Research

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Gregory Sawicki, MD, MPH

Gregory Sawicki, MD, MPH
Department:
Medicine Research
Division
Respiratory Diseases Research
Hospital Title:
Associate Director Cystic Fibrosis Program
Academic Title:
Assistant Professor of Pediatrics, Harvard Medical School
Research Focus Area:
Cystic fibrosisAsthma
Contact Via Email
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Research Overview

Gregory S. Sawicki, MD, MPH, is a pediatric pulmonologist and health services researcher with particular interest in addressing health outcomes, disease self-management, and adherence for children, adolescents, and young adults with chronic respiratory diseases including cystic fibrosis (CF) and asthma.

Dr. Sawicki’s primary research activities are currently focused on the process and outcomes of transition from pediatric to adult focused health care for adolescents with chronic medical conditions. He is conducting a NIH-funded mixed methods qualitative and survey study of adolescents and young adults with CF with the aim of exploring their current experiences with health care transition and disease self-management. In his recent work, he has helped to develop and validate a survey instrument to assess transition readiness for youth with chronic disease, the Transition Readiness Assessment Questionnaire (TRAQ).  This instrument is currently being used in multiple health care transition studies throughout the country. He also is working on the development of quality measures to evaluate the transition to adult care for youth with chronic conditions.

About Gregory Sawicki, MD, MPH

Dr. Sawicki received his MD from Harvard Medical School in 2001. He completed residency in Boston Combined Residency Program in Pediatrics in 2004, followed by fellowship in Pediatric Pulmonology at Boston Children’s Hospital (2004-2007). He also completed the Harvard Pediatric Health Services Research Fellowship in 2007, receiving an MPH in Clinical Effectiveness at the Harvard School of Public Health. Dr. Sawicki is currently the Associate Director of the Cystic Fibrosis Center at Boston Children’s Hospital.

Active Projects

2011-2016 Cystic Fibrosis as a Model for Health Care Transition for Chronically Ill Youth

NHLBI K23 HL105541-01A1
Principal Investigator

The goals of this mentored career development award are to understand the barriers and facilitators of the health care transition process from the perspective of adolescents and young adults with cystic fibrosis. The research will provide important information that can be used in designing health care transition programs for adolescents and young adults with chronic medical conditions.

