Providing safe blood for transfusion remains a challenge despite advances in preventing the transmission of hepatitis B, hepatitis C, AIDS/HIV, West Nile virus (WNV), and transfusion-transmitted bacterial infection. Human errors such as misidentifying patients and drawing blood samples from the wrong person present much more of a risk than transmissible diseases. The introduction of screening practices for the presence of transmissible diseases has greatly improved the safety of the blood supply, while simultaneously shrinking the donor pool, creating blood shortages in the United States and worldwide. In fact, in many industrialized countries, less than 5% of the eligible population is blood donors.
As a result of this shortage, the global medical community has increasingly moved from allogeneic blood transfusions (blood collected from another person) towards autologous ones, in which patients receive their own blood. Intraoperative cell salvage (CS) — the process of collecting blood which is shed during surgery and re-infusing it into patients — reduces the need for allogeneic blood transfusion, results in fewer transfusion-related adverse events, and consequently, leads to greater quality of life and life expectancy as compared to surgery without CS.
As an effective and safe blood conservation strategy, CS also results in fewer transfusion-related reactions and infections. As an effective and safe blood conservation strategy, use of cell salvage has been shown to result in fewer transfusion-related adverse events; with a longer life expectancy for patients as compared to surgical procedures without cell saver. In addition to the patient benefits, the use of cell saver along with autologous blood pre-donation indicates a cost-saving benefit in pediatric surgical procedures. For example, savings from the use of Intraoperative Cell Salvage at Boston Children’s exceeded $213,000 in FY 2010 alone.
Another impetus for autologous transfusion is the position of various religious groups, including Jehovah's Witnesses, on blood transfusions. For religious reasons, Jehovah's Witnesses will not accept any allogeneic transfusions from a volunteer's blood donation, but may accept the use of autologous blood salvaged during surgery to restore their blood volume during the course of an operation.
Additionally, the department would like to explore the use of cell saver in other surgical procedures with the goal of constructing models to predict whether a perioperative blood transfusion is necessary, and if cell saver could be ordered instead of other additional blood products. Furthermore, expansion of intraoperative cell salvage to other pediatric surgical procedures will result in fewer adverse events and increase transfusions of a whole blood product to patients, delivering high levels of clotting factors and other imperative constituents such as viable platelets.
For questions, please contact: