Treatments for Pigmented villonodular synovitis (PVNS) in Children

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Contact the Bone and Soft Tissue Tumor Program

  • 617-355-6021
  • International: +1-617-355-5209
  • Locations

Dana-Farber/Children's Hospital Cancer Center is home to some of the world's most skilled pediatric oncologists. And while we're known for our science-driven approach to treating conditions like red blood cell disorders, our doctors never forget that your child is a child, and not just a patient.

We specialize in innovative, family-centered care. From your first visit, you'll work with a team of professionals who are committed to supporting all of your family's physical and psychosocial needs.

Traditional treatments for pigmented villonodular synovitis
Treatment options will vary greatly, depending on your child's situation, and your child's doctor will discuss the options with you in-depth. Treatment may include:

Surgery
Since PVNS can continue to grow and invade the bone, the treatment of choice is usually an operation called a synovectomy, in which the affected synovial tissue is surgically removed.

Radiation
Our doctors use precisely targeted and dosed radiation to kill cancer cells left behind after your child's surgery. This has been used successfully to control recurrence of PVNS, but is generally avoided in children because of growth issues and the concern about radiation associated malignancy later in life.

What is the recommended long-term care for children treated for pigmented villonodular synovitis?

Children treated for pigmented villonodular synovitis should visit a survivorship clinic every year to:

  • manage disease complications
  • screen for early recurrence of cancer
  • manage late effects of treatment

A typical follow-up visit may include some or all of the following:

  • a physical exam
  • laboratory testing
  • imaging scans

Through the David B. Perini, Jr. Quality of Life Clinic at Dana-Farber Cancer Institute, childhood cancer survivors receive a comprehensive follow-up evaluation from their cancer care team.

  • Our childhood cancer survivorship clinic is held weekly.
  • In addition to meeting with your pediatric oncologists, your child may see one of our endocrinologists, cardiologists, neurologists, neuro-psychologists or alternative/complementary therapy specialists.
  • We also offer the following services:
    • patient and family education
    • psychosocial assessment
    • genetic counseling
    • reproductive and fertility evaluation and counseling
    • opportunities to speak with other childhood cancer survivors
We are grateful to have been ranked #1 on U.S. News & World Report's list of the best children's hospitals in the nation for the third year in a row, an honor we could not have achieved without the patients and families who inspire us to do our very best for them. Thanks to you, Boston Children's is a place where we can write the greatest children's stories ever told.”
- Sandra L. Fenwick, President and CEO

Boston Children's Hospital 300 Longwood Avenue, Boston, MA 02115 617-355-6000 | 800-355-7944

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