Research & Innovation

In the Brain Tumor Center, the care we provide is driven by the latest research. Our team members are leaders in pediatric brain tumor research — and our findings are helping improve our understanding of brain tumors and transform their treatment.

Explore some of our latest research

November 20, 2025

‘Challenge accepted’: Sophia takes on a brain tumor

In 2023, Sophia Mordini landed the role of a lifetime. A competitive dancer, the 12-year-old would play Clara in her company’s production of “The Nutcracker.” But the performance was bittersweet:…

April 16, 2025

Forecasting the future for childhood cancer survivors

Children are much more likely to survive cancer today than 50 years ago. Unfortunately, as adults, many of them develop cardiovascular disease, secondary cancers, or both, believed to result from the…

March 25, 2025

Pediatric high-grade gliomas: Research reveals effective targeting with avapritinib

Pediatric high-grade gliomas, particularly H3K27M diffuse midline gliomas (DMG), are aggressive malignant brain tumors with a poor prognosis. Previous research suggests that platelet-derived growth…

Areas of active research

Clinical trials

The Brain Tumor Center is a member of several major clinical trial consortia. These include the Children’s Oncology Group (COG), the Pediatric Neuro-Oncology Consortium (PNOC), the CONNECT Consortium, and the Pediatric Brain Tumor Consortium (PBTC). This means that we can provide our patients with access to a wide range of clinical trials. 

Selected publications