Pulmonary Vein Stenosis Program | Research & Innovation

Our Pulmonary Vein Stenosis team bases treatment on the latest clinical research. At Boston Children’s, we have one of the world’s most extensive research programs and our scientists work directly with our doctors so that the newest treatments are always available.

Historically, doctors have had to rely on one of the following treatments to care for children with pulmonary vein stenosis:

  • open-heart surgery to widen the narrowed veins and improve blood flow from the lungs back to the heart
  • cardiac catheterization with balloon dilation +/- stent implantation to stretch the vessel or vessels open
  • lung transplantation to replace the lungs and the pulmonary veins

Patients with severe PVS typically require an initial surgery followed by repeat catheter based interventions in order to treat restenosis of the pulmonary veins.

In some cases, a lung transplant may be an option, but this comes with major risks, including rejection of the transplanted lung and serious infection. Patients must also take immunosuppressant drugs for the remainder of their life to reduce the chance of the body rejecting the new lungs.

Using these methods, many children with the most severe form of pulmonary vein stenosis do not survive past early childhood.