David G. Nathan | Medical Services
Specialties
Programs & Services
Languages
- English
David G. Nathan | Education
Medical School
Harvard Medical School
Boston, MA
Internship
Brigham and Women's Hospital
Boston, MA
Residency
Brigham and Women's Hospital
Boston, MA
Fellowship
Brigham and Women's Hospital
Bethesda, MD
David G. Nathan | Certifications
- American Board of Internal Medicine (General)
David G. Nathan | Publications
Correcting the record on anemia of aging: a statistical reanalysis. Blood Adv. 2023 07 25; 7(14):3642-3643. View Correcting the record on anemia of aging: a statistical reanalysis. Abstract
COVID-19, nuclear war, and global warming: lessons for our vulnerable world. Lancet. 2020 06 27; 395(10242):1967-1968. View COVID-19, nuclear war, and global warming: lessons for our vulnerable world. Abstract
The Genetic Landscape of Diamond-Blackfan Anemia. Am J Hum Genet. 2018 12 06; 103(6):930-947. View The Genetic Landscape of Diamond-Blackfan Anemia. Abstract
The Pathophysiology of Acquired Aplastic Anemia: Current Concepts Revisited. Hematol Oncol Clin North Am. 2018 Aug; 32(4):581-594. View The Pathophysiology of Acquired Aplastic Anemia: Current Concepts Revisited. Abstract
Training. Pediatr Blood Cancer. 2018 02; 65(2). View Training. Abstract
Cholesterol: the debate should be terminated. FASEB J. 2017 07; 31(7):2722-2728. View Cholesterol: the debate should be terminated. Abstract
Eulogy for the clinical research center. J Clin Invest. 2016 07 01; 126(7):2388-91. View Eulogy for the clinical research center. Abstract
Thalassemia: a look to the future. Ann N Y Acad Sci. 2016 03; 1368(1):11-5. View Thalassemia: a look to the future. Abstract
Amino acid uptake in erythropoiesis. Sci Signal. 2015 Apr 14; 8(372):fs9. View Amino acid uptake in erythropoiesis. Abstract
A conversation with David Nathan. J Clin Invest. 2014 Dec; 124(12):5090-1. View A conversation with David Nathan. Abstract
Hereditary xerocytosis revisited. Am J Hematol. 2014 Dec; 89(12):1142-6. View Hereditary xerocytosis revisited. Abstract
A tribute to Emil Frei III. J Clin Invest. 2013 Aug 1; 123(8):3188-9. View A tribute to Emil Frei III. Abstract
Pathophysiology and Clinical Manifestations of the ß-Thalassemias. Cold Spring Harb Perspect Med. 2012 Dec 01; 2(12):a011726. View Pathophysiology and Clinical Manifestations of the ß-Thalassemias. Abstract
Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia. J Clin Invest. 2012 Jul; 122(7):2439-43. View Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia. Abstract
Sickle cell disease (SCD), iNKT cells, and regadenoson infusion. Trans Am Clin Climatol Assoc. 2012; 123:312-7; discussion 317-8. View Sickle cell disease (SCD), iNKT cells, and regadenoson infusion. Abstract
Fetal hemoglobin levels and morbidity in untransfused patients with ß-thalassemia intermedia. Blood. 2012 Jan 12; 119(2):364-7. View Fetal hemoglobin levels and morbidity in untransfused patients with ß-thalassemia intermedia. Abstract
Guilt by association. Blood. 2011 Oct 06; 118(14):3758-9. View Guilt by association. Abstract
Reversing the hemoglobin switch. N Engl J Med. 2010 Dec 02; 363(23):2258-60. View Reversing the hemoglobin switch. Abstract
Thalassemia: an overview of 50 years of clinical research. Hematol Oncol Clin North Am. 2010 Dec; 24(6):1005-20. View Thalassemia: an overview of 50 years of clinical research. Abstract
A life-long quest to understand and treat genetic blood disorders. Cell. 2010 Oct 01; 143(1):17-20. View A life-long quest to understand and treat genetic blood disorders. Abstract
Pulmonary hypertension and nitric oxide depletion in sickle cell disease. Blood. 2010 Aug 05; 116(5):687-92. View Pulmonary hypertension and nitric oxide depletion in sickle cell disease. Abstract
Musings on genome medicine: Hepatitis C. Genome Med. 2010 Jan 27; 2(1):4. View Musings on genome medicine: Hepatitis C. Abstract
Sickle cell disease and stroke. Blood. 2009 Dec 10; 114(25):5117-25. View Sickle cell disease and stroke. Abstract
Musings on genome medicine: enzyme-replacement therapy of the lysosomal storage diseases. Genome Med. 2009 Dec 09; 1(12):114. View Musings on genome medicine: enzyme-replacement therapy of the lysosomal storage diseases. Abstract
Musings on genome medicine: Crohn's disease. Genome Med. 2009 Nov 05; 1(11):103. View Musings on genome medicine: Crohn's disease. Abstract
Musings on genome medicine: the slow but inexorable process of medical care reform in the United States. Genome Med. 2009 Oct 12; 1(10):94. View Musings on genome medicine: the slow but inexorable process of medical care reform in the United States. Abstract
Call for a slower approach to health care reform. J Clin Invest. 2009 Oct; 119(10):2847-8. View Call for a slower approach to health care reform. Abstract
Musings on genome medicine: the Obama effect redux. Genome Med. 2009 Sep 11; 1(9):86. View Musings on genome medicine: the Obama effect redux. Abstract
Musings on genome medicine: cholesterol and coronary artery disease. Genome Med. 2009 Jun 08; 1(6):60. View Musings on genome medicine: cholesterol and coronary artery disease. Abstract
