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Brian K. Walsh, PhD

Department of Anesthesiology, Perioperative and Pain Medicine Research
Hospital Title:
Research Coordinator, Critical Care Medicine
Academic Title:
Associate in Anaesthesia, Harvard Medical School
Research Focus Area:
Respiratory Care and EducationMechanical VentilationImplementation Science

Research Overview

I began my healthcare career as a respiratory therapist and quickly developed an interest and passion for research and education. My research career began by focusing on areas within respiratory care that lacked evidence to guide practice; those areas included mechanical ventilation, aerosol delivery, airway clearance, and airway chemistry. This passion led me to several discoveries within each of those areas and the development of several nationally recognized clinical practice guidelines. Being seen as a clinical expert led to opportunities to orient and teach new respiratory therapists. While creating opportunities for the respiratory therapists to learn, I was exposed to the resident and fellowship training process. Soon I was asked to consider teaching and mentoring physicians in the art and science of respiratory care. Within the respiratory therapy community my teaching abilities were becoming clear to senior educators not only by other respiratory therapists, but physicians whom I had the privilege to teach and mentor. Mentors challenged me to take the next step and consider writing on the art and science of respiratory care. These publications and experiences led me to be seen as an international expert and afforded me the opportunity to edit the textbook Neonatal and Pediatric Respiratory Care. This textbook is a market leader for pediatric respiratory care education.


