Research

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Edward R.  Smith, MD

Edward R Smith
Program:
Vascular Biology Program
Department:
Neurosurgery Research
Hospital Title:
Director, Pediatric Cerebrovascular Surgery; Co-Director, Neurosurgical Stroke Program;Co-Director, Center for Head, Neck and Skull Base
Academic Title:
Associate Professor of Neurosurgery, Harvard Medical School
Research Focus Area:
Moyamoya syndromeBrain tumors
Contact:
617-355-6008

Research Overview

Edward Smith is engaged in basic science research on primary brain tumors and cerebrovascular disease. His research is primarily centered on understanding the molecular mechanisms of tumorigenesis and angiogenesis in the central nervous system. This work has included basic science and translational studies investigating adult and pediatric brain tumors, moyamoya disease and cerebral vascular malformations. This research has implicated a class of extracellular matrix proteins, called matrix metalloproteinases (MMPs), in the advent and progression of several disease states of the central nervous system, including brain tumors, moyamoya and vascular malformations.

A major research interest, in conjunction with the lab of Marsha Moses, PhD, director of the Vascular Biology Program, is the study of pediatric cerebral arteriovenous malformations (AVMs). A number of projects have been generously supported by the Lucas Warner AVM research fund, resulting in exciting discoveries relevant to the diagnosis, understanding and treatment of these challenging lesions. Smith's research has been supported by funding from several other sources, including the National Institutes of Health, and is carried out in collaboration with a number of investigators in associated fields, particularly Moses.

Goals of Smith's work include:

  • development of a panel of non-invasive biomarkers for the detection and follow-up of neurosurgical disease;
  • development of novel therapeutic interventions for neurosurgical disease based on regulation of vascular stability;
  • investigation of the molecular mechanisms regulating tumorigenesis and angiogenesis in the central nervous system.

About Edward Smith

Edward R. Smith received an MD from Columbia University. He completed a neurosurgery residency at Massachusetts General Hospital (MGH) and a fellowship in pediatric neurosurgery at Boston Children's Hospital. He also completed a postdoctoral research fellowship at MGH and a clinical research fellowship at Children's. Smith is currently the director of Pediatric Cerebrovascular Surgery and co-director of both the Stroke and Skull Base Centers at Children's. He has been recognized for his clinical work with regional and national awards. He was recently named Chair of the Ethics Committee of the American Society of Pediatric Neurosurgery and voted President-elect of the Young Neurosurgeons Committee of the American Association of Neurologic Surgery. Smith also teaches at Tufts and Harvard Medical Schools, having taught neuroanatomy for over 10 years. He has been an invited speaker at grand rounds at institutions locally and nationally. He gives lectures for the critical care team, the nursing staff and the first responder teams at Children's, and teaching rounds for the neurosurgical department at Children's and Brigham and Women's Hospital.

For a list of Edward R. Smith's publications on PubMed, click here.

 