Musings on genome medicine: cancer genetics and the promise of effective treatment. Genome Med. 2009 May 06; 1(5):49. View Musings on genome medicine: cancer genetics and the promise of effective treatment. Abstract
Musings on genome medicine: gene therapy. Genome Med. 2009 Apr 03; 1(4):38. View Musings on genome medicine: gene therapy. Abstract
Musings on genome medicine: the Obama effect. Genome Med. 2009 Mar 09; 1(3):30. View Musings on genome medicine: the Obama effect. Abstract
Musings on genome medicine: abuse of genetic tests. Genome Med. 2009 Feb 16; 1(2):18. View Musings on genome medicine: abuse of genetic tests. Abstract
Musings on genome medicine: genome wide association studies. Genome Med. 2009 Jan 20; 1(1):3. View Musings on genome medicine: genome wide association studies. Abstract
Judah Folkman, MD, 1933-2008. Pharos Alpha Omega Alpha Honor Med Soc. 2009; 4-8. View Judah Folkman, MD, 1933-2008. Abstract
Targeting the cell death-survival equation. Clin Cancer Res. 2007 Dec 15; 13(24):7250-3. View Targeting the cell death-survival equation. Abstract
Stanley J. Korsmeyer. Proc Am Philos Soc. 2007 Jun; 151(2):243-6. View Stanley J. Korsmeyer. Abstract
Acceptance of the 2006 Kober medal. J Clin Invest. 2007 Apr; 117(4):1107-13. View Acceptance of the 2006 Kober medal. Abstract
The cancer treatment revolution. Trans Am Clin Climatol Assoc. 2007; 118:317-23. View The cancer treatment revolution. Abstract
Ribosomal protein S24 gene is mutated in Diamond-Blackfan anemia. Am J Hum Genet. 2006 Dec; 79(6):1110-8. View Ribosomal protein S24 gene is mutated in Diamond-Blackfan anemia. Abstract
NIH support for basic and clinical research: biomedical researcher angst in 2006. JAMA. 2006 Jun 14; 295(22):2656-8. View NIH support for basic and clinical research: biomedical researcher angst in 2006. Abstract
The several Cs of translational clinical research. J Clin Invest. 2005 Apr; 115(4):795-7. View The several Cs of translational clinical research. Abstract
New developments in iron chelators. Curr Opin Hematol. 2005 Mar; 12(2):129-34. View New developments in iron chelators. Abstract
Thalassemia: the continued challenge. Ann N Y Acad Sci. 2005; 1054:1-10. View Thalassemia: the continued challenge. Abstract
RNA and protein evidence for haplo-insufficiency in Diamond-Blackfan anaemia patients with RPS19 mutations. Br J Haematol. 2004 Oct; 127(1):105-13. View RNA and protein evidence for haplo-insufficiency in Diamond-Blackfan anaemia patients with RPS19 mutations. Abstract
Determination can win the battle. Lancet. 2004 Jul 17-23; 364(9430):301. View Determination can win the battle. Abstract
Acceptance of the 2003 John Howland Award: a journey in clinical research. Pediatr Res. 2004 Aug; 56(2):169-76. View Acceptance of the 2003 John Howland Award: a journey in clinical research. Abstract
Clinical research and the NIH--a report card. N Engl J Med. 2003 Nov 06; 349(19):1860-5. View Clinical research and the NIH--a report card. Abstract
First-trimester sex hormone binding globulin and subsequent gestational diabetes mellitus. Am J Obstet Gynecol. 2003 Jul; 189(1):171-6. View First-trimester sex hormone binding globulin and subsequent gestational diabetes mellitus. Abstract
Deferiprone and hepatic fibrosis. Blood. 2003 Jun 15; 101(12):5089-90; author reply 5090-1. View Deferiprone and hepatic fibrosis. Abstract
Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: a randomised, double-blind, placebo-controlled, dose-escalation trial. Lancet. 2003 May 10; 361(9369):1597-602. View Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: a randomised, double-blind, placebo-controlled, dose-escalation trial. Abstract
Deferiprone versus desferrioxamine in thalassaemia, and T2* validation and utility. Lancet. 2003 Jan 11; 361(9352):183; author reply 183-4. View Deferiprone versus desferrioxamine in thalassaemia, and T2* validation and utility. Abstract
Clinical research: a tale of two studies. Trans Am Clin Climatol Assoc. 2003; 114:219-30; discussion 230-2. View Clinical research: a tale of two studies. Abstract
Academic freedom in clinical research. N Engl J Med. 2002 Oct 24; 347(17):1368-71. View Academic freedom in clinical research. Abstract
A novel diagnostic screen for defects in the Fanconi anemia pathway. Blood. 2002 Dec 15; 100(13):4649-54. View A novel diagnostic screen for defects in the Fanconi anemia pathway. Abstract
Careers in translational clinical research-historical perspectives, future challenges. JAMA. 2002 May 08; 287(18):2424-7. View Careers in translational clinical research-historical perspectives, future challenges. Abstract
Educational-debt relief for clinical investigators--a vote of confidence. N Engl J Med. 2002 Jan 31; 346(5):372-4. View Educational-debt relief for clinical investigators--a vote of confidence. Abstract
Comprehensive cancer centres and the war on cancer. Nat Rev Cancer. 2001 Dec; 1(3):240-5. View Comprehensive cancer centres and the war on cancer. Abstract
