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Paolo Fiorina, MD, PhD

Paolo Fiorina, MD, PhD
Research Center:
Transplant Research Program
Nephrology Research
Hospital Title:
Research Associate
Academic Title:
Assistant Professor of Pediatrics, Harvard Medical School
Research Focus Area:
Transplant ImmunologyDiabetes
Contact Via Email
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Research Overview

Dr. Fiorina’s research focuses on diabetes. In particular, he is interested in three major areas: (1) the treatment of autoimmune diabetes; (2) the replacement of beta cells through islet transplantation; (3) the treatment of diabetic nephropathy. Dr. Fiorina has made significant and innovative contributions in understanding the mechanism underlying the beneficial effects of life expectancy obtained after islet transplantation, even when patients only have partial islet function.

About Paolo Fiorina

Dr. Paolo Fiorina obtained his medical degree from the University of Milan and continued his training at the combined Internal Medicine/PhD program in immunology at Parma University. After studying transplantation immunology for six years at the San Raffaele Scientific Institute in Milan, one of the leading programs in human islet cell transplantation, Dr. Fiorina joined Boston Children's Hospital as a research fellow in 2004. In 2009 he became an Assistant Professor of Nephrology at Boston Children’s/Harvard Medical School.


Publications powered by Harvard Catalyst Profiles
  1. Ben Nasr M, Fiorina P. CXCR4 antagonism overcomes diabetic stem cell mobilopathy. Atherosclerosis. 2016 Aug; 251:512-3.
  2. D'Addio F, Fiorina P. Type 1 Diabetes and Dysfunctional Intestinal Homeostasis. Trends Endocrinol Metab. 2016 Jul; 27(7):493-503.
  3. Ben Nasr M, Bassi R, Usuelli V, Valderrama-Vasquez A, Tezza S, D'Addio F, Fiorina P. The use of hematopoietic stem cells in autoimmune diseases. Regen Med. 2016 Jun; 11(4):395-405.
  4. D'Addio F, La Rosa S, Maestroni A, Jung P, Orsenigo E, Ben Nasr M, Tezza S, Bassi R, Finzi G, Marando A, Vergani A, Frego R, Albarello L, Andolfo A, Manuguerra R, Viale E, Staudacher C, Corradi D, Batlle E, Breault D, Secchi A, Folli F, Fiorina P. Circulating IGF-I and IGFBP3 Levels Control Human Colonic Stem Cell Function and Are Disrupted in Diabetic Enteropathy. Cell Stem Cell. 2015 Oct 1; 17(4):486-98.
  5. Bassi R, Fornoni A, Doria A, Fiorina P. CTLA4-Ig in B7-1-positive diabetic and non-diabetic kidney disease. Diabetologia. 2016 Jan; 59(1):21-9.
  6. Mameli C, Mazzantini S, Ben Nasr M, Fiorina P, Scaramuzza AE, Zuccotti GV. Explaining the increased mortality in type 1 diabetes. World J Diabetes. 2015 Jul 10; 6(7):889-95.
  7. Mounayar M, Kefaloyianni E, Smith B, Solhjou Z, Maarouf OH, Azzi J, Chabtini L, Fiorina P, Kraus M, Briddell R, Fodor W, Herrlich A, Abdi R. PI3ka and STAT1 Interplay Regulates Human Mesenchymal Stem Cell Immune Polarization. Stem Cells. 2015 Jun; 33(6):1892-901.
  8. Ben Nasr M, Fiorina P. Novel therapies for T1D on the horizon. Pharmacol Res. 2015 Aug; 98:1-2.
  9. Ben Nasr M, Vergani A, Avruch J, Liu L, Kefaloyianni E, D'Addio F, Tezza S, Corradi D, Bassi R, Valderrama-Vasquez A, Usuelli V, Kim J, Azzi J, El Essawy B, Markmann J, Abdi R, Fiorina P. Co-transplantation of autologous MSCs delays islet allograft rejection and generates a local immunoprivileged site. Acta Diabetol. 2015 Oct; 52(5):917-27.
  10. Venturini M, Maffi P, Querques G, Agostini G, Piemonti L, Sironi S, De Cobelli F, Fiorina P, Secchi A, Del Maschio A. Hepatic steatosis after islet transplantation: Can ultrasound predict the clinical outcome? A longitudinal study in 108 patients. Pharmacol Res. 2015 Aug; 98:52-9.
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  12. Zandi S, Nakao S, Chun KH, Fiorina P, Sun D, Arita R, Zhao M, Kim E, Schueller O, Campbell S, Taher M, Melhorn MI, Schering A, Gatti F, Tezza S, Xie F, Vergani A, Yoshida S, Ishikawa K, Yamaguchi M, Sasaki F, Schmidt-Ullrich R, Hata Y, Enaida H, Yuzawa M, Yokomizo T, Kim YB, Sweetnam P, Ishibashi T, Hafezi-Moghadam A. ROCK-isoform-specific polarization of macrophages associated with age-related macular degeneration. Cell Rep. 2015 Feb 24; 10(7):1173-86.
  13. Fotino C, Vergani A, Fiorina P, Pileggi A. P2X receptors and diabetes. Curr Med Chem. 2015; 22(7):891-901.
  14. D'Addio F, Margonato D, Pensato U, Borgese L, Potena L, Fiorina P. Novel therapeutic and diagnostic management of heart transplant patients. Heart Lung Vessel. 2015; 7(3):198-207.
  15. Solini A, Usuelli V, Fiorina P. The dark side of extracellular ATP in kidney diseases. J Am Soc Nephrol. 2015 May; 26(5):1007-16.
  16. Fiorentino TV, Owston M, Abrahamian G, La Rosa S, Marando A, Perego C, Di Cairano ES, Finzi G, Capella C, Sessa F, Casiraghi F, Paez A, Adivi A, Davalli A, Fiorina P, Guardado Mendoza R, Comuzzie AG, Sharp M, DeFronzo RA, Halff G, Dick EJ, Folli F. Chronic continuous exenatide infusion does not cause pancreatic inflammation and ductal hyperplasia in non-human primates. Am J Pathol. 2015 Jan; 185(1):139-50.
