Research Overview

The unifying theme in our research is drug delivery and biomaterials. In this multidisciplinary field, the specific application is less important than the development of an approach or set of approaches. The skilled practitioner applies engineering principles, biology, and knowledge of biomaterials to achieve a given goal. While addressing specific disease states is important, the thrust of research is to create methods by which drugs can be delivered to a range of sites in a variety of circumstances, or by which materials can be developed or adapted for biomedical uses. 

About Dr. Daniel S. Kohane

Dr. Daniel S. Kohane obtained his MD and a PhD in Physiology from Boston University. He subsequently completed residencies in Pediatrics (Boston Children's Hospital) and Anesthesiology (Massachusetts general Hospital), followed by a fellowship in Pediatric Critical Care (Boston Children's Hospital). He is currently a Senior Associate in Pediatric Critical Care at Boston Children's Hospital at Harvard Medical School, where he directs the Laboratory for Biomaterials and Drug Delivery. He is also a senior associate in the laboratory of Prof. Robert Langer at the Massachusetts Institute of Technology. Focus of Research: Our research focuses on a wide range of medical problems including pain, peritoneal and other adhesions, surgical glues, vaccine vehicles, intracranial drug delivery, intra-articular drug delivery, patient-controlled drug delivery systems, antifungal surfaces, intracellular delivery of enzymes, ocular and trans-tympanic drug delivery, corneal prostheses, and others. We have employed microparticles and nanoparticles, including polymer systems, liposomes, mesoporous silicates, and others; hydrogels; and combination systems. Other interests include microfluidics, tissue engineering, and surface modification. We have applied our approach in food, beverage, and agricultural research as well. Translational Research: Most of our research is very oriented toward clinical application.

Researcher Services

Researcher Areas

  • Pain
  • Peritoneal and Other Adhesions
  • Intracranial Drug Delivery
  • Microfluidics
  • Tissue Engineering

Research Departments

Research Divisions

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Rwei AY, Wang B, Ji T, Kohane DS. Predicting the tissue depth for remote triggering of drug delivery systems. J Control Release. 2018 Jul 18; 286:55-63. View abstract
  2. McAlvin JB, Wylie RG, Ramchander K, Nguyen MT, Lok CK, Moroi M, Shomorony A, Vasilyev NV, Armstrong P, Yang J, Lieber AM, Okonkwo OS, Karnik R, Kohane DS. Antibody-modified conduits for highly selective cytokine elimination from blood. JCI Insight. 2018 Jul 12; 3(13). View abstract
  3. Yang R, Okonkwo OS, Zurakowski D, Kohane DS. Synergy between chemical permeation enhancers and drug permeation across the tympanic membrane. J Control Release. 2018 Jun 19. View abstract
  4. Rwei AY, Sherburne RT, Zurakowski D, Wang B, Kohane DS. Prolonged Duration Local Anesthesia Using Liposomal Bupivacaine Combined With Liposomal Dexamethasone and Dexmedetomidine. Anesth Analg. 2018 Apr; 126(4):1170-1175. View abstract
  5. Wang Y, Barhoumi A, Tong R, Wang W, Ji T, Deng X, Li L, Lyon SA, Reznor G, Zurakowski D, Kohane DS. BaTiO3-core Au-shell nanoparticles for photothermal therapy and bimodal imaging. Acta Biomater. 2018 May; 72:287-294. View abstract
  6. Cullion K, Santamaria CM, Zhan C, Zurakowski D, Sun T, Pemberton GL, McDannold NJ, Kohane DS. High-frequency, low-intensity ultrasound and microbubbles enhance nerve blockade. J Control Release. 2018 Apr 28; 276:150-156. View abstract
  7. Cullion K, Rwei AY, Kohane DS. Ultrasound-triggered liposomes for on-demand local anesthesia. Ther Deliv. 2018 Jan; 9(1):5-8. View abstract
  8. Liu Q, Santamaria CM, Wei T, Zhao C, Ji T, Yang T, Shomorony A, Wang BY, Kohane DS. Hollow Silica Nanoparticles Penetrate the Peripheral Nerve and Enhance the Nerve Blockade from Tetrodotoxin. Nano Lett. 2018 Jan 10; 18(1):32-37. View abstract
  9. Prieto M, Rwei AY, Alejo T, Wei T, Lopez-Franco MT, Mendoza G, Sebastian V, Kohane DS, Arruebo M. Light-Emitting Photon-Upconversion Nanoparticles in the Generation of Transdermal Reactive-Oxygen Species. ACS Appl Mater Interfaces. 2017 Dec 06; 9(48):41737-41747. View abstract