Neurovisual abnormalities preceding the retinopathy in patients with long-term type 1 diabetes mellitus. Graefes Arch Clin Exp Ophthalmol. 2001 Sep; 239(9):643-8. View Neurovisual abnormalities preceding the retinopathy in patients with long-term type 1 diabetes mellitus. Abstract
Evidence for linkage of familial Diamond-Blackfan anemia to chromosome 8p23.3-p22 and for non-19q non-8p disease. Blood. 2001 Apr 01; 97(7):2145-50. View Evidence for linkage of familial Diamond-Blackfan anemia to chromosome 8p23.3-p22 and for non-19q non-8p disease. Abstract
The National Institutes of Health and clinical research: a progress report. Nat Med. 2000 Nov; 6(11):1201-4. View The National Institutes of Health and clinical research: a progress report. Abstract
Congenital bone marrow failure syndromes. Br J Haematol. 2000 Oct; 111(1):30-42. View Congenital bone marrow failure syndromes. Abstract
One-day ex vivo culture allows effective gene transfer into human nonobese diabetic/severe combined immune-deficient repopulating cells using high-titer vesicular stomatitis virus G protein pseudotyped retrovirus. Blood. 1999 Apr 01; 93(7):2217-24. View One-day ex vivo culture allows effective gene transfer into human nonobese diabetic/severe combined immune-deficient repopulating cells using high-titer vesicular stomatitis virus G protein pseudotyped retrovirus. Abstract
Academia and industry: lessons from the unfortunate events in Toronto. Lancet. 1999 Mar 06; 353(9155):771-2. View Academia and industry: lessons from the unfortunate events in Toronto. Abstract
Iron chelation with oral deferiprone in patients with thalassemia. N Engl J Med. 1998 Dec 03; 339(23):1711-2; author reply 1713-4. View Iron chelation with oral deferiprone in patients with thalassemia. Abstract
Clinical research: perceptions, reality, and proposed solutions. National Institutes of Health Director's Panel on Clinical Research. JAMA. 1998 Oct 28; 280(16):1427-31. View Clinical research: perceptions, reality, and proposed solutions. National Institutes of Health Director's Panel on Clinical Research. Abstract
Pioneers and modern ideas. Prospective on thalassemia. Pediatrics. 1998 Jul; 102(1 Pt 3):281-3; discussion 288-9. View Pioneers and modern ideas. Prospective on thalassemia. Abstract
The beta chain of the interleukin-3 receptor functionally associates with the erythropoietin receptor. Blood. 1997 Sep 01; 90(5):1867-73. View The beta chain of the interleukin-3 receptor functionally associates with the erythropoietin receptor. Abstract
The beta c component of the granulocyte-macrophage colony-stimulating factor (GM-CSF)/interleukin 3 (IL-3)/IL-5 receptor interacts with a hybrid GM-CSF/erythropoietin receptor to influence proliferation and beta-globin mRNA expression. Mol Med. 1996 Nov; 2(6):766-73. View The beta c component of the granulocyte-macrophage colony-stimulating factor (GM-CSF)/interleukin 3 (IL-3)/IL-5 receptor interacts with a hybrid GM-CSF/erythropoietin receptor to influence proliferation and beta-globin mRNA expression. Abstract
Cooperation between core binding factor and adjacent promoter elements contributes to the tissue-specific expression of interleukin-3. J Biol Chem. 1996 Jun 14; 271(24):14020-7. View Cooperation between core binding factor and adjacent promoter elements contributes to the tissue-specific expression of interleukin-3. Abstract
Diamond-Blackfan anemia. Natural history and sequelae of treatment. Medicine (Baltimore). 1996 Mar; 75(2):77-8. View Diamond-Blackfan anemia. Natural history and sequelae of treatment. Abstract
Iron Deficiency Anemia Associated with an Error of Iron Metabolism in Two Siblings: A Thirty Year Follow Up. Hematology. 1996; 1(1):65-73. View Iron Deficiency Anemia Associated with an Error of Iron Metabolism in Two Siblings: A Thirty Year Follow Up. Abstract
An orally active iron chelator. N Engl J Med. 1995 Apr 06; 332(14):953-4. View An orally active iron chelator. Abstract
Survival in medically treated patients with homozygous beta-thalassemia. N Engl J Med. 1994 Sep 01; 331(9):574-8. View Survival in medically treated patients with homozygous beta-thalassemia. Abstract
Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein. Blood. 1993 Feb 15; 81(4):928-34. View Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein. Abstract
Academic careers: choice and activity of graduates of a pediatric residency program 1974-1986. Trans Am Clin Climatol Assoc. 1993; 104:180-95; discussion 195-7. View Academic careers: choice and activity of graduates of a pediatric residency program 1974-1986. Abstract
Hydroxyurea-induced HbF production in anemic primates: augmentation by erythropoietin, hematopoietic growth factors, and sodium butyrate. Exp Hematol. 1992 Nov; 20(10):1156-64. View Hydroxyurea-induced HbF production in anemic primates: augmentation by erythropoietin, hematopoietic growth factors, and sodium butyrate. Abstract
A service chief model for general pediatric inpatient care and residency training. Pediatrics. 1992 Apr; 89(4 Pt 1):601-7. View A service chief model for general pediatric inpatient care and residency training. Abstract