  17. Kleffel S, Vergani A, Tezza S, Ben Nasr M, Niewczas MA, Wong S, Bassi R, D'Addio F, Schatton T, Abdi R, Atkinson M, Sayegh MH, Wen L, Wasserfall CH, O'Connor KC, Fiorina P. Interleukin-10+ regulatory B cells arise within antigen-experienced CD40+ B cells to maintain tolerance to islet autoantigens. Diabetes. 2015 Jan; 64(1):158-71.
  18. Dharnidharka VR, Fiorina P, Harmon WE. Kidney transplantation in children. N Engl J Med. 2014 Aug 7; 371(6):549-58.
  19. Ben Nasr M, D'Addio F, Usuelli V, Tezza S, Abdi R, Fiorina P. The rise, fall, and resurgence of immunotherapy in type 1 diabetes. Pharmacol Res. 2015 Aug; 98:31-8.
  20. Liu K, Vergani A, Zhao P, Ben Nasr M, Wu X, Iken K, Jiang D, Su X, Fotino C, Fiorina P, Visner GA. Inhibition of the purinergic pathway prolongs mouse lung allograft survival. Am J Respir Cell Mol Biol. 2014 Aug; 51(2):300-10.
  21. Tezza S, Ben Nasr M, Vergani A, Valderrama Vasquez A, Maestroni A, Abdi R, Secchi A, Fiorina P. Novel immunological strategies for islet transplantation. Pharmacol Res. 2015 Aug; 98:69-75.
  22. D'Addio F, Valderrama Vasquez A, Ben Nasr M, Franek E, Zhu D, Li L, Ning G, Snarski E, Fiorina P. Autologous nonmyeloablative hematopoietic stem cell transplantation in new-onset type 1 diabetes: a multicenter analysis. Diabetes. 2014 Sep; 63(9):3041-6.
  23. D'Addio F, Trevisani A, Ben Nasr M, Bassi R, El Essawy B, Abdi R, Secchi A, Fiorina P. Harnessing the immunological properties of stem cells as a therapeutic option for diabetic nephropathy. Acta Diabetol. 2014 Dec; 51(6):897-904.
  24. Fiorina P, Vergani A, Bassi R, Niewczas MA, Altintas MM, Pezzolesi MG, D'Addio F, Chin M, Tezza S, Ben Nasr M, Mattinzoli D, Ikehata M, Corradi D, Schumacher V, Buvall L, Yu CC, Chang JM, La Rosa S, Finzi G, Solini A, Vincenti F, Rastaldi MP, Reiser J, Krolewski AS, Mundel PH, Sayegh MH. Role of podocyte B7-1 in diabetic nephropathy. J Am Soc Nephrol. 2014 Jul; 25(7):1415-29.
  25. Batal I, Azzi J, Mounayar M, Abdoli R, Moore R, Lee JY, Rosetti F, Wang C, Fiorina P, Sackstein R, Ichimura T, Abdi R. The mechanisms of up-regulation of dendritic cell activity by oxidative stress. J Leukoc Biol. 2014 Aug; 96(2):283-93.
  26. Bassi R, Vergani A, D'Addio F, Ben Nasr M, Mocci A, Rastaldi MP, Ichimura T, Bonventre JV, Fiorina P. Positive effects of a novel non-peptidyl low molecular weight radical scavenger in renal ischemia/reperfusion: a preliminary report. Springerplus. 2014; 3:158.
  27. Vergani A, Gatti F, Lee KM, D'Addio F, Tezza S, Chin M, Bassi R, Tian Z, Wu E, Maffi P, Ben Nasr M, Kim JI, Secchi A, Markmann JF, Rothstein DM, Turka LA, Sayegh MH, Fiorina P. TIM4 Regulates the Anti-Islet Th2 Alloimmune Response. Cell Transplant. 2015; 24(8):1599-614.
  28. Vergani A, Tezza S, Fotino C, Visner G, Pileggi A, Chandraker A, Fiorina P. The purinergic system in allotransplantation. Am J Transplant. 2014 Mar; 14(3):507-14.
  29. Yu CC, Fornoni A, Weins A, Hakroush S, Maiguel D, Sageshima J, Chen L, Ciancio G, Faridi MH, Behr D, Campbell KN, Chang JM, Chen HC, Oh J, Faul C, Arnaout MA, Fiorina P, Gupta V, Greka A, Burke GW, Mundel P. Abatacept in B7-1-positive proteinuric kidney disease. N Engl J Med. 2013 Dec 19; 369(25):2416-23.
  30. Fiorina P. GABAergic system in ß-cells: from autoimmunity target to regeneration tool. Diabetes. 2013 Nov; 62(11):3674-6.
  31. D'Addio F, Maffi P, Vezzulli P, Vergani A, Mello A, Bassi R, Nano R, Falautano M, Coppi E, Finzi G, D'Angelo A, Fermo I, Pellegatta F, La Rosa S, Magnani G, Piemonti L, Falini A, Folli F, Secchi A, Fiorina P. Islet transplantation stabilizes hemostatic abnormalities and cerebral metabolism in individuals with type 1 diabetes. Diabetes Care. 2014; 37(1):267-76.
  32. Azzi J, Skartsis N, Mounayar M, Magee CN, Batal I, Ting C, Moore R, Riella LV, Ohori S, Abdoli R, Smith B, Fiorina P, Heathcote D, Bakhos T, Ashton-Rickardt PG, Abdi R. Serine protease inhibitor 6 plays a critical role in protecting murine granzyme B-producing regulatory T cells. J Immunol. 2013 Sep 1; 191(5):2319-27.
  33. Riella LV, Dada S, Chabtini L, Smith B, Huang L, Dakle P, Mfarrej B, D'Addio F, Adams LT, Kochupurakkal N, Vergani A, Fiorina P, Mellor AL, Sharpe AH, Yagita H, Guleria I. B7h (ICOS-L) maintains tolerance at the fetomaternal interface. Am J Pathol. 2013 Jun; 182(6):2204-13.