Publications powered by Harvard Catalyst Profiles
  1. Smallwood CD, Walsh BK, Arnold JH, Gouldstone A. Equilibration Time Required for Respiratory System Compliance and Oxygenation Response Following Changes in Positive End-Expiratory Pressure in Mechanically Ventilated Children. Crit Care Med. 2018 Feb 05.
  2. Smallwood CD, Walsh BK. Noninvasive Monitoring of Oxygen and Ventilation. Respir Care. 2017 Jun; 62(6):751-764.
  3. Walsh BK, Smallwood CD. Pediatric Oxygen Therapy: A Review and Update. Respir Care. 2017 Jun; 62(6):645-661.
  4. Kacmarek RM, Walsh BK. The Respiratory Therapy Profession Is at a Crossroads. Respir Care. 2017 03; 62(3):384-386.
  5. Walsh BK, Smallwood CD, Arnold JH. The Quality of Quality Metrics-Reply. Respir Care. 2017 02; 62(2):254-255.
  6. Smallwood CD, Kheir JN, Walsh BK, Mehta NM. Accuracy of Oxygen Consumption and Carbon Dioxide Elimination Measurements in 2 Breath-by-Breath Devices. Respir Care. 2017 Apr; 62(4):475-480.
  7. Walsh BK, Smallwood C, Rettig J, Kacmarek RM, Thompson J, Arnold JH. Daily Goals Formulation and Enhanced Visualization of Mechanical Ventilation Variance Improves Mechanical Ventilation Score. Respir Care. 2017 Mar; 62(3):268-278.
  8. Walsh BK. Is Anything Absolute? Respir Care. 2016 12; 61(12):1711.
  9. Walsh BK, Smallwood CD. Electrical Impedance Tomography During Mechanical Ventilation. Respir Care. 2016 Oct; 61(10):1417-24.
  10. Walsh BK. Next Logical Step. Respir Care. 2016 09; 61(9):1277-8.
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  12. Walsh BK, Smallwood CD, Rettig JS, Thompson JE, Kacmarek RM, Arnold JH. Categorization in Mechanically Ventilated Pediatric Subjects: A Proposed Method to Improve Quality. Respir Care. 2016 Sep; 61(9):1168-78.
  13. Walsh BK, Betit P, Fink JB, Pereira LM, Arnold J. Characterization of Ribavirin Aerosol With Small Particle Aerosol Generator and Vibrating Mesh Micropump Aerosol Technologies. Respir Care. 2016 May; 61(5):577-85.
  14. Rettig JS, Smallwood CD, Walsh BK, Rimensberger PC, Bachman TE, Bollen CW, Duval EL, Gebistorf F, Markhorst DG, Tinnevelt M, Todd M, Zurakowski D, Arnold JH. High-Frequency Oscillatory Ventilation in Pediatric Acute Lung Injury: A Multicenter International Experience. Crit Care Med. 2015 Dec; 43(12):2660-7.
  15. Walsh BK, Davis MD, Hunt JF, Kheir JN, Smallwood CD, Arnold JH. The effects of lung recruitment maneuvers on exhaled breath condensate pH. J Breath Res. 2015 Sep 03; 9(3):036009.
  16. Walsh BK, Rettig JS. Implementation of an inhaled nitric oxide protocol: a paradox or the perfect pair? Respir Care. 2015 May; 60(5):760-1.
  17. Smallwood CD, Walsh BK, Bechard LJ, Mehta NM. Carbon dioxide elimination and oxygen consumption in mechanically ventilated children. Respir Care. 2015 May; 60(5):718-23.
  18. Kaufman DA, Zanelli SA, Gurka MJ, Davis M, Richards CP, Walsh BK. Time outside targeted oxygen saturation range and retinopathy of prematurity. Early Hum Dev. 2014 Sep; 90 Suppl 2:S35-40.
  19. Sheeran PW, Walsh BK, Finley AM, Martin AK, Brenski AC. Management of difficult airway patients and the use of a difficult airway registry at a tertiary care pediatric hospital. Paediatr Anaesth. 2014 Aug; 24(8):819-24.
  20. Davis MD, Walsh BK, Sittig SE, Restrepo RD. AARC clinical practice guideline: blood gas analysis and hemoximetry: 2013. Respir Care. 2013 Oct; 58(10):1694-703.
  21. Walsh BK, Daigle B, DiBlasi RM, Restrepo RD. AARC Clinical Practice Guideline. Surfactant replacement therapy: 2013. Respir Care. 2013 Feb; 58(2):367-75.
  22. Davis MD, Walsh BK, Dwyer ST, Combs C, Vehse N, Paget-Brown A, Pajewski T, Hunt JF. Safety of an alkalinizing buffer designed for inhaled medications in humans. Respir Care. 2013 Jul; 58(7):1226-32.
  23. Kheir JN, Walsh BK, Smallwood CD, Rettig JS, Thompson JE, Gómez-Laberge C, Wolf GK, Arnold JH. Comparison of 2 lung recruitment strategies in children with acute lung injury. Respir Care. 2013 Aug; 58(8):1280-90.
  24. Walsh BK, Green M. Inhaled anesthetic for life-threatening bronchospasm: is it ready for prime time? Respir Care. 2012 Nov; 57(11):1982-3.
  25. Wolf GK, Gómez-Laberge C, Kheir JN, Zurakowski D, Walsh BK, Adler A, Arnold JH. Reversal of dependent lung collapse predicts response to lung recruitment in children with early acute lung injury. Pediatr Crit Care Med. 2012 Sep; 13(5):509-15.
  26. Kheir JN, Scharp LA, Borden MA, Swanson EJ, Loxley A, Reese JH, Black KJ, Velazquez LA, Thomson LM, Walsh BK, Mullen KE, Graham DA, Lawlor MW, Brugnara C, Bell DC, McGowan FX. Oxygen gas-filled microparticles provide intravenous oxygen delivery. Sci Transl Med. 2012 Jun 27; 4(140):140ra88.
  27. Restrepo RD, Walsh BK. Humidification during invasive and noninvasive mechanical ventilation: 2012. Respir Care. 2012 May; 57(5):782-8.
  28. Wolf GK, Walsh BK, Green ML, Arnold JH. Electrical activity of the diaphragm during extubation readiness testing in critically ill children. Pediatr Crit Care Med. 2011 Nov; 12(6):e220-4.
  29. Ferguson LP, Walsh BK, Munhall D, Arnold JH. A spontaneous breathing trial with pressure support overestimates readiness for extubation in children. Pediatr Crit Care Med. 2011 Nov; 12(6):e330-5.
  30. Walsh BK, Hood K, Merritt G. Pediatric airway maintenance and clearance in the acute care setting: how to stay out of trouble. Respir Care. 2011 Sep; 56(9):1424-40; discussion 1440-4.
  31. Steil GM, Eckstein OS, Caplow J, Agus MS, Walsh BK, Wong J. Non-invasive cardiac output and oxygen delivery measurement in an infant with critical anemia. J Clin Monit Comput. 2011 Apr; 25(2):113-9.
  32. Walsh BK, Gentile MA, Grenier BM. Orienting new respiratory therapists into the neonatal/pediatric environment: a survey of educators and managers. Respir Care. 2011 Aug; 56(8):1122-9.
  33. Green ML, Walsh BK, Wolf GK, Arnold JH. Electrocardiographic guidance for the placement of gastric feeding tubes: a pediatric case series. Respir Care. 2011 Apr; 56(4):467-71.
  34. Walsh BK, Crotwell DN, Restrepo RD. Capnography/Capnometry during mechanical ventilation: 2011. Respir Care. 2011 Apr; 56(4):503-9.
  35. Walsh BK, Craig N, Betit P, Thompson JE, Arnold JH. Respiratory distress associated with inadequate mechanical ventilator flow response in a neonate with congenital diaphragmatic hernia. Respir Care. 2010 Mar; 55(3):342-5.
  36. Walsh BK, Brooks TM, Grenier BM. Oxygen therapy in the neonatal care environment. Respir Care. 2009 Sep; 54(9):1193-202.
  37. Walsh BK, Mackey DJ, Pajewski T, Yu Y, Gaston BM, Hunt JF. Exhaled-breath condensate pH can be safely and continuously monitored in mechanically ventilated patients. Respir Care. 2006 Oct; 51(10):1125-31.
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