Careers chosen by graduates of a major pediatrics residency program, 1974-1986. Acad Med. 1992 Apr; 67(4):272-4. View Careers chosen by graduates of a major pediatrics residency program, 1974-1986. Abstract
Restoration of phagocyte function by interferon-gamma in X-linked chronic granulomatous disease occurs at the level of a progenitor cell. Blood. 1990 Dec 15; 76(12):2443-8. View Restoration of phagocyte function by interferon-gamma in X-linked chronic granulomatous disease occurs at the level of a progenitor cell. Abstract
Intrinsic potential for high fetal hemoglobin production in a Druz family with beta-thalassemia is due to an unlinked genetic determinant. Hum Genet. 1990 Dec; 86(2):175-80. View Intrinsic potential for high fetal hemoglobin production in a Druz family with beta-thalassemia is due to an unlinked genetic determinant. Abstract
The effect of desferrithiocin, an oral iron chelator, on T-cell function. Blood. 1990 Nov 15; 76(10):2052-9. View The effect of desferrithiocin, an oral iron chelator, on T-cell function. Abstract
The treatment of Cooley's anemia. Haematologica. 1990 Sep-Oct; 75 Suppl 5:57-65. View The treatment of Cooley's anemia. Abstract
Treatment of Cooley's anemia. Blood. 1990 Aug 01; 76(3):435-44. View Treatment of Cooley's anemia. Abstract
Positive and negative elements regulate human interleukin 3 expression. Proc Natl Acad Sci U S A. 1990 Jul; 87(13):5046-50. View Positive and negative elements regulate human interleukin 3 expression. Abstract
Regulation of hematopoiesis. Pediatr Res. 1990 May; 27(5):423-31. View Regulation of hematopoiesis. Abstract
Oral iron chelators. Semin Hematol. 1990 Apr; 27(2):83-5. View Oral iron chelators. Abstract
Pharmacologic manipulation of fetal hemoglobin in the hemoglobinopathies. Ann N Y Acad Sci. 1990; 612:179-83. View Pharmacologic manipulation of fetal hemoglobin in the hemoglobinopathies. Abstract
The Jeremiah Metzger lecture. Regulation of hematopoiesis. Trans Am Clin Climatol Assoc. 1990; 101:135-53. View The Jeremiah Metzger lecture. Regulation of hematopoiesis. Abstract
The beneficence of neonatal hematopoiesis. N Engl J Med. 1989 Oct 26; 321(17):1190-1. View The beneficence of neonatal hematopoiesis. Abstract
Granulocyte-macrophage colony-stimulating factor and interleukin-3 mRNAs are produced by a small fraction of blood mononuclear cells. Blood. 1989 Oct; 74(5):1525-30. View Granulocyte-macrophage colony-stimulating factor and interleukin-3 mRNAs are produced by a small fraction of blood mononuclear cells. Abstract
Beta-thalassemia due to two novel nucleotide substitutions in consensus acceptor splice sequences of the beta-globin gene. Blood. 1989 Mar; 73(4):914-8. View Beta-thalassemia due to two novel nucleotide substitutions in consensus acceptor splice sequences of the beta-globin gene. Abstract
Expression of human interleukin-3 (multi-CSF) is restricted to human lymphocytes and T-cell tumor lines. Blood. 1989 Mar; 73(4):945-51. View Expression of human interleukin-3 (multi-CSF) is restricted to human lymphocytes and T-cell tumor lines. Abstract
Combinations of recombinant colony-stimulating factors are required for optimal hematopoietic differentiation in serum-deprived culture. Blood. 1989 Feb 15; 73(3):688-93. View Combinations of recombinant colony-stimulating factors are required for optimal hematopoietic differentiation in serum-deprived culture. Abstract
Saudi Arabian sickle cell anemia. A molecular approach. Ann N Y Acad Sci. 1989; 565:143-51. View Saudi Arabian sickle cell anemia. A molecular approach. Abstract
Regulation of the human interleukin-3 gene. Trans Assoc Am Physicians. 1989; 102:240-51. View Regulation of the human interleukin-3 gene. Abstract
Combinations of purified recombinant colony-stimulating factors are required for optimal hematopoietic differentiation. Trans Assoc Am Physicians. 1988; 101:282-7. View Combinations of purified recombinant colony-stimulating factors are required for optimal hematopoietic differentiation. Abstract
Decreased hematopoietic accessory cell function following bone marrow transplantation. Exp Hematol. 1987 Nov; 15(10):1013-21. View Decreased hematopoietic accessory cell function following bone marrow transplantation. Abstract
Leukemia and the regulation of hematopoiesis. Leukemia. 1987 Oct; 1(10):683-96. View Leukemia and the regulation of hematopoiesis. Abstract
Stimulation of human hematopoietic colony formation by recombinant gibbon multi-colony-stimulating factor or interleukin 3. J Clin Invest. 1987 Sep; 80(3):818-23. View Stimulation of human hematopoietic colony formation by recombinant gibbon multi-colony-stimulating factor or interleukin 3. Abstract
Analysis of hemoglobin F production in Saudi Arabian families with sickle cell anemia. Blood. 1987 Sep; 70(3):716-20. View Analysis of hemoglobin F production in Saudi Arabian families with sickle cell anemia. Abstract
Recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) shortens the period of neutropenia after autologous bone marrow transplantation in a primate model. J Clin Invest. 1987 Aug; 80(2):573-7. View Recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) shortens the period of neutropenia after autologous bone marrow transplantation in a primate model. Abstract
Molecular analysis of the high-hemoglobin-F phenotype in Saudi Arabian sickle cell anemia. N Engl J Med. 1987 Jan 29; 316(5):244-50. View Molecular analysis of the high-hemoglobin-F phenotype in Saudi Arabian sickle cell anemia. Abstract
Analysis of high fetal hemoglobin production in sickle cell anemia patients from the Eastern Province of Saudi Arabia. Prog Clin Biol Res. 1987; 251:415-26. View Analysis of high fetal hemoglobin production in sickle cell anemia patients from the Eastern Province of Saudi Arabia. Abstract
Regulation of fetal hemoglobin synthesis in sickle cell anemia. Trans Am Clin Climatol Assoc. 1987; 98:21-8. View Regulation of fetal hemoglobin synthesis in sickle cell anemia. Abstract
Investigations of the simian ontogenic switch from fetal to adult hemoglobin at the progenitor cell level. J Clin Invest. 1986 Dec; 78(6):1497-503. View Investigations of the simian ontogenic switch from fetal to adult hemoglobin at the progenitor cell level. Abstract
High fetal hemoglobin production in sickle cell anemia in the eastern province of Saudi Arabia is genetically determined. Blood. 1986 May; 67(5):1404-10. View High fetal hemoglobin production in sickle cell anemia in the eastern province of Saudi Arabia is genetically determined. Abstract
Dependence of highly enriched human bone marrow progenitors on hemopoietic growth factors and their response to recombinant erythropoietin. J Clin Invest. 1986 Jan; 77(1):74-81. View Dependence of highly enriched human bone marrow progenitors on hemopoietic growth factors and their response to recombinant erythropoietin. Abstract
Bone marrow transplantation for paroxysmal nocturnal hemoglobinuria: eradication of the PNH clone and documentation of complete lymphohematopoietic engraftment. Blood. 1985 Dec; 66(6):1247-50. View Bone marrow transplantation for paroxysmal nocturnal hemoglobinuria: eradication of the PNH clone and documentation of complete lymphohematopoietic engraftment. Abstract
Purification of fetal hematopoietic progenitors and demonstration of recombinant multipotential colony-stimulating activity. J Clin Invest. 1985 Sep; 76(3):1286-90. View Purification of fetal hematopoietic progenitors and demonstration of recombinant multipotential colony-stimulating activity. Abstract
Influence of cell cycle phase-specific agents on simian fetal hemoglobin synthesis. J Clin Invest. 1985 Jun; 75(6):1999-2005. View Influence of cell cycle phase-specific agents on simian fetal hemoglobin synthesis. Abstract
Determination of the hemoglobin F program in human progenitor-derived erythroid cells. J Clin Invest. 1985 Apr; 75(4):1359-68. View Determination of the hemoglobin F program in human progenitor-derived erythroid cells. Abstract
Identification of three accessory cell populations in human bone marrow with erythroid burst-promoting properties. J Clin Invest. 1985 Apr; 75(4):1278-84. View Identification of three accessory cell populations in human bone marrow with erythroid burst-promoting properties. Abstract
Current therapy and new approaches to the treatment of thalassemia major. Ann N Y Acad Sci. 1985; 445:248-55. View Current therapy and new approaches to the treatment of thalassemia major. Abstract
Regulation of fetal hemoglobin synthesis by cell cycle specific drugs. Prog Clin Biol Res. 1985; 191:475-500. View Regulation of fetal hemoglobin synthesis by cell cycle specific drugs. Abstract
Regulation of fetal hemoglobin synthesis in the hemoglobinopathies. Ann N Y Acad Sci. 1985; 445:177-87. View Regulation of fetal hemoglobin synthesis in the hemoglobinopathies. Abstract
Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia. J Clin Invest. 1984 Aug; 74(2):652-6. View Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia. Abstract
Augmentation of fetal-hemoglobin production in anemic monkeys by hydroxyurea. N Engl J Med. 1984 Apr 05; 310(14):869-73. View Augmentation of fetal-hemoglobin production in anemic monkeys by hydroxyurea. Abstract
Hydroxyurea increases fetal hemoglobin production in sickle cell anemia. Trans Assoc Am Physicians. 1984; 97:268-74. View Hydroxyurea increases fetal hemoglobin production in sickle cell anemia. Abstract
Nutrition classics: the Journal of Clinical Investigation, volume 43, 1964. Iron deficiency anemia associated with an error of iron metabolism in two siblings. Nutr Rev. 1983 Oct; 41(10):315-7. View Nutrition classics: the Journal of Clinical Investigation, volume 43, 1964. Iron deficiency anemia associated with an error of iron metabolism in two siblings. Abstract
Evidence for genetic restriction in the suppression of erythropoiesis by a unique subset of T lymphocytes in man. J Clin Invest. 1983 Aug; 72(2):694-706. View Evidence for genetic restriction in the suppression of erythropoiesis by a unique subset of T lymphocytes in man. Abstract