  34. D'Addio F, Ueno T, Clarkson M, Zhu B, Vergani A, Freeman GJ, Sayegh MH, Ansari MJ, Fiorina P, Habicht A. CD160Ig fusion protein targets a novel costimulatory pathway and prolongs allograft survival. PLoS One. 2013; 8(4):e60391.
  35. Vergani A, Fotino C, D'Addio F, Tezza S, Podetta M, Gatti F, Chin M, Bassi R, Molano RD, Corradi D, Gatti R, Ferrero ME, Secchi A, Grassi F, Ricordi C, Sayegh MH, Maffi P, Pileggi A, Fiorina P. Effect of the purinergic inhibitor oxidized ATP in a model of islet allograft rejection. Diabetes. 2013 May; 62(5):1665-75.
  36. D'Addio F, Boenisch O, Magee CN, Yeung MY, Yuan X, Mfarrej B, Vergani A, Ansari MJ, Fiorina P, Najafian N. Prolonged, low-dose anti-thymocyte globulin, combined with CTLA4-Ig, promotes engraftment in a stringent transplant model. PLoS One. 2013; 8(1):e53797.
  37. Vergani A, Tezza S, D'Addio F, Fotino C, Liu K, Niewczas M, Bassi R, Molano RD, Kleffel S, Petrelli A, Soleti A, Ammirati E, Frigerio M, Visner G, Grassi F, Ferrero ME, Corradi D, Abdi R, Ricordi C, Sayegh MH, Pileggi A, Fiorina P. Long-term heart transplant survival by targeting the ionotropic purinergic receptor P2X7. Circulation. 2013 Jan 29; 127(4):463-75.
  38. Fiorina P, Bassi R, Gremizzi C, Vergani A, Caldara R, Mello A, Del Maschio A, De Cobelli F, Perseghin G, Secchi A. 31P-magnetic resonance spectroscopy (31P-MRS) detects early changes in kidney high-energy phosphate metabolism during a 6-month Valsartan treatment in diabetic and non-diabetic kidney-transplanted patients. Acta Diabetol. 2012 Dec; 49 Suppl 1:S133-9.
  39. Lee KM, Yeh H, Zhao G, Wei L, O'Connor M, Stott RT, Soohoo J, Dunussi K, Fiorina P, Deng S, Markmann JF, Kim JI. B-cell depletion improves islet allograft survival with anti-CD45RB. Cell Transplant. 2014 Jan; 23(1):51-8.
  40. Doria A, Niewczas MA, Fiorina P. Can existing drugs approved for other indications retard renal function decline in patients with type 1 diabetes and nephropathy? Semin Nephrol. 2012 Sep; 32(5):437-44.
  41. Fadini GP, Madeddu P, Waltenberger J, Fiorina P. Vascular stem and progenitor cells in diabetic complications. Exp Diabetes Res. 2012; 2012:580343.
  42. Bassi R, Trevisani A, Tezza S, Ben Nasr M, Gatti F, Vergani A, Farina A, Fiorina P. Regenerative therapies for diabetic microangiopathy. Exp Diabetes Res. 2012; 2012:916560.
  43. Azzi J, Moore RF, Elyaman W, Mounayar M, El Haddad N, Yang S, Jurewicz M, Takakura A, Petrelli A, Fiorina P, Ruckle T, Abdi R. The novel therapeutic effect of phosphoinositide 3-kinase-? inhibitor AS605240 in autoimmune diabetes. Diabetes. 2012 Jun; 61(6):1509-18.
  44. Petrelli A, Di Fenza R, Carvello M, Gatti F, Secchi A, Fiorina P. Strategies to reverse endothelial progenitor cell dysfunction in diabetes. Exp Diabetes Res. 2012; 2012:471823.
  45. D'Addio F, Vergani A, Di Fenza R, Tezza S, Bassi R, Fiorina P. [Novel immunological aspects of pediatric kidney transplantation]. G Ital Nefrol. 2012 Jan-Feb; 29(1):44-8.
  46. Denecke C, Ge X, Jurisch A, Kleffel S, Kim IK, Padera RF, Weiland A, Fiorina P, Pratschke J, Tullius SG. Modified CD4(+) T-cell response in recipients of old cardiac allografts. Transpl Int. 2012 Mar; 25(3):328-36.
  47. Fiorina P, Vezzulli P, Bassi R, Gremizzi C, Falautano M, D'Addio F, Vergani A, Chabtini L, Altamura E, Mello A, Caldara R, Scavini M, Magnani G, Falini A, Secchi A. Near normalization of metabolic and functional features of the central nervous system in type 1 diabetic patients with end-stage renal disease after kidney-pancreas transplantation. Diabetes Care. 2012 Feb; 35(2):367-74.
  48. Carvello M, Petrelli A, Vergani A, Lee KM, Tezza S, Chin M, Orsenigo E, Staudacher C, Secchi A, Dunussi-Joannopoulos K, Sayegh MH, Markmann JF, Fiorina P. Inotuzumab ozogamicin murine analog-mediated B-cell depletion reduces anti-islet allo- and autoimmune responses. Diabetes. 2012 Jan; 61(1):155-65.
  49. Petrelli A, Carvello M, Vergani A, Lee KM, Tezza S, Du M, Kleffel S, Chengwen L, Mfarrej BG, Hwu P, Secchi A, Leonard WJ, Young D, Sayegh MH, Markmann JF, Zajac AJ, Fiorina P. IL-21 is an antitolerogenic cytokine of the late-phase alloimmune response. Diabetes. 2011 Dec; 60(12):3223-34.
  50. Salonia A, D'Addio F, Gremizzi C, Briganti A, Dehò F, Caldara R, Orsenigo E, Staudacher C, Socci C, Rigatti P, Secchi A, Montorsi F, Fiorina P. Kidney-pancreas transplantation is associated with near-normal sexual function in uremic type 1 diabetic patients. Transplantation. 2011 Oct 15; 92(7):802-8.
