Benjamin Matthews

Benjamin Matthews, MD

Intensivist, Division of Medicine Critical Care

Assistant Professor in Pediatrics, Harvard Medical School

  • Contact: 617-355-8117

  • Fax: 1-888-883-9238

Medical Services

Specialties

  • Critical Care

Departments

  • Division of Medicine Critical Care
  • Medicine

Programs

  • Intermediate Care Program
  • TEDMED
  • Medicine Intensive Care Unit
To schedule an appointment:

Experience and Education

Education

Mathematics & Biology

University of Toronto,

Toronto, Canada

Mathematics and Biology

McGill University,

Montreal, Canada

Medical School

McGill University,

Montreal, Canada

Pediatrics/PCCM

Hospital for Sick Children,

Toronto, Canada

Pediatrics

Schneider Children's Hospital,

New Hyde Park, NY

Certifications

  • Pediatrics, Pediatric Critical Care Medicine

Publications

Publications powered by Harvard Catalyst
  1. Jurek SC, Hirano-Kobayashi M, Chiang H, Kohane DS, Matthews BD. Prevention of ventilator-induced lung edema by inhalation of nanoparticles releasing ruthenium red. Am J Respir Cell Mol Biol. 2014 Jun; 50(6):1107-17.
  2. Wang Y, Huang Z, Nayak PS, Matthews BD, Warburton D, Shi W, Sanchez-Esteban J. Strain-induced differentiation of fetal type II epithelial cells is mediated via the integrin a6ß1-ADAM17/tumor necrosis factor-a-converting enzyme (TACE) signaling pathway. J Biol Chem. 2013 Aug 30; 288(35):25646-57.
  3. Huh D, Leslie DC, Matthews BD, Fraser JP, Jurek S, Hamilton GA, Thorneloe KS, McAlexander MA, Ingber DE. A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice. Sci Transl Med. 2012 Nov 7; 4(159):159ra147.
  4. Korin N, Kanapathipillai M, Matthews BD, Crescente M, Brill A, Mammoto T, Ghosh K, Jurek S, Bencherif SA, Bhatta D, Coskun AU, Feldman CL, Wagner DD, Ingber DE. Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels. Science. 2012 Aug 10; 337(6095):738-42.
  5. Greenberger S, Yuan S, Walsh LA, Boscolo E, Kang KT, Matthews B, Mulliken JB, Bischoff J. Rapamycin suppresses self-renewal and vasculogenic potential of stem cells isolated from infantile hemangioma. J Invest Dermatol. 2011 Dec; 131(12):2467-76.
  6. Matthews BD, Thodeti CK, Tytell JD, Mammoto A, Overby DR, Ingber DE. Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta1 integrins. Integr Biol (Camb). 2010 Sep; 2(9):435-42.
  7. Huh D, Matthews BD, Mammoto A, Montoya-Zavala M, Hsin HY, Ingber DE. Reconstituting organ-level lung functions on a chip. Science. 2010 Jun 25; 328(5986):1662-8.
  8. Matthews, B, Kohane, D, Ingber, D. Inhaled prophylactic nanotherapy for lung protection from Ventilator induced Lung Injury and Acute Respiratory Distress Syndrome (ARDS). 2010.
  9. Greenberger, S, Yuan, S, Walsh, L., Boscolo, E., Kang, K.T., Matthews, B, Mulliken, J.B., and Bischoff, J. . High-throughput Screen Identifies Rapamycin as a Drug to Suppress Self-Renewal and Vasculogenesis in Infantile Hemangioma. Journal of Cell Investigation (In Review). 2010.
  10. Matthews, B.D, Thodeti, C.K., Tytell, JD., Mammoto, A., Overby, D.R., and Ingber, D.E. . Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface β1 integrins. . Integrative Biology (In Review). 2010.
  11. Show all
  12. Thodeti CK, Matthews B, Ravi A, Mammoto A, Ghosh K, Bracha AL, Ingber DE. TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Circ Res. 2009 May 8; 104(9):1123-30.
  13. Prodhan P, Dela Rosa RS, Shubina M, Haver KE, Matthews BD, Buck S, Kacmarek RM, Noviski NN. Wheeze detection in the pediatric intensive care unit: comparison among physician, nurses, respiratory therapists, and a computerized respiratory sound monitor. Respir Care. 2008 Oct; 53(10):1304-9.
