Fibro-Adipose Vascular Anomaly (FAVA) Symptoms & Causes

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What are the symptoms of a fibro-adipose vascular anomaly?

The most common symptoms of FAVA are:

  • pain, often severe, in the affected limb
  • difficulty moving the affected limb and contracture (e.g., a fixed bending of the arm or flexing of the ankle)
  • mild enlargement of the limb with some visible veins

Patients have been diagnosed with FAVA anywhere between infancy and adulthood; the majority are older children, teens or young adults.

What causes fibro-adipose vascular anomalies?

No one knows what causes FAVA, though recent research revealed mutations in a gene called PIK3CA in some, but not all, cases. Thus far, it appears to be a spontaneous condition, and is not inherited or passed along in families.

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