Osteogenesis Imperfecta Pediatric Research and Clinical Trials

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Research & Innovation

For more than a century, orthopedic surgeons and investigators at Boston Children's Hospital have played a vital role in advancing the field of musculoskeletal research. We’ve developed breakthrough treatments and major advances for lower limb and hip problems, as well as scoliosis, polio, tuberculosis and traumas to the hand and upper extremities.

Our pioneering research helps answer the most pressing questions in pediatric orthopedics today—to provide children with the most innovative care available.

In Boston Children’s Orthopedic Center we take great pride in our basic science and clinical research leaders, who are recognized throughout the world for their achievements. Our orthopedic research team includes:

  • full-time basic scientists
  • 28 clinical investigators
  • a team of research coordinators and statisticians

Understanding and treating brittle bones


A gene in the load-sensing machinery of bone may hold the key to developing new drugs for brittle bone disorders like osteogenesis imperfecta (OI) in children or osteoporosis in adults.

In bones, cells called osteocytes sense “mechanical stress,” like that caused by exercise, and in response call for other cells called osteoblasts to produce more bone tissue, giving the bones greater density and strength.

A team of researchers led by Matthew Warman, MD, of Boston Children's Orthopedic Research Laboratories, has engineered mice with unusually dense bones using mutations in a gene called Lrp5 (which is part of the osteocytes' stress-sensing system) that cause high bone mass in people. Read more.

Studies of developmental hip conditions

Some developmental hip conditions can lead to premature arthritis in young adults, with resulting pain and disability. Our research focuses on understanding the pathomechanics (mechanical forces that adversely change the body's structure and function) of these conditions. With better understanding, we can improve existing therapies and develop new therapies for these conditions.

Orthopedic basic science laboratories

Working in Boston Children’s labs are some of the leading musculoskeletal researchers in the nation. Our labs include:

Children speak about what it’s like to be a medical research subject

View a video of a day in the life of Children’s Clinical and Translational Study Unit, through the eyes of children who are “giving back” to science.

We are grateful to have been ranked #1 on U.S. News & World Report's list of the best children's hospitals in the nation for the third year in a row, an honor we could not have achieved without the patients and families who inspire us to do our very best for them. Thanks to you, Boston Children's is a place where we can write the greatest children's stories ever told.”
- Sandra L. Fenwick, President and CEO

Boston Children's Hospital 300 Longwood Avenue, Boston, MA 02115 617-355-6000 | 800-355-7944

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