Publications

Publications powered by Harvard Catalyst Profiles
  1. Forno E, Weiner DJ, Mullen J, Sawicki G, Kurland G, Han YY, Cloutier MM, Canino G, Weiss ST, Litonjua AA, Celedón JC. Obesity and Airway Dysanapsis in Children With and Without Asthma. Am J Respir Crit Care Med. 2016 Aug 23.
  2. Kenney LB, Melvin P, Fishman LN, O'Sullivan-Oliveira J, Sawicki GS, Ziniel S, Diller L, Fernandes SM. Transition and transfer of childhood cancer survivors to adult care: A national survey of pediatric oncologists. Pediatr Blood Cancer. 2016 Jul 27.
  3. Suthoff ED, Bonafede M, Limone B, O'Callaghan L, Sawicki GS, Wagener JS. Healthcare resource utilization associated with ivacaftor use in patients with cystic fibrosis. J Med Econ. 2016 Sep; 19(9):845-51.
  4. Putman MS, Greenblatt LB, Sicilian L, Uluer A, Lapey A, Sawicki G, Gordon CM, Bouxsein ML, Finkelstein JS. Young adults with cystic fibrosis have altered trabecular microstructure by ITS-based morphological analysis. Osteoporos Int. 2016 Aug; 27(8):2497-505.
  5. Davies JC, Cunningham S, Harris WT, Lapey A, Regelmann WE, Sawicki GS, Southern KW, Robertson S, Green Y, Cooke J, Rosenfeld M. Safety, pharmacokinetics, and pharmacodynamics of ivacaftor in patients aged 2-5 years with cystic fibrosis and a CFTR gating mutation (KIWI): an open-label, single-arm study. Lancet Respir Med. 2016 Feb; 4(2):107-15.
  6. Tarshish Y, Huang L, Jackson FI, Edwards J, Fligor B, Wilkins A, Uluer A, Sawicki G, Kenna M. Risk Factors for Hearing Loss in Patients with Cystic Fibrosis. J Am Acad Audiol. 2016 Jan; 27(1):6-12.
  7. Sawicki GS, Garvey KC, Toomey SL, Williams KA, Chen Y, Hargraves JL, Leblanc J, Schuster MA, Finkelstein JA. Development and Validation of the Adolescent Assessment of Preparation for Transition: A Novel Patient Experience Measure. J Adolesc Health. 2015 Sep; 57(3):282-7.
  8. Simoneau T, Sawicki GS, Milliren CE, Feldman HA, Gordon CM. A randomized controlled trial of vitamin D replacement strategies in pediatric CF patients. J Cyst Fibros. 2016 Mar; 15(2):234-41.
  9. Cohen SE, Hooper SR, Javalkar K, Haberman C, Fenton N, Lai H, Mahan JD, Massengill S, Kelly M, Cantú G, Medeiros M, Phillips A, Sawicki G, Wood D, Johnson M, Benton MH, Ferris M. Self-Management and Transition Readiness Assessment: Concurrent, Predictive and Discriminant Validation of the STARx Questionnaire. J Pediatr Nurs. 2015 Sep-Oct; 30(5):668-76.
  10. Wisk LE, Finkelstein JA, Sawicki GS, Lakoma M, Toomey SL, Schuster MA, Galbraith AA. Predictors of timing of transfer from pediatric- to adult-focused primary care. JAMA Pediatr. 2015 Jun; 169(6):e150951.
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  12. Sawicki GS, Chou W, Raimundo K, Trzaskoma B, Konstan MW. Randomized trial of efficacy and safety of dornase alfa delivered by eRapid nebulizer in cystic fibrosis patients. J Cyst Fibros. 2015 Nov; 14(6):777-83.
  13. Schechter MS, Regelmann WE, Sawicki GS, Rasouliyan L, VanDevanter DR, Rosenfeld M, Pasta D, Morgan W, Konstan MW. Antibiotic treatment of signs and symptoms of pulmonary exacerbations: a comparison by care site. Pediatr Pulmonol. 2015 May; 50(5):431-40.
  14. Sawicki GS, Kelemen S, Weitzman ER. Ready, set, stop: mismatch between self-care beliefs, transition readiness skills, and transition planning among adolescents, young adults, and parents. Clin Pediatr (Phila). 2014 Oct; 53(11):1062-8.
  15. Wood DL, Sawicki GS, Miller MD, Smotherman C, Lukens-Bull K, Livingood WC, Ferris M, Kraemer DF. The Transition Readiness Assessment Questionnaire (TRAQ): its factor structure, reliability, and validity. Acad Pediatr. 2014 Jul-Aug; 14(4):415-22.
  16. Virgin FW, Huang L, Roberson DW, Sawicki GS. Inter-hospital variation in the frequency of sinus surgery in children with cystic fibrosis. Pediatr Pulmonol. 2014 Apr 2.
