Research

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Kristen Tropea Leeman, MD

Kristen Leeman MD
Lab:
Kim Laboratory
Department:
Medicine Research
Division
Newborn Medicine Research
Hospital Title:
Physician in Medicine
Academic Title:
Instructor in Pediatrics, Harvard Medical School
Research Focus Area:
Lung Stem Cell Biology
Contact Via Email
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Research Overview

My research focuses on basic science discoveries that bridge newborn medicine and lung stem cell biology. My work is based in the laboratory of Dr. Carla Kim at the Harvard Stem Cell Institute at Boston Children’s Hospital. My project goals focus on the role of lung stem cells in lung injury and repair. I recently published work showing for the first time using lineage tracing techniques that bronchiolar progenitor cells are capable of contributing to alveolar repair after injury. I am currently investigating the regulation of lung stem cell differentiation in the setting of injury, microenvironmental changes, and the extremes of age. I am also investigating the role of mesenchymal stem cell treatment on bronchioalveolar stem cells (BASCs) after lung injury and repair. For my current research work, I have been honored to receive a NIH K12 Child Research Center Grant, a Pulmonary Fibrosis Foundation IM Rosenzweig Young Investigator Award, an Ikaria Advancing Newborn grant and an AMA Foundation SEED grant.

About Kristen Leeman, MD

I was raised in Richmond, Virginia and attended University of North Carolina at Chapel Hill. I received my M.D. from University of Virginia and completed my residency in Pediatrics at the University of North Carolina at Chapel Hill. I then completed my Neonatology Fellowship at the Harvard Neonatal-Perinatal Fellowship Program at Boston Children’s Hospital and was honored to serve as Chief Fellow during my last year of training. I am currently a faculty member of the Department of Newborn Medicine at Boston Children’s and a clinical attending physician in the Neonatal Intensive Care Unit providing care to critically ill infants. I am also the Director of the Newborn Medicine Basic Science and Translational Research Seminar Series and the Co-Director of the Division of Newborn Medicine Summer Student Research Program.

Publications

Publications powered by Harvard Catalyst Profiles
  1. Casey A, Dirks F, Liang OD, Harrach H, Schuette-Nuetgen K, Leeman K, Kim CF, Gerard C, Subramaniam M. Bone marrow-derived multipotent stromal cells attenuate inflammation in obliterative airway disease in mouse tracheal allografts. Stem Cells Int. 2014; 2014:468927.
  2. Lakshmanan A, Leeman KT, Brodsky D, Parad R. Evaluation of a web-based portal to improve resident education by neonatology fellows. Med Educ Online. 2014; 19:24403.
  3. Sinkevicius KW, Kriegel C, Bellaria KJ, Lee J, Lau AN, Leeman KT, Zhou P, Beede AM, Fillmore CM, Caswell D, Barrios J, Wong KK, Sholl LM, Schlaeger TM, Bronson RT, Chirieac LR, Winslow MM, Haigis MC, Kim CF. Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10299-304.
  4. Leeman KT, Fillmore CM, Kim CF. Lung stem and progenitor cells in tissue homeostasis and disease. Curr Top Dev Biol. 2014; 107:207-33.
  5. Ghanta S, Leeman KT, Christou H. An update on pharmacologic approaches to bronchopulmonary dysplasia. Semin Perinatol. 2013 Apr; 37(2):115-23.
  6. Tropea K, Christou H. Current pharmacologic approaches for prevention and treatment of bronchopulmonary dysplasia. Int J Pediatr. 2012; 2012:598606.
  7. Bassett E, Vaisman A, Tropea KA, McCall CM, Masutani C, Hanaoka F, Chaney SG. Frameshifts and deletions during in vitro translesion synthesis past Pt-DNA adducts by DNA polymerases beta and eta. DNA Repair (Amst). 2002 Dec 5; 1(12):1003-16.
  8. Tropea KA, Leder E, Aslam M, Lau AN, Raiser DM, Lee JH, Balasubramaniam V, Fredenburgh LE, Alex Mitsialis S, Kourembanas S, Kim CF. Bronchioalveolar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2012 May 1; 302(9):L829-37.
  9. Leeman KT, Dobson L, Towne M, Dukhovny D, Joshi M, Stoler J, Agrawal PB. NPHP3 mutations are associated with neonatal onset multiorgan polycystic disease in two siblings. J Perinatol. 2014 May; 34(5):410-1.
  10. Christou H, Dizon ML, Farrow KN, Jadcherla SR, Leeman KT, Maheshwari A, Rubin LP, Stansfield BK, Rowitch DH. Sustaining careers of physician-scientists in neonatology and pediatric critical care medicine: formulating supportive departmental policies. Pediatr Res. 2016 Nov; 80(5):635-640.
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