  10. Rwei AY, Wang BY, Ji T, Zhan C, Kohane DS. Enhanced Triggering of Local Anesthetic Particles by Photosensitization and Photothermal Effect Using a Common Wavelength. Nano Lett. 2017 Nov 08; 17(11):7138-7145. View abstract
  11. Rwei AY, Paris JL, Wang B, Wang W, Axon CD, Vallet-Regí M, Langer R, Kohane DS. Ultrasound-triggered local anaesthesia. Nat Biomed Eng. 2017; 1:644-653. View abstract
  12. Yang R, Wei T, Goldberg H, Wang W, Cullion K, Kohane DS. Getting Drugs Across Biological Barriers. Adv Mater. 2017 Oct; 29(37). View abstract
  13. Santamaria CM, Zhan C, McAlvin JB, Zurakowski D, Kohane DS. Tetrodotoxin, Epinephrine, and Chemical Permeation Enhancer Combinations in Peripheral Nerve Blockade. Anesth Analg. 2017 06; 124(6):1804-1812. View abstract
  14. Agulnik A, Kelly DP, Bruccoleri R, Yuskaitis C, Ebrahimi-Fakhari D, Sahin M, Burns MM, Kohane DS. Combination Clearance Therapy and Barbiturate Coma for Severe Carbamazepine Overdose. Pediatrics. 2017 May; 139(5). View abstract
  15. Kelmansky R, McAlvin BJ, Nyska A, Dohlman JC, Chiang HH, Hashimoto M, Kohane DS, Mizrahi B. Strong tissue glue with tunable elasticity. Acta Biomater. 2017 04 15; 53:93-99. View abstract
  16. Rwei AY, Zhan C, Wang B, Kohane DS. Multiply repeatable and adjustable on-demand phototriggered local anesthesia. J Control Release. 2017 04 10; 251:68-74. View abstract
  17. Zhan C, Wang W, Santamaria C, Wang B, Rwei A, Timko BP, Kohane DS. Ultrasensitive Phototriggered Local Anesthesia. Nano Lett. 2017 02 08; 17(2):660-665. View abstract
  18. Santamaria CM, Woodruff A, Yang R, Kohane DS. Drug delivery systems for prolonged duration local anesthesia. Mater Today (Kidlington). 2017 Jan-Feb; 20(1):22-31. View abstract
  19. Gusztak R, Hamilton S, Manning MJ, Lincoln P, Walsh B, Kohane D, Mehta N. 1074: SEVERITY OF HEMODYNAMIC INSTABILITY AROUND HIGH-DOSE VASOACTIVE SYRINGE CHANGES IN THE PICU. Crit Care Med. 2016 Dec; 44(12 Suppl 1):344. View abstract
  20. Zaman P, Wang J, Blau A, Wang W, Li T, Kohane DS, Loscalzo J, Zhang YY. Incorporation of heparin-binding proteins into preformed dextran sulfate-chitosan nanoparticles. Int J Nanomedicine. 2016; 11:6149-6159. View abstract
  21. Liu Q, Zhan C, Kohane DS. Phototriggered Drug Delivery Using Inorganic Nanomaterials. Bioconjug Chem. 2017 01 18; 28(1):98-104. View abstract
  22. Li M, Li L, Zhan C, Kohane DS. Core-Shell Nanostars for Multimodal Therapy and Imaging. Theranostics. 2016; 6(13):2306-2313. View abstract
  23. Yang R, Sabharwal V, Okonkwo OS, Shlykova N, Tong R, Lin LY, Wang W, Guo S, Rosowski JJ, Pelton SI, Kohane DS. Treatment of otitis media by transtympanic delivery of antibiotics. Sci Transl Med. 2016 09 14; 8(356):356ra120. View abstract
  24. Ciolino JB, Ross AE, Tulsan R, Watts AC, Wang RF, Zurakowski D, Serle JB, Kohane DS. Latanoprost-Eluting Contact Lenses in Glaucomatous Monkeys. Ophthalmology. 2016 10; 123(10):2085-92. View abstract
  25. Kohane DS. Drug delivery, biomaterials and nanomedicine: an interview with Daniel S Kohane. Future Sci OA. 2016 Sep; 2(3):FSO138. View abstract
  26. Liu Q, Wang W, Zhan C, Yang T, Kohane DS. Enhanced Precision of Nanoparticle Phototargeting in Vivo at a Safe Irradiance. Nano Lett. 2016 Jul 13; 16(7):4516-20. View abstract
  27. Liu Q, Zhan C, Barhoumi A, Wang W, Santamaria C, McAlvin JB, Kohane DS. A Supramolecular Shear-Thinning Anti-Inflammatory Steroid Hydrogel. Adv Mater. 2016 Aug; 28(31):6680-6. View abstract
  28. Guo S, Nakagawa Y, Barhoumi A, Wang W, Zhan C, Tong R, Santamaria C, Kohane DS. Extended Release of Native Drug Conjugated in Polyketal Microparticles. J Am Chem Soc. 2016 05 18; 138(19):6127-30. View abstract
  29. Salvador-Culla B, Jeong KJ, Kolovou PE, Chiang HH, Chodosh J, Dohlman CH, Kohane DS. Titanium Coating of the Boston Keratoprosthesis. Transl Vis Sci Technol. 2016 Apr; 5(2):17. View abstract
  30. Li L, Tong R, Li M, Kohane DS. Self-assembled gemcitabine-gadolinium nanoparticles for magnetic resonance imaging and cancer therapy. Acta Biomater. 2016 Mar; 33:34-9. View abstract
  31. Zhan C, Wang W, McAlvin JB, Guo S, Timko BP, Santamaria C, Kohane DS. Phototriggered Local Anesthesia. Nano Lett. 2016 Jan 13; 16(1):177-81. View abstract
  32. Rwei AY, Lee JJ, Zhan C, Liu Q, Ok MT, Shankarappa SA, Langer R, Kohane DS. Repeatable and adjustable on-demand sciatic nerve block with phototriggerable liposomes. Proc Natl Acad Sci U S A. 2015 Dec 22; 112(51):15719-24. View abstract