  51. Bassi R, Fiorina P. Impact of islet transplantation on diabetes complications and quality of life. Curr Diab Rep. 2011 Oct; 11(5):355-63.
  52. Fiorina P, Voltarelli J, Zavazava N. Immunological applications of stem cells in type 1 diabetes. Endocr Rev. 2011 Dec; 32(6):725-54.
  53. Huang Y, Chen P, Zhang CB, Ko GJ, Ruiz M, Fiorina P, Hussain MA, Wasowska BA, Rabb H, Womer KL. Kidney-derived mesenchymal stromal cells modulate dendritic cell function to suppress alloimmune responses and delay allograft rejection. Transplantation. 2010 Dec 27; 90(12):1307-11.
  54. Fiorina P, Jurewicz M, Vergani A, Petrelli A, Carvello M, D'Addio F, Godwin JG, Law K, Wu E, Tian Z, Thoma G, Kovarik J, La Rosa S, Capella C, Rodig S, Zerwes HG, Sayegh MH, Abdi R. Targeting the CXCR4-CXCL12 axis mobilizes autologous hematopoietic stem cells and prolongs islet allograft survival via programmed death ligand 1. J Immunol. 2011 Jan 1; 186(1):121-31.
  55. Petrelli A, Maestroni A, Fadini GP, Belloni D, Venturini M, Albiero M, Kleffel S, Mfarrej BG, Maschio AD, Maffi P, Avogaro A, Ferrero E, Zerbini G, Secchi A, Fiorina P. Improved function of circulating angiogenic cells is evident in type 1 diabetic islet-transplanted patients. Am J Transplant. 2010 Dec; 10(12):2690-700.
  56. Jurewicz M, Yang S, Augello A, Godwin JG, Moore RF, Azzi J, Fiorina P, Atkinson M, Sayegh MH, Abdi R. Congenic mesenchymal stem cell therapy reverses hyperglycemia in experimental type 1 diabetes. Diabetes. 2010 Dec; 59(12):3139-47.
  57. Vergani A, D'Addio F, Jurewicz M, Petrelli A, Watanabe T, Liu K, Law K, Schuetz C, Carvello M, Orsenigo E, Deng S, Rodig SJ, Ansari JM, Staudacher C, Abdi R, Williams J, Markmann J, Atkinson M, Sayegh MH, Fiorina P. A novel clinically relevant strategy to abrogate autoimmunity and regulate alloimmunity in NOD mice. Diabetes. 2010 Sep; 59(9):2253-64.
  58. Fiorina P, Pietramaggiori G, Scherer SS, Jurewicz M, Mathews JC, Vergani A, Thomas G, Orsenigo E, Staudacher C, La Rosa S, Capella C, Carothers A, Zerwes HG, Luzi L, Abdi R, Orgill DP. The mobilization and effect of endogenous bone marrow progenitor cells in diabetic wound healing. Cell Transplant. 2010; 19(11):1369-81.
  59. Fiorina P. beta-Cells step up in controlling the autoimmune response. Diabetes. 2010 Aug; 59(8):1861-4.
  60. Venturini M, Angeli E, Maffi P, Losio C, Pozzi P, Paties C, Cellina M, De Cobelli F, Fiorina P, Secchi A, Del Maschio A. Liver focal fatty changes at ultrasound after islet transplantation: an early sign of altered graft function? Diabet Med. 2010 Aug; 27(8):960-4.
  61. Oberholzer J, Kinzer K, Fiorina P. The anti-LFA-1 trial in islet transplantation. Am J Transplant. 2010 Aug; 10(8):1725-6.
  62. Francese R, Fiorina P. Immunological and regenerative properties of cord blood stem cells. Clin Immunol. 2010 Sep; 136(3):309-22.
  63. Folli F, Guzzi V, Perego L, Coletta DK, Finzi G, Placidi C, La Rosa S, Capella C, Socci C, Lauro D, Tripathy D, Jenkinson C, Paroni R, Orsenigo E, Cighetti G, Gregorini L, Staudacher C, Secchi A, Bachi A, Brownlee M, Fiorina P. Proteomics reveals novel oxidative and glycolytic mechanisms in type 1 diabetic patients' skin which are normalized by kidney-pancreas transplantation. PLoS One. 2010; 5(3):e9923.
  64. Venturini M, Losio C, Del Maschio A, Maffi P, Fiorina P, Gremizzi C, Secchi A. Kidney-pancreas transplantation does not improve retinal arterial flow velocities in type 1 diabetic uremic patients. Transplantation. 2010 Jan 27; 89(2):261-3.
  65. Vergani A, Clissi B, Sanvito F, Doglioni C, Fiorina P, Pardi R. Laser capture microdissection as a new tool to assess graft-infiltrating lymphocytes gene profile in islet transplantation. Cell Transplant. 2009; 18(8):827-32.
  66. Fiorina P, Jurewicz M, Augello A, Vergani A, Dada S, La Rosa S, Selig M, Godwin J, Law K, Placidi C, Smith RN, Capella C, Rodig S, Adra CN, Atkinson M, Sayegh MH, Abdi R. Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes. J Immunol. 2009 Jul 15; 183(2):993-1004.
  67. Fiorina P, Sayegh MH. B cell-targeted therapies in autoimmunity: rationale and progress. F1000 Biol Rep. 2009; 1:39.
  68. Cighetti G, Fermo I, Aman CS, Ferraroni M, Secchi A, Fiorina P, Paroni R. Dimethylarginines in complicated type 1 diabetes: roles of insulin, glucose, and oxidative stress. Free Radic Biol Med. 2009 Aug 1; 47(3):307-11.
  69. Ueno T, Tanaka K, Jurewicz M, Murayama T, Guleria I, Fiorina P, Paez JC, Augello A, Vergani A, Wong M, Smith RN, Abdi R. Divergent role of donor dendritic cells in rejection versus tolerance of allografts. J Am Soc Nephrol. 2009 Mar; 20(3):535-44.
  70. Fiorina P, Shapiro AM, Ricordi C, Secchi A. The clinical impact of islet transplantation. Am J Transplant. 2008 Oct; 8(10):1990-7.
