A randomized controlled trial (RCT) investigating whether the local anesthetic injection of liposomal bupivacaine during posterior spinal fusion (PSF) for AIS is more effective in reducing acute postoperative opioid consumption compared to an equal volume injection of 0.25% bupivacaine with epinephrine for patients aged 10 to 17, with 128 patients randomly assigned to one of two arms: liposomal bupivacaine or 0.25% bupivacaine with epinephrine.
RECRUITING
Inclusion Criteria:
* ≥10 years old and ≤17 years old at assessment
* Diagnosis of Adolescent Idiopathic Scoliosis
* Planned surgical treatment of progressive spinal deformity with posterior spinal fusion
Exclusion Criteria:
* Diagnosis of neuromuscular, syndromic, or congenital scoliosis
* History of known allergy to local anesthesia
* Chronic pre-operative opioid consumptions
* Any other analgesic treatment for chronic pain before surgery
* Psychiatric or neurological disorders
* Cannot fluently read or speak English
NA
ALL
10 Years
17 Years
2025-10-22
This field has been modified from ClinicalTrials.gov to show a contact specific to Boston Children's.
This field has been modified from ClinicalTrials.gov to show a contact specific to Boston Children's.
DRUG
DRUG
Bupivacaine liposome injectable suspension
Bupivacaine Hydrochloride and Epinephrine Injection
For more information and to contact the study team: