Hyperbilirubinemia and Jaundice Symptoms & Causes

LIke ThisLIke ThisLIke ThisLIke ThisLIke This

What causes hyperbilirubinemia?         

During pregnancy, the placenta excretes bilirubin. When your baby is born, your baby’s liver must take over this function. There are several causes of hyperbilirubinemia and jaundice, including:

  • physiologic jaundice– occurs as a “normal” response to your baby’s limited ability to excrete bilirubin in the first days of life

  • breast milk jaundice – about 2 percent of breastfed babies develop jaundice after the first week

  • breastfeeding jaundice– occurs in some baby’s in the first week due to low intake or dehydration

  • jaundice from hemolysis– a condition that results from the breakdown of red blood cells due to hemolytic disease of the newborn (Rh disease), polycythemia or hemorrhage

  • inadequate liver function due to infection or other factors

Who is affected by hyperbilirubinemia?

 About 60 percent of term newborns and 80 percent of premature babies develop jaundice. Infants of diabetic mothers and of mothers with Rh disease are more likely to develop hyperbilirubinemia and jaundice.

Why is hyperbilirubinemia a concern?

Although low levels of bilirubin are not usually a concern, large amounts can circulate to tissues in the brain and may cause seizures and brain damage. This is a condition called kernicterus.

What are the symptoms of hyperbilirubinemia?

Symptoms may include:

  • yellow coloring of your baby’s skin (usually beginning on the face and moving down the body)
  • poor feeding or lethargy
Boston Children’s is so much more than a hospital—it’s a community of researchers, clinicians, administrators, support staff, innovators, teachers, patients and families, all working together to make the impossible possible. ”
- Sandra L. Fenwick, President and CEO

Boston Children's Hospital
300 Longwood Avenue, Boston, MA 02115
For Patients: 617-355-6000
For Referring Providers: 844-BCH-PEDS | 844-224-7337

Close