Publications

Publications powered by Harvard Catalyst Profiles
  1. Pricola Fehnel K, Duggins-Warf M, Zurakowski D, McKee-Proctor M, Majumder R, Raber M, Han X, Smith ER. Using urinary bFGF and TIMP3 levels to predict the presence of juvenile pilocytic astrocytoma and establish a distinct biomarker signature. J Neurosurg Pediatr. 2016 Oct; 18(4):396-407.
  2. Smith ER. Structural causes of ischemic and hemorrhagic stroke in children: moyamoya and arteriovenous malformations. Curr Opin Pediatr. 2015 Dec; 27(6):706-11.
  3. Smith ER. Moyamoya Biomarkers. J Korean Neurosurg Soc. 2015 Jun; 57(6):415-21.
  4. See AP, Ropper AE, Underberg DL, Robertson RL, Scott RM, Smith ER. Down syndrome and moyamoya: clinical presentation and surgical management. J Neurosurg Pediatr. 2015 Jul; 16(1):58-63.
  5. Baird LC, Smith ER, Ichord R, Piccoli DA, Bernard TJ, Spinner NB, Scott RM, Kamath BM. Moyamoya syndrome associated with Alagille syndrome: outcome after surgical revascularization. J Pediatr. 2015 Feb; 166(2):470-3.
  6. Thakrar R, Robson CD, Vargas SO, Meara JG, Rahbar R, Smith ER. Benign triton tumor: multidisciplinary approach to diagnosis and treatment. Pediatr Dev Pathol. 2014 Sep-Oct; 17(5):400-5.
  7. Gross BA, Scott RM, Smith ER. Management of brain arteriovenous malformations. Lancet. 2014 May 10; 383(9929):1635.
  8. Yanamadala V, Lin N, Walcott BP, Baird LC, Smith ER. Spontaneous regression of an epidermoid cyst of the cavernous sinus. J Clin Neurosci. 2014 Aug; 21(8):1433-5.
  9. Gross BA, Stone SS, Smith ER. Occipital pial synangiosis. Acta Neurochir (Wien). 2014 Jul; 156(7):1297-300.
  10. Gross BA, Smith ER, Goumnerova L, Proctor MR, Madsen JR, Scott RM. Resection of supratentorial lobar cavernous malformations in children: clinical article.. J Neurosurg Pediatr. 2013 Oct; 12(4):367-73.
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  12. Ginat DT, Smith ER, Robertson RL, Scott RM, Schaefer PW. Imaging after direct and indirect extracranial-intracranial bypass surgery. AJR Am J Roentgenol. 2013 Jul; 201(1):W124-32.
  13. Gross BA, Smith ER, Scott RM. Cavernous malformations of the basal ganglia in children. J Neurosurg Pediatr. 2013 Aug; 12(2):171-4.
  14. Singla A, Lin N, Ho AL, Scott RM, Smith ER. Vascular collateralization along ventriculoperitoneal shunt catheters in moyamoya disease. J Neurosurg Pediatr. 2013 Jun; 11(6):710-2.
  15. Koss M, Scott RM, Irons MB, Smith ER, Ullrich NJ. Moyamoya syndrome associated with neurofibromatosis Type 1: perioperative and long-term outcome after surgical revascularization. J Neurosurg Pediatr. 2013 Apr; 11(4):417-25.
  16. Ahn ES, Scott RM, Robertson RL, Smith ER. Chorea in the clinical presentation of moyamoya disease: results of surgical revascularization and a proposed clinicopathological correlation. J Neurosurg Pediatr. 2013 Mar; 11(3):313-9.
  17. Smith ER. Moyamoya arteriopathy. Curr Treat Options Neurol. 2012 Dec; 14(6):549-56.
  18. Khoriaty E, McClain CD, Permaul P, Smith ER, Rachid R. Intraoperative anaphylaxis induced by the gelatin component of thrombin-soaked gelfoam in a pediatric patient. Ann Allergy Asthma Immunol. 2012 Mar; 108(3):209-10.
  19. Maher CO, Klimo P, Smith ER. Incidentally discovered lesions. Neurosurg Focus. 2011 Dec; 31(6):1 p preceding E1.
  20. Kim AH, Kasliwal MK, McNeish B, Silvera VM, Proctor MR, Smith ER. Features of the lumbar spine on magnetic resonance images following sectioning of filum terminale. J Neurosurg Pediatr. 2011 Oct; 8(4):384-9.
  21. Moftakhar P, Smith ER, Choulakian A, Scott RM, Danielpour M. Moyamoya disease in children with congenital dwarfing conditions. Pediatr Neurosurg. 2010; 46(5):373-80.
  22. Nahed BV, Ferreira M, Babu MA, Terry AR, Walcott BP, Kahle KT, Smith ER. Dural scalp and intracranial hemangiomas causing hydrocephalus and venous sinus thrombosis in an infant. J Child Neurol. 2011 Jun; 26(6):777-81.
  23. Magge SN, Smyth MD, Governale LS, Goumnerova L, Madsen J, Munro B, Nalbach SV, Proctor MR, Scott RM, Smith ER. Idiopathic syrinx in the pediatric population: a combined center experience. J Neurosurg Pediatr. 2011 Jan; 7(1):30-6.
  24. Klimo P, Maher CO, Smith ER. Preface: introduction to pediatric vascular neurosurgery. Neurosurg Clin N Am. 2010 Jul; 21(3):xiii-xiv.