  17. Sawicki GS, Heller KS, Demars N, Robinson WM. Motivating adherence among adolescents with cystic fibrosis: youth and parent perspectives. Pediatr Pulmonol. 2015 Feb; 50(2):127-36.
  18. Sharma N, O'Hare K, Antonelli RC, Sawicki GS. Transition care: future directions in education, health policy, and outcomes research. Acad Pediatr. 2014 Mar-Apr; 14(2):120-7.
  19. Simoneau T, Bazzaz O, Sawicki GS, Gordon C. Vitamin D status in children with cystic fibrosis. Associations with inflammation and bacterial colonization. Ann Am Thorac Soc. 2014 Feb; 11(2):205-10.
  20. Fernandes SM, O'Sullivan-Oliveira J, Landzberg MJ, Khairy P, Melvin P, Sawicki GS, Ziniel S, Kenney LB, Garvey KC, Sobota A, O'Brien R, Nigrovic PA, Sharma N, Fishman LN. Transition and transfer of adolescents and young adults with pediatric onset chronic disease: the patient and parent perspective. J Pediatr Rehabil Med. 2014; 7(1):43-51.
  21. Cleveland RH, Stamoulis C, Sawicki G, Kelliher E, Zucker EJ, Wood C, Zurakowski D, Lee E. Brasfield and Wisconsin scoring systems have equal value as outcome assessment tools of cystic fibrosis lung disease. Pediatr Radiol. 2014 May; 44(5):529-34.
  22. Dill EJ, Dawson R, Sellers DE, Robinson WM, Sawicki GS. Longitudinal trends in health-related quality of life in adults with cystic fibrosis. Chest. 2013 Sep; 144(3):981-9.
  23. Sawicki G, Allen JL. Claim-based analyses of inhaled corticosteroid refill rates for asthma: who's kidding whom? Ann Am Thorac Soc. 2013 Apr; 10(2):149-50.
  24. Sawicki GS, Ren CL, Konstan MW, Millar SJ, Pasta DJ, Quittner AL. Treatment complexity in cystic fibrosis: trends over time and associations with site-specific outcomes. J Cyst Fibros. 2013 Sep; 12(5):461-7.
  25. Sawicki GS, Ayyagari R, Zhang J, Signorovitch JE, Fan L, Swallow E, Latremouille-Viau D, Wu EQ, Shi L. A pulmonary exacerbation risk score among cystic fibrosis patients not receiving recommended care. Pediatr Pulmonol. 2013 Oct; 48(10):954-61.
  26. Fernandes SM, Khairy P, Fishman L, Melvin P, O'Sullivan-Oliveira J, Sawicki GS, Ziniel S, Breitinger P, Williams R, Takahashi M, Landzberg MJ. Referral patterns and perceived barriers to adult congenital heart disease care: results of a survey of U.S. pediatric cardiologists. J Am Coll Cardiol. 2012 Dec 11; 60(23):2411-8.
  27. Sawicki GS, Tiddens H. Managing treatment complexity in cystic fibrosis: challenges and opportunities. Pediatr Pulmonol. 2012 Jun; 47(6):523-33.
  28. Quittner AL, Sawicki GS, McMullen A, Rasouliyan L, Pasta DJ, Yegin A, Konstan MW. Erratum to: Psychometric evaluation of the Cystic Fibrosis Questionnaire-Revised in a national, US sample. Qual Life Res. 2012 Sep; 21(7):1279-90.
  29. Palm K, Sawicki G, Rosen R. The impact of reflux burden on Pseudomonas positivity in children with cystic fibrosis. Pediatr Pulmonol. 2012 Jun; 47(6):582-7.
  30. Quittner AL, Sawicki GS, McMullen A, Rasouliyan L, Pasta DJ, Yegin A, Konstan MW. Psychometric evaluation of the Cystic Fibrosis Questionnaire-Revised in a national sample. Qual Life Res. 2012 Sep; 21(7):1267-78.
  31. Dellon EP, Sawicki GS, Shores MD, Wolfe J, Hanson LC. Physician practices for communicating with patients with cystic fibrosis about the use of noninvasive and invasive mechanical ventilation. Chest. 2012 Apr; 141(4):1010-7.
  32. Palm K, Simoneau T, Sawicki G, Rhein L. Assessment of current strategies for weaning premature infants from supplemental oxygen in the outpatient setting. Adv Neonatal Care. 2011 Oct; 11(5):349-56.
  33. Sawicki GS, Whitworth R, Gunn L, Butterfield R, Lukens-Bull K, Wood D. Receipt of health care transition counseling in the national survey of adult transition and health. Pediatrics. 2011 Sep; 128(3):e521-9.
