I find that forming a diagnostic and therapeutic alliance with parents can really positively impact the lives of patients and their families.

EDUCATION

Medical School

  • Faculty of Medicine, Catholic University of Leuven , 2002 , Leuven , Belgium

Residency

Adult Neurology
  • VU University Medical Center Amsterdam , 2003 , Amsterdam , Netherlands

Residency

Adult Neurology
  • Haga Teaching Hospital , 2006 , Houten , Netherlands

Fellowship

Epilepsy & Clinical Neurophysiology
  • Boston Children's Hospital , 2007 , Boston , MA

Residency

Child Neurology
  • Boston Children's Hospital , 2010 , Boston , MA

Internship

Pediatrics
  • Boston Combined Residency Program (BCRP) , 2011 , Boston , MA

Fellowship

Neuroimaging at Neurology (ABPN Neuroscience Track)
  • Boston Children's Hospital , 2012 , Boston , MA

Philosophy of Care

It is amazing that science can be applied to humans, so it is less abstract than mathematics or physics. But it is exactly the clinical application of novel technologies and innovations that can drive patient care forward and change the field.

Clinically, I am amazed by how hard work and a sustained effort in care can make a difference, not on a group level, but for individual patients. I believe strongly in “putting up a good fight”, as it often pays off. In that, I find that forming a diagnostic and therapeutic alliance with parents, and if needed with colleagues, can really positively impact the lives of patients and their families.

PROFESSIONAL HISTORY

I was trained as an adult neurologist, a child neurologist and clinical neurophysiologist, and have expertise in EEG signal processing, advanced neuroimaging and their clinical application to patients.

Throughout my career I have operated on the boundary between clinical care and cutting edge novel technologies. For children undergoing epilepsy surgery, we provide tailored imaging and EEG solutions for specific clinical problems, to optimize the chances of successful surgery and minimize surgical injury to functional areas. These innovations include the clinical application of patient-specific DTI tractography, 3D-renderings of the subdural electrode grids on the MRI brain surface, quantitative validation of the use of EEG during the Wada test, novel approaches to electrical source analysis.

I am the dedicated epileptologist in the multidisciplinary TSC program at Boston Children's Hospital, and TSC forms a major research focus. We have described an altered microstructural integrity in autism, suggesting the use of DTI as a biomarker for neurological outcome in TSC. Next, using EEG functional connectivity measures, we found alterations of brain network properties common to both idiopathic and TSC-related autism. More recently, we have described that tubers are neither static nor discrete over time.

CERTIFICATIONS

  • American Board of Psychiatry and Neurology, Child and Adolescent Neurology
  • American Board of Psychiatry and Neurology, Epilepsy
  • American Board of Clinical Neurophysiology

