Research

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Elizabeth Mullen, MD

Elizabeth A. Mullen, MD, FAAP
Research Center:
Dana-Farber/Boston Children’s Cancer and Blood Disorders Center
Department:
Medicine Research
Division
Hematology/Oncology Research
Hospital Title:
Principal Investigator
Academic Title:
Instructor in Pediatrics, Harvard Medical School
Research Focus Area:
Hematology/Oncology
Contact:
617-632-1938
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Research Overview

Dr. Mullen conducts clinical research in Renal Tumors. She is the Children?s Hospital Principal Investigator for multiple Children?s Oncology Group (COG) investigational protocols on the classification and treatment of Pediatric Renal Tumors. She is also Vice-Chair of the COG study on the Biology and Classification of Renal Tumors, and the Vice-Chair of the study of the treatment of Very Low Risk and Standard Risk Wilms Tumor. The ongoing COG studies in renal tumors aim to improve the treatment of children with renal tumors by helping to define which patients need more intensive treatment, and which patients can be spared exposure to some treatments with chemotherapy and radiation therapy.

Focus of Research

Dr. Mullen's research is directed towards understanding the best management for children with pediatric renal tumors. Increased understanding of appropriate risk stratification of patients with renal tumors, and adjustment of therapy based on response during therapy will hopefully lead to better overall cure rates, while minimizing the long term effects of therapy for survivors of pediatric renal tumors. Dr. Mullen is also interested in defining appropriate surveillance testing for patients after completion of treatment for their tumor.

Translational Research

In a cross-discipline collaboration with other faculty members at Children's Hospital and the Dana-Farber (Dr. Hanno Steen/Dr. Alex Kentsis/Dr. Carlos Rodriguez-Galindo,) Dr. Mullen is investigating the use of the technique of urine proteonomics to find urinary markers of renal tumors.

About Dr. Elizabeth Mullen

Dr. Mullen received her BA at Wellesley College, her MD at Yale University, and completed her internship and residency at Boston Children's Hospital. She also completed her fellowship in Pediatric Hematology/Oncology in the Children's Hospital/Dana-Farber Cancer Institute.

Key Publications

  • EA Mullen. Pediatric Renal Tumors: Pediatric Nephrology, 6th Edn. Vol 2. Springer-Verlag Berlin Heidelberg Publishing, 2009.

  • M Metzger, C Stewart, B Freeman, III, C Billups, F Hoffer, J Wu, M Coppes, R Grant, M Chintagumpala, EA Mullen, C Alvarado, N Daw, J Dome. Topotecan Is Active Against Wilms' Tumor: Results of a Multi-Institutional Phase II Study. Journal of Clinical Oncology. 2007: Volume 25, No 21 (July 20): 3130-3136
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RELATED RESEARCH CENTER

Dana-Farber/Boston Children’s Cancer and Blood Disorders Center

Dana-Farber/Boston Children's Cancer and Blood Disorders Center is one of the top research centers in the world for pediatric cancers and blood diseases. It brings together laboratory scientists and clinical researchers from Dana-Farber Cancer Institute and Boston Children’s Hospital in a single program. We investigate pediatric cancers and non-malignant blood disorders from every angle—from examining cells under the microscope to tracking the effectiveness of current drug regimens using the most advanced molecular methods—so that we can create better treatments for children seen here and around the world.

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