  34. Sawicki GS, Signorovitch JE, Zhang J, Latremouille-Viau D, von Wartburg M, Wu EQ, Shi L. Reduced mortality in cystic fibrosis patients treated with tobramycin inhalation solution. Pediatr Pulmonol. 2012 Jan; 47(1):44-52.
  35. Gaffin JM, Sheehan WJ, Morrill J, Cinar M, Borras Coughlin IM, Sawicki GS, Twarog FJ, Young MC, Schneider LC, Phipatanakul W. Tree nut allergy, egg allergy, and asthma in children. Clin Pediatr (Phila). 2011 Feb; 50(2):133-9.
  36. Sawicki GS, Rasouliyan L, McMullen AH, Wagener JS, McColley SA, Pasta DJ, Quittner AL. Longitudinal assessment of health-related quality of life in an observational cohort of patients with cystic fibrosis. Pediatr Pulmonol. 2011 Jan; 46(1):36-44.
  37. Demars N, Uluer A, Sawicki GS. Employment experiences among adolescents and young adults with cystic fibrosis. Disabil Rehabil. 2011; 33(11):922-6.
  38. Sawicki GS, Vilk Y, Schatz M, Kleinman K, Abrams A, Madden J. Uncontrolled asthma in a commercially insured population from 2002 to 2007: trends, predictors, and costs. J Asthma. 2010 Jun; 47(5):574-80.
  39. Tuchman LK, Schwartz LA, Sawicki GS, Britto MT. Cystic fibrosis and transition to adult medical care. Pediatrics. 2010 Mar; 125(3):566-73.
  40. Galbraith AA, Smith LA, Bokhour B, Miroshnik IL, Sawicki GS, Glauber JH, Hohman KH, Gay C, Lieu TA. Asthma care quality for children with minority-serving providers. Arch Pediatr Adolesc Med. 2010 Jan; 164(1):38-45.
  41. Sawicki GS, Lukens-Bull K, Yin X, Demars N, Huang IC, Livingood W, Reiss J, Wood D. Measuring the transition readiness of youth with special healthcare needs: validation of the TRAQ--Transition Readiness Assessment Questionnaire. J Pediatr Psychol. 2011 Mar; 36(2):160-71.
  42. Oreskovic NM, Sawicki GS, Kinane TB, Winickoff JP, Perrin JM. Travel patterns to school among children with asthma. Clin Pediatr (Phila). 2009 Jul; 48(6):632-40.
  43. Sawicki GS, Rasouliyan L, Ren CL. The impact of MRSA on lung function in patients with cystic fibrosis. Am J Respir Crit Care Med. 2009 Apr 15; 179(8):734-5; author reply 735.
  44. Sawicki GS, Rasouliyan L, Pasta DJ, Regelmann WE, Wagener JS, Waltz DA, Ren CL. The impact of incident methicillin resistant Staphylococcus aureus detection on pulmonary function in cystic fibrosis. Pediatr Pulmonol. 2008 Nov; 43(11):1117-23.
  45. Sawicki GS, Dill EJ, Asher D, Sellers DE, Robinson WM. Advance care planning in adults with cystic fibrosis. J Palliat Med. 2008 Oct; 11(8):1135-41.
  46. Sawicki GS, Lu FL, Valim C, Cleveland RH, Colin AA. Necrotising pneumonia is an increasingly detected complication of pneumonia in children. Eur Respir J. 2008 Jun; 31(6):1285-91.
  47. Sawicki GS, Smith L, Bokhour B, Gay C, Hohman KH, Galbraith AA, Lieu TA. Periodic use of inhaled steroids in children with mild persistent asthma: what are pediatricians recommending? Clin Pediatr (Phila). 2008 Jun; 47(5):446-51.
  48. Kharasch VS, Dumas HM, Haley SM, Sawicki GS, Ludlow LH, Wright EA, Jones DT, O'Brien JE. Bronchoscopy findings in children and young adults with tracheostomy due to congenital anomalies and neurological impairment. J Pediatr Rehabil Med. 2008; 1(2):137-43.
  49. Sawicki GS, Sellers DE, McGuffie K, Robinson W. Adults with cystic fibrosis report important and unmet needs for disease information. J Cyst Fibros. 2007 Nov 30; 6(6):411-6.
  50. Battistini L, Borsellino G, Sawicki G, Poccia F, Salvetti M, Ristori G, Brosnan CF. Phenotypic and cytokine analysis of human peripheral blood gamma delta T cells expressing NK cell receptors. J Immunol. 1997 Oct 15; 159(8):3723-30.
  51. Lee EY, Vargas SO, Sawicki GS, Boyer D, Grant FD, Voss SD. Mucoepidermoid carcinoma of bronchus in a pediatric patient: (18)F-FDG PET findings. Pediatr Radiol. 2007 Dec; 37(12):1278-82.
