Microvillus Inclusion Disease (MVID)

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Division of Gastroenterology Hepatology and Nutrition

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What is microvillus inclusion disease?

Microvillus inclusion disease (MVID) is a rare genetic disease of the intestine that causes severe diarrhea and an inability to absorb nutrients. It usually starts soon after birth and is one of a group of disorders termed congenital diarrheas.

In MVID, the surface of the cells that line the intestine does not develop normally. This causes these cells not to work properly to absorb fluid and nutrients coming into the intestine.

Several genes have been identified that are thought to be involved in MVID. Infants and children with this disease usually need specialized intravenous nutrition (parenteral nutrition) in order to grow normally and avoid dehydration.

What are the symptoms of microvillus inclusion disease?

Signs of MVID usually show up within hours or days after birth. However, sometimes the symptoms show up later (around two months after birth) and are less severe.

Generally, babies have severe, watery diarrhea that doesn't go away and cannot absorb the nutrients that they eat. This can lead to other severe complications, such as life-threatening dehydration, requiring the infant to be hospitalized. There may also be related poor weight gain.

What causes microvillus inclusion disease?

MVID is inherited as an autosomal recessive genetic trait. This means that both parents must carry a copy of the affected gene in order to pass the disease on to their child. In some families, more than one child is affected. The genes that have been identified include Myosin 5b and Syntaxin 3.

How we care for microvillus inclusion disease

The Boston Children’s Hospital Division of Gastroenterology, Hepatology and Nutrition Program specializes in diagnosing and treating children with complex intestinal disorders, like microvillus inclusion disease. Our team works closely with multiple specialties, including the Home Parenteral Nutrition Program, to provide expert, family-centered care for infants, children and adolescents. Contact us for more information.

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