  33. Lim DK, Wylie RG, Langer R, Kohane DS. Selective binding of C-6 OH sulfated hyaluronic acid to the angiogenic isoform of VEGF(165). Biomaterials. 2016 Jan; 77:130-138. View abstract
  34. Tong R, Kohane DS. New Strategies in Cancer Nanomedicine. Annu Rev Pharmacol Toxicol. 2016; 56:41-57. View abstract
  35. Barhoumi A, Liu Q, Kohane DS. Ultraviolet light-mediated drug delivery: Principles, applications, and challenges. J Control Release. 2015 Dec 10; 219:31-42. View abstract
  36. Rwei AY, Wang W, Kohane DS. Photoresponsive nanoparticles for drug delivery. Nano Today. 2015 Aug 01; 10(4):451-467. View abstract
  37. Wang W, Liu Q, Zhan C, Barhoumi A, Yang T, Wylie RG, Armstrong PA, Kohane DS. Efficient Triplet-Triplet Annihilation-Based Upconversion for Nanoparticle Phototargeting. Nano Lett. 2015 Oct 14; 15(10):6332-8. View abstract
  38. Barhoumi A, Salvador-Culla B, Kohane DS. Nonlinear Optics: NIR-Triggered Drug Delivery by Collagen-Mediated Second Harmonic Generation (Adv. Healthcare Mater. 8/2015). Adv Healthc Mater. 2015 Jun; 4(8):1108. View abstract
  39. McAlvin JB, Zhan C, Dohlman JC, Kolovou PE, Salvador-Culla B, Kohane DS. Corneal Anesthesia With Site 1 Sodium Channel Blockers and Dexmedetomidine. Invest Ophthalmol Vis Sci. 2015 Jun; 56(6):3820-6. View abstract
  40. Barhoumi A, Salvador-Culla B, Kohane DS. NIR-triggered drug delivery by collagen-mediated second harmonic generation. Adv Healthc Mater. 2015 Jun 03; 4(8):1159-63. View abstract
  41. Bader AR, Li T, Wang W, Kohane DS, Loscalzo J, Zhang YY. Preparation and characterization of SDF-1a-chitosan-dextran sulfate nanoparticles. J Vis Exp. 2015 Jan 22; (95):52323. View abstract
  42. Li L, Tong R, Chu H, Wang W, Langer R, Kohane DS. Aptamer photoregulation in vivo. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17099-103. View abstract
  43. Taniguchi EV, Kalout P, Pasquale LR, Kohane DS, Ciolino JB. Clinicians' perspectives on the use of drug-eluting contact lenses for the treatment of glaucoma. Ther Deliv. 2014 Oct; 5(10):1077-83. View abstract
  44. Monteiro IP, Gabriel D, Timko BP, Hashimoto M, Karajanagi S, Tong R, Marques AP, Reis RL, Kohane DS. A two-component pre-seeded dermal-epidermal scaffold. Acta Biomater. 2014 Dec; 10(12):4928-4938. View abstract
  45. Timko BP, Kohane DS. Prospects for near-infrared technology in remotely triggered drug delivery. Expert Opin Drug Deliv. 2014 Nov; 11(11):1681-5. View abstract
  46. Barhoumi A, Wang W, Zurakowski D, Langer RS, Kohane DS. Photothermally targeted thermosensitive polymer-masked nanoparticles. Nano Lett. 2014 Jul 09; 14(7):3697-701. View abstract
  47. Jurek SC, Hirano-Kobayashi M, Chiang H, Kohane DS, Matthews BD. Prevention of ventilator-induced lung edema by inhalation of nanoparticles releasing ruthenium red. Am J Respir Cell Mol Biol. 2014 Jun; 50(6):1107-17. View abstract
  48. Kohane DS, Kohane D. Interview with Daniel Kohane. Ther Deliv. 2014 Apr; 5(4):387-9. View abstract
  49. McAlvin JB, Padera RF, Shankarappa SA, Reznor G, Kwon AH, Chiang HH, Yang J, Kohane DS. Multivesicular liposomal bupivacaine at the sciatic nerve. Biomaterials. 2014 May; 35(15):4557-64. View abstract
  50. Timko BP, Arruebo M, Shankarappa SA, McAlvin JB, Okonkwo OS, Mizrahi B, Stefanescu CF, Gomez L, Zhu J, Zhu A, Santamaria J, Langer R, Kohane DS. Near-infrared-actuated devices for remotely controlled drug delivery. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):1349-54. View abstract
  51. Hoare T, Yeo Y, Bellas E, Bruggeman JP, Kohane DS. Prevention of peritoneal adhesions using polymeric rheological blends. Acta Biomater. 2014 Mar; 10(3):1187-93. View abstract
  52. Tong R, Chiang HH, Kohane DS. Photoswitchable nanoparticles for in vivo cancer chemotherapy. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19048-53. View abstract
  53. Gabriel D, Cohen-Karni T, Huang D, Chiang HH, Kohane DS. Photoactive electrospun fibers for inducing cell death. Adv Healthc Mater. 2014 Apr; 3(4):494-9. View abstract
  54. Yin T, Bader AR, Hou TK, Maron BA, Kao DD, Qian R, Kohane DS, Handy DE, Loscalzo J, Zhang YY. SDF-1a in glycan nanoparticles exhibits full activity and reduces pulmonary hypertension in rats. Biomacromolecules. 2013 Nov 11; 14(11):4009-20. View abstract
  55. Ciolino JB, Stefanescu CF, Ross AE, Salvador-Culla B, Cortez P, Ford EM, Wymbs KA, Sprague SL, Mascoop DR, Rudina SS, Trauger SA, Cade F, Kohane DS. In vivo performance of a drug-eluting contact lens to treat glaucoma for a month. Biomaterials. 2014 Jan; 35(1):432-9. View abstract