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. van der Poest Clement EA, Sahin M, Peters JM. Vigabatrin for Epileptic Spasms and Tonic Seizures in Tuberous Sclerosis Complex. J Child Neurol. 2018 Jul; 33(8):519-524. View abstract
  2. Winawer MR, Griffin NG, Samanamud J, Baugh EH, Rathakrishnan D, Ramalingam S, Zagzag D, Schevon CA, Dugan P, Hegde M, Sheth SA, McKhann GM, Doyle WK, Grant GA, Porter BE, Mikati MA, Muh CR, Malone CD, Bergin AMR, Peters JM, McBrian DK, Pack AM, Akman CI, LaCoursiere CM, Keever KM, Madsen JR, Yang E, Lidov HGW, Shain C, Allen AS, Canoll PD, Crino PB, Poduri AH, Heinzen EL. Somatic SLC35A2 variants in the brain are associated with intractable neocortical epilepsy. Ann Neurol. 2018 Apr 20. View abstract
  3. Harini C, Sharda S, Bergin AM, Poduri A, Yuskaitis CJ, Peters JM, Rakesh K, Kapur K, Pearl PL, Prabhu SP. Detailed Magnetic Resonance Imaging (MRI) Analysis in Infantile Spasms. J Child Neurol. 2018 May; 33(6):405-412. View abstract
  4. Benjamin CFA, Li AX, Blumenfeld H, Constable RT, Alkawadri R, Bickel S, Helmstaedter C, Meletti S, Bronen R, Warfield SK, Peters JM, Reutens D, Polczynska M, Spencer DD, Hirsch LJ. Presurgical language fMRI: Clinical practices and patient outcomes in epilepsy surgical planning. Hum Brain Mapp. 2018 Mar 12. View abstract
  5. Vega C, Sánchez Fernández I, Peters J, Thome-Souza MS, Jackson M, Takeoka M, Wilkening GN, Pearl PL, Chapman K, Loddenkemper T. Response to clobazam in continuous spike-wave during sleep. Dev Med Child Neurol. 2018 03; 60(3):283-289. View abstract
  6. Davis PE, Filip-Dhima R, Sideridis G, Peters JM, Au KS, Northrup H, Bebin EM, Wu JY, Krueger D, Sahin M. Presentation and Diagnosis of Tuberous Sclerosis Complex in Infants. Pediatrics. 2017 Dec; 140(6). View abstract
  7. Hyde DE, Tomas-Fernandez X, Stone SS, Peters J, Warfield SK. Localization of stereo-electroencephalography signals using a finite difference complete electrode model. Conf Proc IEEE Eng Med Biol Soc. 2017 07; 2017:3600-3603. View abstract
  8. Guerriero RM, Patel AA, Walsh B, Baumer FM, Shah AS, Peters JM, Rodan LH, Agrawal PB, Pearl PL, Takeoka M. Systemic Manifestations in Pyridox(am)ine 5'-Phosphate Oxidase Deficiency. Pediatr Neurol. 2017 Nov; 76:47-53. View abstract
  9. Sánchez Fernández I, Peters JM, Akhondi-Asl A, Klehm J, Warfield SK, Loddenkemper T. Reduced thalamic volume in patients with Electrical Status Epilepticus in Sleep. Epilepsy Res. 2017 02; 130:74-80. View abstract
  10. Erem B, Hyde DE, Peters JM, Duffy FH, Warfield SK. Dynamic Electrical Source Imaging (DESI) of Seizures and Interictal Epileptic Discharges Without Ensemble Averaging. IEEE Trans Med Imaging. 2017 01; 36(1):98-110. View abstract
  11. Erem B, Martinez Orellana R, Hyde DE, Peters JM, Duffy FH, Stovicek P, Warfield SK, MacLeod RS, Tadmor G, Brooks DH. Extensions to a manifold learning framework for time-series analysis on dynamic manifolds in bioelectric signals. Phys Rev E. 2016 04; 93(4):042218. View abstract
  12. Patel AA, Ciccone O, Njau A, Shanungu S, Grollnek AK, Fredrick F, Hodgeman R, Sideridis GD, Kapur K, Harini C, Kija E, Peters JM. A pediatric epilepsy diagnostic tool for use in resource-limited settings: A pilot study. Epilepsy Behav. 2016 06; 59:57-61. View abstract
  13. Baumer FM, Peters JM, El Achkar CM, Pearl PL. SCN2A-Related Early-Onset Epileptic Encephalopathy Responsive to Phenobarbital. J Pediatr Epilepsy. 2016 Mar; 5(1):42-46. View abstract
  14. Taquet M, Scherrer B, Boumal N, Peters JM, Macq B, Warfield SK. Improved fidelity of brain microstructure mapping from single-shell diffusion MRI. Med Image Anal. 2015 Dec; 26(1):268-86. View abstract
