Research

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Joshua Mauney, PhD

Josh Mauney, PhD
Department:
Urology Research
Hospital Title:
Staff Scientist
Academic Title:
Assistant Professor of Surgery, Harvard Medical School
Research Focus Area:
Tissue EngineeringUrinary and Gastrointestinal Tract Surgical ResearchBiomaterials
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Research Overview

My research focuses on the development of novel tissue engineering strategies for hollow organ repair and regeneration. Specifically, I investigate the utility of silk scaffolds as platforms for urogenital, gastrointestinal, and respiratory tissue reconstruction. By deciphering how variations in scaffold processing parameters can affect the in vivo performance of silk biomaterials, we seek to develop 3-D matrix designs with optimal structural, mechanical, and degradation profiles capable of restoring function in defects associated with traumatic injury and fibrotic diseases. In collaboration with our clinical partner, Dr. Carlos Estrada, MD, we employ both small and large animal models of tissue repair in the bladder, urethra, small intestine, esophagus, and trachea. In addition, my laboratory explores the mechanisms of constructive remodeling of tissue engineered constructs by delineating how host tissue microenvironments interact, populate, and integrate into scaffold environments in vivo. Our overall goal is the creation of clinically-useful scaffold configurations for hollow organ regeneration by engineering materials which fulfill structural and mechanical requirements of native tissues as well as present microenvironmental cues necessary for host tissue integration and defect consolidation. My comprehensive background in silk-based biomaterial fabrication methods coupled with my expertise in stem cell biology uniquely positions my lab as a pioneer in the creation of novel strategies for hollow organ regeneration.

Key Publications

Tu DD, Chung YG, Gil ES, Seth A, Franck D, Cristofaro V, Sullivan MP, Di Vizio D, Gomez P 3rd, Adam RM, Kaplan DL, Estrada CR Jr, Mauney JR. Bladder tissue regeneration using acellular bi-layer silk scaffolds in a large animal model of augmentation cystoplasty. Biomaterials. 2013 Nov;34(34):8681-9. PMID: 23953839.

Chung YG, Tu D, Franck D, Gil ES, Algarrahi K, Adam RM, Kaplan DL, Estrada CR Jr, Mauney JR. Acellular bi-layer silk fibroin scaffolds support tissue regeneration in a rabbit model of onlay urethroplasty. PLoS One. 2014 Mar 14;9(3):e91592. PMID: 24632740.

Chung YG, Algarrahi K, Franck D, Duong DD, Adam RM, Kaplan DL, Estrada CR, Mauney JR. The Use of Bi-layer Silk Fibroin Scaffolds and Small Intestinal Submucosa Matrices to Support Bladder Tissue Regeneration in a Rat Model of Spinal Cord Injury. 2014 Biomaterials. Aug;35(26):7452-9. PMID: 24917031.

Algarrahi K, Franck D, Ghezzi C, Cristafaro V, Yang X, Sullivan MP, Chung YG, Affas S, Jennings R, Kaplan DL, Estrada CR, Mauney JR. Acellular Bi-Layer Silk Fibroin Scaffolds Support Functional Tissue Regeneration in a Rat Model of Onlay Esophagoplasty. Biomaterials. 2015 Jun;53:149-59.2015. PMID: 25890715

See a complete list of published work in my bibliography.

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