  56. Gabriel D, Monteiro IP, Huang D, Langer R, Kohane DS. A photo-triggered layered surface coating producing reactive oxygen species. Biomaterials. 2013 Dec; 34(38):9763-9. View abstract
  57. Tian B, Shankarappa SA, Chang HH, Tong R, Kohane DS. Biodegradable mesostructured polymer membranes. Nano Lett. 2013 Sep 11; 13(9):4410-5. View abstract
  58. Lim DK, Barhoumi A, Wylie RG, Reznor G, Langer RS, Kohane DS. Enhanced photothermal effect of plasmonic nanoparticles coated with reduced graphene oxide. Nano Lett. 2013 Sep 11; 13(9):4075-9. View abstract
  59. Mizrahi B, Khoo X, Chiang HH, Sher KJ, Feldman RG, Lee JJ, Irusta S, Kohane DS. Long-lasting antifouling coating from multi-armed polymer. Langmuir. 2013 Aug 13; 29(32):10087-94. View abstract
  60. Wang L, Shankarappa SA, Tong R, Ciolino JB, Tsui JH, Chiang HH, Kohane DS. Topical drug formulations for prolonged corneal anesthesia. Cornea. 2013 Jul; 32(7):1040-5. View abstract
  61. Hashimoto M, Tong R, Kohane DS. Microdevices for nanomedicine. Mol Pharm. 2013 Jun 03; 10(6):2127-44. View abstract
  62. Mizrahi B, Shankarappa SA, Hickey JM, Dohlman JC, Timko BP, Whitehead KA, Lee JJ, Langer R, Anderson DG, Kohane DS. A Stiff Injectable Biodegradable Elastomer. Adv Funct Mater. 2013 Mar 25; 23(12):1527-1533. View abstract
  63. McAlvin JB, Reznor G, Shankarappa SA, Stefanescu CF, Kohane DS. Local toxicity from local anesthetic polymeric microparticles. Anesth Analg. 2013 Apr; 116(4):794-803. View abstract
  64. Shankarappa SA, Kohane DS. Controlled-release systems in neuropathic pain. Pain Manag. 2013 Mar; 3(2):91-3. View abstract
  65. Lee JJ, Jeong KJ, Hashimoto M, Kwon AH, Rwei A, Shankarappa SA, Tsui JH, Kohane DS. Synthetic ligand-coated magnetic nanoparticles for microfluidic bacterial separation from blood. Nano Lett. 2014 Jan 08; 14(1):1-5. View abstract
  66. Wang LY, Tong R, Kohane DS. Synthesis and proton NMR spectroscopy of intra-vesicular gamma-aminobutyric acid (GABA). Conf Proc IEEE Eng Med Biol Soc. 2013; 2013:1093-5. View abstract
  67. Heller DA, Levi Y, Pelet JM, Doloff JC, Wallas J, Pratt GW, Jiang S, Sahay G, Schroeder A, Schroeder JE, Chyan Y, Zurenko C, Querbes W, Manzano M, Kohane DS, Langer R, Anderson DG. Modular 'click-in-emulsion' bone-targeted nanogels. Adv Mater. 2013 Mar 13; 25(10):1449-54. View abstract
  68. Hashimoto M, Langer R, Kohane DS. Benchtop fabrication of microfluidic systems based on curable polymers with improved solvent compatibility. Lab Chip. 2013 Jan 21; 13(2):252-9. View abstract
  69. Khoo X, Simons EJ, Chiang HH, Hickey JM, Sabharwal V, Pelton SI, Rosowski JJ, Langer R, Kohane DS. Formulations for trans-tympanic antibiotic delivery. Biomaterials. 2013 Jan; 34(4):1281-8. View abstract
  70. Timko BP, Kohane DS. Materials to clinical devices: technologies for remotely triggered drug delivery. Clin Ther. 2012 Nov; 34(11):S25-35. View abstract
  71. Shankarappa SA, Tsui JH, Kim KN, Reznor G, Dohlman JC, Langer R, Kohane DS. Prolonged nerve blockade delays the onset of neuropathic pain. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17555-60. View abstract
  72. Cohen-Karni T, Jeong KJ, Tsui JH, Reznor G, Mustata M, Wanunu M, Graham A, Marks C, Bell DC, Langer R, Kohane DS. Nanocomposite gold-silk nanofibers. Nano Lett. 2012 Oct 10; 12(10):5403-6. View abstract
  73. Shankarappa SA, Sagie I, Tsui JH, Chiang HH, Stefanescu C, Zurakowski D, Kohane DS. Duration and local toxicity of sciatic nerve blockade with coinjected site 1 sodium-channel blockers and quaternary lidocaine derivatives. Reg Anesth Pain Med. 2012 Sep-Oct; 37(5):483-9. View abstract
  74. Tian B, Liu J, Dvir T, Jin L, Tsui JH, Qing Q, Suo Z, Langer R, Kohane DS, Lieber CM. Macroporous nanowire nanoelectronic scaffolds for synthetic tissues. Nat Mater. 2012 Nov; 11(11):986-94. View abstract
  75. Tong R, Kohane DS. Shedding light on nanomedicine. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2012 Nov-Dec; 4(6):638-62. View abstract
  76. Cohen-Karni T, Langer R, Kohane DS. The smartest materials: the future of nanoelectronics in medicine. ACS Nano. 2012 Aug 28; 6(8):6541-5. View abstract
  77. Hoare T, Young S, Lawlor MW, Kohane DS. Thermoresponsive nanogels for prolonged duration local anesthesia. Acta Biomater. 2012 Oct; 8(10):3596-605. View abstract
  78. Weldon CB, Tsui JH, Shankarappa SA, Nguyen VT, Ma M, Anderson DG, Kohane DS. Electrospun drug-eluting sutures for local anesthesia. J Control Release. 2012 Aug 10; 161(3):903-9. View abstract