  15. Peters JM, Prohl AK, Tomas-Fernandez XK, Taquet M, Scherrer B, Prabhu SP, Lidov HG, Singh JM, Jansen FE, Braun KP, Sahin M, Warfield SK, Stamm A. Tubers are neither static nor discrete: Evidence from serial diffusion tensor imaging. Neurology. 2015 Nov 03; 85(18):1536-45. View abstract
  16. Wu JY, Peters JM, Goyal M, Krueger D, Sahin M, Northrup H, Au KS, Cutter G, Bebin EM. Clinical Electroencephalographic Biomarker for Impending Epilepsy in Asymptomatic Tuberous Sclerosis Complex Infants. Pediatr Neurol. 2016 Jan; 54:29-34. View abstract
  17. Davis PE, Peters JM, Krueger DA, Sahin M. Tuberous Sclerosis: A New Frontier in Targeted Treatment of Autism. Neurotherapeutics. 2015 Jul; 12(3):572-83. View abstract
  18. Walsh BH, Baumer FM, Bernson-Leung ME, Lerou P, Peters JM. Teaching video neuroimages: nonepileptic myoclonus in a neonate following severe hypoxic-ischemic injury. Neurology. 2015 Mar 24; 84(12):e90. View abstract
  19. Im K, Ahtam B, Haehn D, Peters JM, Warfield SK, Sahin M, Ellen Grant P. Altered Structural Brain Networks in Tuberous Sclerosis Complex. Cereb Cortex. 2016 May; 26(5):2046-58. View abstract
  20. Pinto AL, Fernández IS, Peters JM, Manganaro S, Singer JM, Vendrame M, Prabhu SP, Loddenkemper T, Kothare SV. Localization of sleep spindles, k-complexes, and vertex waves with subdural electrodes in children. J Clin Neurophysiol. 2014 Aug; 31(4):367-74. View abstract
  21. Thome-Souza S, Kadish NE, Ramgopal S, Sánchez Fernández I, Bergin AM, Bolton J, Harini C, Libenson M, Olson H, Peters J, Poduri A, Rotenberg A, Takeoka M, Kothare SV, Kapur K, Bourgeois BF, Loddenkemper T. Safety and retention rate of rufinamide in 300 patients: a single pediatric epilepsy center experience. Epilepsia. 2014 Aug; 55(8):1235-44. View abstract
  22. Sánchez Fernández I, Chapman K, Peters JM, Klehm J, Jackson MC, Berg AT, Loddenkemper T. Treatment for continuous spikes and waves during sleep (CSWS): survey on treatment choices in North America. Epilepsia. 2014 Jul; 55(7):1099-108. View abstract
  23. Klehm J, Thome-Souza S, Sánchez Fernández I, Bergin AM, Bolton J, Harini C, Kadish NE, Libenson M, Peters J, Poduri A, Rotenberg A, Takeoka M, Bourgeois B, Loddenkemper T. Clobazam: effect on frequency of seizures and safety profile in different subgroups of children with epilepsy. Pediatr Neurol. 2014 Jul; 51(1):60-6. View abstract
  24. Taquet M, Scherrer B, Peters JM, Prabhu SP, Warfield SK. A fully Bayesian inference framework for population studies of the brain microstructure. Med Image Comput Comput Assist Interv. 2014; 17(Pt 1):25-32. View abstract
  25. Peters JM, Fernández IS. Insult to injury: transient encephalopathy in a brain-injured adolescent. J Paediatr Child Health. 2014 May; 50(5):411-4. View abstract
  26. Tanaka N, Peters JM, Prohl AK, Takaya S, Madsen JR, Bourgeois BF, Dworetzky BA, Hämäläinen MS, Stufflebeam SM. Clinical value of magnetoencephalographic spike propagation represented by spatiotemporal source analysis: correlation with surgical outcome. Epilepsy Res. 2014 Feb; 108(2):280-8. View abstract
  27. Taquet M, Scherrer B, Commowick O, Peters JM, Sahin M, Macq B, Warfield SK. A mathematical framework for the registration and analysis of multi-fascicle models for population studies of the brain microstructure. IEEE Trans Med Imaging. 2014 Feb; 33(2):504-17. View abstract
  28. Sánchez Fernández I, Peters JM, An S, Bergin AM, Takeoka M, Rotenberg A, Kothare SV, Riviello JJ, Loddenkemper T. Long-term response to high-dose diazepam treatment in continuous spikes and waves during sleep. Pediatr Neurol. 2013 Sep; 49(3):163-170.e4. View abstract
