Dr. Oottamasathien, is the Director of Innovation and Technology Development in the Department of Urology at Boston Children’s Hospital and an Associate Professor of Surgery at Harvard Medical School. He is a board-certified pediatric urologist specializing in complex hypospadias surgery and general pediatric urologic conditions. Dr. Oottamasathien earned his medical degree from the University of Colorado School of Medicine and completed his urology residency at the University of Colorado at Denver and Health Sciences Center. He then completed his pediatric urology fellowship at Vanderbilt University in 2007. From 2007 to 2017, he was the Director of Pediatric Urology Basic Science Research at the University of Utah and for the past four years at Massachusetts General Hospital. His research involving models, mechanisms, and new generation therapeutics to treat bladder inflammation and pain conditions (Interstitial Cystitis/Painful Bladder Syndrome) set the foundation for obtaining both K12 and R01 grants from the NIH. Recently his work on radiation-induced proctitis was awarded another 5-year R01 grant from the NIH, in conjunction with collaborators at the University of Utah. Currently, his research efforts revolve around models and mechanisms that drive various urologic conditions and developing innovative biopolymers for therapeutics and/or drug delivery.
Approach to Care
Simply, it’s our kids. When I was an intern and resident in general surgery, I found myself truly loving my pediatric surgery rotations. I quickly realized that I loved to take care of the kids. Now a father of three, I’ve gained an even deeper appreciation about their health and well-being. I will continue to devote my career at BCH towards caring for our children with urologic needs.
Publications
Real-Time Bladder Volume Monitoring for Pediatric Patients Using a Commercially Available Wearable Ultrasound Device. View Abstract
An Oligomeric Sulfated Hyaluronan and Silk-Elastinlike Polymer Combination Protects against Murine Radiation Induced Proctitis. View Abstract
Silk-elastinlike copolymers enhance bioaccumulation of semisynthetic glycosaminoglycan ethers for prevention of radiation induced proctitis. View Abstract
Temperature-responsive silk-elastinlike protein polymer enhancement of intravesical drug delivery of a therapeutic glycosaminoglycan for treatment of interstitial cystitis/painful bladder syndrome. View Abstract
Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells. View Abstract
Unilateral open extravesical ureteral reimplanation with contralateral dextronomer/hyaluronic acid injection performed as an outpatient therapy. View Abstract
IL-33 mast cell axis is central in LL-37 induced bladder inflammation and pain in a murine interstitial cystitis model. View Abstract
Amniotic therapeutic biomaterials in urology: current and future applications. View Abstract
Bladder pain in an LL-37 interstitial cystitis and painful bladder syndrome model. View Abstract
Combination of Extracorporeal Shockwave Lithotripsy and Ureteroscopy for Large Staghorn Calculi in a Pediatric Patient: Case Report. View Abstract
Silk-elastinlike protein polymers enhance the efficacy of a therapeutic glycosaminoglycan for prophylactic treatment of radiation-induced proctitis. View Abstract
Childhood Cancer Risk in the Siblings and Cousins of Men with Poor Semen Quality. View Abstract
Prevention of sinonasal inflammation by a synthetic glycosaminoglycan. View Abstract
Topical cathelicidin (LL-37) an innate immune peptide induces acute olfactory epithelium inflammation in a mouse model. View Abstract
Urologic problems in spina bifida patients transitioning to adult care. View Abstract
Prevention of anti-microbial peptide LL-37-induced apoptosis and ATP release in the urinary bladder by a modified glycosaminoglycan. View Abstract
LL-37 induced cystitis and the receptor for advanced glycation end-products (RAGE) pathway. View Abstract
Padded self-adhesive strap immobilization following newborn bladder exstrophy closure: the Utah straps. View Abstract
Physiological relevance of LL-37 induced bladder inflammation and mast cells. View Abstract
Pediatric urinary stone composition in the United States. View Abstract
A murine model of inflammatory bladder disease: cathelicidin peptide induced bladder inflammation and treatment with sulfated polysaccharides. View Abstract
Metastatic Crohn's disease of the penis in a pediatric patient. View Abstract
Parameatal urethral cysts in prepubertal males. View Abstract