  79. Gabriel D, Dvir T, Kohane DS. Delivering bioactive molecules as instructive cues to engineered tissues. Expert Opin Drug Deliv. 2012 Apr; 9(4):473-92. View abstract
  80. Tong R, Hemmati HD, Langer R, Kohane DS. Photoswitchable nanoparticles for triggered tissue penetration and drug delivery. J Am Chem Soc. 2012 May 30; 134(21):8848-55. View abstract
  81. Timko BP, Kohane DS. Injectable scaffolds achieve sustained siRNA release for tissue repair. Nanomedicine (Lond). 2012 Mar; 7(3):315-6. View abstract
  82. Timko BP, Kohane DS. External electric fields trigger drug release from new hydrogel formulation. Nanomedicine (Lond). 2012 Mar; 7(3):316. View abstract
  83. Timko BP, Kohane DS. Novel resonating nanowire arrays function as highly sensitive biosensors. Nanomedicine (Lond). 2012 Mar; 7(3):315. View abstract
  84. Shichor I, Shomron N, Lawlor MW, Bae SA, Zoldan J, Langer R, Kohane DS. Toxicogenomic analysis of a sustained release local anesthetic delivery system. Biomaterials. 2012 May; 33(13):3586-93. View abstract
  85. Epstein-Barash H, Stefanescu CF, Kohane DS. An in situ cross-linking hybrid hydrogel for controlled release of proteins. Acta Biomater. 2012 May; 8(5):1703-9. View abstract
  86. Hoare T, Sivakumaran D, Stefanescu CF, Lawlor MW, Kohane DS. Nanogel scavengers for drugs: local anesthetic uptake by thermoresponsive nanogels. Acta Biomater. 2012 Apr; 8(4):1450-8. View abstract
  87. Dvir T, Timko BP, Brigham MD, Naik SR, Karajanagi SS, Levy O, Jin H, Parker KK, Langer R, Kohane DS. Nanowired three-dimensional cardiac patches. Nat Nanotechnol. 2011 Sep 25; 6(11):720-5. View abstract
  88. Wang L, Jeong KJ, Chiang HH, Zurakowski D, Behlau I, Chodosh J, Dohlman CH, Langer R, Kohane DS. Hydroxyapatite for keratoprosthesis biointegration. Invest Ophthalmol Vis Sci. 2011 Sep 22; 52(10):7392-9. View abstract
  89. Dvir T, Bauer M, Schroeder A, Tsui JH, Anderson DG, Langer R, Liao R, Kohane DS. Nanoparticles targeting the infarcted heart. Nano Lett. 2011 Oct 12; 11(10):4411-4. View abstract
  90. Malavia NK, Zurakowski D, Schroeder A, Princiotto AM, Laury AR, Barash HE, Sodroski J, Langer R, Madani N, Kohane DS. Liposomes for HIV prophylaxis. Biomaterials. 2011 Nov; 32(33):8663-8. View abstract
  91. Ciolino JB, Hudson SP, Mobbs AN, Hoare TR, Iwata NG, Fink GR, Kohane DS. A prototype antifungal contact lens. Invest Ophthalmol Vis Sci. 2011 Aug 09; 52(9):6286-91. View abstract
  92. Mizrahi B, Irusta S, McKenna M, Stefanescu C, Yedidsion L, Myint M, Langer R, Kohane DS. Microgels for efficient protein purification. Adv Mater. 2011 Sep 22; 23(36):H258-62. View abstract
  93. Jeong KJ, Kohane DS. Surface modification and drug delivery for biointegration. Ther Deliv. 2011 Jun; 2(6):737-52. View abstract
  94. Mizrahi B, Stefanescu CF, Yang C, Lawlor MW, Ko D, Langer R, Kohane DS. Elasticity and safety of alkoxyethyl cyanoacrylate tissue adhesives. Acta Biomater. 2011 Aug; 7(8):3150-7. View abstract
  95. Weldon C, Tian B, Kohane DS. Nanotechnology for surgeons. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011 May-Jun; 3(3):223-8. View abstract
  96. Hoare T, Timko BP, Santamaria J, Goya GF, Irusta S, Lau S, Stefanescu CF, Lin D, Langer R, Kohane DS. Magnetically triggered nanocomposite membranes: a versatile platform for triggered drug release. Nano Lett. 2011 Mar 09; 11(3):1395-400. View abstract
  97. Kohane DS, Langer R. Drug delivery and translation. Drug Deliv Transl Res. 2011 Feb; 1(1):4-6. View abstract
  98. Dvir T, Timko BP, Kohane DS, Langer R. Nanotechnological strategies for engineering complex tissues. Nat Nanotechnol. 2011 Jan; 6(1):13-22. View abstract
  99. Timko BP, Dvir T, Kohane DS. Remotely triggerable drug delivery systems. Adv Mater. 2010 Nov 24; 22(44):4925-43. View abstract
  100. Yang F, Cho SW, Son SM, Hudson SP, Bogatyrev S, Keung L, Kohane DS, Langer R, Anderson DG. Combinatorial extracellular matrices for human embryonic stem cell differentiation in 3D. Biomacromolecules. 2010 Aug 09; 11(8):1909-14. View abstract
  101. Epstein-Barash H, Orbey G, Polat BE, Ewoldt RH, Feshitan J, Langer R, Borden MA, Kohane DS. A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug delivery. Biomaterials. 2010 Jul; 31(19):5208-17. View abstract
  102. Sagie I, Kohane DS. Prolonged sensory-selective nerve blockade. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3740-5. View abstract