  71. Fiorina P, Vergani A, Dada S, Jurewicz M, Wong M, Law K, Wu E, Tian Z, Abdi R, Guleria I, Rodig S, Dunussi-Joannopoulos K, Bluestone J, Sayegh MH. Targeting CD22 reprograms B-cells and reverses autoimmune diabetes. Diabetes. 2008 Nov; 57(11):3013-24.
  72. Abdi R, Fiorina P, Adra CN, Atkinson M, Sayegh MH. Immunomodulation by mesenchymal stem cells: a potential therapeutic strategy for type 1 diabetes. Diabetes. 2008 Jul; 57(7):1759-67.
  73. Fiorina P, Jurewicz M, Vergani A, Augello A, Paez J, Ricchiuti V, Tchipachvili V, Sayegh MH, Abdi R. Phenotypic and functional differences between wild-type and CCR2-/- dendritic cells: implications for islet transplantation. Transplantation. 2008 Apr 15; 85(7):1030-8.
  74. Paolo Fiorina and Mohamed Sayegh. CD22 to cure type 1 diabetes. 2008.
  75. Scherer SS, Pietramaggiori G, Mathews JC, Chan R, Fiorina P, Orgill DP. ?Wound healing kinetics of the genetically diabetic mouse. Wounds. 2008 Jan; 20(1):18-28.
  76. Fiorina P, Vergani A, Petrelli A, D'Addio F, Monti L, Abdi R, Bosi E, Maffi P, Secchi A. Metabolic and immunological features of the failing islet-transplanted patient. Diabetes Care. 2008 Mar; 31(3):436-8.
  77. Fiorina P, Secchi A. Pancreatic islet cell transplant for treatment of diabetes. Endocrinol Metab Clin North Am. 2007 Dec; 36(4):999-1013; ix.
  78. Izawa A, Ueno T, Jurewicz M, Ito T, Tanaka K, Takahashi M, Ikeda U, Sobolev O, Fiorina P, Smith RN, Hynes RO, Abdi R. Importance of donor- and recipient-derived selectins in cardiac allograft rejection. J Am Soc Nephrol. 2007 Nov; 18(11):2929-36.
  79. Ansari MJ, Fiorina P, Dada S, Guleria I, Ueno T, Yuan X, Trikudanathan S, Smith RN, Freeman G, Sayegh MH. Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice. Clin Immunol. 2008 Feb; 126(2):140-7.
  80. Del Carro U, Fiorina P, Amadio S, De Toni Franceschini L, Petrelli A, Menini S, Martinelli Boneschi F, Ferrari S, Pugliese G, Maffi P, Comi G, Secchi A. Evaluation of polyneuropathy markers in type 1 diabetic kidney transplant patients and effects of islet transplantation: neurophysiological and skin biopsy longitudinal analysis. Diabetes Care. 2007 Dec; 30(12):3063-9.
  81. Guleria I, Gubbels Bupp M, Dada S, Fife B, Tang Q, Ansari MJ, Trikudanathan S, Vadivel N, Fiorina P, Yagita H, Azuma M, Atkinson M, Bluestone JA, Sayegh MH. Mechanisms of PDL1-mediated regulation of autoimmune diabetes. Clin Immunol. 2007 Oct; 125(1):16-25.
  82. Lacy-Hulbert A, Ueno T, Ito T, Jurewicz M, Izawa A, Smith RN, Chase CM, Tanaka K, Fiorina P, Russell PS, Auchincloss H, Sayegh MH, Hynes RO, Abdi R. Beta 3 integrins regulate lymphocyte migration and cytokine responses in heart transplant rejection. Am J Transplant. 2007 May; 7(5):1080-90.
  83. Fiorina P, Perseghin G, De Cobelli F, Gremizzi C, Petrelli A, Monti L, Maffi P, Luzi L, Secchi A, Del Maschio A. Altered kidney graft high-energy phosphate metabolism in kidney-transplanted end-stage renal disease type 1 diabetic patients: a cross-sectional analysis of the effect of kidney alone and kidney-pancreas transplantation. Diabetes Care. 2007 Mar; 30(3):597-603.
  84. Fiorina P, Jurewicz M, Tanaka K, Behazin N, Augello A, Vergani A, von Andrian UH, Von Adrian U, Smith NR, Sayegh MH, Abdi R. Characterization of donor dendritic cells and enhancement of dendritic cell efflux with CC-chemokine ligand 21: a novel strategy to prolong islet allograft survival. Diabetes. 2007 Apr; 56(4):912-20.
  85. Maffi P, Bertuzzi F, De Taddeo F, Magistretti P, Nano R, Fiorina P, Caumo A, Pozzi P, Socci C, Venturini M, del Maschio A, Secchi A. Kidney function after islet transplant alone in type 1 diabetes: impact of immunosuppressive therapy on progression of diabetic nephropathy. Diabetes Care. 2007 May; 30(5):1150-5.
  86. Venturini M, Fiorina P, Maffi P, Losio C, Vergani A, Secchi A, Del Maschio A. Early increase of retinal arterial and venous blood flow velocities at color Doppler imaging in brittle type 1 diabetes after islet transplant alone. Transplantation. 2006 May 15; 81(9):1274-7.
  87. Fiorina P, Ansari MJ, Jurewicz M, Barry M, Ricchiuti V, Smith RN, Shea S, Means TK, Auchincloss H, Luster AD, Sayegh MH, Abdi R. Role of CXC chemokine receptor 3 pathway in renal ischemic injury. J Am Soc Nephrol. 2006 Mar; 17(3):716-23.
  88. Orsenigo E, Socci C, Fiorina P, Zuber V, Secchi A, Di Carlo V, Staudacher C. Cardiovascular benefits of simultaneous pancreas-kidney transplant versus kidney alone transplant in diabetic patients. Transplant Proc. 2005 Oct; 37(8):3570-1.
  89. Perseghin G, Fiorina P, De Cobelli F, Scifo P, Esposito A, Canu T, Danna M, Gremizzi C, Secchi A, Luzi L, Del Maschio A. Cross-sectional assessment of the effect of kidney and kidney-pancreas transplantation on resting left ventricular energy metabolism in type 1 diabetic-uremic patients: a phosphorous-31 magnetic resonance spectroscopy study. J Am Coll Cardiol. 2005 Sep 20; 46(6):1085-92.
  90. Fiorina P, Folli F, Ferrero E, Orsenigo E, Finzi G, Mazzolari G, Placidi C, Perego L, La Rosa S, Melandri M, Monti L, Capella C, D'Angelo A, Staudacher C, Secchi A. Morphological and functional differences in haemostatic axis between kidney transplanted and end-stage renal disease patients. Transpl Int. 2005 Sep; 18(9):1036-47.
  91. Orsenigo E, Socci C, Carlucci M, Zuber V, Fiorina P, Gavazzi F, Secchi A, Di Carlo V, Staudacher C. Multivariate analysis of factors affecting patient and graft survival after renal transplant. Transplant Proc. 2005 Jul-Aug; 37(6):2461-3.
  92. Fiorina P, Venturini M, Folli F, Losio C, Maffi P, Placidi C, La Rosa S, Orsenigo E, Socci C, Capella C, Del Maschio A, Secchi A. Natural history of kidney graft survival, hypertrophy, and vascular function in end-stage renal disease type 1 diabetic kidney-transplanted patients: beneficial impact of pancreas and successful islet cotransplantation. Diabetes Care. 2005 Jun; 28(6):1303-10.
  93. Fiorina P, Gremizzi C, Maffi P, Caldara R, Tavano D, Monti L, Socci C, Folli F, Fazio F, Astorri E, Del Maschio A, Secchi A. Islet transplantation is associated with an improvement of cardiovascular function in type 1 diabetic kidney transplant patients. Diabetes Care. 2005 Jun; 28(6):1358-65.
  94. Perego L, Pizzocri P, Corradi D, Maisano F, Paganelli M, Fiorina P, Barbieri M, Morabito A, Paolisso G, Folli F, Pontiroli AE. Circulating leptin correlates with left ventricular mass in morbid (grade III) obesity before and after weight loss induced by bariatric surgery: a potential role for leptin in mediating human left ventricular hypertrophy. J Clin Endocrinol Metab. 2005 Jul; 90(7):4087-93.
  95. Paroni R, Fermo I, Fiorina P, Cighetti G. Determination of asymmetric and symmetric dimethylarginines in plasma of hyperhomocysteinemic subjects. Amino Acids. 2005 Jun; 28(4):389-94.
  96. Orsenigo E, Fiorina P, Dell'Antonio G, Cristallo M, Socci C, Invernizzi L, Maffi P, Secchi A, Di Carlo V. Gastrointestinal bleeding from enterically drained transplanted pancreas. Transpl Int. 2005 Mar; 18(3):296-302.
  97. Venturini M, Angeli E, Maffi P, Fiorina P, Bertuzzi F, Salvioni M, De Cobelli F, Socci C, Aldrighetti L, Losio C, Di Carlo V, Secchi A, Del Maschio A. Technique, complications, and therapeutic efficacy of percutaneous transplantation of human pancreatic islet cells in type 1 diabetes: the role of US. Radiology. 2005 Feb; 234(2):617-24.
  98. Orsenigo E, Beretta E, Fiacco E, Scaltrini F, Veronesi P, Invernizzi L, Gini P, Fiorina P, Di Carlo V. Management of papillary microcarcinoma of the thyroid gland. Eur J Surg Oncol. 2004 Dec; 30(10):1104-6.
  99. Fiorina P, Torriani G, Gremizzi C, Davalli AM, Orsenigo E, Bruno Ventre M, Dell'Antonio G, Carlo VD, Rossini S, Secchi A. Selective intra-graft apoptosis and down-regulation of lymphocyte bcl-2, iNOs and CD95L expression in kidney-pancreas transplanted patients after anti-Thymoglobulin induction. Transpl Int. 2004 Nov; 17(10):603-8.
  100. Orsenigo E, Cristallo M, Socci C, Castoldi R, La Rocca E, Invernizzi D, Fiorina P, Beneduce A, Secchi A, Staudacher C, Di Carlo V. [Simultaneous pancreas-kidney transplantation: a single center experience on 148 cases]. Ann Ital Chir. 2004 Sep-Oct; 75(5):541-6.
  101. Fiorina P, Corradi D, Pinelli S, Maestri R, Lagrasta C, Buscaglia M, Davalli A, Folli F, Astorri E. Apoptotic/mytogenic pathways during human heart development. Int J Cardiol. 2004 Sep; 96(3):409-17.
  102. Fiorina P, Folli F, D'Angelo A, Finzi G, Pellegatta F, Guzzi V, Fedeli C, Della Valle P, Usellini L, Placidi C, Bifari F, Belloni D, Ferrero E, Capella C, Secchi A. Normalization of multiple hemostatic abnormalities in uremic type 1 diabetic patients after kidney-pancreas transplantation. Diabetes. 2004 Sep; 53(9):2291-300.
  103. Fiorina P, Pattoneri P, Paganelli C, Secchi A, Calbiani B, Astorri E. Correlation between non-reversible thallium-201 myocardial perfusion defect and ECG criteria in the diagnosis of apical myocardial infarction. Int J Cardiol. 2004 Jun; 95(2-3):251-4.
  104. Orsenigo E, Fiorina P, Cristallo M, Socci C, La Rocca E, Maffi P, Invernizzi L, Zuber V, Secchi A, Di Carlo V. Long-term survival after kidney and kidney-pancreas transplantation in diabetic patients. Transplant Proc. 2004 May; 36(4):1072-5.
  105. De Cobelli F, Fiorina P, Perseghin G, Magnone M, Venturini M, Zerbini G, Zanello A, Mazzolari G, Monti L, Di Carlo V, Secchi A, Del Maschio A. L-arginine-induced vasodilation of the renal vasculature is preserved in uremic type 1 diabetic patients after kidney and pancreas but not after kidney-alone transplantation. Diabetes Care. 2004 Apr; 27(4):947-54.