  29. Peters JM, Taquet M, Prohl AK, Scherrer B, van Eeghen AM, Prabhu SP, Sahin M, Warfield SK. Diffusion tensor imaging and related techniques in tuberous sclerosis complex: review and future directions. Future Neurol. 2013 Sep; 8(5):583-597. View abstract
  30. Sánchez Fernández I, Chapman KE, Peters JM, Harini C, Rotenberg A, Loddenkemper T. Continuous Spikes and Waves during Sleep: Electroclinical Presentation and Suggestions for Management. Epilepsy Res Treat. 2013; 2013:583531. View abstract
  31. Taquet M, Peters JM. [The brain functional network of children with autism: redundancy and disconnection]. Med Sci (Paris). 2013 Jun-Jul; 29(6-7):567-9. View abstract
  32. Taimouri V, Akhondi-Asl A, Tomas-Fernandez X, Peters JM, Prabhu SP, Poduri A, Takeoka M, Loddenkemper T, Bergin AM, Harini C, Madsen JR, Warfield SK. Electrode localization for planning surgical resection of the epileptogenic zone in pediatric epilepsy. Int J Comput Assist Radiol Surg. 2014 Jan; 9(1):91-105. View abstract
  33. Peters JM, Taquet M, Vega C, Jeste SS, Fernández IS, Tan J, Nelson CA, Sahin M, Warfield SK. Brain functional networks in syndromic and non-syndromic autism: a graph theoretical study of EEG connectivity. BMC Med. 2013 Feb 27; 11:54. View abstract
  34. Weisenfeld NI, Peters JM, Tsai PT, Prabhu SP, Dies KA, Sahin M, Warfield SK. A magnetic resonance imaging study of cerebellar volume in tuberous sclerosis complex. Pediatr Neurol. 2013 Feb; 48(2):105-10. View abstract
  35. Chavakula V, Sánchez Fernández I, Peters JM, Popli G, Bosl W, Rakhade S, Rotenberg A, Loddenkemper T. Automated quantification of spikes. Epilepsy Behav. 2013 Feb; 26(2):143-52. View abstract
  36. Akhondi-Asl A, Hans A, Scherrer B, Peters JM, Warfield SK. Whole Brain Group Network Analysis Using Network Bias and Variance Parameters. 2012; (in press):Proc IEEE Int Conf Biom Imag. View abstract
  37. Sánchez Fernández I, Loddenkemper T, Peters JM, Kothare SV. Electrical status epilepticus in sleep: clinical presentation and pathophysiology. Pediatr Neurol. 2012 Dec; 47(6):390-410. View abstract
  38. Fernández IS, Chapman KE, Peters JM, Kothare SV, Nordli DR, Jensen FE, Berg AT, Loddenkemper T. The tower of Babel: survey on concepts and terminology in electrical status epilepticus in sleep and continuous spikes and waves during sleep in North America. Epilepsia. 2013 Apr; 54(4):741-50. View abstract
  39. Lewis WW, Sahin M, Scherrer B, Peters JM, Suarez RO, Vogel-Farley VK, Jeste SS, Gregas MC, Prabhu SP, Nelson CA, Warfield SK. Impaired language pathways in tuberous sclerosis complex patients with autism spectrum disorders. Cereb Cortex. 2013 Jul; 23(7):1526-32. View abstract
  40. Fernández IS, Peters JM, Hadjiloizou S, Prabhu SP, Zarowski M, Stannard KM, Takeoka M, Rotenberg A, Kothare SV, Loddenkemper T. Clinical staging and electroencephalographic evolution of continuous spikes and waves during sleep. Epilepsia. 2012 Jul; 53(7):1185-95. View abstract
  41. Sánchez Fernández I, Hadjiloizou S, Eksioglu Y, Peters JM, Takeoka M, Tas E, Abdelmoumen I, Rotenberg A, Kothare SV, Riviello JJ, Loddenkemper T. Short-term response of sleep-potentiated spiking to high-dose diazepam in electric status epilepticus during sleep. Pediatr Neurol. 2012 May; 46(5):312-8. View abstract
  42. Akhondi-Asl A, Hans A, Scherrer B, Peters JM, Warfield SK. WHOLE BRAIN GROUP NETWORK ANALYSIS USING NETWORK BIAS AND VARIANCE PARAMETERS. Proc IEEE Int Symp Biomed Imaging. 2012 May; 2012:1511-1514. View abstract
  43. Sánchez Fernández I, Takeoka M, Tas E, Peters JM, Prabhu SP, Stannard KM, Gregas M, Eksioglu Y, Rotenberg A, Riviello JJ, Kothare SV, Loddenkemper T. Early thalamic lesions in patients with sleep-potentiated epileptiform activity. Neurology. 2012 May 29; 78(22):1721-7. View abstract