  103. Hoare T, Bellas E, Zurakowski D, Kohane DS. Rheological blends for drug delivery. II. Prolongation of nerve blockade, biocompatibility, and in vitro-in vivo correlations. J Biomed Mater Res A. 2010 Feb; 92(2):586-95. View abstract
  104. Hoare T, Zurakowski D, Langer R, Kohane DS. Rheological blends for drug delivery. I. Characterization in vitro. J Biomed Mater Res A. 2010 Feb; 92(2):575-85. View abstract
  105. Dvir T, Banghart MR, Timko BP, Langer R, Kohane DS. Photo-targeted nanoparticles. Nano Lett. 2010 Jan; 10(1):250-4. View abstract
  106. Hudson SP, Langer R, Fink GR, Kohane DS. Injectable in situ cross-linking hydrogels for local antifungal therapy. Biomaterials. 2010 Feb; 31(6):1444-52. View abstract
  107. George PM, Saigal R, Lawlor MW, Moore MJ, LaVan DA, Marini RP, Selig M, Makhni M, Burdick JA, Langer R, Kohane DS. Three-dimensional conductive constructs for nerve regeneration. J Biomed Mater Res A. 2009 Nov; 91(2):519-27. View abstract
  108. Hoare T, Santamaria J, Goya GF, Irusta S, Lin D, Lau S, Padera R, Langer R, Kohane DS. A magnetically triggered composite membrane for on-demand drug delivery. Nano Lett. 2009 Oct; 9(10):3651-7. View abstract
  109. Xu Q, Hashimoto M, Dang TT, Hoare T, Kohane DS, Whitesides GM, Langer R, Anderson DG. Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flow-focusing device for controlled drug delivery. Small. 2009 Jul; 5(13):1575-81. View abstract
  110. Ciolino JB, Dohlman CH, Kohane DS. Contact lenses for drug delivery. Semin Ophthalmol. 2009 May-Jun; 24(3):156-60. View abstract
  111. Epstein-Barash H, Shichor I, Kwon AH, Hall S, Lawlor MW, Langer R, Kohane DS. Prolonged duration local anesthesia with minimal toxicity. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):7125-30. View abstract
  112. Ciolino JB, Hoare TR, Iwata NG, Behlau I, Dohlman CH, Langer R, Kohane DS. A drug-eluting contact lens. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3346-52. View abstract
  113. Simons EJ, Bellas E, Lawlor MW, Kohane DS. Effect of chemical permeation enhancers on nerve blockade. Mol Pharm. 2009 Jan-Feb; 6(1):265-73. View abstract
  114. Xu P, Gullotti E, Tong L, Highley CB, Errabelli DR, Hasan T, Cheng JX, Kohane DS, Yeo Y. Intracellular drug delivery by poly(lactic-co-glycolic acid) nanoparticles, revisited. Mol Pharm. 2009 Jan-Feb; 6(1):190-201. View abstract
  115. Domnina YA, Yeo Y, Tse JY, Bellas E, Kohane DS. Spray-dried lipid-hyaluronan-polymethacrylate microparticles for drug delivery in the peritoneum. J Biomed Mater Res A. 2008 Dec 01; 87(3):825-31. View abstract
  116. Hudson SP, Padera RF, Langer R, Kohane DS. The biocompatibility of mesoporous silicates. Biomaterials. 2008 Oct; 29(30):4045-55. View abstract
  117. Tsifansky MD, Yeo Y, Evgenov OV, Bellas E, Benjamin J, Kohane DS. Microparticles for inhalational delivery of antipseudomonal antibiotics. AAPS J. 2008 Jun; 10(2):254-60. View abstract
  118. Padera R, Bellas E, Tse JY, Hao D, Kohane DS. Local myotoxicity from sustained release of bupivacaine from microparticles. Anesthesiology. 2008 May; 108(5):921-8. View abstract
  119. Kohane DS, Langer R. Polymeric biomaterials in tissue engineering. Pediatr Res. 2008 May; 63(5):487-91. View abstract
  120. Evgenov OV, Kohane DS, Bloch KD, Stasch JP, Volpato GP, Bellas E, Evgenov NV, Buys ES, Gnoth MJ, Graveline AR, Liu R, Hess DR, Langer R, Zapol WM. Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation. Am J Respir Crit Care Med. 2007 Dec 01; 176(11):1138-45. View abstract
  121. Zumbuehl A, Ferreira L, Kuhn D, Astashkina A, Long L, Yeo Y, Iaconis T, Ghannoum M, Fink GR, Langer R, Kohane DS. Antifungal hydrogels. Proc Natl Acad Sci U S A. 2007 Aug 07; 104(32):12994-8. View abstract
  122. Yeo Y, Kohane DS. Polymers in the prevention of peritoneal adhesions. Eur J Pharm Biopharm. 2008 Jan; 68(1):57-66. View abstract
  123. Yeo Y, Adil M, Bellas E, Astashkina A, Chaudhary N, Kohane DS. Prevention of peritoneal adhesions with an in situ cross-linkable hyaluronan hydrogel delivering budesonide. J Control Release. 2007 Jul 31; 120(3):178-85. View abstract
  124. Yeo Y, Bellas E, Highley CB, Langer R, Kohane DS. Peritoneal adhesion prevention with an in situ cross-linkable hyaluronan gel containing tissue-type plasminogen activator in a rabbit repeated-injury model. Biomaterials. 2007 Sep; 28(25):3704-13. View abstract