Synthesis of hemoglobin F in adult simian erythroid progenitor-derived colonies. J Clin Invest. 1982 Oct; 70(4):752-61. View Synthesis of hemoglobin F in adult simian erythroid progenitor-derived colonies. Abstract
Clinical removal of iron. Annu Rev Med. 1982; 33:509-19. View Clinical removal of iron. Abstract
Exercise-induced hemolysis in xerocytosis. Erythrocyte dehydration and shear sensitivity. J Clin Invest. 1981 Sep; 68(3):631-8. View Exercise-induced hemolysis in xerocytosis. Erythrocyte dehydration and shear sensitivity. Abstract
Heterogeneity of DNA deletion in gamma delta beta-thalassemia. J Clin Invest. 1981 Mar; 67(3):878-84. View Heterogeneity of DNA deletion in gamma delta beta-thalassemia. Abstract
Control of the simian fetal hemoglobin switch at the progenitor cell level. J Clin Invest. 1981 Feb; 67(2):458-66. View Control of the simian fetal hemoglobin switch at the progenitor cell level. Abstract
The molecular genetics of thalassemia. Adv Hum Genet. 1981; 11:233-80. View The molecular genetics of thalassemia. Abstract
Treatment of acute myelogenous leukemia in children and adults. N Engl J Med. 1980 Aug 28; 303(9):473-8. View Treatment of acute myelogenous leukemia in children and adults. Abstract
Aplastic and hypoplastic anemia. Pediatr Clin North Am. 1980 May; 27(2):217-35. View Aplastic and hypoplastic anemia. Abstract
New approaches to the transfusion management of thalassemia. Blood. 1980 Jan; 55(1):55-60. View New approaches to the transfusion management of thalassemia. Abstract
F-cell regulation. Ann N Y Acad Sci. 1980; 344:219-32. View F-cell regulation. Abstract
Monocytes do not inhibit peripheral blood erythroid burst forming unit colony formation. J Clin Invest. 1980 Jan; 65(1):219-23. View Monocytes do not inhibit peripheral blood erythroid burst forming unit colony formation. Abstract
Prenatal diagnosis of hemoglobinopathies: the New England approach. Ann N Y Acad Sci. 1980; 344:151-64. View Prenatal diagnosis of hemoglobinopathies: the New England approach. Abstract
Prenatal diagnosis of hemoglobinopathies. Clin Perinatol. 1979 Sep; 6(2):275-91. View Prenatal diagnosis of hemoglobinopathies. Abstract
Progress in thalassemia research. Nature. 1979 Jul 26; 280(5720):275-6. View Progress in thalassemia research. Abstract
The molecular basis of alpha-thalassemias: frequent occurrence of dysfunctional alpha loci among non-Asians with Hb H disease. Cell. 1979 May; 17(1):33-42. View The molecular basis of alpha-thalassemias: frequent occurrence of dysfunctional alpha loci among non-Asians with Hb H disease. Abstract
Partial deletion of beta-globin gene DNA in certain patients with beta 0-thalassemia. Proc Natl Acad Sci U S A. 1979 May; 76(5):2400-4. View Partial deletion of beta-globin gene DNA in certain patients with beta 0-thalassemia. Abstract
Application of endonuclease mapping to the analysis and prenatal diagnosis of thalassemias caused by globin-gene deletion. N Engl J Med. 1978 Jul 27; 299(4):166-72. View Application of endonuclease mapping to the analysis and prenatal diagnosis of thalassemias caused by globin-gene deletion. Abstract
Antenatal diagnosis of thalassaemia major. Br Med J. 1978 Feb 11; 1(6109):350-3. View Antenatal diagnosis of thalassaemia major. Abstract
Erythroid precursors in congenital hypoplastic (Diamond-Blackfan) anemia. J Clin Invest. 1978 Feb; 61(2):489-98. View Erythroid precursors in congenital hypoplastic (Diamond-Blackfan) anemia. Abstract
Treatment of iron overload in adults with continuous parenteral desferrioxamine. Am J Med. 1977 Dec; 63(6):958-66. View Treatment of iron overload in adults with continuous parenteral desferrioxamine. Abstract
Continuous subcutaneous administration of deferoxamine in patients with iron overload. N Engl J Med. 1977 08 25; 297(8):418-23. View Continuous subcutaneous administration of deferoxamine in patients with iron overload. Abstract
Evaluation of continuous desferrioxamine administration in adults with transfusional hemosiderosis. Trans Assoc Am Physicians. 1977; 90:335-41. View Evaluation of continuous desferrioxamine administration in adults with transfusional hemosiderosis. Abstract
Prenatal diagnosis of hemoglobinopathies: detection of alpha-thalassemia trait and of sickle cell disease in utero. Hemoglobin. 1977; 1(4):395-400. View Prenatal diagnosis of hemoglobinopathies: detection of alpha-thalassemia trait and of sickle cell disease in utero. Abstract
Fetal research: an investigator's view. Villanova Law Rev. 1977 Jan; 22(2):384-94. View Fetal research: an investigator's view. Abstract
Prenatal diagnosis of hemoglobinopathies. A review of 15 cases. N Engl J Med. 1976 Dec 23; 295(26):1437-43. View Prenatal diagnosis of hemoglobinopathies. A review of 15 cases. Abstract
The thalassemias. N Engl J Med. 1976 Sep 23; 295(13):710-4. View The thalassemias. Abstract
Reassessment of the use of desferrioxamine B in iron overload. N Engl J Med. 1976 Jun 24; 294(26):1421-3. View Reassessment of the use of desferrioxamine B in iron overload. Abstract
