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Boston Children's has launched the world's 1st program dedicated to offering hand transplants to children who qualify.
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Up to 15 percent of women suffer from endometriosis, in which tissue normally found in the uterus grows elsewhere in the body. Now, a discovery that certain immune cells trigger angiogenesis—the formation of new blood vessels—opens the possibility of more effective, less toxic treatments.
Angiogenesis, which stimulates growth of cancerous tumors, also encourages small, symptomless endometriosis lesions to enlarge, causing pelvic pain and infertility. Working in a mouse model, research fellow Ofer Fainaru, MD, PhD, and colleagues in Vascular Biology found that dendritic cells, part of the immune system, invade endometriosis lesions, and that new vessels soon form nearby. Fainaru thinks the dendritic cells send signals that attract endothelial cells, which help build blood vessels, to the lesions.
If the findings hold true in humans, Fainaru hopes to find a way to kill or alter dendritic cells so that endometriosis lesions remain tiny and harmless. The study was published online in September by the journal FASEB; Judah Folkman, MD, director of the Vascular Biology Program, was senior author.
We are grateful to have been ranked #1 on U.S. News & World Report's list of the best children's hospitals in the nation for the third year in a row, an honor we could not have achieved without the patients and families who inspire us to do our very best for them. Thanks to you, Boston Children's is a place where we can write the greatest children's stories ever told.”