  14. Stamenovic D, Rosenblatt N, Montoya-Zavala M, Matthews BD, Hu S, Suki B, Wang N, Ingber DE. Rheological behavior of living cells is timescale-dependent. Biophys J. 2007 Oct 15; 93(8):L39-41.
  15. Lele TP, Sero JE, Matthews BD, Kumar S, Xia S, Montoya-Zavala M, Polte T, Overby D, Wang N, Ingber DE. Tools to study cell mechanics and mechanotransduction. Methods Cell Biol. 2007; 83:443-72.
  16. Lele T, Sero J, Matthews BD, Kumar S, Xia S, Montoya-Zavala M, Polte T, Overby DR, Wang N and Ingber DE. . Tools to study cell mechanotransduction. In: Wang Y, Discher D., editors. Methods in Cell Biology. 2007; 441-472.
  17. Matthews BD, Thodeti CK and Ingber DE. . Integrin-dependent force transmission to mechanosensitive ion channels. In: Hammill O, editors. Mechanosensitive Ion Channels. 2007; 59-85.
  18. Dandapani SV, Sugimoto H, Matthews BD, Kolb RJ, Sinha S, Gerszten RE, Zhou J, Ingber DE, Kalluri R, Pollak MR. Alpha-actinin-4 is required for normal podocyte adhesion. J Biol Chem. 2007 Jan 5; 282(1):467-77.
  19. Matthews BD, Overby DR, Mannix R, Ingber DE. Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels. J Cell Sci. 2006 Feb 1; 119(Pt 3):508-18.
  20. Alon R, Feigelson SW, Manevich E, Rose DM, Schmitz J, Overby DR, Winter E, Grabovsky V, Shinder V, Matthews BD, Sokolovsky-Eisenberg M, Ingber DE, Benoit M, Ginsberg MH. Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain. J Cell Biol. 2005 Dec 19; 171(6):1073-84.
  21. Overby DR, Matthews BD, Alsberg E, Ingber DE. Novel dynamic rheological behavior of individual focal adhesions measured within single cells using electromagnetic pulling cytometry. Acta Biomater. 2005 May; 1(3):295-303.
  22. Matthews BD, Overby DR, Alenghat FJ, Karavitis J, Numaguchi Y, Allen PG, Ingber DE. Mechanical properties of individual focal adhesions probed with a magnetic microneedle. Biochem Biophys Res Commun. 2004 Jan 16; 313(3):758-64.
  23. Alkharouf NW, Matthews BF. SGMD: the Soybean Genomics and Microarray Database. Nucleic Acids Res. 2004 Jan 1; 32(Database issue):D398-400.
  24. Matthews, B. D., LaVan, D. A., Overby, D. R., Karavitis, J. and Ingber, D. E. . Electromagnetic needles with submicron pole tip radii for nanomanipulation of biomolecules and living cells. Applied Physics Letters. 2004; 85:2968-2970..
  25. Matthews BD, Noviski N. Management of oxygenation in pediatric acute hypoxemic respiratory failure. Pediatr Pulmonol. 2001 Dec; 32(6):459-70.
  26. Tsakiridis T, Tong P, Matthews B, Tsiani E, Bilan PJ, Klip A, Downey GP. Role of the actin cytoskeleton in insulin action. Microsc Res Tech. 1999 Oct 15; 47(2):79-92.
  27. Oddos J, Grange T, Carr KD, Matthews B, Roux J, Richard-Foy H, Pictet R. Nucleotide sequence of 10 kilobases of rat tyrosine aminotransferase gene 5' flanking region. Nucleic Acids Res. 1989 Nov 11; 17(21):8877-8.
To schedule an appointment:

Locations

We are grateful to have been ranked #1 on U.S. News & World Report's list of the best children's hospitals in the nation for the third year in a row, an honor we could not have achieved without the patients and families who inspire us to do our very best for them. Thanks to you, Boston Children's is a place where we can write the greatest children's stories ever told.”
- Sandra L. Fenwick, President and CEO

Boston Children's Hospital 300 Longwood Avenue, Boston, MA 02115 617-355-6000 | 800-355-7944

Close