Prenatal diagnosis of sickle-cell anemia and alpha G Philadelphia. Study of a Fetus also at risk for H b S/beta+-thalassemia. N Engl J Med. 1976 May 06; 294(19):1040-1. View Prenatal diagnosis of sickle-cell anemia and alpha G Philadelphia. Study of a Fetus also at risk for H b S/beta+-thalassemia. Abstract
The acute and transient nature of idiopathic immune hemolytic anemia in childhood. J Pediatr. 1976 May; 88(5):780-3. View The acute and transient nature of idiopathic immune hemolytic anemia in childhood. Abstract
Molecular pathology of the thalassemias. Adv Intern Med. 1976; 21:97-128. View Molecular pathology of the thalassemias. Abstract
The molecular genetics of thalassemia. Birth Defects Orig Artic Ser. 1976; 12(8):145-59. View The molecular genetics of thalassemia. Abstract
Expression of the beta-thalassemia gene in the first trimester fetus. Proc Natl Acad Sci U S A. 1975 Sep; 72(9):3633-7. View Expression of the beta-thalassemia gene in the first trimester fetus. Abstract
Antenatal diagnosis of hemoglobinopathies: social and technical considerations. Semin Hematol. 1975 Jul; 12(3):305-21. View Antenatal diagnosis of hemoglobinopathies: social and technical considerations. Abstract
Hemoglobin Syracuse (alpha2beta2-143(H21)His leads to Pro), a new high-affinity variant detected by special electrophoretic methods. Observations on the auto-oxidation of normal and variant hemoglobins. J Clin Invest. 1975 Mar; 55(3):469-77. View Hemoglobin Syracuse (alpha2beta2-143(H21)His leads to Pro), a new high-affinity variant detected by special electrophoretic methods. Observations on the auto-oxidation of normal and variant hemoglobins. Abstract
Thalassemia. Annu Rev Med. 1975; 26:345-51. View Thalassemia. Abstract
Progress in the methodology for antenatal diagnosis of the beta chain hemoglobinopathies. Trans Assoc Am Physicians. 1975; 88:168-76. View Progress in the methodology for antenatal diagnosis of the beta chain hemoglobinopathies. Abstract
Ethical problems in fetal research. J Gen Educ. 1975; 27(3):165-75. View Ethical problems in fetal research. Abstract
Globin translation in thalassemic bone marrow. Ann N Y Acad Sci. 1974 Nov 29; 241(0):253-61. View Globin translation in thalassemic bone marrow. Abstract
In utero diagnosis of hemoglobinopathies. Hemoglobin synthesis in fetal red cells. N Engl J Med. 1974 05 09; 290(19):1067-8. View In utero diagnosis of hemoglobinopathies. Hemoglobin synthesis in fetal red cells. Abstract
Relation of beta to gamma synthesis during the first trimester: an approach to prenatal diagnosis of thalassemia. Pediatr Res. 1974 May; 8(5):553-60. View Relation of beta to gamma synthesis during the first trimester: an approach to prenatal diagnosis of thalassemia. Abstract
Intrauterine diagnosis of thalassemia. Ann N Y Acad Sci. 1974; 232(0):145-51. View Intrauterine diagnosis of thalassemia. Abstract
Translational control of hemoglobin synthesis in thalassemic bone marrow. Ann N Y Acad Sci. 1974; 232(0):40-3. View Translational control of hemoglobin synthesis in thalassemic bone marrow. Abstract
Effects of cyanate and 2,3-diphosphoglycerate on sickling. Relationship to oxygenation. J Clin Invest. 1973 Oct; 52(10):2542-7. View Effects of cyanate and 2,3-diphosphoglycerate on sickling. Relationship to oxygenation. Abstract
The mortality of acquired aplastic anemia in children. Blood. 1972 Aug; 40(2):153-62. View The mortality of acquired aplastic anemia in children. Abstract
Equal synthesis of - and -globin chains in erythroid precursors in heterozygous -thalassemia. J Clin Invest. 1972 Jul; 51(7):1906-9. View Equal synthesis of - and -globin chains in erythroid precursors in heterozygous -thalassemia. Abstract
Energy metabolism in human erythrocytes. II. Effects of glucose depletion. J Clin Invest. 1972 Jun; 51(6):1547-54. View Energy metabolism in human erythrocytes. II. Effects of glucose depletion. Abstract
Thalassemia. N Engl J Med. 1972 Mar 16; 286(11):586-94. View Thalassemia. Abstract
Changes in fatty acid metabolism after erythrocyte peroxidation: stimulation of a membrane repair process. J Clin Invest. 1972 Feb; 51(2):338-44. View Changes in fatty acid metabolism after erythrocyte peroxidation: stimulation of a membrane repair process. Abstract
Gamma-beta thalassemia: a cause of hemolytic disease of the newborn. N Engl J Med. 1972 Jan 20; 286(3):129-34. View Gamma-beta thalassemia: a cause of hemolytic disease of the newborn. Abstract
Oxidant injury of caucasian glucose-6-phosphate dehydrogenase-deficient red blood cells by phagocytosing leukocytes during infection. J Clin Invest. 1971 Dec; 50(12):2466-73. View Oxidant injury of caucasian glucose-6-phosphate dehydrogenase-deficient red blood cells by phagocytosing leukocytes during infection. Abstract
Amino acid oxidase of leukocytes in relation to H 2 O 2 -mediated bacterial killing. J Clin Invest. 1971 Sep; 50(9):1985-91. View Amino acid oxidase of leukocytes in relation to H 2 O 2 -mediated bacterial killing. Abstract
Energy metabolism in human erythrocytes. I. Effects of sodium fluoride. J Clin Invest. 1971 Aug; 50(8):1731-7. View Energy metabolism in human erythrocytes. I. Effects of sodium fluoride. Abstract
