Research

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Constance S. Houck, MD, FAAP

Houck Connie MD
Department:
Department of Anesthesiology, Perioperative and Pain Medicine Research
Research Focus Area:
Perioperative outcomes and Perioperative pain management

Research Overview

My clinical and research activities are focused on modalities to reduce acute, procedural and postoperative pain in children. My recent work has focused on specific modalities to reduce pain for children undergoing open and robot-assisted laparoscopic urologic surgery. This has involved clinical research with the intravenous nonsteroidal medication, ketorolac, evaluating its safety and efficacy as well as its effect on bladder hyperreactivity (bladder spasms) after urologic surgery and the development of new treatment modalities to reduce diffuse abdominal and shoulder pain after laparoscopic surgery. I have recently expanded my research and advocacy focus to investigation of perioperative outcomes after common pediatric surgeries. As clinical director of the surgical hospitalist program at Boston Children's Hospital at Waltham and a member of the American College of Surgeons Task Force for Children's Surgical Care, I am involved in local and national outcomes research for children's surgery.

Publications

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  1. Ko RR, Pinyavat T, Stylianos S, Lambert SM, Anderson RC, Gallin PF, Maxwell LG, Ward CG, Deshpande JK, Houck CS. Optimal Timing of Surgical Procedures in Pediatric Patients. J Neurosurg Anesthesiol. 2016 Oct; 28(4):395-399.
  2. Tobias JD, Green TP, Coté CJ. Codeine: Time To Say "No". Pediatrics. 2016 Sep 19.
  3. Yu RN, Houck CS, Casta A, Blum RH. Institutional Policy Changes to Prevent Cardiac Toxicity Associated With Bupivacaine Penile Blockade in Infants. A A Case Rep. 2016 Aug 1; 7(3):71-5.
  4. Muñoz CJ, Nguyen HT, Houck CS. Robotic surgery and anesthesia for pediatric urologic procedures. Curr Opin Anaesthesiol. 2016 Jun; 29(3):337-44.
  5. Polaner DM, Houck CS. Critical Elements for the Pediatric Perioperative Anesthesia Environment. Pediatrics. 2015 Dec; 136(6):1200-5.
  6. Oldham KT, Fallat M, Barnhart D, Derkay C, Deshpande J, Georgeson K, Hirschl R, Houck C, Mooney D, Moss RL, Sawin R, Tuggle D. Reply to a Letter to the Editor. J Pediatr Surg. 2015 Aug; 50(8):1434-6.
  7. Oldham KT, Deshpande JK, Houck C, Martin L. Reply: To PMID 24468231. J Am Coll Surg. 2014 Aug; 219(2):327.
  8. Klein MD. Referral to pediatric surgical specialists. Pediatrics. 2014 Feb; 133(2):350-6.
  9. Galinkin J, Koh JL. Recognition and management of iatrogenically induced opioid dependence and withdrawal in children. Pediatrics. 2014 Jan; 133(1):152-5.
  10. Optimal resources for children's surgical care in the United States. J Am Coll Surg. 2014 Mar; 218(3):479-87, 487.e1-4.
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  12. Srougi V, Yorioka M, Sanchez DC, Onal B, Houck CS, Nguyen HT. The feasibility of robotic urologic surgery in infants and toddlers. J Pediatr Urol. 2013 Dec; 9(6 Pt B):1198-203.
  13. Hollman GA, Banks DM, Berkenbosch JW, Boswinkel JP, Eickhoff JC, Fagin D, Hagen SA, Hales RL, Houck CS, Kaur T, Kost S, Lowrie L, Nishisaki A, Scherrer PD, Stephenson L, Stormorken A, Cravero JP. Development, implementation, and initial participant feedback of a pediatric sedation provider course. Teach Learn Med. 2013; 25(3):249-57.
  14. Barbosa JA, Barayan G, Gridley CM, Sanchez DC, Passerotti CC, Houck CS, Nguyen HT. Parent and patient perceptions of robotic vs open urological surgery scars in children. J Urol. 2013 Jul; 190(1):244-50.
  15. Fein JA, Zempsky WT, Cravero JP. Relief of pain and anxiety in pediatric patients in emergency medical systems. Pediatrics. 2012 Nov; 130(5):e1391-405.
  16. Rowe CK, Pierce MW, Tecci KC, Houck CS, Mandell J, Retik AB, Nguyen HT. A comparative direct cost analysis of pediatric urologic robot-assisted laparoscopic surgery versus open surgery: could robot-assisted surgery be less expensive? J Endourol. 2012 Jul; 26(7):871-7.
  17. Marchini GS, Hong YK, Minnillo BJ, Diamond DA, Houck CS, Meier PM, Passerotti CC, Kaplan JR, Retik AB, Nguyen HT. Robotic assisted laparoscopic ureteral reimplantation in children: case matched comparative study with open surgical approach. J Urol. 2011 May; 185(5):1870-5.
