Melissa Hazen, MD
Rheumatologist, Hospital Medicine and Rheumatology Program
Assistant Professor of Pediatrics, Harvard Medical School
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Melissa Hazen, MD
Rheumatologist, Hospital Medicine and Rheumatology Program
Assistant Professor of Pediatrics, Harvard Medical School
Medical Services
Languages
English
Spanish
Education
Undergraduate School
Harvard University
Cambridge
MA
Medical School
Yale University School of Medicine
New Haven
CT
Internship
Boston Combined Residency Program (BCRP)
Boston
MA
Residency
Boston Combined Residency Program (BCRP)
Boston
MA
Fellowship
Pediatric Rheumatology
Boston Children's Hospital
Boston
MA
Certifications
American Board of Pediatrics (General)
American Board of Pediatrics (Rheumatology)
Professional History
Dr. Hazen is a graduate of Harvard University and the Yale School of Medicine and completed her pediatric residency and rheumatology fellowship training at the Boston Children's Hospital where she has remained on faculty as a pediatric Division of General Pediatrics and rheumatology attending. Dr. Hazen's clinical practice is devoted to the care of complex patients, including hospitalized children and children with immune-mediated illness. She is the co-founder and co-director of a multidisciplinary clinic, the MAID clinic, devoted the the care of and improving the understanding of children with monogenic immune dysregulatory syndromes. She is the director of quality improvement for the Rheumatology Program and is the site PI for a national pediatric rheumatology quality improvement collaborative, PR-COIN. She is interested in the intersection of pediatric Division of General Pediatrics, rheumatology, and quality improvement, and she has co-developed clinical practice guidelines for the care of patients with rheumatic disease (eg HLH/MAS, KD, FUO) for use by hospitalists and sub-specialists.
Publications
Sex Differences in B Cells From the Joints of Children With Oligoarticular Juvenile Idiopathic Arthritis. View Abstract
Multidisciplinary approach to treating complex immune dysregulation disorders: an adaptive model for institutional implementation. View Abstract
Universal health-related social needs screening in a paediatric rheumatology clinic. View Abstract
Using a collaborative learning health system approach to improve disease activity outcomes in children with juvenile idiopathic arthritis in the Pediatric Rheumatology Care and Outcomes Improvement Network. View Abstract
Pediatric Rheumatology Care and Outcomes Improvement Network's Quality Measure Set to Improve Care of Children With Juvenile Idiopathic Arthritis. View Abstract
Incidence and Risk Factors for Eosinophilia and Lung Disease in Biologic-Exposed Children With Systemic Juvenile Idiopathic Arthritis. View Abstract
Disordered T cell-B cell interactions in autoantibody-positive inflammatory arthritis. View Abstract
Dr. Degar et al reply. View Abstract
Longitudinal assessment of preparation for care transition among adolescents and young adults with rheumatologic disease: a single-center pilot study. View Abstract
An Evidence-Based Guideline Improves Outcomes for Patients With Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome. View Abstract
Consensus Approach to a Treat-to-target Strategy in Juvenile Idiopathic Arthritis Care: Report From the 2020 PR-COIN Consensus Conference. View Abstract
Proteomics based markers of clinical pain severity in juvenile idiopathic arthritis. View Abstract
Vestibular Evaluation and Management of Children with Sensorineural Hearing Loss. View Abstract
Th1 polarization defines the synovial fluid T cell compartment in oligoarticular juvenile idiopathic arthritis. View Abstract
A multidisciplinary assessment of pain in juvenile idiopathic arthritis. View Abstract
Distinct clinical and immunological features of SARS-CoV-2-induced multisystem inflammatory syndrome in children. View Abstract
Vasculitis as a Major Morbidity Factor in Patients With Partial RAG Deficiency. View Abstract
Providing Inpatient Medical Care to Children With Autism Spectrum Disorder. View Abstract
On the Alert for Cytokine Storm: Immunopathology in COVID-19. View Abstract
Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis. View Abstract
The immunologic features of patients with early-onset and polyautoimmunity. View Abstract
Defining a new immune deficiency syndrome: MAN2B2-CDG. View Abstract
Emergent high fatality lung disease in systemic juvenile arthritis. View Abstract
Outcomes and Treatment Strategies for Autoimmunity and Hyperinflammation in Patients with RAG Deficiency. View Abstract
Calm in the midst of cytokine storm: a collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome. View Abstract
Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases. View Abstract
Next-Generation Sequencing Reveals Restriction and Clonotypic Expansion of Treg Cells in Juvenile Idiopathic Arthritis. View Abstract
Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia. View Abstract
Trainee and program director perceptions of quality improvement and patient safety education: preparing for the next accreditation system. View Abstract
Expanding the spectrum of recombination-activating gene 1 deficiency: a family with early-onset autoimmunity. View Abstract
A taste of periodic fever syndromes. View Abstract
Pulmonary hypertension and other potentially fatal pulmonary complications in systemic juvenile idiopathic arthritis. View Abstract
Multiple juvenile idiopathic arthritis subtypes demonstrate proinflammatory IgG glycosylation. View Abstract
Hypogalactosylation of serum N-glycans fails to predict clinical response to methotrexate and TNF inhibition in rheumatoid arthritis. View Abstract
Regulation of human neutrophil Fc? receptor IIa by C5a receptor promotes inflammatory arthritis in mice. View Abstract
Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis. View Abstract
Mutations of the hemophagocytic lymphohistiocytosis-associated gene UNC13D in a patient with systemic juvenile idiopathic arthritis. View Abstract
Mutations of the HLH-associated gene UNC13D (MUNC13-4) in a patient with systemic juvenile idiopathic arthritis View Abstract
Mutations of the HLH-associated gene UNC13D (MUNC13-4) in a patient with systemic juvenile idiopathic arthritis View Abstract
Adjuvant IL-7 or IL-15 overcomes immunodominance and improves survival of the CD8+ memory cell pool View Abstract
Escape from Immune Surveillance Does Not Result in Tolerance to Tumor-Associated Antigens View Abstract
Characterization of the Immune Responses to the Tumor-Associated HY-Antigen View Abstract
Progressive Tumor Growth in a Model Tumor Antigen System Does Not Induce Immunologic Tolerance but Appears to Induce Weak Immunity Toward Tumor Antigens View Abstract