  106. Orsenigo E, Socci C, Fiorina P, Cristallo M, Castoldi R, Gavazzi F, La Rocca E, Invernizzi L, Secchi A, Di Carlo V. Simultaneous pancreas-kidney transplantation: short- and long-term results. Transplant Proc. 2004 Apr; 36(3):586-8.
  107. Fiorina P, Folli F, Zerbini G, Maffi P, Gremizzi C, Di Carlo V, Socci C, Bertuzzi F, Kashgarian M, Secchi A. Islet transplantation is associated with improvement of renal function among uremic patients with type I diabetes mellitus and kidney transplants. J Am Soc Nephrol. 2003 Aug; 14(8):2150-8.
  108. Orsenigo E, De Cobelli F, Salvioni M, Cristallo M, Fiorina P, Del Maschio A, Di Carlo V, Secchi A. Successful endovascular treatment for gastroduodenal artery pseudoaneurysm with an arteriovenous fistula after pancreas transplantation. Transpl Int. 2003 Sep; 16(9):694-6.
  109. Galbiati F, Polastri L, Thorens B, Dupraz P, Fiorina P, Cavallaro U, Christofori G, Davalli AM. Molecular pathways involved in the antineoplastic effects of calcitriol on insulinoma cells. Endocrinology. 2003 May; 144(5):1832-41.
  110. Fiorina P, Folli F, Maffi P, Placidi C, Venturini M, Finzi G, Bertuzzi F, Davalli A, D'Angelo A, Socci C, Gremizzi C, Orsenigo E, La Rosa S, Ponzoni M, Cardillo M, Scalamogna M, Del Maschio A, Capella C, Di Carlo V, Secchi A. Islet transplantation improves vascular diabetic complications in patients with diabetes who underwent kidney transplantation: a comparison between kidney-pancreas and kidney-alone transplantation. Transplantation. 2003 Apr 27; 75(8):1296-301.
  111. Fiorina P, Folli F, Bertuzzi F, Maffi P, Finzi G, Venturini M, Socci C, Davalli A, Orsenigo E, Monti L, Falqui L, Uccella S, La Rosa S, Usellini L, Properzi G, Di Carlo V, Del Maschio A, Capella C, Secchi A. Long-term beneficial effect of islet transplantation on diabetic macro-/microangiopathy in type 1 diabetic kidney-transplanted patients. Diabetes Care. 2003 Apr; 26(4):1129-36.
  112. Orsenigo E, Fiorina P et al. . Diagnosis and treatment of familial papillary thyroid carcinoma. Endocrinochirurgia: Verso il millenio. 2003; 235-242.
  113. Orsenigo E, Beretta E, Gini P, Verrecchia F, Invernizzi L, Fiorina P, Di Carlo V. A report of six cases of familial papillary thyroid cancer. Eur J Surg Oncol. 2003 Mar; 29(2):185-7.
  114. Orsenigo E, Cristallo M, Socci C, Castoldi R, Fiorina P, Invernizzi L, Caldara R, Secchi A, Di Carlo V. Successful surgical salvage of pancreas allograft. Transplantation. 2003 Jan 27; 75(2):233-6.
  115. Polastri L, Galbiati F, Bertuzzi F, Fiorina P, Nano R, Gregori S, Aldrighetti L, Pozza G, Secchi A, Adorini L, Davalli AM. Secretory defects induced by immunosuppressive agents on human pancreatic beta-cells. Acta Diabetol. 2002 Dec; 39(4):229-33.
  116. Galbiati F, Polastri L, Gregori S, Freschi M, Casorati M, Cavallaro U, Fiorina P, Bertuzzi F, Zerbi A, Pozza G, Adorini L, Folli F, Christofori G, Davalli AM. Antitumorigenic and antiinsulinogenic effects of calcitriol on insulinoma cells and solid beta-cell tumors. Endocrinology. 2002 Oct; 143(10):4018-30.
  117. Orsenigo E, Castoldi R, Socci C, Cristallo M, Fiorina P, La Rocca E, Invernizzi L, Secchi A, Di Carlo V. Advantages and disadvantages of enteric versus bladder diversion in simultaneous kidney-pancreas transplantation. Chir Ital. 2002 Jul-Aug; 54(4):429-36.
  118. Fiorina P, Secchi S. . The effects of pancreas transplantation on the course of secondary diabetic complications. Graft. 2002; (5):303-307..
  119. Fiorina P, de Cobelli F, Fragasso G, Fazio R, Pozza G, Del Maschio A, Secchi A. Magnetic resonance image (MRI) of an acquired aorto-pulmonary fistula, associated with cerebral and paradoxical embolism. Int J Cardiol. 2002 Apr; 83(1):85-6.
  120. Orsenigo E, Cristallo M, Socci C, Castoldi R, Secchi A, Colombo R, Invernizzi L, Fiorina P, Naspro R, Di Carlo V. Urological complications after simultaneous renal and pancreatic transplantation. Eur J Surg. 2002; 168(11):609-13.
  121. La Rocca E, Fiorina P, di Carlo V, Astorri E, Rossetti C, Lucignani G, Fazio F, Giudici D, Cristallo M, Bianchi G, Pozza G, Secchi A. Cardiovascular outcomes after kidney-pancreas and kidney-alone transplantation. Kidney Int. 2001 Nov; 60(5):1964-71.
  122. Fiorina P, Secchi A. . Wie effectiv ist pancreas transplant. Transplant Link. 2001; 46-52. .
  123. Fiorina P, La Rocca E, Venturini M, Minicucci F, Fermo I, Paroni R, D'Angelo A, Sblendido M, Di Carlo V, Cristallo M, Del Maschio A, Pozza G, Secchi A. Effects of kidney-pancreas transplantation on atherosclerotic risk factors and endothelial function in patients with uremia and type 1 diabetes. Diabetes. 2001 Mar; 50(3):496-501.
  124. Astorri E, Fiorina P, Pattoneri P, Paganelli C. Persistent ST segment elevation in a patient with metastatic involvement of the heart. Minerva Cardioangiol. 2001 Feb; 49(1):81-5.