  44. Fernández IS, Peters J, Takeoka M, Rotenberg A, Prabhu S, Gregas M, Riviello JJ, Kothare S, Loddenkemper T. Patients with electrical status epilepticus in sleep share similar clinical features regardless of their focal or generalized sleep potentiation of epileptiform activity. J Child Neurol. 2013 Jan; 28(1):83-9. View abstract
  45. Peters JM, Tomas-Fernandez M, van Putten MJ, Loddenkemper T. Behavioral measures and EEG monitoring using the Brain Symmetry Index during the Wada test in children. Epilepsy Behav. 2012 Mar; 23(3):247-53. View abstract
  46. Peters JM, Madhavan VL, Kazacos KR, Husson RN, Dangoudoubiyam S, Soul JS. Good outcome with early empiric treatment of neural larva migrans due to Baylisascaris procyonis. Pediatrics. 2012 Mar; 129(3):e806-11. View abstract
  47. Taquet M, Scherrer B, Commowick O, Peters J, Sahin M, Macq B, Warfield SK. Registration and analysis of white matter group differences with a multi-fiber model. Med Image Comput Comput Assist Interv. 2012; 15(Pt 3):313-20. View abstract
  48. Peters JM, Sahin M, Vogel-Farley VK, Jeste SS, Nelson CA, Gregas MC, Prabhu SP, Scherrer B, Warfield SK. Loss of white matter microstructural integrity is associated with adverse neurological outcome in tuberous sclerosis complex. Acad Radiol. 2012 Jan; 19(1):17-25. View abstract
  49. Kelly TG, Madhavan VL, Peters JM, Kazacos KR, Silvera VM. Spinal cord involvement in a child with raccoon roundworm (Baylisascaris procyonis) meningoencephalitis. Pediatr Radiol. 2012 Mar; 42(3):369-73. View abstract
  50. Loddenkemper T, Fernández IS, Peters JM. Continuous spike and waves during sleep and electrical status epilepticus in sleep. J Clin Neurophysiol. 2011 Apr; 28(2):154-64. View abstract
  51. Pier DB, Hallbergson A, Peters JM. Guillain-Barré syndrome in a child with pain: lessons learned from a late diagnosis. Acta Paediatr. 2010 Oct; 99(10):1589-91. View abstract
  52. Depositario-Cabacar DT, Peters JM, Pong AW, Roth J, Rotenberg A, Riviello JJ, Takeoka M. High-dose intravenous levetiracetam for acute seizure exacerbation in children with intractable epilepsy. Epilepsia. 2010 Jul; 51(7):1319-22. View abstract
  53. Peters JM, Maclean AV, Young GS. Rapid resolution of diffusion weighted MRI abnormality in a patient with a stuttering stroke. BMJ Case Rep. 2010; 2010. View abstract
  54. Sánchez Fernández I, Peters JM. Picture of the month--quiz case. Moyamoya disease. Arch Pediatr Adolesc Med. 2009 Feb; 163(2):179-80. View abstract
  55. Kingma R, Peters JM, Coene LN. Intracranial penetration of a halo pin causing an epileptic seizure. J Bone Joint Surg Br. 2006 Dec; 88(12):1654-5. View abstract
  56. Peters JM, Padberg M, Nederveen PJ, Tavy DL, van Putten MJAM. Tijdschr Neurol Neurochir. Neuromonitoring met on-line qEEG tijdens carotisendarteriectomie: ervaringen met de Brain Symmetry Index. 2005; 106(4):143-150. View abstract
  57. van Putten MJ, Peters JM, Mulder SM, de Haas JA, Bruijninckx CM, Tavy DL. A brain symmetry index (BSI) for online EEG monitoring in carotid endarterectomy. Clin Neurophysiol. 2004 May; 115(5):1189-94. View abstract
  58. Peters JM, Waber DP, McAnulty GB, Duffy FH. Event-related correlations in learning impaired children during A hybrid go/no-go choice reaction visual-motor task. Clin Electroencephalogr. 2003 Jul; 34(3):99-109. View abstract
  59. Peters JM, Vriens EM, Stam CJ. Tijdschr Neurol Neurochir. Continue EEG-monitoring op de intensive care. 2003; 104(5):276-282. View abstract
  60. Peters JM, Camfield CS, Camfield PR. Population study of benign rolandic epilepsy: is treatment needed? Neurology. 2001 Aug 14; 57(3):537-9. View abstract