Research

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Lauren A Henderson, MD, MMSc

Hospital Title:
Attending Physician in Rheumatology
Academic Title:
Instructor in Pediatrics, Harvard Medical School

Research Overview:

Dr. Henderson is an Attending Physician in Rheumatology at Boston Children’s Hospital and an Instructor in Pediatrics at Harvard Medical School. She oversees the daily operations of the New-onset JIA Registry and the Rheumatic Diseases of Childhood Biorepository at Boston Children’s Hospital. In addition, she serves as the subcommittee chair for the CARRA (Childhood Arthritis and Rheumatology Research Alliance) federated biorepository that includes more than 60 pediatric rheumatology sites in the US and Canada. Her research focuses on the role of regulatory T cells in the pathogenesis of juvenile idiopathic arthritis.

Relevant Studies:

Study Name: Biologic Phenotyping of Juvenile Arthritis
Goals of the Study: This study seeks to pre-treatment biosamples from patients with new-onset JIA to enable related translational research.
Requirements of Participants: Previously untreated JIA or other arthritis developing before age 18. Healthy controls also enrolled. Contributing patients provide a single blood sample before starting treatment.

Study Name: Studies of Rheumatic Diseases of Childhood
Goals of the Study: This study seeks to enroll patients with rheumatic diseases of any kind, and at any stage, to enable related translational research.
Requirements of Participants: Contributing patients provide a single sample at the time of enrollment.

Publications

Henderson LA, Volpi S, Frugoni F, Janssen E, Kim S, Sundel RP, Dedeoglu F, Lo MS, Hazen MM, Beth Son M, Mathieu R, Zurakowski D, Yu N, Lebedeva T, Fuhlbrigge RC, Walter JE, Nee Lee Y, Nigrovic PA, Notarangelo LD. Next-Generation Sequencing Reveals Restriction and Clonotypic Expansion of Treg Cells in Juvenile Idiopathic Arthritis. Arthritis Rheumatol. 2016 Jul;68(7):1758-68. doi: 10.1002/art.39606. PubMed PMID: 26815131.

Resnick CM, Vakilian PM, Breen M, Zurakowski D, Caruso P, Henderson L, Nigrovic PA, Kaban LB, Peacock ZS. Quantifying temporomandibular joint synovitis in children with juvenile idiopathic arthritis. Arthritis Care Res (Hoboken). 2016 Apr 25. doi: 10.1002/acr.22911. [Epub ahead of print] PubMed PMID: 27110936.

Henderson LA, Frugoni F, Hopkins G, de Boer H, Pai SY, Lee YN, Walter JE, Hazen MM, Notarangelo LD. Expanding the spectrum of recombination-activating gene 1 deficiency: a family with early-onset autoimmunity. J Allergy Clin Immunol. 2013 Oct;132(4):969-71.e1-2. doi: 10.1016/j.jaci.2013.06.032. Epub 2013 Jul 24. PubMed PMID: 23891352; PubMed Central PMCID: PMC3874115.

First reported case of Omenn syndrome in a patient with reticular dysgenesis.J Allergy Clin Immunol. 2013 Apr;131(4):1227-30, 1230.e1-3. doi: 10.1016/j.jaci.2012.07.045. Epub 2012 Sep 24. PubMed PMID: 23014587; PubMed Central PMCID: PMC3894621.

Henderson LA, Loring SH, Gill RR, Liao KP, Ishizawar R, Kim S, Perlmutter-Goldenson R, Rothman D, Son MB, Stoll ML, Zemel LS, Sandborg C, Dellaripa PF, Nigrovic PA. Shrinking lung syndrome as a manifestation of pleuritis: a new model based on pulmonary physiological studies. J Rheumatol. 2013 Mar;40(3):273-81. doi: 10.3899/jrheum.121048. Epub 2013 Feb 1. PubMed PMID: 23378468; PubMed Central PMCID: PMC4112073.

Henderson LA, Zurakowski D, Angeles-Han ST, Lasky A, Rabinovich CE, Lo MS; Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry Investigators. Medication use in juvenile uveitis patients enrolled in the Childhood Arthritis and Rheumatology Research Alliance Registry. Pediatr Rheumatol

 

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