  52. Sawicki GS, Sellers DE, Robinson WM. Self-reported physical and psychological symptom burden in adults with cystic fibrosis. J Pain Symptom Manage. 2008 Apr; 35(4):372-80.
  53. Sawicki GS, Sellers DE, Robinson WM. Associations between illness perceptions and health-related quality of life in adults with cystic fibrosis. J Psychosom Res. 2011 Feb; 70(2):161-7.
  54. Sawicki GS, Sellers DE, Robinson WM. High treatment burden in adults with cystic fibrosis: challenges to disease self-management. J Cyst Fibros. 2009 Mar; 8(2):91-6.
  55. Sawicki GS, Strunk RC, Schuemann B, Annett R, Weiss S, Fuhlbrigge AL. Patterns of inhaled corticosteroid use and asthma control in the Childhood Asthma Management Program Continuation Study. Ann Allergy Asthma Immunol. 2010 Jan; 104(1):30-5.
  56. McGuffie K, Sellers DE, Sawicki GS, Robinson WM. Self-reported involvement of family members in the care of adults with CF. J Cyst Fibros. 2008 Mar; 7(2):95-101.
  57. Putman MS, Milliren CE, Derrico N, Uluer A, Sicilian L, Lapey A, Sawicki G, Gordon CM, Bouxsein ML, Finkelstein JS. Compromised bone microarchitecture and estimated bone strength in young adults with cystic fibrosis. J Clin Endocrinol Metab. 2014 Sep; 99(9):3399-407.
  58. Sawicki GS, McKone EF, Pasta DJ, Millar SJ, Wagener JS, Johnson CA, Konstan MW. Sustained Benefit from ivacaftor demonstrated by combining clinical trial and cystic fibrosis patient registry data. Am J Respir Crit Care Med. 2015 Oct 1; 192(7):836-42.
  59. Sawicki GS, Dasenbrook E, Fink AK, Schechter MS. Rate of Uptake of Ivacaftor Use after U.S. Food and Drug Administration Approval among Patients Enrolled in the U.S. Cystic Fibrosis Foundation Patient Registry. Ann Am Thorac Soc. 2015 Aug; 12(8):1146-52.
  60. Cleveland RH, Sawicki GS, Stamoulis C. Similar performance of Brasfield and Wisconsin scoring systems in young children with cystic fibrosis. Pediatr Radiol. 2015 Oct; 45(11):1624-8.
  61. Linnemann RW, O'Malley PJ, Friedman D, Georgiopoulos AM, Buxton D, Altstein LL, Sicilian L, Lapey A, Sawicki GS, Moskowitz SM. Development and evaluation of a palliative care curriculum for cystic fibrosis healthcare providers. J Cyst Fibros. 2016 Jan; 15(1):90-5.
  62. Sawicki GS, Goss CH. Tackling the increasing complexity of CF care. Pediatr Pulmonol. 2015 Oct; 50 Suppl 40:S74-9.
  63. Sanders DB, Fink A, Mayer-Hamblett N, Schechter MS, Sawicki GS, Rosenfeld M, Flume PA, Morgan WJ. Early Life Growth Trajectories in Cystic Fibrosis are Associated with Pulmonary Function at Age 6 Years. J Pediatr. 2015 Nov; 167(5):1081-8.e1.
  64. Ferris DP, Sawicki GS, Domingo A. Powered lower limb orthoses for gait rehabilitation. Top Spinal Cord Inj Rehabil. 2005; 11(2):34-49.
  65. Ferris DP, Sawicki GS, Daley MA. A PHYSIOLOGIST'S PERSPECTIVE ON ROBOTIC EXOSKELETONS FOR HUMAN LOCOMOTION. Int J HR. 2007 Sep; 4(3):507-528.
  66. Danos N, Holt NC, Sawicki GS, Azizi E. Modeling age-related changes in muscle-tendon dynamics during cyclical contractions in the rat gastrocnemius. J Appl Physiol (1985). 2016 Oct 1; 121(4):1004-1012.
  67. Bishay LC, Sawicki GS. Strategies to optimize treatment adherence in adolescent patients with cystic fibrosis. Adolesc Health Med Ther. 2016; 7:117-124.
  68. Aqul A, Jonas MM, Harney S, Raza R, Sawicki GS, Mitchell PD, Fawaz R. Correlation of Transient Elastography With Severity of Cystic Fibrosis Related Liver Disease. J Pediatr Gastroenterol Nutr. 2016 Oct 25.
  69. Greenberg J, Palmer JB, Chan WW, Correia CE, Whalley D, Shannon P, Sawicki GS. Treatment satisfaction in cystic fibrosis: early patient experience with tobramycin inhalation powder. Patient Prefer Adherence. 2016; 10:2163-2169.
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