Selective reticulocyte destruction in erythrocyte pyruvate kinase deficiency. J Clin Invest. 1971 Mar; 50(3):688-99. View Selective reticulocyte destruction in erythrocyte pyruvate kinase deficiency. Abstract
Endogenous production of carbon monoxide in normal and erythroblastotic newborn infants. J Clin Invest. 1971 Jan; 50(1):1-8. View Endogenous production of carbon monoxide in normal and erythroblastotic newborn infants. Abstract
Normal and variant isoenzymes of human blood cell hexokinase and the isoenzyme patterns in hemolytic anemia. Blood. 1970 Aug; 36(2):219-27. View Normal and variant isoenzymes of human blood cell hexokinase and the isoenzyme patterns in hemolytic anemia. Abstract
Correction of metabolic deficiencies in the leukocytes of patients with chronic granulomatous disease. J Clin Invest. 1970 May; 49(5):865-70. View Correction of metabolic deficiencies in the leukocytes of patients with chronic granulomatous disease. Abstract
Mild thalassemia: the result of interactions of alpha and beta thalassemia genes. J Clin Invest. 1970 Apr; 49(4):635-42. View Mild thalassemia: the result of interactions of alpha and beta thalassemia genes. Abstract
Mild thalassemia--a guide to therapy. N Engl J Med. 1969 Dec 11; 281(24):1363-4. View Mild thalassemia--a guide to therapy. Abstract
Unbalanced globin chain synthesis in alpha-thalassemia heterozygotes. Ann N Y Acad Sci. 1969 Nov 20; 165(1):288-94. View Unbalanced globin chain synthesis in alpha-thalassemia heterozygotes. Abstract
Globin chain synthesis in the alpha thalassemia syndromes. J Clin Invest. 1969 Nov; 47(11):2512-22. View Globin chain synthesis in the alpha thalassemia syndromes. Abstract
Failure of nitro blue tetrazolium reduction in the phagocytic vacuoles of leukocytes in chronic granulomatous disease. J Clin Invest. 1969 Oct; 48(10):1895-904. View Failure of nitro blue tetrazolium reduction in the phagocytic vacuoles of leukocytes in chronic granulomatous disease. Abstract
Influence of hemoglobin precipitation on erythrocyte metabolism in alpha and beta thalassemia. J Clin Invest. 1969 Jan; 48(1):33-41. View Influence of hemoglobin precipitation on erythrocyte metabolism in alpha and beta thalassemia. Abstract
Stages in the incorporation of fatty acids into red blood cells. J Clin Invest. 1968 May; 47(5):1096-108. View Stages in the incorporation of fatty acids into red blood cells. Abstract
Erythrocyte production and metabolism in anephric and uremic men. Ann N Y Acad Sci. 1968 Mar 29; 149(1):539-43. View Erythrocyte production and metabolism in anephric and uremic men. Abstract
Hemoglobin F and beta thalassemia. Science. 1967 Sep 01; 157(3792):1079. View Hemoglobin F and beta thalassemia. Abstract
THE METABOLISM OF THE INDIVIDUAL C14 LABELED HEMOGLOBINS IN PATIENTS WITH H-THALASSEMIA, WITH OBSERVATIONS ON RADIOCHROMATE BINDING TO THE HEMOGLOBINS DURING RED CELL SURVIVAL. J Clin Invest. 1965 Feb; 44:315-25. View THE METABOLISM OF THE INDIVIDUAL C14 LABELED HEMOGLOBINS IN PATIENTS WITH H-THALASSEMIA, WITH OBSERVATIONS ON RADIOCHROMATE BINDING TO THE HEMOGLOBINS DURING RED CELL SURVIVAL. Abstract
ERYTHROPOIESIS IN ANEPHRIC MAN. J Clin Invest. 1964 Nov; 43:2158-65. View ERYTHROPOIESIS IN ANEPHRIC MAN. Abstract
THALASSEMIA TRAIT. GENETIC COMBINATIONS OF INCREASED FETAL AND A2 HEMOGLOBINS. N Engl J Med. 1964 Jun 04; 270:1212-7. View THALASSEMIA TRAIT. GENETIC COMBINATIONS OF INCREASED FETAL AND A2 HEMOGLOBINS. Abstract
IRON DEFICIENCY ANEMIA ASSOCIATED WITH AN ERROR OF IRON METABOLISM IN TWO SIBLINGS. J Clin Invest. 1964 Mar; 43:510-21. View IRON DEFICIENCY ANEMIA ASSOCIATED WITH AN ERROR OF IRON METABOLISM IN TWO SIBLINGS. Abstract
THE TURNOVER OF HEMOGLOBINS A, F, AND A(2) IN THE PERIPHERAL BLOOD OF THREE PATIENTS WITH THALASSEMIA. J Clin Invest. 1963 Nov; 42(11):1678-88. View THE TURNOVER OF HEMOGLOBINS A, F, AND A(2) IN THE PERIPHERAL BLOOD OF THREE PATIENTS WITH THALASSEMIA. Abstract
THE EFFECT OF ANDROGENS ON SOME ASPECTS OF BODY COMPOSITION AND ERYTHROPOISIS IN OCTOGENARIAN MALES. Ann N Y Acad Sci. 1963 Sep 26; 110:965-77. View THE EFFECT OF ANDROGENS ON SOME ASPECTS OF BODY COMPOSITION AND ERYTHROPOISIS IN OCTOGENARIAN MALES. Abstract
Erythroid cell maturation and hemoglobin synthesis in megaloblastic anemia. J Clin Invest. 1962 May; 41:1086-93. View Erythroid cell maturation and hemoglobin synthesis in megaloblastic anemia. Abstract
The synthesis of heme and globin in the maturing human erythroid cell. J Clin Invest. 1961 Jun; 40:940-6. View The synthesis of heme and globin in the maturing human erythroid cell. Abstract
Hypochromic anemia and hemochromatosis--response to combined testosterone, pyridoxine, and liver extract therapy. Trans Am Clin Climatol Assoc. 1961; 73:121-35. View Hypochromic anemia and hemochromatosis--response to combined testosterone, pyridoxine, and liver extract therapy. Abstract
The passage of ammonia across the blood-brain-barrier and its relation to blood pH. J Clin Invest. 1958 Dec; 37(12):1724-8. View The passage of ammonia across the blood-brain-barrier and its relation to blood pH. Abstract