I was trained as an adult neurologist, a child neurologist and clinical neurophysiologist, and have expertise in EEG signal processing, advanced neuroimaging and their clinical application to patients.
Throughout my career I have operated on the boundary between clinical care and cutting edge novel technologies. For children undergoing epilepsy surgery, we provide tailored imaging and EEG solutions for specific clinical problems, to optimize the chances of successful surgery and minimize surgical injury to functional areas. These innovations include the clinical application of patient-specific DTI tractography, 3D-renderings of the subdural electrode grids on the MRI brain surface, quantitative validation of the use of EEG during the Wada test, novel approaches to electrical source analysis.
I am the dedicated epileptologist in the multidisciplinary TSC program at Boston Children's Hospital, and TSC forms a major research focus. We have described an altered microstructural integrity in autism, suggesting the use of DTI as a biomarker for neurological outcome in TSC. Next, using EEG functional connectivity measures, we found alterations of brain network properties common to both idiopathic and TSC-related autism. More recently, we have described that tubers are neither static nor discrete over time.