Research

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Neeraj  Surana, MD, PhD

Neeraj Surana MD PhD
Department:
Medicine Research
Division
Infectious Diseases Research
Hospital Title:
Assistant in Medicine
Academic Title:
Instructor in Pediatrics, Harvard Medical School
Research Focus Area:
ImmunologyMicrobiota
Contact Via Email
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Research Overview

The human body is estimated to contain 100 trillion bacteria–at least 10 times the number of human cells present. Dr. Surana’s research explores the nexus between these bacteria normally present in the body–collectively referred to as the microbiota–and the host immune system. His work focuses on two primary areas: 1. identifying specific bacteria that have immunomodulatory effects, and 2. understanding the mechanisms through which the host recognizes these immunomodulatory commensal organisms. Dr. Surana uses a combination of immunological tools, germ-free and gnotobiotic mice, and relevant animal models of disease to refine the biological mechanisms underlying the intricate balance between intestinal health and disease. Appreciating how the microbiota and the intestinal immune system are intertwined is critical to understanding the development and maintenance of mucosal immunity. Gaining insight into these relationships will allow future work to focus on clinically-relevant means of manipulating these mechanisms to treat patients with inflammatory conditions.

About Neeraj Surana

Dr. Surana received undergraduate degrees in Biology, Economics, and Biochemistry at Indiana University. He subsequently joined the MD/PhD program at Washington University School of Medicine. During his graduate work in the laboratory of Joseph St. Geme, III, Dr. Surana studied mechanisms of protein secretion in gram-negative bacteria. He completed his pediatric residency and fellowship in pediatric infectious diseases at Boston Children’s Hospital. In 2010, Dr. Surana joined the laboratory of Dennis Kasper in the Department of Microbiology and Immunobiology at Harvard Medical School to study the interactions between the microbiota and the host immune system. He joined the faculty of the Division of Infectious Diseases at Boston Children’s Hospital in 2012.

Publications

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  1. Gauguet S, D'Ortona S, Ahnger-Pier K, Duan B, Surana NK, Lu R, Cywes-Bentley C, Gadjeva M, Shan Q, Priebe GP, Pier GB. Intestinal Microbiota of Mice Influences Resistance to Staphylococcus aureus Pneumonia. Infect Immun. 2015 Oct; 83(10):4003-14.
  2. Surana NK, Kasper DL. Deciphering the tête-à-tête between the microbiota and the immune system. J Clin Invest. 2014 Oct; 124(10):4197-203.
  3. Chen VL, Surana NK, Duan J, Kasper DL. Role of murine intestinal interleukin-1 receptor 1-expressing lymphoid tissue inducer-like cells in Salmonella infection. PLoS One. 2013; 8(6):e65405.
  4. Chung H, Pamp SJ, Hill JA, Surana NK, Edelman SM, Troy EB, Reading NC, Villablanca EJ, Wang S, Mora JR, Umesaki Y, Mathis D, Benoist C, Relman DA, Kasper DL. Gut immune maturation depends on colonization with a host-specific microbiota. Cell. 2012 Jun 22; 149(7):1578-93.
  5. Surana NK, Kasper DL. The yin yang of bacterial polysaccharides: lessons learned from B. fragilis PSA. Immunol Rev. 2012 Jan; 245(1):13-26.
  6. Cotter SE, Surana NK, Grass S, St Geme JW. Trimeric autotransporters require trimerization of the passenger domain for stability and adhesive activity. J Bacteriol. 2006 Aug; 188(15):5400-7.
  7. Meng G, Surana NK, St Geme JW, Waksman G. Structure of the outer membrane translocator domain of the Haemophilus influenzae Hia trimeric autotransporter. EMBO J. 2006 Jun 7; 25(11):2297-304.
  8. Surana NK, Buscher AZ, Hardy GG, Grass S, Kehl-Fie T, St Geme JW. Translocator proteins in the two-partner secretion family have multiple domains. J Biol Chem. 2006 Jun 30; 281(26):18051-8.
  9. Cotter SE, Surana NK, St Geme JW. Trimeric autotransporters: a distinct subfamily of autotransporter proteins. Trends Microbiol. 2005 May; 13(5):199-205.
  10. Surana NK, St Geme JW. Lymphangitis after self-administration of lipopolysaccharide. N Engl J Med. 2005 Mar 3; 352(9):944-5.
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  12. Surana NK, Grass S, Hardy GG, Li H, Thanassi DG, Geme JW. Evidence for conservation of architecture and physical properties of Omp85-like proteins throughout evolution. Proc Natl Acad Sci U S A. 2004 Oct 5; 101(40):14497-502.
  13. Surana NK, Cutter D, Barenkamp SJ, St Geme JW. The Haemophilus influenzae Hia autotransporter contains an unusually short trimeric translocator domain. J Biol Chem. 2004 Apr 9; 279(15):14679-85.
  14. Matsumura I, Wallingford JB, Surana NK, Vize PD, Ellington AD. Directed evolution of the surface chemistry of the reporter enzyme beta-glucuronidase. Nat Biotechnol. 1999 Jul; 17(7):696-701.
  15. Couter CJ, Surana NK. Isolation and Flow Cytometric Characterization of Murine Small Intestinal Lymphocytes. J Vis Exp. 2016 May 8; (111).
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