  125. Yeo Y, Ito T, Bellas E, Highley CB, Marini R, Kohane DS. In situ cross-linkable hyaluronan hydrogels containing polymeric nanoparticles for preventing postsurgical adhesions. Ann Surg. 2007 May; 245(5):819-24. View abstract
  126. Yeo Y, Geng W, Ito T, Kohane DS, Burdick JA, Radisic M. Photocrosslinkable hydrogel for myocyte cell culture and injection. J Biomed Mater Res B Appl Biomater. 2007 May; 81(2):312-22. View abstract
  127. Ito T, Yeo Y, Highley CB, Bellas E, Kohane DS. Dextran-based in situ cross-linked injectable hydrogels to prevent peritoneal adhesions. Biomaterials. 2007 Aug; 28(23):3418-26. View abstract
  128. Kohane DS. Microparticles and nanoparticles for drug delivery. Biotechnol Bioeng. 2007 Feb 01; 96(2):203-9. View abstract
  129. Ito T, Fraser IP, Yeo Y, Highley CB, Bellas E, Kohane DS. Anti-inflammatory function of an in situ cross-linkable conjugate hydrogel of hyaluronic acid and dexamethasone. Biomaterials. 2007 Apr; 28(10):1778-86. View abstract
  130. Padera RF, Tse JY, Bellas E, Kohane DS. Tetrodotoxin for prolonged local anesthesia with minimal myotoxicity. Muscle Nerve. 2006 Dec; 34(6):747-53. View abstract
  131. Jia X, Yeo Y, Clifton RJ, Jiao T, Kohane DS, Kobler JB, Zeitels SM, Langer R. Hyaluronic acid-based microgels and microgel networks for vocal fold regeneration. Biomacromolecules. 2006 Dec; 7(12):3336-44. View abstract
  132. Ito T, Yeo Y, Highley CB, Bellas E, Benitez CA, Kohane DS. The prevention of peritoneal adhesions by in situ cross-linking hydrogels of hyaluronic acid and cellulose derivatives. Biomaterials. 2007 Feb; 28(6):975-83. View abstract
  133. Yeo Y, Burdick JA, Highley CB, Marini R, Langer R, Kohane DS. Peritoneal application of chitosan and UV-cross-linkable chitosan. J Biomed Mater Res A. 2006 Sep 15; 78(4):668-75. View abstract
  134. Fukuda J, Khademhosseini A, Yeo Y, Yang X, Yeh J, Eng G, Blumling J, Wang CF, Kohane DS, Langer R. Micromolding of photocrosslinkable chitosan hydrogel for spheroid microarray and co-cultures. Biomaterials. 2006 Oct; 27(30):5259-67. View abstract
  135. Yeo Y, Highley CB, Bellas E, Ito T, Marini R, Langer R, Kohane DS. In situ cross-linkable hyaluronic acid hydrogels prevent post-operative abdominal adhesions in a rabbit model. Biomaterials. 2006 Sep; 27(27):4698-705. View abstract
  136. Karp JM, Yeo Y, Geng W, Cannizarro C, Yan K, Kohane DS, Vunjak-Novakovic G, Langer RS, Radisic M. A photolithographic method to create cellular micropatterns. Biomaterials. 2006 Sep; 27(27):4755-64. View abstract
  137. Kohane DS, Tse JY, Yeo Y, Padera R, Shubina M, Langer R. Biodegradable polymeric microspheres and nanospheres for drug delivery in the peritoneum. J Biomed Mater Res A. 2006 May; 77(2):351-61. View abstract
  138. Barnet CS, Louis DN, Kohane DS. Tissue injury from tricyclic antidepressants used as local anesthetics. Anesth Analg. 2005 Dec; 101(6):1838-43. View abstract
  139. Colombo G, Padera R, Langer R, Kohane DS. Prolonged duration local anesthesia with lipid-protein-sugar particles containing bupivacaine and dexamethasone. J Biomed Mater Res A. 2005 Nov 01; 75(2):458-64. View abstract
  140. Yeo Y, Bellas E, Firestone W, Langer R, Kohane DS. Complex coacervates for thermally sensitive controlled release of flavor compounds. J Agric Food Chem. 2005 Sep 21; 53(19):7518-25. View abstract
  141. Levenberg S, Rouwkema J, Macdonald M, Garfein ES, Kohane DS, Darland DC, Marini R, van Blitterswijk CA, Mulligan RC, D'Amore PA, Langer R. Engineering vascularized skeletal muscle tissue. Nat Biotechnol. 2005 Jul; 23(7):879-84. View abstract
  142. Kohane DS, Ingelfinger JR, Nimkin K, Wu CL. Case records of the Massachusetts General Hospital. Case 16-2005. A nine-year-old girl with headaches and hypertension. N Engl J Med. 2005 May 26; 352(21):2223-31. View abstract
  143. LaVan DA, Padera RF, Friedmann TA, Sullivan JP, Langer R, Kohane DS. In vivo evaluation of tetrahedral amorphous carbon. Biomaterials. 2005 Feb; 26(5):465-73. View abstract
  144. Chen PC, Park YJ, Chang LC, Kohane DS, Bartlett RH, Langer R, Yang VC. Injectable microparticle-gel system for prolonged and localized lidocaine release. I. In vitro characterization. J Biomed Mater Res A. 2004 Sep 01; 70(3):412-9. View abstract
  145. Chen PC, Kohane DS, Park YJ, Bartlett RH, Langer R, Yang VC. Injectable microparticle-gel system for prolonged and localized lidocaine release. II. In vivo anesthetic effects. J Biomed Mater Res A. 2004 Sep 01; 70(3):459-66. View abstract