  125. Fiorina P, La Rocca E, Astorri E, Lucignani G, Rossetti C, Fazio F, Giudici D, di Carlo V, Cristallo M, Pozza G, Secchi A. Reversal of left ventricular diastolic dysfunction after kidney-pancreas transplantation in type 1 diabetic uremic patients. Diabetes Care. 2000 Dec; 23(12):1804-10.
  126. La Rocca E, Fiorina P, Astorri E, Rossetti C, Lucignani G, Fazio F, Giudici D, Castoldi R, Bianchi G, Di Carlo V, Pozza G, Secchi A. Patient survival and cardiovascular events after kidney-pancreas transplantation: comparison with kidney transplantation alone in uremic IDDM patients. Cell Transplant. 2000 Nov-Dec; 9(6):929-32.
  127. Astorri E, Bonetti A, Fiorina P. ECG mimicking acute myocardial infarction during heart involvement by lung neoplasm. Int J Cardiol. 2000 Jul 31; 74(2-3):225-6.
  128. Fiorina P. Reversibilità della disfunzione diastolica, endoteliale e della macroangiopatia. Ruolo dell’euglicemia indotta da trapianto di pancreas. Parma Diabete . 2000; 28-37.
  129. Fiorina P, Astorri E, Albertini R, Secchi A, Mello A, Lanfredini M, Craveri A, Olivetti G, Quaini F. Soluble antiapoptotic molecules and immune activation in chronic heart failure and unstable angina pectoris. J Clin Immunol. 2000 Mar; 20(2):101-6.
  130. Fiorina P, Lattuada G, Silvestrini C, Ponari O, Dall'Aglio P. Disruption of nocturnal melatonin rhythm and immunological involvement in ischaemic stroke patients. Scand J Immunol. 1999 Aug; 50(2):228-31.
  131. Fiorina P. et al. . Coronary occlusion after recurrent myocardial perfusion abnormalities in a Young SLE patient. J Cardiovascular Diagnosis and Procedures. 1999; 16(2):32-36.
  132. Astorri E, Fiorina P, Grattagliano C, Medici D, Pinelli S, Albertini D, Pincolini S, Barboso G, Albertini R. Cardiac Troponin T to evaluate myocardial protection via intermittent cold blood or continuous warm blood cardioplegia in coronary artery bypass grafting. J Cardiovasc Surg (Torino). 1998 Dec; 39(6):797-802.
  133. Fiorina P, Lanfredini M, Montanari A, Peca MG, Veronelli A, Mello A, Astorri E, Craveri A. Plasma homocysteine and folate are related to arterial blood pressure in type 2 diabetes mellitus. Am J Hypertens. 1998 Sep; 11(9):1100-7.
  134. Lanfredini M, Fiorina P, Peca MG, Veronelli A, Mello A, Astorri E, Dall'Aglio P, Craveri A. Fasting and post-methionine load homocyst(e)ine values are correlated with microalbuminuria and could contribute to worsening vascular damage in non-insulin-dependent diabetes mellitus patients. Metabolism. 1998 Aug; 47(8):915-21.
  135. Secchi A, Caldara R, La Rocca E, Fiorina P, Di Carlo V. Cardiovascular disease and neoplasms after pancreas transplantation. Lancet. 1998 Jul 4; 352(9121):65; author reply 66.
  136. Astorri E, Fiorina P, Ridolo E, Contini GA, Albertini D, Dall'Aglio P. [Doppler echocardiographic study of left ventricular function in patients with systemic lupus erythematosus]. Cardiologia. 1997 Nov; 42(11):1179-83.
  137. Astorri E, Fiorina P et al . Myocarditis due to Legionella Pneumophila: a case report . Journal of Cardiovascular Diagnosis and Procedures. 1997; 14:177-179.
  138. Astorri E, Fiorina P, Contini GA, Albertini D, Magnati G, Astorri A, Lanfredini M. Isolated and preclinical impairment of left ventricular filling in insulin-dependent and non-insulin-dependent diabetic patients. Clin Cardiol. 1997 Jun; 20(6):536-40.
  139. Astorri E, Fiorina P, Contini GA, Albertini D, Ridolo E, Dall'Aglio P. Diastolic impairment in asymptomatic systemic lupus erythematosus patients. Clin Rheumatol. 1997 May; 16(3):320-1.
  140. Astorri E, Fiorina P, Gavaruzzi G, Astorri A, Magnati G. Left ventricular function in insulin-dependent and in non-insulin-dependent diabetic patients: radionuclide assessment. Cardiology. 1997 Mar-Apr; 88(2):152-5.
  141. Astorri E, Manzetti G, Emanuelli C, Bianchi C, Garini A, Fiorina P. [Myocarditis in legionellosis. A case report]. Minerva Cardioangiol. 1996 Sep; 44(9):429-31.
  142. Astorri E, Fiorina P et al. . Miocardite in corso di Legionellosi . Minerva Cardioangiologica. 1996; 44:429-31.
  143. Astorri E, Contini GA, Fiorina P, Gavaruzzi G, Fesani F. Myocardial indium-111 antimyosin uptake after uncomplicated coronary artery bypass surgery. Int J Cardiol. 1996 Aug; 55(3):239-44.
  144. Astorri E, Fiorina P, Gavaruzzi G, Contini GA, Fesani F. Perioperative myocardial cell damage assessed by immunoradiometric assay of beta-myosin heavy chain serum levels in patients undergoing coronary bypass surgery. Int J Cardiol. 1996 Jul 26; 55(2):157-62.
  145. Bianchi C, Fiorina P et al. . Diagnosi di tromboembolia polmonare mediante ecocardiografia transesofagea. Minerva Cardioangiologica. 1996; 44:369-372..
  146. Fiorina P, Lattuada G, Ponari O, Silvestrini C, DallAglio P. Impaired nocturnal melatonin excretion and changes of immunological status in ischaemic stroke patients. Lancet. 1996 Mar 9; 347(9002):692-3.
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