  25. Scott RM, Smith ER. Introduction: moyamoya disease. Neurosurg Focus. 2009 Apr; 26(4):E1.
  26. Nahed BV, Ferreira M, Naunheim MR, Kahle KT, Proctor MR, Smith ER. Intracranial vasospasm with subsequent stroke after traumatic subarachnoid hemorrhage in a 22-month-old child. J Neurosurg Pediatr. 2009 Apr; 3(4):311-5.
  27. Scott RM, Smith ER. Moyamoya disease and moyamoya syndrome. N Engl J Med. 2009 Mar 19; 360(12):1226-37.
  28. Agarwalla PK, Dunn IF, Turner CD, Ligon KL, Schneider KA, Smith ER. A novel TP53 germline mutation in a family with a history of multiple malignancies: case report and review of the literature. Pediatr Neurosurg. 2008; 44(6):501-8.
  29. Grondin RT, Scott RM, Smith ER. Pediatric brain tumors. Adv Pediatr. 2009; 56:249-69.
  30. Jha RM, Klimo P, Smith ER. Foramen magnum stenosis from overgrowth of the opisthion in a child with achondroplasia. J Neurosurg Pediatr. 2008 Aug; 2(2):136-8.
  31. Agarwalla PK, Dunn IF, Scott RM, Smith ER. Tethered cord syndrome. Neurosurg Clin N Am. 2007 Jul; 18(3):531-47.
  32. Smith ER, Manfredi M, Scott RM, Black PM, Moses MA. A recurrent craniopharyngioma illustrates the potential usefulness of urinary matrix metalloproteinases as noninvasive biomarkers: case report. Neurosurgery. 2007 Jun; 60(6):E1148-9; discussion E1149.
  33. Klimo P, Khalil A, Slotkin JR, Smith ER, Scott RM, Goumnerova LC. Wound complications associated with the use of bovine serum albumin-glutaraldehyde surgical adhesive in pediatric patients. Neurosurgery. 2007 Apr; 60(4 Suppl 2):305-9; discussion 309.
  34. Smith ER, Butler WE, Barker FG. Is there a "July phenomenon" in pediatric neurosurgery at teaching hospitals? J Neurosurg. 2006 Sep; 105(3 Suppl):169-76.
  35. Kim AH, Maher CO, Smith ER. Lumbar intramedullary spinal schistosomiasis presenting as progressive paraparesis: case report. Neurosurgery. 2006 May; 58(5):E996; discussion E996.
  36. Smith ER, Scott RM. Surgical management of moyamoya syndrome. Skull Base. 2005 Feb; 15(1):15-26.
  37. Smith ER, Madsen JR. Neurosurgical aspects of critical care neurology. Semin Pediatr Neurol. 2004 Jun; 11(2):169-78.
  38. Smith ER, Madsen JR. Cerebral pathophysiology and critical care neurology: basic hemodynamic principles, cerebral perfusion, and intracranial pressure. Semin Pediatr Neurol. 2004 Jun; 11(2):89-104.
  39. Smith ER, Butler WE, Barker FG. Craniotomy for resection of pediatric brain tumors in the United States, 1988 to 2000: effects of provider caseloads and progressive centralization and specialization of care. Neurosurgery. 2004 Mar; 54(3):553-63; discussion 563-5.
  40. Smith ER, Butler WE, Barker FG. In-hospital mortality rates after ventriculoperitoneal shunt procedures in the United States, 1998 to 2000: relation to hospital and surgeon volume of care. J Neurosurg. 2004 Feb; 100(2 Suppl Pediatrics):90-7.
  41. Smith ER, Chapman PH, Ogilvy CS. Far posterior subtemporal approach to the dorsolateral brainstem and tentorial ring: technique and clinical experience. Neurosurgery. 2003 Feb; 52(2):364-8; discussion 368-9.
  42. Smith ER, Butler WE, Ogilvy CS. Surgical approaches to vascular anomalies of the child's brain. Curr Opin Neurol. 2002 Apr; 15(2):165-71.
  43. Smith ER, Ott M, Wain J, Louis DN, Chiocca EA. Massive growth of a meningioma into the brachial plexus and thoracic cavity after intraspinal and supraclavicular resection. Case report and review of the literature. J Neurosurg. 2002 Jan; 96(1 Suppl):107-11.
  44. Roach ES, Golomb MR, Adams R, Biller J, Daniels S, Deveber G, Ferriero D, Jones BV, Kirkham FJ, Scott RM, Smith ER. Management of stroke in infants and children: a scientific statement from a Special Writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young. Stroke. 2008 Sep; 39(9):2644-91.
  45. Jea A, Smith ER, Robertson R, Scott RM. Moyamoya syndrome associated with Down syndrome: outcome after surgical revascularization. Pediatrics. 2005 Nov; 116(5):e694-701.
  46. Smith ER, Carter BS, Ogilvy CS. Proposed use of prophylactic decompressive craniectomy in poor-grade aneurysmal subarachnoid hemorrhage patients presenting with associated large sylvian hematomas. Neurosurgery. 2002 Jul; 51(1):117-24; discussion 124.
  47. Smith ER, Scott RM. Cavernous malformations. Neurosurg Clin N Am. 2010 Jul; 21(3):483-90.
