Research

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Min Dong, PhD

Department:
Urology Research
Hospital Title:
Research Associate
Academic Title:
Assistant Professor
Research Focus Area:
botulinum neurotoxins, bacterial toxins, synaptic vesicles, membrane trafficking, clostridium difficile toxins, protein engineering and therapeuticsMolecular, structural, and cellular mechanisms of bacterial toxinssynaptic vesiclesmembrane traffickingclostridium difficile toxinsprotein engineering and therapeutics
Contact:
857-218-4232
Contact Via Email
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Lab website: http://donglab.hms.harvard.edu

Publications

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  1. Peng L, Adler M, Demogines A, Borrell A, Liu H, Tao L, Tepp WH, Zhang SC, Johnson EA, Sawyer SL, Dong M. Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins. PLoS Pathog. 2014 Jul; 10(7):e1004177.
  2. Lü J, Yang J, Dong M, Sahin O. Nanomechanical spectroscopy of synthetic and biological membranes. Nanoscale. 2014 Jul 7; 6(13):7604-8.
  3. Zhang Z, Song J, Besenbacher F, Dong M, Gothelf KV. Self-assembly of DNA origami and single-stranded tile structures at room temperature. Angew Chem Int Ed Engl. 2013 Aug 26; 52(35):9219-23.
  4. Song J, Zhang Z, Zhang S, Liu L, Li Q, Xie E, Gothelf KV, Besenbacher F, Dong M. Isothermal hybridization kinetics of DNA assembly of two-dimensional DNA origami. Small. 2013 Sep 9; 9(17):2954-9.
  5. Zhang S, Andreasen M, Nielsen JT, Liu L, Nielsen EH, Song J, Ji G, Sun F, Skrydstrup T, Besenbacher F, Nielsen NC, Otzen DE, Dong M. Coexistence of ribbon and helical fibrils originating from hIAPP(20-29) revealed by quantitative nanomechanical atomic force microscopy. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):2798-803.
  6. Peng L, Liu H, Ruan H, Tepp WH, Stoothoff WH, Brown RH, Johnson EA, Yao WD, Zhang SC, Dong M. Cytotoxicity of botulinum neurotoxins reveals a direct role of syntaxin 1 and SNAP-25 in neuron survival. Nat Commun. 2013; 4:1472.
  7. Pfeffer C, Larsen S, Song J, Dong M, Besenbacher F, Meyer RL, Kjeldsen KU, Schreiber L, Gorby YA, El-Naggar MY, Leung KM, Schramm A, Risgaard-Petersen N, Nielsen LP. Filamentous bacteria transport electrons over centimetre distances. Nature. 2012 Nov 8; 491(7423):218-21.
  8. Song J, Arbona JM, Zhang Z, Liu L, Xie E, Elezgaray J, Aime JP, Gothelf KV, Besenbacher F, Dong M. Direct visualization of transient thermal response of a DNA origami. J Am Chem Soc. 2012 Jun 20; 134(24):9844-7.
  9. Chen M, Gao S, Dong M, Song J, Yang C, Howard KA, Kjems J, Besenbacher F. Chitosan/siRNA nanoparticles encapsulated in PLGA nanofibers for siRNA delivery. ACS Nano. 2012 Jun 26; 6(6):4835-44.
  10. Song J, Kahveci D, Chen M, Guo Z, Xie E, Xu X, Besenbacher F, Dong M. Enhanced catalytic activity of lipase encapsulated in PCL nanofibers. Langmuir. 2012 Apr 10; 28(14):6157-62.
  11. Show all
  12. Song J, Chen M, Olesen MB, Wang C, Havelund R, Li Q, Xie E, Yang R, Bøggild P, Wang C, Besenbacher F, Dong M. Direct electrospinning of Ag/polyvinylpyrrolidone nanocables. Nanoscale. 2011 Dec; 3(12):4966-71.
  13. Dong M, Sahin O. A nanomechanical interface to rapid single-molecule interactions. Nat Commun. 2011; 2:247.
  14. Liu H, Tørring T, Dong M, Rosen CB, Besenbacher F, Gothelf KV. DNA-templated covalent coupling of G4 PAMAM dendrimers. J Am Chem Soc. 2010 Dec 29; 132(51):18054-6.
  15. Dong M, Husale S, Sahin O. Determination of protein structural flexibility by microsecond force spectroscopy. Nat Nanotechnol. 2009 Aug; 4(8):514-7.
  16. Peng L, Tepp WH, Johnson EA, Dong M. Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors. PLoS Pathog. 2011 Mar; 7(3):e1002008.
  17. Peng L, Berntsson RP, Tepp WH, Pitkin RM, Johnson EA, Stenmark P, Dong M. Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins. J Cell Sci. 2012 Jul 1; 125(Pt 13):3233-42.
  18. Michelow IC, Dong M, Mungall BA, Yantosca LM, Lear C, Ji X, Karpel M, Rootes CL, Brudner M, Houen G, Eisen DP, Kinane TB, Takahashi K, Stahl GL, Olinger GG, Spear GT, Ezekowitz RA, Schmidt EV. A novel L-ficolin/mannose-binding lectin chimeric molecule with enhanced activity against Ebola virus. J Biol Chem. 2010 Aug 6; 285(32):24729-39.
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