Research

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Eva  Guinan, MD

Research Center:
Dana-Farber/Boston Children’s Cancer and Blood Disorders Center
Department:
Medicine Research
Division
Hematology/Oncology Research
Hospital Title:
Associate in Medicine
Academic Title:
Associate Professor of Pediatrics, Harvard Medical School
Research Focus Area:
Transplant Immunology
Contact:
617-632-4932
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Research Overview

Eva Guinan's research focuses on overcoming problems related to allogenicity in transplantation, decreasing treatment related toxicity, and managing bone marrow failure syndromes. She also works with Harvard University collaborators on ways to spur more innovative translational research. Allogeneic transplantation is limited, in large part, by the ability to find donors of suitable histocompatibility. Global immunosuppression has been an incomplete and highly toxic approach to this problem. Current understanding of T cell activation suggests that blocking B7-CD28 interactions of the costimulatory pathway for human T helper cells may provide an innovative and effective way of producing antigen-specific T cell hyporesponsiveness. Guinan and colleagues are applying these various strategies to the transplant setting. Another area of active investigation is the development of novel agents for prevention or treatment of treatment-related toxicity.

About Eva Guinan

Eva Guinan received her MD from Harvard Medical School. She completed an internship and residency at Children's Hospital Boston and a fellowship at Children's Hospital/Dana Farber Cancer Institute. Dr. Guinan received the Clare and Richard Morse Research Award, 2000 the Clinical Translational Scientist Award, Burroughs Wellcome, 1999 and the Distinguished Service Award of the Fanconi Anemia Research Foundation in 2009.

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RELATED RESEARCH CENTER

Dana-Farber/Boston Children’s Cancer and Blood Disorders Center

Dana-Farber/Boston Children's Cancer and Blood Disorders Center is one of the top research centers in the world for pediatric cancers and blood diseases. It brings together laboratory scientists and clinical researchers from Dana-Farber Cancer Institute and Boston Children’s Hospital in a single program. We investigate pediatric cancers and non-malignant blood disorders from every angle—from examining cells under the microscope to tracking the effectiveness of current drug regimens using the most advanced molecular methods—so that we can create better treatments for children seen here and around the world.

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