  48. Ellis MJ, Armstrong D, Vachhrajani S, Kulkarni AV, Dirks PB, Drake JM, Smith ER, Scott RM, Orbach DB. Angioarchitectural features associated with hemorrhagic presentation in pediatric cerebral arteriovenous malformations. J Neurointerv Surg. 2013 May; 5(3):191-5.
  49. Nahed BV, Darbar A, Doiron R, Saad A, Robson CD, Smith ER. Acute hydrocephalus secondary to obstruction of the foramen of monro and cerebral aqueduct caused by a choroid plexus cyst in the lateral ventricle. Case report. J Neurosurg. 2007 Sep; 107(3 Suppl):236-9.
  50. Kasliwal MK, Rogers GF, Ramkissoon S, Moses-Gardner A, Kurek KC, Smith ER. A rare case of psammomatoid ossifying fibroma in the sphenoid bone reconstructed using autologous particulate exchange cranioplasty. J Neurosurg Pediatr. 2011 Mar; 7(3):238-43.
  51. Smith ER, Zurakowski D, Saad A, Scott RM, Moses MA. Urinary biomarkers predict brain tumor presence and response to therapy. Clin Cancer Res. 2008 Apr 15; 14(8):2378-86.
  52. Smith ER, Scott RM. Moyamoya: epidemiology, presentation, and diagnosis. Neurosurg Clin N Am. 2010 Jul; 21(3):543-51.
  53. Walcott BP, Smith ER, Scott RM, Orbach DB. Dural arteriovenous fistulae in pediatric patients: associated conditions and treatment outcomes. J Neurointerv Surg. 2013 Jan 1; 5(1):6-9.
  54. Robison NJ, Prabhu SP, Sun P, Chi SN, Kieran MW, Manley PE, Cohen LE, Goumnerova L, Smith ER, Scott RM, London WB, Ullrich NJ. Predictors of neoplastic disease in children with isolated pituitary stalk thickening. Pediatr Blood Cancer. 2013 Oct; 60(10):1630-5.
  55. Walcott BP, Smith ER, Scott RM, Orbach DB. Pial arteriovenous fistulae in pediatric patients: associated syndromes and treatment outcome. J Neurointerv Surg. 2013 Jan 1; 5(1):10-4.
  56. Dunn IF, Agarwalla PK, Papanastassiou AM, Butler WE, Smith ER. Multiple pilocytic astrocytomas of the cerebellum in a 17-year-old patient with neurofibromatosis type I. Childs Nerv Syst. 2007 Oct; 23(10):1191-4.
  57. Qaiser R, Scott RM, Smith ER. Identification of an association between Robinow syndrome and moyamoya. Pediatr Neurosurg. 2009; 45(1):69-72.
  58. Smith ER, Scott RM. Progression of disease in unilateral moyamoya syndrome. Neurosurg Focus. 2008; 24(2):E17.
  59. Codd PJ, Scott RM, Smith ER. Seckel syndrome and moyamoya. J Neurosurg Pediatr. 2009 Apr; 3(4):320-4.
  60. Smith ER, McClain CD, Heeney M, Scott RM. Pial synangiosis in patients with moyamoya syndrome and sickle cell anemia: perioperative management and surgical outcome. Neurosurg Focus. 2009 Apr; 26(4):E10.
  61. Lin N, Baird L, Koss M, Kopecky KE, Gone E, Ullrich NJ, Scott RM, Smith ER. Discovery of asymptomatic moyamoya arteriopathy in pediatric syndromic populations: radiographic and clinical progression. Neurosurg Focus. 2011 Dec; 31(6):E6.
  62. Smith ER, Scott RM. Spontaneous occlusion of the circle of Willis in children: pediatric moyamoya summary with proposed evidence-based practice guidelines. A review. J Neurosurg Pediatr. 2012 Apr; 9(4):353-60.
  63. Lohani S, Madsen JR, Bergin AM, Smith ER. Moyamoya disease with mesial temporal sclerosis. J Neurosurg Pediatr. 2013 Jun; 11(6):713-6.
  64. Lin N, Aronson JP, Manjila S, Smith ER, Scott RM. Treatment of Moyamoya disease in the adult population with pial synangiosis. J Neurosurg. 2014 Mar; 120(3):612-7.
  65. Jackson EM, Lin N, Manjila S, Scott RM, Smith ER. Pial synangiosis in patients with moyamoya younger than 2 years of age. J Neurosurg Pediatr. 2014 Apr; 13(4):420-5.
  66. Gross BA, Storey A, Orbach DB, Scott RM, Smith ER. Microsurgical treatment of arteriovenous malformations in pediatric patients: the Boston Children's Hospital experience. J Neurosurg Pediatr. 2015 Jan; 15(1):71-7.
  67. Gross BA, Smith ER, Scott RM, Orbach DB. Intracranial aneurysms in the youngest patients: characteristics and treatment challenges. Pediatr Neurosurg. 2015; 50(1):18-25.
  68. Lin N, Smith ER, Scott RM, Orbach DB. Safety of neuroangiography and embolization in children: complication analysis of 697 consecutive procedures in 394 patients. J Neurosurg Pediatr. 2015 Oct; 16(4):432-8.
  69. Titsworth WL, Scott RM, Smith ER. National Analysis of 2454 Pediatric Moyamoya Admissions and the Effect of Hospital Volume on Outcomes. Stroke. 2016 May; 47(5):1303-11.
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