Diane Stafford

Diane E.J. Stafford, MD

Associate Physician, Fellowship Program Director

Assistant Professor of Pediatrics, Harvard Medical School

    Contact: 617-355-7476
  • Fax: 617-730-0194

Medical Services


  • Puberty (Precocious and Delayed)
  • Endocrinology


  • Endocrinology
  • Medicine


  • English


  • Diabetes Program
  • Endocrinology Program
To schedule an appointment: Call 617-355-7476 or Request an Appointment

Experience and Education



Harvard College, 1986

Boston, MA

Medical School

University of Connecticut School of Medicine, 1992

Farmington, CT

Internship, Pediatrics

Lucile Salter Packard Children's Hospital, 1993

Palo Alto, CA

Pediatrics Residency

Lucile Salter Packard Children's Hospital, 1995

Palo Alto, CA

Pediatric Endocrinology Fellowship

Boston Children's Hospital, 1999

Boston, MA


Professional History

Dr. Stafford completed her training in Pediatric Endocrinology at Boston Children's Hospital and has remained on staff since that time. She specializes in the care of children with precocious and delayed puberty and has become one of the country's experts in the care of endocrinopathy in children with Prader Willi Syndrome.


Publications powered by Harvard Catalyst Profiles
  1. McCandless SE, Yanovski JA, Miller J, Fu C, Bird LM, Salehi P, Chan CL, Stafford D, Abuzzahab MJ, Viskochil D, Barlow SE, Angulo M, Myers SE, Whitman BY, Styne D, Roof E, Dykens EM, Scheimann AO, Malloy J, Zhuang D, Taylor K, Hughes TE, Kim DD, Butler MG. Effects of MetAP2 inhibition on hyperphagia and body weight in Prader-Willi syndrome: A randomized, double-blind, placebo-controlled trial. Diabetes Obes Metab. 2017 Dec; 19(12):1751-1761.
  2. Shoffstall AJ, Gaebler JA, Kreher NC, Niecko T, Douglas D, Strong TV, Miller JL, Stafford DE, Butler MG. The High Direct Medical Costs of Prader-Willi Syndrome. J Pediatr. 2016 Aug; 175:137-43.
  3. Miloslavsky EM, Boyer D, Winn AS, Stafford DE, McSparron JI. Fellows as Teachers: Raising the Educational Bar. Ann Am Thorac Soc. 2016 Apr; 13(4):465-8.
  4. Bravo GL, Poje AB, Perissinotti I, Marcondes BF, Villamar MF, Manzardo AM, Luque L, LePage JF, Stafford D, Fregni F, Butler MG. Transcranial direct current stimulation reduces food-craving and measures of hyperphagia behavior in participants with Prader-Willi syndrome. Am J Med Genet B Neuropsychiatr Genet. 2016 Mar; 171B(2):266-75.
  5. Engebretsen L, Steffen K, Bahr R, Broderick C, Dvorak J, Janarv PM, Johnson A, Leglise M, Mamisch TC, McKay D, Micheli L, Schamasch P, Singh GD, Stafford DE, Steen H. The International Olympic Committee Consensus statement on age determination in high-level young athletes. Br J Sports Med. 2010 Jun; 44(7):476-84.
  6. Carswell J, Stafford D. Normal Physical Growth and Development. Adolescent Health Care: A Practical Guide, ed. Neinstein L, Gordon C, Katzman D, Rosen D, Woods E. 2008; 3-26.
  7. Stafford DE. Altered hypothalamic-pituitary-ovarian axis function in young female athletes: implications and recommendations for management. Treat Endocrinol. 2005; 4(3):147-54.
  8. Stafford, D. Delayed Puberty. Clinical Management of Pediatric Endocrine Disorders, ed. Radovick S, MacGillivray M H. 2003; 383-397.
  9. Stafford DE, Gordon CM. Adolescent androgen abnormalities. Curr Opin Obstet Gynecol. 2002 Oct; 14(5):445-51.
  10. Ferry R J, Kelley A, Grimberg A, Koo-McCoy S, Shapiro M J, Fellows K E, Glaser B, Aguilar-Bryan L, Stafford D, Stanley, C A . Calcium-stimulated insulin secretion in diffuse and focal forms of congenital hyperinsulinism. J Peds. 2002; 137(2):239-246.
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  12. Wolfe A, Kim HH, Tobet S, Stafford DE, Radovick S. Identification of a discrete promoter region of the human GnRH gene that is sufficient for directing neuron-specific expression: a role for POU homeodomain transcription factors. Mol Endocrinol. 2002 Mar; 16(3):435-49.
  13. Grimberg A, Ferry RJ, Kelly A, Koo-McCoy S, Polonsky K, Glaser B, Permutt MA, Aguilar-Bryan L, Stafford D, Thornton PS, Baker L, Stanley CA. Dysregulation of insulin secretion in children with congenital hyperinsulinism due to sulfonylurea receptor mutations. Diabetes. 2001 Feb; 50(2):322-8.
  14. Ferry RJ, Kelly A, Grimberg A, Koo-McCoy S, Shapiro MJ, Fellows KE, Glaser B, Aguilar-Bryan L, Stafford DE, Stanley CA. Calcium-stimulated insulin secretion in diffuse and focal forms of congenital hyperinsulinism. J Pediatr. 2000 Aug; 137(2):239-46.
  15. Radovick S, Kim H, Stafford D, Wolfe A, Zakaria M. Regulation of gonadotropin-releasing hormone (GnRH) gene expression. Current Opinion in Endocrinology and Diabetes. 2000; 7(3).
  16. Radovick S, Kim H, Stafford D, Wolfe A, Zakaria M. Transcriptional development of the Hypothalamic-Pituitary-Gonadal Axis. Developmental Endocrinology: From Research to Clinical Practice, ed. Eugster E, Pescovitz O. 2000; 243-260.
  17. Stafford D, Wolfe A, Radovick S. Isolation of a novel transcription factor regulating GnRH gene expression. Pediatric Academic Societies Annual Meeting, San Francisco, CA. 1999; Abstract #567.
  18. Stafford D, Wolfe A, Radovick S. Developmental regulation of gonadotropin-releasing hormone (GnRH) gene expression: differentially expressed cDNAs in GnRH-secreting cell lines. 80th Annual Meeting, Endocrine Society, New Orleans, LA. 1998; Abstract #OR5-4.
  19. Wolfe A, Stafford D, Radovick S. Cell-specific expression and regulation of the GnRH gene. 80th Annual Meeting, Endocrine Society, New Orleans, LA. 1998; Abstract #S31-2.
To schedule an appointment: Call 617-355-7476 or Request an Appointment


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