  146. Haining WN, Anderson DG, Little SR, von Bergwelt-Baildon MS, Cardoso AA, Alves P, Kosmatopoulos K, Nadler LM, Langer R, Kohane DS, von Berwelt-Baildon MS. pH-triggered microparticles for peptide vaccination. J Immunol. 2004 Aug 15; 173(4):2578-85. View abstract
  147. Jia X, Colombo G, Padera R, Langer R, Kohane DS. Prolongation of sciatic nerve blockade by in situ cross-linked hyaluronic acid. Biomaterials. 2004 Aug; 25(19):4797-804. View abstract
  148. Barnet CS, Tse JY, Kohane DS. Site 1 sodium channel blockers prolong the duration of sciatic nerve blockade from tricyclic antidepressants. Pain. 2004 Jul; 110(1-2):432-8. View abstract
  149. Thomas TT, Kohane DS, Wang A, Langer R. Microparticulate formulations for the controlled release of interleukin-2. J Pharm Sci. 2004 May; 93(5):1100-9. View abstract
  150. Colombo G, Langer R, Kohane DS. Effect of excipient composition on the biocompatibility of bupivacaine-containing microparticles at the sciatic nerve. J Biomed Mater Res A. 2004 Mar 15; 68(4):651-9. View abstract
  151. Kohane DS, Anderson DG, Yu C, Langer R. pH-triggered release of macromolecules from spray-dried polymethacrylate microparticles. Pharm Res. 2003 Oct; 20(10):1533-8. View abstract
  152. Fauza DO, Kohane DS, Beeuwkes EB, Clayton N, Maher TJ. Local anesthetics inhibit uterine activity in vitro. Possible application on preterm labor prevention and treatment. Fetal Diagn Ther. 2003 Sep-Oct; 18(5):292-6. View abstract
  153. Kohane DS, Smith SE, Louis DN, Colombo G, Ghoroghchian P, Hunfeld NG, Berde CB, Langer R. Prolonged duration local anesthesia from tetrodotoxin-enhanced local anesthetic microspheres. Pain. 2003 Jul; 104(1-2):415-21. View abstract
  154. Kohane DS, Holmes GL, Chau Y, Zurakowski D, Langer R, Cha BH. Effectiveness of muscimol-containing microparticles against pilocarpine-induced focal seizures. Epilepsia. 2002 Dec; 43(12):1462-8. View abstract
  155. Kohane DS, Plesnila N, Thomas SS, Le D, Langer R, Moskowitz MA. Lipid-sugar particles for intracranial drug delivery: safety and biocompatibility. Brain Res. 2002 Aug 16; 946(2):206-13. View abstract
  156. Kohane DS, Lipp M, Kinney RC, Anthony DC, Louis DN, Lotan N, Langer R. Biocompatibility of lipid-protein-sugar particles containing bupivacaine in the epineurium. J Biomed Mater Res. 2002 Mar 05; 59(3):450-9. View abstract
  157. Plesnila N, Zinkel S, Le DA, Amin-Hanjani S, Wu Y, Qiu J, Chiarugi A, Thomas SS, Kohane DS, Korsmeyer SJ, Moskowitz MA. BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia. Proc Natl Acad Sci U S A. 2001 Dec 18; 98(26):15318-23. View abstract
  158. Kohane DS, Lu NT, Crosa GA, Kuang Y, Berde CB. High concentrations of adrenergic antagonists prolong sciatic nerve blockade by tetrodotoxin. Acta Anaesthesiol Scand. 2001 Aug; 45(7):899-905. View abstract
  159. Kohane DS, Lu NT, Cairns BE, Berde CB. Effects of adrenergic agonists and antagonists on tetrodotoxin-induced nerve block. Reg Anesth Pain Med. 2001 May-Jun; 26(3):239-45. View abstract
  160. Kohane DS, Lipp M, Kinney RC, Lotan N, Langer R. Sciatic nerve blockade with lipid-protein-sugar particles containing bupivacaine. Pharm Res. 2000 Oct; 17(10):1243-9. View abstract
  161. Kohane DS, Lu NT, Gökgöl-Kline AC, Shubina M, Kuang Y, Hall S, Strichartz GR, Berde CB. The local anesthetic properties and toxicity of saxitonin homologues for rat sciatic nerve block in vivo. Reg Anesth Pain Med. 2000 Jan-Feb; 25(1):52-9. View abstract
  162. Kohane DS, Kuang Y, Lu NT, Langer R, Strichartz GR, Berde CB. Vanilloid receptor agonists potentiate the in vivo local anesthetic activity of percutaneously injected site 1 sodium channel blockers. Anesthesiology. 1999 Feb; 90(2):524-34. View abstract
  163. Kohane DS, Sankar WN, Shubina M, Hu D, Rifai N, Berde CB. Sciatic nerve blockade in infant, adolescent, and adult rats: a comparison of ropivacaine with bupivacaine. Anesthesiology. 1998 Nov; 89(5):1199-208; discussion 10A. View abstract
  164. Kohane DS, Yieh J, Lu NT, Langer R, Strichartz GR, Berde CB. A re-examination of tetrodotoxin for prolonged duration local anesthesia. Anesthesiology. 1998 Jul; 89(1):119-31. View abstract
  165. Kohane DS, Sarzani R, Schwartz JH, Chobanian AV, Brecher P. Stress-induced proteins in aortic smooth muscle cells and aorta of hypertensive rats. Am J Physiol. 1990 Jun; 258(6 Pt 2):H1699-705. View abstract