  18. Minnillo BJ, Cruz JA, Sayao RH, Passerotti CC, Houck CS, Meier PM, Borer JG, Diamond DA, Retik AB, Nguyen HT. Long-term experience and outcomes of robotic assisted laparoscopic pyeloplasty in children and young adults. J Urol. 2011 Apr; 185(4):1455-60.
  19. Kumar P, Denson SE, Mancuso TJ. Premedication for nonemergency endotracheal intubation in the neonate. Pediatrics. 2010 Mar; 125(3):608-15.
  20. Ross AK, Ahmed Z, Wise-Faberowski L, Flack S, Gooden C, Houck CS, Malviya S, Monitto C, Olutoye OA, Polaner D, Reynolds P, Valley R. Society for Pediatric Anesthesia/American Academy of Pediatrics/Congenital Cardiac Anesthesia Society: winter meeting review. Anesth Analg. 2010 Jan 1; 110(1):266-71.
  21. Freilich DA, Houck CS, Meier PM, Passerotti CC, Retik AB, Nguyen HT. The effectiveness of aerosolized intraperitoneal bupivacaine in reducing postoperative pain in children undergoing robotic-assisted laparoscopic pyeloplasty. J Pediatr Urol. 2008 Oct; 4(5):337-40.
  22. Houck CS, Sethna NF. Transdermal analgesia with local anesthetics in children: review, update and future directions. Expert Rev Neurother. 2005 Sep; 5(5):625-34.
  23. Fallat ME, Deshpande JK. Do-not-resuscitate orders for pediatric patients who require anesthesia and surgery. Pediatrics. 2004 Dec; 114(6):1686-92.
  24. Zempsky WT, Cravero JP. Relief of pain and anxiety in pediatric patients in emergency medical systems. Pediatrics. 2004 Nov; 114(5):1348-56.
  25. Houck CS, Khodorova A, Reale AM, Strichartz GR, Davar G. Sensory fibers resistant to the actions of tetrodotoxin mediate nocifensive responses to local administration of endothelin-1 in rats. Pain. 2004 Aug; 110(3):719-26.
  26. Polaner DM, Houck CS, Rockoff MA, Mancuso TJ, Finley GA, Maxwell LG, Cravero J, Kain ZN, Bell C, Bosenberg A, Zwass M, Valley R, Agarwal R, Savarese A, Rice LJ, Coté CJ, Davidson PJ, Ferrari LR, Davis PJ. Sedation, risk, and safety: do we really have data at last? Pediatrics. 2001 Oct; 108(4):1006-8.
  27. Winickoff JP, Houck CS, Rothman EL, Bauchner H. Verve and Jolt: deadly new Internet drugs. Pediatrics. 2000 Oct; 106(4):829-30.
  28. Orf J, Thomas SH, Ahmed W, Wiebe L, Chamberlin P, Wedel SK, Houck C. Appropriateness of endotracheal tube size and insertion depth in children undergoing air medical transport. Pediatr Emerg Care. 2000 Oct; 16(5):321-7.
  29. Park JM, Houck CS, Sethna NF, Sullivan LJ, Atala A, Borer JG, Cilento BG, Diamond DA, Peters CA, Retik AB, Bauer SB. Ketorolac suppresses postoperative bladder spasms after pediatric ureteral reimplantation. Anesth Analg. 2000 Jul; 91(1):11-5.
  30. Casta A, Quackenbush EJ, Houck CS, Korson MS. Perioperative white matter degeneration and death in a patient with a defect in mitochondrial oxidative phosphorylation. Anesthesiology. 1997 Aug; 87(2):420-5.
  31. Hart LS, Berns SD, Houck CS, Boenning DA. The value of end-tidal CO2 monitoring when comparing three methods of conscious sedation for children undergoing painful procedures in the emergency department. Pediatr Emerg Care. 1997 Jun; 13(3):189-93.
  32. Casta A, Houck CS. Acute intraoperative endotracheal tube obstruction associated with a heat and moisture exchanger in an infant. Anesth Analg. 1997 Apr; 84(4):939-40.
  33. Houck CS. Pediatric pain management and therapeutic strategies. J Back Musculoskelet Rehabil. 1997 Jan 1; 9(3):265-78.
  34. Collins JJ, Geake J, Grier HE, Houck CS, Thaler HT, Weinstein HJ, Twum-Danso NY, Berde CB. Patient-controlled analgesia for mucositis pain in children: a three-period crossover study comparing morphine and hydromorphone. J Pediatr. 1996 Nov; 129(5):722-8.
  35. Houck CS, Wilder RT, McDermott JS, Sethna NF, Berde CB. Safety of intravenous ketorolac therapy in children and cost savings with a unit dosing system. J Pediatr. 1996 Aug; 129(2):292-6.
  36. Rusy LM, Houck CS, Sullivan LJ, Ohlms LA, Jones DT, McGill TJ, Berde CB. A double-blind evaluation of ketorolac tromethamine versus acetaminophen in pediatric tonsillectomy: analgesia and bleeding. Anesth Analg. 1995 Feb; 80(2):226-9.
  37. Houck CS, Berde C. Pain management in pediatrics. West J Med. 1993 Feb; 158(2):178-9.
  38. Valairucha S, Seefelder C, Houck CS. Thoracic epidural catheters placed by the caudal route in infants: the importance of radiographic confirmation. Paediatr Anaesth. 2002 Jun; 12(5):424-8.
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